ES2013978A4 - Compuestos de enlace ionico bifuncionales macrociclicos, complejos de ellos y sus anticuerpos conjugados - Google Patents

Compuestos de enlace ionico bifuncionales macrociclicos, complejos de ellos y sus anticuerpos conjugados

Info

Publication number
ES2013978A4
ES2013978A4 ES89111497T ES89111497T ES2013978A4 ES 2013978 A4 ES2013978 A4 ES 2013978A4 ES 89111497 T ES89111497 T ES 89111497T ES 89111497 T ES89111497 T ES 89111497T ES 2013978 A4 ES2013978 A4 ES 2013978A4
Authority
ES
Spain
Prior art keywords
complexes
conjugated antibodies
ionic link
macrocyclic bifunctional
link compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES89111497T
Other languages
English (en)
Inventor
Roberta C Cheng
William A Fordyce
William F Goeckeler
William F Kruper
Sharon Baughman
Joseph R Garlich
Garrymcmillan Kiefer
Jaime J Simon
David A Wilson
Richard Keith Frank
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of ES2013978A4 publication Critical patent/ES2013978A4/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
    • A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
ES89111497T 1988-06-24 1989-06-23 Compuestos de enlace ionico bifuncionales macrociclicos, complejos de ellos y sus anticuerpos conjugados Pending ES2013978A4 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21149688A 1988-06-24 1988-06-24
US37095689A 1989-06-21 1989-06-21

Publications (1)

Publication Number Publication Date
ES2013978A4 true ES2013978A4 (es) 1990-06-16

Family

ID=26906194

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89111497T Pending ES2013978A4 (es) 1988-06-24 1989-06-23 Compuestos de enlace ionico bifuncionales macrociclicos, complejos de ellos y sus anticuerpos conjugados

Country Status (20)

Country Link
US (1) US5435990A (es)
EP (2) EP0420942A1 (es)
JP (1) JP2831073B2 (es)
KR (1) KR0137930B1 (es)
AT (1) ATE120457T1 (es)
AU (1) AU634167B2 (es)
BR (1) BR8907507A (es)
CA (1) CA1341373C (es)
DE (2) DE68921941T2 (es)
DK (1) DK175393B1 (es)
ES (1) ES2013978A4 (es)
FI (2) FI103792B1 (es)
GR (1) GR900300034T1 (es)
HK (1) HK60696A (es)
HU (1) HU219485B (es)
IE (1) IE67273B1 (es)
IL (1) IL90730A0 (es)
NO (1) NO179008C (es)
NZ (1) NZ229700A (es)
WO (1) WO1989012631A1 (es)

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EP0420942A1 (en) 1991-04-10
NO900869D0 (no) 1990-02-23
AU3979489A (en) 1990-01-12
HU894432D0 (en) 1992-02-28
DK49390A (da) 1990-02-23
FI906368A0 (fi) 1990-12-21
IE892045L (en) 1989-12-24
NO900869L (no) 1990-04-11
NZ229700A (en) 1993-01-27
DK175393B1 (da) 2004-09-20
HUT70200A (en) 1995-09-28
FI982303L (fi) 1998-10-23
CA1341373C (en) 2002-07-02
HK60696A (en) 1996-04-19
DE68921941D1 (de) 1995-05-04
EP0353450A1 (en) 1990-02-07
EP0353450B1 (en) 1995-03-29
FI982303A0 (fi) 1998-10-23
KR900701765A (ko) 1990-12-04
IE67273B1 (en) 1996-03-20
GR900300034T1 (en) 1991-07-31
AU634167B2 (en) 1993-02-18
NO179008B (no) 1996-04-09
FI103792B (fi) 1999-09-30
BR8907507A (pt) 1991-06-11
JPH04504247A (ja) 1992-07-30
HU219485B (hu) 2001-04-28
DE68921941T2 (de) 1995-07-27
IL90730A0 (en) 1990-01-18
NO179008C (no) 1996-07-17
US5435990A (en) 1995-07-25
ATE120457T1 (de) 1995-04-15
KR0137930B1 (en) 1998-05-15
FI117889B (fi) 2007-04-13
JP2831073B2 (ja) 1998-12-02
DK49390D0 (da) 1990-02-23
WO1989012631A1 (en) 1989-12-28
DE353450T1 (de) 1990-09-06
FI103792B1 (fi) 1999-09-30

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