ATE525351T1 - Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung - Google Patents

Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung

Info

Publication number: ATE525351T1
Authority: AT; Austria
Prior art keywords: phenyl; substituted; bipyrrolidinecarbonic; acid amides; therapeutic use
Prior art date: 2007-10-17

Application number

AT08839959T

Other languages

English (en)

Inventor

Werngard Czechtizky

Zhongli Gao

William J Hurst

Lothar Schwink

Siegfried Stengelin

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-17

Filing date

2008-10-14

Publication date

2011-10-15

2008-10-14 Application filed by Sanofi Sa filed Critical Sanofi Sa

2011-10-15 Application granted granted Critical

2011-10-15 Publication of ATE525351T1 publication Critical patent/ATE525351T1/de

Links

150000001408 amides Chemical class 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
102000004384 Histamine H3 receptors Human genes 0.000 abstract 2
108090000981 Histamine H3 receptors Proteins 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
KFIOZBMCNUODPK-UHFFFAOYSA-N n-phenyl-1-pyrrolidin-1-ylpyrrolidine-2-carboxamide Chemical class C1CCN(N2CCCC2)C1C(=O)NC1=CC=CC=C1 KFIOZBMCNUODPK-UHFFFAOYSA-N 0.000 abstract 2
210000003169 central nervous system Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000000543 intermediate Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008177 pharmaceutical agent Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

AT08839959T 2007-10-17 2008-10-14 Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung ATE525351T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US98059907P	2007-10-17	2007-10-17
PCT/US2008/079757 WO2009052062A1 (en)	2007-10-17	2008-10-14	Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof

Publications (1)

Publication Number	Publication Date
ATE525351T1 true ATE525351T1 (de)	2011-10-15

Family

ID=40247942

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08839959T ATE525351T1 (de)	2007-10-17	2008-10-14	Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung

Country Status (25)

Country	Link
US (2)	US8088808B2 (de)
EP (1)	EP2212283B1 (de)
JP (1)	JP5377503B2 (de)
KR (1)	KR20100072077A (de)
CN (1)	CN101903340B (de)
AT (1)	ATE525351T1 (de)
AU (1)	AU2008312635B2 (de)
BR (1)	BRPI0818581A2 (de)
CA (1)	CA2702467C (de)
CY (1)	CY1112083T1 (de)
DK (1)	DK2212283T3 (de)
ES (1)	ES2372332T3 (de)
HR (1)	HRP20110762T1 (de)
IL (1)	IL205001A (de)
MA (1)	MA31858B1 (de)
MX (1)	MX2010003949A (de)
MY (1)	MY151348A (de)
NZ (1)	NZ584690A (de)
PL (1)	PL2212283T3 (de)
PT (1)	PT2212283E (de)
RS (1)	RS52235B (de)
RU (1)	RU2477720C2 (de)
SI (1)	SI2212283T1 (de)
WO (1)	WO2009052062A1 (de)
ZA (1)	ZA201002115B (de)

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* Cited by examiner, † Cited by third party
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PL2212283T3 (pl) *	2007-10-17	2012-01-31	Sanofi Sa	Podstawione karboksyamidy N-fenylobipirolidyny i ich zastosowanie terapeutyczne
MX2010004003A (es)	2007-10-17	2010-04-30	Sanofi Aventis	N-fenil-pirrolidinilmetlipirrolidin amidas sustituidas y uso terapeutico de las mismas.
CN101903339B (zh) *	2007-10-17	2012-06-27	赛诺菲-安万特	取代的n-苯基-联吡咯烷羧酰胺及其治疗用途
CA2702933C (en)	2007-10-17	2012-12-18	Sanofi-Aventis	Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof
AR074467A1 (es)	2008-12-05	2011-01-19	Sanofi Aventis	Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras.
AR074466A1 (es)	2008-12-05	2011-01-19	Sanofi Aventis	Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3.
SA110310332B1 (ar)	2009-05-01	2013-12-10	Astrazeneca Ab	مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل )
JP2013526530A (ja) *	2010-05-11	2013-06-24	サノフイ	置換されたｎ−フェニルスピロラクタムビピロリジン、その製造及び治療上の使用
TW201206939A (en)	2010-05-11	2012-02-16	Sanofi Aventis	Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof
JP5766278B2 (ja)	2010-05-11	2015-08-19	サノフイ	置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用
WO2011143162A1 (en) *	2010-05-11	2011-11-17	Sanofi	Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof
TW201206910A (en)	2010-05-11	2012-02-16	Sanofi Aventis	Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof
AR081034A1 (es) *	2010-05-11	2012-05-30	Sanofi Aventis	Derivados de n-heteroaril tetrahidro-isoquinolina sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central
JP5833105B2 (ja)	2010-05-11	2015-12-16	サノフイ	置換ｎ−ヘテロアリールスピロラクタムビピロリジン類、その製造及び治療的使用
SG186275A1 (en)	2010-07-06	2013-01-30	Astrazeneca Ab	Therapeutic agents 976
UY34194A (es)	2011-07-15	2013-02-28	Astrazeneca Ab	?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad?
JP2013232564A (ja) *	2012-04-27	2013-11-14	National Institute Of Advanced Industrial & Technology	半導体装置および半導体装置の製造方法
CN103694163A (zh) *	2012-09-27	2014-04-02	上海先声药物研究有限公司	作为钾通道调节剂的化合物
HK1216300A1 (zh)	2013-01-10	2016-11-04	Grünenthal GmbH	作为crac通道抑制剂的基於吡唑基的甲醯胺i
US9078899B2 (en)	2013-01-10	2015-07-14	Gruenenthal Gmbh	Pyrazolyl-based carboxamides II
EP3366683A1 (de)	2017-02-28	2018-08-29	Acousia Therapeutics GmbH	Zyklische amide, acetamide und harnstoffe als kalium kanal öffner

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PE20020507A1 (es) *	2000-10-17	2002-06-25	Schering Corp	Compuestos no-imidazoles como antagonistas del receptor histamina h3
WO2004037257A1 (en) *	2002-10-23	2004-05-06	Janssen Pharmaceutica, N.V.	Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators
US7223788B2 (en) *	2003-02-14	2007-05-29	Sanofi-Aventis Deutschland Gmbh	Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
DE10306250A1 (de) *	2003-02-14	2004-09-09	Aventis Pharma Deutschland Gmbh	Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JP5052497B2 (ja)	2005-03-17	2012-10-17	イーライリリーアンドカンパニー	ヒスタミンｈ３受容体アンタゴニストとしてのピロリジン誘導体
BRPI0608653A2 (pt) *	2005-04-01	2010-11-30	Lilly Co Eli	composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto ou um sal do mesmo
ES2370518T3 (es) *	2005-07-01	2011-12-19	Eli Lilly And Company	Agentes receptores h3 de histamina, preparación y usos terapéuticos.
US7943605B2 (en) *	2005-10-27	2011-05-17	Ucb Pharma S.A.	Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses
JP5175228B2 (ja) *	2006-02-15	2013-04-03	サノフイ	新規なアザシクリル置換アリールジヒドロイソキノリノン、それらの製造方法及び薬剤としてそれらの使用
PL2212283T3 (pl) *	2007-10-17	2012-01-31	Sanofi Sa	Podstawione karboksyamidy N-fenylobipirolidyny i ich zastosowanie terapeutyczne
MX2010004003A (es)	2007-10-17	2010-04-30	Sanofi Aventis	N-fenil-pirrolidinilmetlipirrolidin amidas sustituidas y uso terapeutico de las mismas.
CA2702933C (en) *	2007-10-17	2012-12-18	Sanofi-Aventis	Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof
CN101903339B (zh) *	2007-10-17	2012-06-27	赛诺菲-安万特	取代的n-苯基-联吡咯烷羧酰胺及其治疗用途

2008
- 2008-10-14 PL PL08839959T patent/PL2212283T3/pl unknown
- 2008-10-14 HR HR20110762T patent/HRP20110762T1/hr unknown
- 2008-10-14 KR KR1020107010769A patent/KR20100072077A/ko not_active Ceased
- 2008-10-14 AT AT08839959T patent/ATE525351T1/de active
- 2008-10-14 SI SI200830416T patent/SI2212283T1/sl unknown
- 2008-10-14 ES ES08839959T patent/ES2372332T3/es active Active
- 2008-10-14 CA CA2702467A patent/CA2702467C/en not_active Expired - Fee Related
- 2008-10-14 CN CN2008801212081A patent/CN101903340B/zh not_active Expired - Fee Related
- 2008-10-14 AU AU2008312635A patent/AU2008312635B2/en not_active Ceased
- 2008-10-14 JP JP2010530049A patent/JP5377503B2/ja not_active Expired - Fee Related
- 2008-10-14 PT PT08839959T patent/PT2212283E/pt unknown
- 2008-10-14 RS RS20110522A patent/RS52235B/sr unknown
- 2008-10-14 EP EP08839959A patent/EP2212283B1/de active Active
- 2008-10-14 BR BRPI0818581-6A patent/BRPI0818581A2/pt not_active IP Right Cessation
- 2008-10-14 NZ NZ584690A patent/NZ584690A/en not_active IP Right Cessation
- 2008-10-14 WO PCT/US2008/079757 patent/WO2009052062A1/en not_active Ceased
- 2008-10-14 RU RU2010119528/04A patent/RU2477720C2/ru not_active IP Right Cessation
- 2008-10-14 DK DK08839959.7T patent/DK2212283T3/da active
- 2008-10-14 MY MYPI20101299 patent/MY151348A/en unknown
- 2008-10-14 MX MX2010003949A patent/MX2010003949A/es active IP Right Grant
2010
- 2010-03-15 US US12/724,028 patent/US8088808B2/en not_active Expired - Fee Related
- 2010-03-25 ZA ZA2010/02115A patent/ZA201002115B/en unknown
- 2010-04-11 IL IL205001A patent/IL205001A/en not_active IP Right Cessation
- 2010-05-17 MA MA32850A patent/MA31858B1/fr unknown
2011
- 2011-11-18 US US13/299,574 patent/US8252824B2/en not_active Expired - Fee Related
- 2011-11-24 CY CY20111101151T patent/CY1112083T1/el unknown

Also Published As

Publication number	Publication date
CA2702467C (en)	2012-11-27
PL2212283T3 (pl)	2012-01-31
AU2008312635B2 (en)	2013-05-16
EP2212283A1 (de)	2010-08-04
ZA201002115B (en)	2010-12-29
IL205001A (en)	2014-06-30
US20100173949A1 (en)	2010-07-08
CA2702467A1 (en)	2009-04-23
WO2009052062A1 (en)	2009-04-23
CY1112083T1 (el)	2015-11-04
SI2212283T1 (sl)	2011-12-30
US8088808B2 (en)	2012-01-03
NZ584690A (en)	2011-09-30
DK2212283T3 (da)	2011-12-19
CN101903340A (zh)	2010-12-01
PT2212283E (pt)	2011-11-03
BRPI0818581A2 (pt)	2015-07-21
HK1146053A1 (en)	2011-05-13
IL205001A0 (en)	2010-11-30
EP2212283B1 (de)	2011-09-21
ES2372332T3 (es)	2012-01-18
MY151348A (en)	2014-05-15
JP2011500693A (ja)	2011-01-06
US20120065234A1 (en)	2012-03-15
KR20100072077A (ko)	2010-06-29
RU2010119528A (ru)	2011-11-27
CN101903340B (zh)	2013-03-27
MX2010003949A (es)	2010-04-30
RS52235B (sr)	2012-10-31
HRP20110762T1 (hr)	2011-11-30
US8252824B2 (en)	2012-08-28
MA31858B1 (fr)	2010-11-01
AU2008312635A1 (en)	2009-04-23
RU2477720C2 (ru)	2013-03-20
JP5377503B2 (ja)	2013-12-25

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Publication	Publication Date	Title
ATE525351T1 (de)	2011-10-15	Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung
ATE525350T1 (de)	2011-10-15	Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung
ATE534625T1 (de)	2011-12-15	Substituierte n-phenyl-bipyrrolidinharnstoffe und deren therapeutische verwendung
MY150210A (en)	2013-12-13	Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators
MX2010009752A (es)	2010-09-30	Compuestos de oxadiazoantraceno para el tratamiento de diabetes.
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ATE479691T1 (de)	2010-09-15	4,5,6,7-tetrahydrothienoä2,3-cüpyridine als h3- modulatoren
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