ATE525351T1 - Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung - Google Patents

Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung

Info

Publication number: ATE525351T1
Authority: AT; Austria
Prior art keywords: phenyl; substituted; bipyrrolidinecarbonic; acid amides; therapeutic use
Prior art date: 2007-10-17

Application number

AT08839959T

Other languages

English (en)

Inventor

Werngard Czechtizky

Zhongli Gao

William J Hurst

Lothar Schwink

Siegfried Stengelin

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-17

Filing date

2008-10-14

Publication date

2011-10-15

2008-10-14 Application filed by Sanofi Sa filed Critical Sanofi Sa

2011-10-15 Application granted granted Critical

2011-10-15 Publication of ATE525351T1 publication Critical patent/ATE525351T1/de

Links

150000001408 amides Chemical class 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
102000004384 Histamine H3 receptors Human genes 0.000 abstract 2
108090000981 Histamine H3 receptors Proteins 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
KFIOZBMCNUODPK-UHFFFAOYSA-N n-phenyl-1-pyrrolidin-1-ylpyrrolidine-2-carboxamide Chemical class C1CCN(N2CCCC2)C1C(=O)NC1=CC=CC=C1 KFIOZBMCNUODPK-UHFFFAOYSA-N 0.000 abstract 2
210000003169 central nervous system Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000000543 intermediate Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008177 pharmaceutical agent Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Immunology (AREA)
Psychiatry (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

AT08839959T 2007-10-17 2008-10-14 Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung ATE525351T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US98059907P	2007-10-17	2007-10-17
PCT/US2008/079757 WO2009052062A1 (en)	2007-10-17	2008-10-14	Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof

Publications (1)

Publication Number	Publication Date
ATE525351T1 true ATE525351T1 (de)	2011-10-15

Family

ID=40247942

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08839959T ATE525351T1 (de)	2007-10-17	2008-10-14	Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung

Country Status (25)

Country	Link
US (2)	US8088808B2 (de)
EP (1)	EP2212283B1 (de)
JP (1)	JP5377503B2 (de)
KR (1)	KR20100072077A (de)
CN (1)	CN101903340B (de)
AT (1)	ATE525351T1 (de)
AU (1)	AU2008312635B2 (de)
BR (1)	BRPI0818581A2 (de)
CA (1)	CA2702467C (de)
CY (1)	CY1112083T1 (de)
DK (1)	DK2212283T3 (de)
ES (1)	ES2372332T3 (de)
HR (1)	HRP20110762T1 (de)
IL (1)	IL205001A (de)
MA (1)	MA31858B1 (de)
MX (1)	MX2010003949A (de)
MY (1)	MY151348A (de)
NZ (1)	NZ584690A (de)
PL (1)	PL2212283T3 (de)
PT (1)	PT2212283E (de)
RS (1)	RS52235B (de)
RU (1)	RU2477720C2 (de)
SI (1)	SI2212283T1 (de)
WO (1)	WO2009052062A1 (de)
ZA (1)	ZA201002115B (de)

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SI2212282T1 (sl) *	2007-10-17	2012-01-31	Sanofi Sa	Substituirani n-fenil-bipirolidin karboksamidi in njihova terapevtska uporaba
SI2215058T1 (sl)	2007-10-17	2012-03-30	Sanofi Sa	Substituirane N fenil bipirolidin sečnine in njihova terapevtska uporaba
EP2205558B1 (de)	2007-10-17	2012-07-25	Sanofi	Substituierte n-phenylpyrrolidinylmethylpyrrolidinamide und deren therapeutische verwendung als modulatoren des histamin-h3-rezeptors
ES2372332T3 (es) *	2007-10-17	2012-01-18	Sanofi	N-fenil-bipirrolidina carboxamidas sustituidas y su uso terapéutico.
AR074466A1 (es)	2008-12-05	2011-01-19	Sanofi Aventis	Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3.
AR074467A1 (es) *	2008-12-05	2011-01-19	Sanofi Aventis	Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras.
SA110310332B1 (ar)	2009-05-01	2013-12-10	Astrazeneca Ab	مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل )
WO2011143148A1 (en) *	2010-05-11	2011-11-17	Sanofi	Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof
TW201206444A (en) *	2010-05-11	2012-02-16	Sanofi Aventis	Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
EP2569280B1 (de)	2010-05-11	2015-02-25	Sanofi	Substituierte Phenyl-Cycloalkyl-Pyrrolidin- (Piperidin)-Spirolactame und -amide, ihre Herstellung und therapeutische Verwendung
TW201206898A (en) *	2010-05-11	2012-02-16	Sanofi Aventis	Substituted N-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof
EP2569294B1 (de) *	2010-05-11	2015-03-11	Sanofi	Substituierte n-heteroaryl bipyrrolidin carboxamiden , deren herstellung und therapeutische verwendung
AR081498A1 (es)	2010-05-11	2012-09-19	Sanofi Aventis	Derivados de n-alquil -y n-acil-tetrahidroisoquinolina sustituidos, preparacion y su uso terapeutico de los mismos
EP2569297A1 (de)	2010-05-11	2013-03-20	Sanofi	Substituierte n-heterocycloalkyl-bipyrrolidinphenylamidderivate, ihre zubereitung und therapeutische verwendung
AU2011275547B2 (en) *	2010-07-06	2015-10-29	Astrazeneca Ab	Therapeutic agents 976
UY34194A (es)	2011-07-15	2013-02-28	Astrazeneca Ab	?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad?
JP2013232564A (ja) *	2012-04-27	2013-11-14	National Institute Of Advanced Industrial & Technology	半導体装置および半導体装置の製造方法
CN108250128A (zh) *	2012-09-27	2018-07-06	江苏先声药业有限公司	作为钾通道调节剂的化合物
KR20150103752A (ko)	2013-01-10	2015-09-11	그뤼넨탈 게엠베하	Crac 채널 억제제로서의 피라졸릴계 카복스아미드 ⅱ
AR094412A1 (es)	2013-01-10	2015-07-29	Gruenenthal Gmbh	Carboxamidas basadas en pirazolilo i
EP3366683A1 (de)	2017-02-28	2018-08-29	Acousia Therapeutics GmbH	Zyklische amide, acetamide und harnstoffe als kalium kanal öffner

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PE20020507A1 (es) *	2000-10-17	2002-06-25	Schering Corp	Compuestos no-imidazoles como antagonistas del receptor histamina h3
EP1556046A1 (de) *	2002-10-23	2005-07-27	Janssen Pharmaceutica N.V.	Phenylpiperidine und phenylpyrrolidine als histamin-h3-rezeptor-modulatoren
DE10306250A1 (de) *	2003-02-14	2004-09-09	Aventis Pharma Deutschland Gmbh	Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7223788B2 (en) *	2003-02-14	2007-05-29	Sanofi-Aventis Deutschland Gmbh	Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
BRPI0608523A2 (pt)	2005-03-17	2010-11-16	Lilly Co Eli	composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para inibir receptor de histamina h3 em um mamìfero, para tratar ou prevenir um distúrbio do sistema nervoso, para tratar ou prevenir obesidade e para tratar ou prevenir um distúrbio ou doença, e, uso de um composto ou um sal do mesmo
AU2006232871B9 (en) *	2005-04-01	2011-11-24	Eli Lilly And Company	Histamine H3 receptor agents, preparation and therapeutic uses
MX2007016216A (es) *	2005-07-01	2008-03-11	Lilly Co Eli	Agenes del receptor de histamina h3, preparacion y usos terapeuticos.
CA2627234A1 (en) *	2005-10-27	2007-05-03	Ucb Pharma, S.A.	Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses
WO2007093364A1 (en) *	2006-02-15	2007-08-23	Sanofi-Aventis	Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
SI2212282T1 (sl) *	2007-10-17	2012-01-31	Sanofi Sa	Substituirani n-fenil-bipirolidin karboksamidi in njihova terapevtska uporaba
ES2372332T3 (es) *	2007-10-17	2012-01-18	Sanofi	N-fenil-bipirrolidina carboxamidas sustituidas y su uso terapéutico.
EP2205558B1 (de)	2007-10-17	2012-07-25	Sanofi	Substituierte n-phenylpyrrolidinylmethylpyrrolidinamide und deren therapeutische verwendung als modulatoren des histamin-h3-rezeptors
SI2215058T1 (sl)	2007-10-17	2012-03-30	Sanofi Sa	Substituirane N fenil bipirolidin sečnine in njihova terapevtska uporaba

2008
- 2008-10-14 ES ES08839959T patent/ES2372332T3/es active Active
- 2008-10-14 SI SI200830416T patent/SI2212283T1/sl unknown
- 2008-10-14 MX MX2010003949A patent/MX2010003949A/es active IP Right Grant
- 2008-10-14 WO PCT/US2008/079757 patent/WO2009052062A1/en not_active Ceased
- 2008-10-14 PL PL08839959T patent/PL2212283T3/pl unknown
- 2008-10-14 RU RU2010119528/04A patent/RU2477720C2/ru not_active IP Right Cessation
- 2008-10-14 CA CA2702467A patent/CA2702467C/en not_active Expired - Fee Related
- 2008-10-14 EP EP08839959A patent/EP2212283B1/de active Active
- 2008-10-14 NZ NZ584690A patent/NZ584690A/en not_active IP Right Cessation
- 2008-10-14 CN CN2008801212081A patent/CN101903340B/zh not_active Expired - Fee Related
- 2008-10-14 AU AU2008312635A patent/AU2008312635B2/en not_active Ceased
- 2008-10-14 JP JP2010530049A patent/JP5377503B2/ja not_active Expired - Fee Related
- 2008-10-14 BR BRPI0818581-6A patent/BRPI0818581A2/pt not_active IP Right Cessation
- 2008-10-14 MY MYPI20101299 patent/MY151348A/en unknown
- 2008-10-14 HR HR20110762T patent/HRP20110762T1/hr unknown
- 2008-10-14 DK DK08839959.7T patent/DK2212283T3/da active
- 2008-10-14 PT PT08839959T patent/PT2212283E/pt unknown
- 2008-10-14 RS RS20110522A patent/RS52235B/sr unknown
- 2008-10-14 KR KR1020107010769A patent/KR20100072077A/ko not_active Ceased
- 2008-10-14 AT AT08839959T patent/ATE525351T1/de active
2010
- 2010-03-15 US US12/724,028 patent/US8088808B2/en not_active Expired - Fee Related
- 2010-03-25 ZA ZA2010/02115A patent/ZA201002115B/en unknown
- 2010-04-11 IL IL205001A patent/IL205001A/en not_active IP Right Cessation
- 2010-05-17 MA MA32850A patent/MA31858B1/fr unknown
2011
- 2011-11-18 US US13/299,574 patent/US8252824B2/en not_active Expired - Fee Related
- 2011-11-24 CY CY20111101151T patent/CY1112083T1/el unknown

Also Published As

Publication number	Publication date
MY151348A (en)	2014-05-15
JP5377503B2 (ja)	2013-12-25
CA2702467A1 (en)	2009-04-23
CN101903340B (zh)	2013-03-27
US20120065234A1 (en)	2012-03-15
IL205001A (en)	2014-06-30
NZ584690A (en)	2011-09-30
CA2702467C (en)	2012-11-27
RS52235B (sr)	2012-10-31
DK2212283T3 (da)	2011-12-19
JP2011500693A (ja)	2011-01-06
IL205001A0 (en)	2010-11-30
KR20100072077A (ko)	2010-06-29
RU2010119528A (ru)	2011-11-27
MX2010003949A (es)	2010-04-30
US8252824B2 (en)	2012-08-28
PL2212283T3 (pl)	2012-01-31
PT2212283E (pt)	2011-11-03
BRPI0818581A2 (pt)	2015-07-21
EP2212283B1 (de)	2011-09-21
CY1112083T1 (el)	2015-11-04
EP2212283A1 (de)	2010-08-04
ZA201002115B (en)	2010-12-29
HK1146053A1 (en)	2011-05-13
HRP20110762T1 (hr)	2011-11-30
WO2009052062A1 (en)	2009-04-23
ES2372332T3 (es)	2012-01-18
US20100173949A1 (en)	2010-07-08
AU2008312635A1 (en)	2009-04-23
SI2212283T1 (sl)	2011-12-30
CN101903340A (zh)	2010-12-01
US8088808B2 (en)	2012-01-03
RU2477720C2 (ru)	2013-03-20
MA31858B1 (fr)	2010-11-01
AU2008312635B2 (en)	2013-05-16

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Publication	Publication Date	Title
ATE525351T1 (de)	2011-10-15	Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung
ATE525350T1 (de)	2011-10-15	Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung
ATE534625T1 (de)	2011-12-15	Substituierte n-phenyl-bipyrrolidinharnstoffe und deren therapeutische verwendung
MY150210A (en)	2013-12-13	Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators
MX2010009752A (es)	2010-09-30	Compuestos de oxadiazoantraceno para el tratamiento de diabetes.
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