ATE54417T1 - Radioaktiv markierte antikoerperstuecke. - Google Patents
Radioaktiv markierte antikoerperstuecke.Info
- Publication number
- ATE54417T1 ATE54417T1 AT85306486T AT85306486T ATE54417T1 AT E54417 T1 ATE54417 T1 AT E54417T1 AT 85306486 T AT85306486 T AT 85306486T AT 85306486 T AT85306486 T AT 85306486T AT E54417 T1 ATE54417 T1 AT E54417T1
- Authority
- AT
- Austria
- Prior art keywords
- radionuclide metal
- radiotagged
- antibody fragments
- metal ions
- disclosed
- Prior art date
Links
- 229910021645 metal ion Inorganic materials 0.000 abstract 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000004697 chelate complex Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000007822 coupling agent Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/650,127 US4837003A (en) | 1984-09-13 | 1984-09-13 | Radiolabeled antibody fragments |
| EP85306486A EP0174853B1 (de) | 1984-09-13 | 1985-09-12 | Radioaktiv markierte Antikörperstücke |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE54417T1 true ATE54417T1 (de) | 1990-07-15 |
Family
ID=24607586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85306486T ATE54417T1 (de) | 1984-09-13 | 1985-09-12 | Radioaktiv markierte antikoerperstuecke. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4837003A (de) |
| EP (3) | EP0174853B1 (de) |
| JP (1) | JPH0647557B2 (de) |
| AT (1) | ATE54417T1 (de) |
| AU (1) | AU595164B2 (de) |
| CA (1) | CA1276878C (de) |
| DE (1) | DE3578625D1 (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4659839A (en) * | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
| US5393512A (en) * | 1985-01-14 | 1995-02-28 | Vanderheyden; Jean-Luc | Stable therapeutic radionuclide compositions and methods for preparation thereof |
| US4732974A (en) * | 1986-03-05 | 1988-03-22 | Mallinckrodt, Inc. | Metal ion labeling of carrier molecules |
| US5082930A (en) * | 1986-05-29 | 1992-01-21 | Mallinckrodt Medical, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| DE3728599A1 (de) * | 1986-12-10 | 1988-06-23 | Hoechst Ag | Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz |
| US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
| US5227474A (en) * | 1987-02-13 | 1993-07-13 | Abbott Laboratories | Bifunctional chelating agents |
| US5245026A (en) * | 1987-09-24 | 1993-09-14 | Abbott Laboratories | Metal containing 8-hydroxyquinoline chelating agents |
| US5021567A (en) * | 1987-09-24 | 1991-06-04 | Abbott Laboratories | 8-hydroxyquinoline chelating agents |
| AU619218B2 (en) * | 1987-11-06 | 1992-01-23 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
| US5612016A (en) * | 1988-04-01 | 1997-03-18 | Immunomedics, Inc. | Conjugates of antibodies and bifunctional ligands |
| EP0339389B1 (de) * | 1988-04-25 | 1993-09-22 | F. Hoffmann-La Roche Ag | Diagnose-Hilfsmittel |
| US5094950A (en) * | 1988-06-07 | 1992-03-10 | Nihon Medi-Physics Co., Ltd. | Diethylenetriamine pentaacetic acid derivatives |
| US5250702A (en) * | 1988-06-07 | 1993-10-05 | Nihon Medi-Physics Co., Ltd. | Diethylenetriamine pentaacetic acid derivatives |
| US5208007A (en) * | 1988-11-22 | 1993-05-04 | Board Of Regents Of The University Of Oklahoma | Isotopic tracer composition and method for making and using same |
| EP0493526A4 (en) * | 1989-09-22 | 1992-08-26 | Neorx Corporation | Stable therapeutic radionuclide compositions and methods for preparation thereof |
| US5273743A (en) * | 1990-03-09 | 1993-12-28 | Hybritech Incorporated | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
| US5091542A (en) * | 1990-03-09 | 1992-02-25 | Hybritech Incorporated | Tris-maleimido compounds as intermediates in trifunctional antibody synthesis |
| US5011676A (en) * | 1990-03-27 | 1991-04-30 | Thomas Jefferson University | Method to directly radiolabel antibodies for diagnostic imaging and therapy |
| US5219556A (en) * | 1990-07-09 | 1993-06-15 | Mallinckrodt Medical, Inc. | Stabilized therapeutic radiopharmaceutical complexes |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| CA2070961C (en) * | 1991-06-14 | 2004-12-07 | Michael Chorev | Thiol-reactive maleimido-based radiolabeling reagents |
| GB9123947D0 (en) * | 1991-11-12 | 1992-01-02 | Imp Cancer Res Tech | Therapeutic compounds |
| US5371184A (en) * | 1992-02-05 | 1994-12-06 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
| ATE203417T1 (de) * | 1992-02-05 | 2001-08-15 | Mallinckrodt Inc | Radioaktiv markierte somatostatin |
| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US6749853B1 (en) * | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| WO1993017719A1 (en) * | 1992-03-13 | 1993-09-16 | Diatech, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR IMAGING INFLAMMATION |
| US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5346686A (en) * | 1992-10-05 | 1994-09-13 | Mallinckrodt Medical, Inc. | Labelled interleukin-8 and medical uses thereof |
| US5605671A (en) * | 1992-10-05 | 1997-02-25 | The Regents Of The University Of Michigan | Radiolabeled neutrophil activating peptides for imaging |
| US5413778A (en) * | 1992-10-05 | 1995-05-09 | The Regents Of The University Of Michigan | Labelled monocyte chemoattractant protein material and medical uses thereof |
| WO1994009128A1 (en) * | 1992-10-22 | 1994-04-28 | Mallinckrodt Medical, Inc. | Therapeutic treatment for inhibiting vascular restenosis |
| DE19505960A1 (de) * | 1995-02-21 | 1996-08-22 | Deutsches Krebsforsch | Konjugat zur individuellen Dosierung von Arzneimitteln |
| EP0932417B1 (de) * | 1996-10-17 | 2003-03-05 | Immunomedics, Inc. | Nichtantigenes toxinkonjugat und fusionsprotein eines internalisierendes rezeptorsystems |
| NZ508873A (en) * | 1998-07-13 | 2003-10-31 | Univ Texas | Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids |
| ES2533255T3 (es) * | 1998-07-13 | 2015-04-08 | Board Of Regents, The University Of Texas System | Utilización de anticuerpos anti-aminofosfolípidos para el tratamiento del cáncer |
| US6406693B1 (en) * | 1998-07-13 | 2002-06-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
| US6818213B1 (en) * | 1998-07-13 | 2004-11-16 | Board Of Regents, The University Of Texas System | Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids |
| US20020197694A1 (en) * | 2001-06-20 | 2002-12-26 | Weiping Shao | Conjugates of reduced antibodies and biomolecules |
| US20030031627A1 (en) * | 2001-07-31 | 2003-02-13 | Mallinckrodt Inc. | Internal image antibodies for optical imaging and therapy |
| US9487823B2 (en) | 2002-12-20 | 2016-11-08 | Qiagen Gmbh | Nucleic acid amplification |
| US8043834B2 (en) * | 2003-03-31 | 2011-10-25 | Qiagen Gmbh | Universal reagents for rolling circle amplification and methods of use |
| EP1641829A1 (de) * | 2003-07-09 | 2006-04-05 | Schering AG | Emitter-bindende peptide die eine ver nderung der spektralen emissionseigenschaften des emitters bewirken |
| US8309303B2 (en) | 2005-04-01 | 2012-11-13 | Qiagen Gmbh | Reverse transcription and amplification of RNA with simultaneous degradation of DNA |
| EP1762627A1 (de) | 2005-09-09 | 2007-03-14 | Qiagen GmbH | Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3927193A (en) * | 1973-05-18 | 1975-12-16 | Hoffmann La Roche | Localization of tumors by radiolabelled antibodies |
| US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
| US4331647A (en) * | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| JPH036125B2 (de) * | 1980-03-03 | 1991-01-29 | Miruton Deebitsudo Goorudenbaagu | |
| JPS57106626A (en) * | 1980-12-22 | 1982-07-02 | Teijin Ltd | Cytotoxic protein complex and its preparation |
| EP0090025A4 (de) * | 1981-09-28 | 1984-01-12 | Roberto Luis Ceriani | Kennzeichnung einer spezifischen brustdrüse. |
| NO169947C (no) * | 1981-10-27 | 1992-08-26 | Hybritech Inc | Fremgangsmaate for fremstilling av et monoklonalt antistoff til et tumorassosiert antigen |
| US4429008B1 (en) * | 1981-12-10 | 1995-05-16 | Univ California | Thiol reactive liposomes |
| CA1203164A (en) * | 1982-03-09 | 1986-04-15 | Thomas J. Mckearn | Antibody conjugates |
| US4454106A (en) * | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
| US4434236A (en) * | 1982-10-20 | 1984-02-28 | E. I. Du Pont De Nemours & Co. | Immunoassay wherein labeled antibody is displaced from immobilized analyte-analogue |
| JPS59215321A (ja) * | 1983-05-23 | 1984-12-05 | Sumitomo Chem Co Ltd | 二官能性配位子化合物を結合した反応性高分子 |
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| FR2566271B1 (fr) * | 1984-06-20 | 1986-11-07 | Sanofi Sa | Nouveaux conjugues cytotoxiques utilisables en therapeutique et procede d'obtention |
| US4659839A (en) * | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
-
1984
- 1984-09-13 US US06/650,127 patent/US4837003A/en not_active Expired - Fee Related
-
1985
- 1985-09-11 AU AU47376/85A patent/AU595164B2/en not_active Ceased
- 1985-09-12 EP EP85306486A patent/EP0174853B1/de not_active Expired - Lifetime
- 1985-09-12 DE DE8585306486T patent/DE3578625D1/de not_active Expired - Fee Related
- 1985-09-12 CA CA000490611A patent/CA1276878C/en not_active Expired - Lifetime
- 1985-09-12 EP EP90111068A patent/EP0397213A1/de not_active Withdrawn
- 1985-09-12 EP EP19890116236 patent/EP0350972A3/de not_active Withdrawn
- 1985-09-12 AT AT85306486T patent/ATE54417T1/de not_active IP Right Cessation
- 1985-09-13 JP JP60201927A patent/JPH0647557B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0174853B1 (de) | 1990-07-11 |
| AU595164B2 (en) | 1990-03-29 |
| JPS6172723A (ja) | 1986-04-14 |
| EP0397213A1 (de) | 1990-11-14 |
| AU4737685A (en) | 1986-03-20 |
| CA1276878C (en) | 1990-11-27 |
| EP0174853A2 (de) | 1986-03-19 |
| US4837003A (en) | 1989-06-06 |
| EP0350972A2 (de) | 1990-01-17 |
| EP0350972A3 (de) | 1990-09-05 |
| DE3578625D1 (de) | 1990-08-16 |
| EP0174853A3 (en) | 1987-03-25 |
| JPH0647557B2 (ja) | 1994-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE54417T1 (de) | Radioaktiv markierte antikoerperstuecke. | |
| PT1157041E (pt) | Anticorpos para terapia e diagnostico de cancro | |
| DE3162157D1 (en) | 99m tc labeled diagnostic compositions and method for making the same | |
| ATE79372T1 (de) | Markierte antikoerperfragmente. | |
| ES8405071A1 (es) | Un procedimiento de preparacion de conjugados inmunoenzimaticos. | |
| FI861150L (fi) | Monoklonala antikroppar mot metallkelat. | |
| DE3766157D1 (de) | Kupplungsmittel zum radiomarkieren von proteinen. | |
| ES2060002T3 (es) | Compuestos formadores de quelatos para la complejacion de isotopos radiactivos, sus complejos con metales, asi como su utilizacion en diagnostico y terapia. | |
| KR900701765A (ko) | 마이크로사이클릭 이작용성 킬레이트제, 이들의 착화합물 및 이들의 항체 결합물 | |
| IL78993A (en) | Antibodies and kit for use in radiotherapy and radioimmunoassay utilizing the same | |
| ES539927A0 (es) | Un metodo de marcar un agente terapeutico o diagnostico con un ion de metal radiactivo | |
| PT630265E (pt) | Peptidos marcados com tecnecio 99m para processamento de imagem de inflamacao | |
| DE69531613D1 (de) | Einführung einer thiol-gruppe in proteine für die radioimmundetektion und radioimmuntherapie auf der basis von radionukliden | |
| ES8706965A1 (es) | Un metodo de formacion de un conjugado de proteina y quelato metalico | |
| DK0419387T3 (da) | Hidtil ukendte hydrofile derivater, terapeutisk og diagnostisk anvendelse, diagnostiske eller terapeutiske kit og immunologiske reagenser | |
| ATE296312T1 (de) | Metalkomplexbildner | |
| EP0173648A3 (de) | Monoklonale Antikörper gegen Glykokonjugate, Verfahren zu ihrer Herstellung und Verwendungen | |
| HU911929D0 (en) | Process for the production of conjugates containing orto ligating functional group from chelate complexes and joint antibodies or antibody fragments and the medical preparations containing thereof | |
| DE69014300D1 (de) | Radioaktive markierung von proteinen. | |
| EP0221821A3 (de) | Aerosolzusammensetzung für in-vivo-Abbildung und Therapie | |
| UA29225A (uk) | Спосіб прогнозування ефективності комплексної терапії гострих обструктивних бронхітів у дітей |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |