ATE546426T1 - Kristallisierung von iodixanol mittels ultraschall - Google Patents

Kristallisierung von iodixanol mittels ultraschall

Info

Publication number: ATE546426T1
Authority: AT; Austria
Prior art keywords: iodixanol; ultrasound; crystallization; bis; dihydroxypropylaminocarbonyl
Prior art date: 2009-07-21

Application number

AT09177714T

Other languages

English (en)

Inventor

Khalid Hussain

Original Assignee

Ge Healthcare As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-07-21

Filing date

2009-12-02

Publication date

2012-03-15

2009-12-02 Application filed by Ge Healthcare As filed Critical Ge Healthcare As

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE546426T1 publication Critical patent/ATE546426T1/de

Links

NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 title abstract 3
229960004359 iodixanol Drugs 0.000 title abstract 3
238000002425 crystallisation Methods 0.000 title abstract 2
230000008025 crystallization Effects 0.000 title abstract 2
238000002604 ultrasonography Methods 0.000 title abstract 2
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT09177714T 2009-07-21 2009-12-02 Kristallisierung von iodixanol mittels ultraschall ATE546426T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US22710809P	2009-07-21	2009-07-21

Publications (1)

Publication Number	Publication Date
ATE546426T1 true ATE546426T1 (de)	2012-03-15

Family

ID=41506447

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT09177714T ATE546426T1 (de)	2009-07-21	2009-12-02	Kristallisierung von iodixanol mittels ultraschall

Country Status (7)

Country	Link
US (1)	US7999135B2 (de)
EP (1)	EP2277856B1 (de)
KR (1)	KR101076126B1 (de)
CN (1)	CN101962338B (de)
AT (1)	ATE546426T1 (de)
ES (1)	ES2379910T3 (de)
PL (1)	PL2277856T3 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2891523A1 (en) *	2012-11-19	2014-05-22	Jiangsu Hansoh Pharmaceutical Co., Ltd.	Pyrrole sulfonamide derivative, preparation method for same, and medical application thereof
CN111777525B (zh) *	2019-04-04	2021-08-27	成都西岭源药业有限公司	一种碘克沙醇的精制方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE20733T1 (de)	1982-11-08	1986-08-15	Nyegaard & Co As	Roentgenkontrastmittel.
ES2103252T3 (es)	1995-05-23	1999-04-01	Fructamine Spa	Procedimiento para la preparacion de un dicloruro de acido dicarboxilico.
US5763650A (en)	1995-05-23	1998-06-09	Fructamine S.P.A.	Process for the preparation of a halosubstituted aromatic acid
US5705692A (en)	1996-09-27	1998-01-06	Abbott Laboratories	Process for the preparation of iohexol
GB9624612D0 (en)	1996-11-26	1997-01-15	Nycomed Imaging As	Process
GB9720969D0 (en)	1997-10-02	1997-12-03	Nycomed Imaging As	Process
GB9903109D0 (en)	1999-02-11	1999-04-07	Nycomed Imaging As	Process
US7357835B2 (en)	2002-05-31	2008-04-15	Accentus Plc	Production of crystalline materials by using high intensity ultrasound
NO20043305D0 (no) *	2004-08-09	2004-08-09	Amersham Health As	Preparation of lodixanol
EP1782797A1 (de)	2005-11-02	2007-05-09	Pharmatex Italia Srl	Verfahren zur Herstellung von sterilen pulverförmigen pharmazeutischen Verbindungen
NO20055643D0 (no)	2005-11-29	2005-11-29	Amersham Health As	Preparation of lodixanol
EP1966110B1 (de) *	2005-12-19	2013-04-24	Ge Healthcare As	Verfahren zur aufreinigung von iodixanol
CN101293855B (zh) *	2007-04-27	2012-08-29	上海冠杰生物医药科技有限公司	一种碘克沙醇的纯化方法

2009
- 2009-11-04 US US12/611,977 patent/US7999135B2/en active Active
- 2009-12-02 ES ES09177714T patent/ES2379910T3/es active Active
- 2009-12-02 EP EP09177714A patent/EP2277856B1/de active Active
- 2009-12-02 AT AT09177714T patent/ATE546426T1/de active
- 2009-12-02 PL PL09177714T patent/PL2277856T3/pl unknown
2010
- 2010-07-20 KR KR1020100069813A patent/KR101076126B1/ko not_active Expired - Fee Related
- 2010-07-21 CN CN2010102411772A patent/CN101962338B/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20110021827A1 (en)	2011-01-27
EP2277856A1 (de)	2011-01-26
KR101076126B1 (ko)	2011-10-21
CN101962338B (zh)	2013-07-17
ES2379910T3 (es)	2012-05-04
KR20110009037A (ko)	2011-01-27
CN101962338A (zh)	2011-02-02
US7999135B2 (en)	2011-08-16
PL2277856T3 (pl)	2012-07-31
EP2277856B1 (de)	2012-02-22

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