ATE546452T1 - Pyrazolopyrrolderivate als proteinkinaseinhibitoren - Google Patents

Pyrazolopyrrolderivate als proteinkinaseinhibitoren

Info

Publication number: ATE546452T1
Authority: AT; Austria
Prior art keywords: compounds; protein kinase; pyrazolopyrrol; derivatives; kinase inhibitors
Prior art date: 2003-09-23

Application number

AT04785111T

Other languages

English (en)

Inventor

Hayley Binch

Simon Everitt

Francesca Mazzei

Daniel Robinson

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-23

Filing date

2004-09-23

Publication date

2012-03-15

2004-09-23 Application filed by Vertex Pharma filed Critical Vertex Pharma

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE546452T1 publication Critical patent/ATE546452T1/de

Links

229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
239000003909 protein kinase inhibitor Substances 0.000 title 1
GZTPJDLYPMPRDF-UHFFFAOYSA-N pyrrolo[3,2-c]pyrazole Chemical class N1=NC2=CC=NC2=C1 GZTPJDLYPMPRDF-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
102000001253 Protein Kinase Human genes 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
108060006633 protein kinase Proteins 0.000 abstract 2
101000600756 Homo sapiens 3-phosphoinositide-dependent protein kinase 1 Proteins 0.000 abstract 1
101001117146 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Proteins 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Immunology (AREA)
Hematology (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Gastroenterology & Hepatology (AREA)
Virology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT04785111T 2003-09-23 2004-09-23 Pyrazolopyrrolderivate als proteinkinaseinhibitoren ATE546452T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US50523603P	2003-09-23	2003-09-23
PCT/US2004/031610 WO2005030776A1 (en)	2003-09-23	2004-09-23	Pyrazolopyrrole derivatives as protein kinase inhibitors

Publications (1)

Publication Number	Publication Date
ATE546452T1 true ATE546452T1 (de)	2012-03-15

Family

ID=34392996

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04785111T ATE546452T1 (de)	2003-09-23	2004-09-23	Pyrazolopyrrolderivate als proteinkinaseinhibitoren

Country Status (7)

Country	Link
US (2)	US7652135B2 (de)
EP (1)	EP1668013B1 (de)
JP (1)	JP2007506787A (de)
AT (1)	ATE546452T1 (de)
AU (1)	AU2004276341B2 (de)
CA (1)	CA2539549A1 (de)
WO (1)	WO2005030776A1 (de)

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MXPA06003150A (es) *	2003-09-17	2006-08-31	Johnson & Johnson	Compuestos heterociclicos fusionados.
MEP0808A (xx) *	2005-12-21	2010-02-10	Pfizer Prod Inc	Karbonilamino pirolopirayoli, snažni inhibitori kinaza
ES2442491T3 (es)	2006-03-03	2014-02-11	Nerviano Medical Sciences S.R.L.	Biciclopirazoles activos como inhibidores de cinasa
CA2646316C (en)	2006-03-15	2016-05-24	Theralogics, Inc.	Methods of treating muscular wasting diseases using nf-kb activation inhibitors
AR060358A1 (es)	2006-04-06	2008-06-11	Novartis Vaccines & Diagnostic	Quinazolinas para la inhibicion de pdk 1
US20070286864A1 (en) *	2006-06-09	2007-12-13	Buck Elizabeth A	Combined treatment with an EGFR kinase inhibitor and an agent that sensitizes tumor cells to the effects of EGFR kinase inhibitors
WO2008070823A2 (en)	2006-12-07	2008-06-12	University Of South Florida	Substrate-mimetic akt inhibitor
CA2683695C (en)	2007-04-12	2013-06-18	Pfizer Inc.	3-amido-pyrrolo[3,4-c]pyrazole-5(1h,4h,6h) carbaldehyde derivatives
AU2008256940A1 (en) *	2007-05-25	2008-12-04	Elan Pharmaceuticals, Inc.	Pyrazolopyrrolidines as inhibitors of gamma secretase
RU2012116003A (ru)	2009-09-21	2013-10-27	Ф.Хоффманн-Ля Рош Аг	Макроциклические ингибиторы jak
KR102020485B1 (ko)	2013-01-11	2019-09-11	삼성디스플레이 주식회사	블록 공중합체, 그 형성 방법 및 패턴 형성 방법
CA2938626A1 (en)	2013-07-26	2015-01-29	John Rothman	Compositions to improve the therapeutic benefit of bisantrene
WO2016109684A2 (en) *	2014-12-30	2016-07-07	Novira Therapeutics, Inc.	Derivatives and methods of treating hepatitis b infections
WO2017087318A1 (en) *	2015-11-20	2017-05-26	Mingsight Pharmaceuticals, Inc.	Treatment of autoimmune disease
WO2017115372A1 (en)	2015-12-30	2017-07-06	Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd	Pt(IV) PRODRUGS
CN113164459B (zh)	2018-09-28	2024-09-03	詹森药业有限公司	单酰基甘油脂肪酶调节剂
EP4005638A4 (de) *	2019-07-29	2023-07-05	Takeda Pharmaceutical Company Limited	Heterocyclische verbindung
ES3037365T3 (en) *	2019-09-30	2025-10-01	Janssen Pharmaceutica Nv	Radiolabelled mgl pet ligands
CN115073471B (zh) *	2021-03-11	2023-03-21	沈阳药科大学	吡唑并四氢吡咯类衍生物、其制备方法和在医药上的应用

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JP2003500386A (ja)	1999-05-24	2003-01-07	シーオーアールセラピューティクスインコーポレイテッド	Ｘａ因子阻害剤
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DE10023486C1 (de)	2000-05-09	2002-03-14	Schering Ag	Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel
US6897231B2 (en)	2000-07-31	2005-05-24	Signal Pharmaceuticals, Inc.	Indazole derivatives as JNK inhibitors and compositions and methods related thereto
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DK1318997T3 (da) *	2000-09-15	2006-09-25	Vertex Pharma	Pyrazolforbindelser der er nyttige som proteinkinase-inhibitorer
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AU2003244632A1 (en)	2002-07-25	2004-02-25	Pharmacia Italia S.P.A.	Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
UA81790C2 (uk)	2002-12-19	2008-02-11	Фармация Италия С.П.А.	Заміщені піролопіразольні похідні як інгібітори кінази
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US7141568B2 (en) *	2003-07-09	2006-11-28	Pfizer Italia S.R.L.	Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them

2004
- 2004-09-23 WO PCT/US2004/031610 patent/WO2005030776A1/en not_active Ceased
- 2004-09-23 AU AU2004276341A patent/AU2004276341B2/en not_active Ceased
- 2004-09-23 JP JP2006528284A patent/JP2007506787A/ja active Pending
- 2004-09-23 CA CA002539549A patent/CA2539549A1/en not_active Abandoned
- 2004-09-23 AT AT04785111T patent/ATE546452T1/de active
- 2004-09-23 EP EP04785111A patent/EP1668013B1/de not_active Expired - Lifetime
- 2004-09-23 US US10/949,714 patent/US7652135B2/en not_active Expired - Fee Related
2009
- 2009-12-09 US US12/634,136 patent/US8642779B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2007506787A (ja)	2007-03-22
US20050101594A1 (en)	2005-05-12
WO2005030776A1 (en)	2005-04-07
US20100087467A1 (en)	2010-04-08
EP1668013B1 (de)	2012-02-22
AU2004276341A1 (en)	2005-04-07
AU2004276341B2 (en)	2011-04-14
CA2539549A1 (en)	2005-04-07
EP1668013A1 (de)	2006-06-14
US8642779B2 (en)	2014-02-04
US7652135B2 (en)	2010-01-26

Publication	Publication Date	Title
ATE546452T1 (de)	2012-03-15	Pyrazolopyrrolderivate als proteinkinaseinhibitoren
ATE473980T1 (de)	2010-07-15	Triazolopyridazine als proteinkinase-inhibitoren
TW200607505A (en)	2006-03-01	Fused heterocyclic kinase inhibitors
LTC1934174I2 (lt)	2018-01-10	Azetinidai kaip MEK inhibitoriai, skirti proliferacinių ligų gydymui
NO20043531L (no)	2004-10-25	Indazolforbindelser som er nyttige som proteinkinaseinhibitorer
NO20071915L (no)	2007-05-18	Diaminotriazolforbindelser nyttige som proteinkinaseinhibitorer
DE60214703D1 (de)	2006-10-26	Thiazolverbindungen, die sich als inhibitoren von proteinkinasen eignen
SE0402735D0 (sv)	2004-11-09	Novel compounds
ATE371656T1 (de)	2007-09-15	Heteroaryl-pyrimidinderivate als jak-inhibitoren
EA200501849A1 (ru)	2006-06-30	Производные пиразолохиназолина: способ получения и применение в качестве ингибиторов киназ
DE602004011199D1 (de)	2008-02-21	5-phenylthiazolderivate und deren verwendung als p13-kinase-inhibitoren
EA201070167A1 (ru)	2013-07-30	Замещенные производные индазола, активные как ингибиторы киназы
MX2008012422A (es)	2008-10-09	Derivados de furano y tiofeno, pirrol substituido con pirimidinil y piridil como inhibidores de cinasa.
MXPA03010961A (es)	2004-02-27	Compuestos de tiazol utiles como inhibidores de proteinas cinasas.
IL184898A0 (en)	2007-12-03	Pyrrolopyrimidine derivatives and pharmaceutical compositions containing the same
ATE514699T1 (de)	2011-07-15	Substituierte pyrrolopyrazolderivate als kinaseinhibitoren
MX2009011964A (es)	2009-12-01	Derivados heterociclicos pirrolo-nitrogenosos, su preparacion y uso farmaceutico.
ATE532789T1 (de)	2011-11-15	Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
ATE493418T1 (de)	2011-01-15	Dihydrofuropyrimidine als akt- proteinkinaseinhibitoren
EA200600209A1 (ru)	2006-06-30	ПРОИЗВОДНЫЕ ПИРРОЛО[3,4-c]ПИРАЗОЛА, ОБЛАДАЮЩИЕ АКТИВНОСТЬЮ КАК ИНГИБИТОРЫ КИНАЗЫ
IL188942A0 (en)	2008-04-13	Benzimidazole derivatives and pharmaceutical compositions containing the same
TW200700392A (en)	2007-01-01	Novel compounds
MX2007004248A (es)	2007-06-12	Derivados heterociclicos de bisarilurea sustituidos como inhibidores de cinasa.
DE60106409D1 (de)	2004-11-18	3-aminopyrazole als inhibitoren von cyclinabhängigen kinasen
IL179206A0 (en)	2007-03-08	Pyrrolylpyrimidine derivatives and pharmaceutical compositions containing the same