ATE546439T1 - Heterocyclische modulatoren der glucocorticoidrezeptor-, ap-1- und/oder nf-kb- aktivität und deren verwendung - Google Patents

Heterocyclische modulatoren der glucocorticoidrezeptor-, ap-1- und/oder nf-kb- aktivität und deren verwendung

Info

Publication number: ATE546439T1
Authority: AT; Austria
Prior art keywords: sup; glucocorticoid receptor; activity; diseases; diabetes
Prior art date: 2005-01-13

Application number

AT06718214T

Other languages

English (en)

Inventor

Bingwei YANG

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-13

Filing date

2006-01-13

Publication date

2012-03-15

2006-01-13 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE546439T1 publication Critical patent/ATE546439T1/de

Links

102000003676 Glucocorticoid Receptors Human genes 0.000 title abstract 2
108090000079 Glucocorticoid Receptors Proteins 0.000 title abstract 2
102000003945 NF-kappa B Human genes 0.000 title abstract 2
108010057466 NF-kappa B Proteins 0.000 title abstract 2
230000000694 effects Effects 0.000 title abstract 2
208000008589 Obesity Diseases 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
206010012601 diabetes mellitus Diseases 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
230000002757 inflammatory effect Effects 0.000 abstract 2
235000020824 obesity Nutrition 0.000 abstract 2
208000026278 immune system disease Diseases 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
230000003637 steroidlike Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Obesity (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Child & Adolescent Psychology (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Transplantation (AREA)

AT06718214T 2005-01-13 2006-01-13 Heterocyclische modulatoren der glucocorticoidrezeptor-, ap-1- und/oder nf-kb- aktivität und deren verwendung ATE546439T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US64376005P	2005-01-13	2005-01-13
PCT/US2006/001117 WO2006076509A1 (en)	2005-01-13	2006-01-13	Heterocyclic modulators of the glucocorticoid receptor, ap-1, and/or nf-kb activity and use thereof

Publications (1)

Publication Number	Publication Date
ATE546439T1 true ATE546439T1 (de)	2012-03-15

Family

ID=36228744

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06718214T ATE546439T1 (de)	2005-01-13	2006-01-13	Heterocyclische modulatoren der glucocorticoidrezeptor-, ap-1- und/oder nf-kb- aktivität und deren verwendung

Country Status (6)

Country	Link
US (1)	US7317024B2 (de)
EP (1)	EP1841750B1 (de)
JP (1)	JP2008526977A (de)
AT (1)	ATE546439T1 (de)
ES (1)	ES2381278T3 (de)
WO (1)	WO2006076509A1 (de)

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US7605264B2 (en) *	2004-01-16	2009-10-20	Bristol-Myers Squibb Company	Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7625921B2 (en) *	2004-01-16	2009-12-01	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7326728B2 (en) *	2004-01-16	2008-02-05	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κβ activity and use thereof
US7273881B2 (en) *	2004-01-16	2007-09-25	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7569689B2 (en) *	2004-01-16	2009-08-04	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7253283B2 (en) *	2004-01-16	2007-08-07	Bristol-Myers Squibb Company	Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US8034940B2 (en)	2006-08-09	2011-10-11	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2011154413A1 (en)	2010-06-07	2011-12-15	Fritz-Lipmann-Insitut E. V. Leibniz-Institut Für Altersforschung	Agent against glucocorticoid-induced osteoporosis
ES2540562T3 (es)	2010-10-05	2015-07-10	Purdue Pharma L.P.	Compuestos de quinazolina como bloqueadores de canales de sodio
US8652527B1 (en)	2013-03-13	2014-02-18	Upsher-Smith Laboratories, Inc	Extended-release topiramate capsules
US9101545B2 (en)	2013-03-15	2015-08-11	Upsher-Smith Laboratories, Inc.	Extended-release topiramate capsules
CN110105346B (zh)	2013-10-14	2023-03-10	卫材R&D管理有限公司	选择性取代的喹啉化合物
CN105636945B (zh)	2013-10-14	2017-11-17	卫材R&D管理有限公司	选择性取代的喹啉化合物
CN114014747B (zh) *	2021-08-30	2023-12-08	海南师范大学	一种多羟基环己烯类化合物及其制备方法与应用
CN115974723B (zh) *	2022-12-27	2024-10-25	中国药科大学	甲酰胺乙撑蒽类化合物、包含其的药物组合物及其应用

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2006
- 2006-01-12 US US11/330,511 patent/US7317024B2/en not_active Expired - Lifetime
- 2006-01-13 AT AT06718214T patent/ATE546439T1/de active
- 2006-01-13 WO PCT/US2006/001117 patent/WO2006076509A1/en not_active Ceased
- 2006-01-13 ES ES06718214T patent/ES2381278T3/es not_active Expired - Lifetime
- 2006-01-13 EP EP06718214A patent/EP1841750B1/de not_active Expired - Lifetime
- 2006-01-13 JP JP2007551378A patent/JP2008526977A/ja active Pending

Also Published As

Publication number	Publication date
ES2381278T3 (es)	2012-05-24
EP1841750A1 (de)	2007-10-10
WO2006076509A1 (en)	2006-07-20
JP2008526977A (ja)	2008-07-24
US20060154962A1 (en)	2006-07-13
EP1841750B1 (de)	2012-02-22
US7317024B2 (en)	2008-01-08

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