BRPI0514169A - processo para a produção de iodixanol - Google Patents
processo para a produção de iodixanolInfo
- Publication number
- BRPI0514169A BRPI0514169A BRPI0514169-9A BRPI0514169A BRPI0514169A BR PI0514169 A BRPI0514169 A BR PI0514169A BR PI0514169 A BRPI0514169 A BR PI0514169A BR PI0514169 A BRPI0514169 A BR PI0514169A
- Authority
- BR
- Brazil
- Prior art keywords
- iodixanol
- production
- crude product
- triiodo
- isophthalamide
- Prior art date
Links
- NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 title abstract 3
- 229960004359 iodixanol Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 abstract 2
- 239000012043 crude product Substances 0.000 abstract 2
- BHCBLTRDEYPMFZ-UHFFFAOYSA-N 5-acetamido-1-n,3-n-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound CC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I BHCBLTRDEYPMFZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940126062 Compound A Drugs 0.000 abstract 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000006471 dimerization reaction Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
PROCESSO PARA A PRODUçãO DE IODIXANOL Processo para a produção de iodixanol através da execução de um processo de purificação do produto bruto em um solvente compreendendo 1-metóxi-2-propanol. O produto bruto poderá ser obtido em solução aquosa, a partir da dimerização de 5-acetamido-N,N<39>-bis(2,3-di- hidroxipropil)-2,4,6-triiodo-isoftalamida ("Composto A").
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20043305A NO20043305D0 (no) | 2004-08-09 | 2004-08-09 | Preparation of lodixanol |
| PCT/NO2005/000287 WO2006016815A1 (en) | 2004-08-09 | 2005-08-08 | Preparation of iodixanol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0514169A true BRPI0514169A (pt) | 2008-06-03 |
Family
ID=35013342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0514169-9A BRPI0514169A (pt) | 2004-08-09 | 2005-08-08 | processo para a produção de iodixanol |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8445724B2 (pt) |
| EP (1) | EP1778621B1 (pt) |
| JP (1) | JP5048490B2 (pt) |
| KR (1) | KR101188596B1 (pt) |
| CN (1) | CN101001831B (pt) |
| AU (1) | AU2005272229B2 (pt) |
| BR (1) | BRPI0514169A (pt) |
| CA (1) | CA2575088C (pt) |
| ES (1) | ES2386792T3 (pt) |
| MX (1) | MX2007001624A (pt) |
| NO (1) | NO20043305D0 (pt) |
| PL (1) | PL1778621T3 (pt) |
| PT (1) | PT1778621E (pt) |
| RU (1) | RU2385316C2 (pt) |
| WO (1) | WO2006016815A1 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO342021B1 (no) * | 2005-07-29 | 2018-03-12 | Ge Healthcare As | Kontinuerlig krystalliseringsprosess |
| NO20053676D0 (no) | 2005-07-29 | 2005-07-29 | Amersham Health As | Crystallisation Process |
| NO20055643D0 (no) * | 2005-11-29 | 2005-11-29 | Amersham Health As | Preparation of lodixanol |
| US7968745B2 (en) | 2005-12-19 | 2011-06-28 | Ge Healthcare As | Purification process of iodixanol |
| US8962886B2 (en) * | 2009-07-21 | 2015-02-24 | Ge Healthcare As | Synthesis of iodixanol in methanol |
| US8969619B2 (en) * | 2009-07-21 | 2015-03-03 | Ge Healthcare As | Synthesis of iodixanol in propyleneglycol |
| US8962887B2 (en) * | 2009-07-21 | 2015-02-24 | Ge Healthcare As | Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol |
| US7754918B1 (en) * | 2009-07-21 | 2010-07-13 | Ge Healthcare As | Crystallization of iodixanol in isopropanol and methanol |
| US7999135B2 (en) * | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using ultrasound |
| US7999134B2 (en) * | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using milling |
| EP2504298B1 (en) | 2009-11-26 | 2016-09-21 | iMAX Diagnostic Imaging Holding Limited | Preparation and purification of iodixanol |
| GB2496971A (en) * | 2011-11-25 | 2013-05-29 | Ge Healthcare As | Preparation of X-ray contrast agents |
| KR20150061635A (ko) | 2012-09-27 | 2015-06-04 | 지이 헬스케어 에이에스 | 아이오포르미놀의 중간체 화합물의 제조법 |
| AU2013323982B2 (en) | 2012-09-27 | 2017-11-23 | Ge Healthcare As | Preparation of Ioforminol, an X-ray contrast agent |
| EP2917174B1 (en) * | 2012-11-12 | 2018-09-12 | Ge Healthcare As | Preparation of intermediates of x-ray contrast agents |
| JP6342421B2 (ja) | 2012-12-19 | 2018-06-13 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | X線造影剤の精製 |
| CN111777525B (zh) * | 2019-04-04 | 2021-08-27 | 成都西岭源药业有限公司 | 一种碘克沙醇的精制方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL110391A (en) * | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the crystallization of iopamidol |
| GB9720969D0 (en) | 1997-10-02 | 1997-12-03 | Nycomed Imaging As | Process |
| ITMI20010773A1 (it) * | 2001-04-11 | 2002-10-11 | Chemi Spa | Processo per la produzione di ioexolo ad elevata purezza |
| NO20053687D0 (no) * | 2005-07-29 | 2005-07-29 | Amersham Health As | Crystallisation Process. |
-
2004
- 2004-08-09 NO NO20043305A patent/NO20043305D0/no unknown
-
2005
- 2005-08-08 PL PL05771995T patent/PL1778621T3/pl unknown
- 2005-08-08 KR KR1020077003077A patent/KR101188596B1/ko not_active Expired - Fee Related
- 2005-08-08 PT PT05771995T patent/PT1778621E/pt unknown
- 2005-08-08 CN CN2005800269464A patent/CN101001831B/zh not_active Expired - Lifetime
- 2005-08-08 JP JP2007525566A patent/JP5048490B2/ja not_active Expired - Lifetime
- 2005-08-08 MX MX2007001624A patent/MX2007001624A/es active IP Right Grant
- 2005-08-08 AU AU2005272229A patent/AU2005272229B2/en not_active Ceased
- 2005-08-08 WO PCT/NO2005/000287 patent/WO2006016815A1/en not_active Ceased
- 2005-08-08 US US11/573,283 patent/US8445724B2/en active Active
- 2005-08-08 RU RU2007104091/04A patent/RU2385316C2/ru active
- 2005-08-08 CA CA2575088A patent/CA2575088C/en not_active Expired - Fee Related
- 2005-08-08 ES ES05771995T patent/ES2386792T3/es not_active Expired - Lifetime
- 2005-08-08 BR BRPI0514169-9A patent/BRPI0514169A/pt not_active Application Discontinuation
- 2005-08-08 EP EP05771995A patent/EP1778621B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20090253935A1 (en) | 2009-10-08 |
| US8445724B2 (en) | 2013-05-21 |
| JP2008509214A (ja) | 2008-03-27 |
| JP5048490B2 (ja) | 2012-10-17 |
| AU2005272229B2 (en) | 2011-04-28 |
| PL1778621T3 (pl) | 2012-11-30 |
| ES2386792T3 (es) | 2012-08-30 |
| RU2385316C2 (ru) | 2010-03-27 |
| CA2575088A1 (en) | 2006-02-16 |
| RU2007104091A (ru) | 2008-09-20 |
| CN101001831B (zh) | 2011-08-03 |
| KR101188596B1 (ko) | 2012-10-05 |
| CN101001831A (zh) | 2007-07-18 |
| NO20043305D0 (no) | 2004-08-09 |
| EP1778621A1 (en) | 2007-05-02 |
| CA2575088C (en) | 2012-10-30 |
| EP1778621B1 (en) | 2012-06-13 |
| MX2007001624A (es) | 2008-10-27 |
| PT1778621E (pt) | 2012-07-13 |
| AU2005272229A1 (en) | 2006-02-16 |
| WO2006016815A1 (en) | 2006-02-16 |
| KR20070057793A (ko) | 2007-06-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ITMI20041627A1 (it) | Processo per il recupero di tirosolo idrossitirosolo e altri componenti fenolici da acque di vegetazione e metodo di ossidazione catalitica di tirosolo a idrossitirosolo | |
| BRPI0821444A2 (pt) | Processo para a produção de um produto de reação, e, sistema para a produção de componentes de combinação da gasolina de volatilidade alta e qualidade alta | |
| EA200900474A1 (ru) | Способ получения мемантина и его гидрохлорида | |
| ECSP077317A (es) | Procedimiento para producir derivados de amina opticamente activos | |
| BRPI0500616A (pt) | processos para aperfeiçoar uma ou mais caracterìsticas de desempenho de um ou mais catalisadores de óxido metálico, e para produzir ácidos carboxìlicos insaturados | |
| BRPI0812602A2 (pt) | "método para a produção de um ou mais álcoois c2-c4, método para a produção de um álcool cn+m, método de purificação de um ou mais álcoois, método para a produção de um álcool purificado e aparelho para produzir um álcool purificado" | |
| BRPI0807669A2 (pt) | Processo para produzir um produto de cumento tendo uma pureza de pelo menos 99,50 por cento | |
| ITMI20021737A1 (it) | Processo di purificazione di nanotubi di carbonio. | |
| BRPI0811311A2 (pt) | Catalisador de epoxidação, um processo para a preparação do catalisador, e um processo para a produção de um óxido de olefina, um 1,2-diol, um éter 1,2-diol, um 1,2-carbonato, ou uma alcanolamina. | |
| BR0307236A (pt) | Processo para fabricação de compostos orgânicos | |
| BRPI0415203A (pt) | pentanóis reestruturados, um processo para sua produção e seu uso como agentes antiinflamatórios | |
| BR112012012033A2 (pt) | processo para preparar ácido fórmico | |
| DE602006009619D1 (de) | Verfahren zur herstellung von 1-amino-3,5-dimethyladamantan-hydrochlorid | |
| BR112012033462A2 (pt) | processo para preparar ácido fórmico | |
| BRPI0607224A2 (pt) | processo para preparação de ciclohexanona e ciclohexanol | |
| CO6511258A2 (es) | Proceso fotoquimico para preparar artemisinina | |
| BR112012021120A2 (pt) | processo para a conversão do composto nitro aromático em aminas | |
| ATE482188T1 (de) | Verfahren zur synthese von 3-hydroxyglutaronitril | |
| BRPI0906005A2 (pt) | Processo para purificar epiclorihidrina, processo para produzir epiclorohidrina e aparelho para produzir epiclorohidrina purificada | |
| AR051341A1 (es) | Proceso para la preparacion de derivados de [1,4,5]-oxadiazepina | |
| BRPI0517465A (pt) | processo para a produção de maltodextrinas e maltodextrinas | |
| BRPI0415019A (pt) | processo para a purificação da mesotriona | |
| NO20033058D0 (no) | Prosess | |
| EA201001521A1 (ru) | Способ синтеза этинилциклопропана | |
| BRPI0918277B8 (pt) | "processo para produzir cristais de prata, cristais de prata, catalisador de prata e uso dos referidos cristais" |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |