ATE543810T1 - Hemmer des 5-lipoxygenase aktivierenden proteins (flap) - Google Patents

Hemmer des 5-lipoxygenase aktivierenden proteins (flap)

Info

Publication number
ATE543810T1
ATE543810T1 AT07837478T AT07837478T ATE543810T1 AT E543810 T1 ATE543810 T1 AT E543810T1 AT 07837478 T AT07837478 T AT 07837478T AT 07837478 T AT07837478 T AT 07837478T AT E543810 T1 ATE543810 T1 AT E543810T1
Authority
AT
Austria
Prior art keywords
lipoxygenase
inhibitors
flap
activate protein
formula
Prior art date
Application number
AT07837478T
Other languages
English (en)
Inventor
Anthony Ogawa
Feroze Ujjainwalla
Bunte Ellen Vande
Lin Chu
Debra Ondeyka
Ihor Kopka
Bing Li
Hyun Ok
Minal Patel
Jinyou Xu
Rosemary Sisco
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE543810T1 publication Critical patent/ATE543810T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
AT07837478T 2006-09-01 2007-08-29 Hemmer des 5-lipoxygenase aktivierenden proteins (flap) ATE543810T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84175806P 2006-09-01 2006-09-01
US93388607P 2007-06-08 2007-06-08
US96159807P 2007-07-23 2007-07-23
PCT/US2007/018991 WO2008030369A1 (en) 2006-09-01 2007-08-29 Inhibitors of 5 -lipoxygenase activating protein ( flap)

Publications (1)

Publication Number Publication Date
ATE543810T1 true ATE543810T1 (de) 2012-02-15

Family

ID=38925607

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07837478T ATE543810T1 (de) 2006-09-01 2007-08-29 Hemmer des 5-lipoxygenase aktivierenden proteins (flap)

Country Status (7)

Country Link
US (1) US8440672B2 (de)
EP (1) EP2064204B1 (de)
JP (1) JP2010502615A (de)
AT (1) ATE543810T1 (de)
AU (1) AU2007293373A1 (de)
CA (1) CA2666686A1 (de)
WO (1) WO2008030369A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2013174B1 (de) 2006-04-11 2013-05-08 Merck Sharp & Dohme Corp. Substituierte diarylalkane
JP2010502615A (ja) 2006-09-01 2010-01-28 メルク エンド カムパニー インコーポレーテッド ５−リポキシゲナーゼ活性化タンパク質（ｆｌａｐ）の阻害剤
AU2008266960A1 (en) * 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. Diphenyl substituted alkanes
JP5552121B2 (ja) 2008-09-04 2014-07-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のインドリジン阻害剤
US20110201649A1 (en) * 2008-09-19 2011-08-18 Sumitomo Chemical Company, Limited agricultural composition
EP2509975B1 (de) 2009-12-04 2014-04-23 Boehringer Ingelheim International GmbH Benzimidazolhemmer der leukotrienproduktion
US9518032B2 (en) 2010-04-30 2016-12-13 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of USP1 deubiquitinating enzyme activity
AU2011292285A1 (en) * 2010-08-16 2013-01-31 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
EP2609092B1 (de) 2010-08-26 2015-04-01 Boehringer Ingelheim International GmbH Oxadiazolhemmer der leukotrienproduktion
US8580825B2 (en) 2010-09-23 2013-11-12 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
BR112013008638A2 (pt) * 2010-09-23 2016-06-21 Boehringer Ingelheim Int inibidores de oxadiazol de produção de leucotrieno
JP5928958B2 (ja) 2010-10-29 2016-06-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のベンゾイミダゾールインヒビター
JP5789888B2 (ja) 2010-11-01 2015-10-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のベンゾイミダゾールインヒビター
EP2651930B1 (de) 2010-12-16 2015-10-28 Boehringer Ingelheim International GmbH Biarylamidhemmer der leukotrienproduktion
WO2013116182A1 (en) * 2012-01-31 2013-08-08 Boehringer Ingelheim International Gmbh Heterocyclic compounds as inhibitors of leukotriene production
AR089853A1 (es) * 2012-02-01 2014-09-24 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso
EP2865756A1 (de) 2013-10-22 2015-04-29 Sylentis, S.A.U. siRNA und deren Verwendung in Verfahren und Zusammensetzungen zur Hemmung der Expression des FLAP-Gens
US9725425B1 (en) 2014-02-25 2017-08-08 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer
WO2016065584A1 (en) * 2014-10-30 2016-05-06 Merck Sharp & Dohme Corp. Piperidine oxadiazole and thiadiazole orexin receptor antagonists
WO2016149126A1 (en) 2015-03-13 2016-09-22 The Board Of Trustees Of The Leland Stanford Junior University Ltb4 inhibition to prevent and treat human lymphedema

Family Cites Families (24)

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HU186654B (en) * 1982-12-28 1985-09-30 Richter Gedeon Vegyeszet Process for producing new pyridine derivatives, acid additional salts and quaternary salts and pharmaceutical compositions containing them
US4853398A (en) * 1987-04-13 1989-08-01 Eli Lilly And Company Leukotriene antagonists and use thereas
US6051573A (en) * 1994-06-28 2000-04-18 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with non-steroidal glucocorticoid antagonists
US5668146A (en) 1995-10-03 1997-09-16 Abbott Laboratories Symmetrical bis-heteroarylmethoxyphenyliminoxyalkyl carboxylates as inhibitors of leukotriene biosynthesis
US5795900A (en) * 1995-10-03 1998-08-18 Abbott Laboratories Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis
US6468781B1 (en) * 1999-07-08 2002-10-22 Bristol-Myers Squibb Company Stereoselective reductive amination of ketones
EP1097236A4 (de) * 1998-07-15 2006-10-04 Bristol Myers Squibb Co Stereoselective, reduktive Aminierung von Ketonen
CA2364653A1 (en) * 1999-02-25 2000-08-31 Merck Frosst Canada & Co. Pde iv inhibiting compounds, compositions and methods of treatment
AU2002215360A1 (en) * 2000-10-17 2002-04-29 Pcbu Services, Inc. Production of alpha-hydroxy-carboxylic acids using a coupled enzyme system
DE10112401A1 (de) * 2001-03-13 2002-09-19 Degussa Alkohol-Dehydrogenase und deren Verwendung
US20040104937A1 (en) * 2001-03-26 2004-06-03 Hyun-Gi An Multimedia calendar system
JP2007524615A (ja) 2003-06-20 2007-08-30 コーリー ファーマシューティカル ゲーエムベーハー 低分子トール様レセプター（ｔｌｒ）アンタゴニスト
CN1829519A (zh) 2003-07-24 2006-09-06 默克公司 二苯基取代的环烷烃类,含有它们的组合物和应用的方法
CA2561267A1 (en) * 2004-03-30 2005-10-20 Merck & Co., Inc. 2-aminothiazole compounds useful as aspartyl protease inhibitors
WO2006044602A2 (en) 2004-10-18 2006-04-27 Merck & Co., Inc. Diphenyl substituted alkanes as flap inhiibitors
AU2006223508A1 (en) 2005-03-09 2006-09-21 Merck Frosst Canada Ltd Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use
UY29610A1 (es) * 2005-06-21 2007-01-31 Cancer Rec Tech Ltd Aril-alquilaminas y heteroaril-alquilaminas como inhibidores de la quinasa proteínica
EP1911738A4 (de) * 2005-07-29 2009-12-16 Takeda Pharmaceutical Phenoxyalkansäureverbindung
EP1954128A4 (de) 2005-11-04 2010-09-22 Merck Sharp & Dohme Diphenylmethanderivate als hemmer der leukotrien-biosynthese
EP2013174B1 (de) 2006-04-11 2013-05-08 Merck Sharp & Dohme Corp. Substituierte diarylalkane
JP2010502615A (ja) 2006-09-01 2010-01-28 メルク エンド カムパニー インコーポレーテッド ５−リポキシゲナーゼ活性化タンパク質（ｆｌａｐ）の阻害剤
AU2008266960A1 (en) 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. Diphenyl substituted alkanes
EP2209761A4 (de) * 2007-10-10 2012-01-04 Merck Sharp & Dohme Diphenyl-substituierte cycloalkane
AU2009217518A1 (en) 2008-02-28 2009-09-03 Merck Sharp & Dohme Corp. 2-aminoimidazole beta-secretase inhibitors for the treatment of Alzheimer's disease

Also Published As

Publication number Publication date
EP2064204A1 (de) 2009-06-03
US8440672B2 (en) 2013-05-14
EP2064204B1 (de) 2012-02-01
US20100168076A1 (en) 2010-07-01
WO2008030369A1 (en) 2008-03-13
AU2007293373A1 (en) 2008-03-13
CA2666686A1 (en) 2008-03-13
JP2010502615A (ja) 2010-01-28

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