ATE546457T1 - Verfahren und zusammensetzungen zur herstellung von c-3' und c-4' -anthracyclin antibiotika - Google Patents

Verfahren und zusammensetzungen zur herstellung von c-3' und c-4' -anthracyclin antibiotika

Info

Publication number
ATE546457T1
ATE546457T1 AT00935417T AT00935417T ATE546457T1 AT E546457 T1 ATE546457 T1 AT E546457T1 AT 00935417 T AT00935417 T AT 00935417T AT 00935417 T AT00935417 T AT 00935417T AT E546457 T1 ATE546457 T1 AT E546457T1
Authority
AT
Austria
Prior art keywords
anthracycline antibiotics
compositions
producing
preparation
aromatic ring
Prior art date
Application number
AT00935417T
Other languages
English (en)
Inventor
Waldemar Priebe
Izabela Fokt
Teresa Przewloka
Marta Krawczyk
Piotr Skibicki
Grzegorz Grynkiewicz
Roman Perez-Soler
Original Assignee
Waldemar Priebe
Izabela Fokt
Teresa Przewloka
Marta Krawczyk
Piotr Skibicki
Grzegorz Grynkiewicz
Roman Perez-Soler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Waldemar Priebe, Izabela Fokt, Teresa Przewloka, Marta Krawczyk, Piotr Skibicki, Grzegorz Grynkiewicz, Roman Perez-Soler filed Critical Waldemar Priebe
Application granted granted Critical
Publication of ATE546457T1 publication Critical patent/ATE546457T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00935417T 1999-03-19 2000-03-15 Verfahren und zusammensetzungen zur herstellung von c-3' und c-4' -anthracyclin antibiotika ATE546457T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12550599P 1999-03-19 1999-03-19
PCT/IB2000/000527 WO2000056267A2 (en) 1999-03-19 2000-03-15 Methods and compositions for the manufacture of c-3' and c-4' anthracycline antibiotics

Publications (1)

Publication Number Publication Date
ATE546457T1 true ATE546457T1 (de) 2012-03-15

Family

ID=22420031

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00935417T ATE546457T1 (de) 1999-03-19 2000-03-15 Verfahren und zusammensetzungen zur herstellung von c-3' und c-4' -anthracyclin antibiotika

Country Status (6)

Country Link
US (3) US6673907B2 (de)
EP (1) EP1165578B1 (de)
AT (1) ATE546457T1 (de)
AU (1) AU778910B2 (de)
CA (1) CA2366681C (de)
WO (1) WO2000056267A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0114654D0 (en) * 2001-06-15 2001-08-08 Pharmacia & Upjohn Spa Anti-tumor compound
DK1423126T3 (da) * 2001-08-14 2008-02-04 Valderm Aps Behandling af hyperproliferative lidelser på kropsoverflader
US20050208037A1 (en) * 2003-10-21 2005-09-22 Board Of Regents, The University Of Texas System Thioredoxin increases redox-cycling of anticancer agents thereby sensitizes cancer cells to apoptosis
SE0401066D0 (sv) * 2004-04-22 2004-04-22 Stefan Sjoeberg Chemical Derivatives
US7737123B2 (en) * 2005-05-12 2010-06-15 The Ohio State University Research Foundation Multidrug resistant anticancer anthracyclines
DE06848583T1 (de) * 2005-12-13 2011-03-17 Solux Corporation, San Diego Verfahren zur herstellung von 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
AU2007248019B2 (en) * 2006-05-03 2012-10-11 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Chimeric T cell receptors and related materials and methods of use
CA2653770A1 (en) * 2006-06-01 2007-12-06 Reata Pharmaceuticals, Inc. Combination of chemotherapeutic compounds for treating cancer
PL380561A1 (pl) * 2006-09-05 2008-03-17 Szeja Wiesław Prochem Szeja Sposób otrzymywania pochodnych antracyklin
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US10358439B2 (en) 2015-09-16 2019-07-23 Board Of Regents, The University Of Texas System DNA binding agents with a minor groove binding tail

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL124284B1 (en) * 1979-10-17 1983-01-31 Politechnika Gdanska Process for preparing n-glycosyl derivatives of antibiotics from anthracyclines group
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
FR2648137A1 (fr) * 1989-06-07 1990-12-14 Hoechst Lab Nouvelles anthracyclines, leur procede de preparation ainsi que medicaments les contenant
DE4119472A1 (de) * 1991-06-13 1992-12-17 Merck Patent Gmbh Verfahren zur stereoselektiven herstellung von gal-(alpha)(1-3)/gal-(beta)(1-4)/glcnac-trisacchariden und von neuen (beta)(1-3)-verknuepften oligolactosaminen ueber neue partiell alkylierte glykale
WO1994020114A1 (en) * 1993-03-12 1994-09-15 Board Of Regents, The University Of Texas System Anthracyclines with unusually high activity against cells resistant to doxorubicin and its analogs

Also Published As

Publication number Publication date
CA2366681C (en) 2009-12-22
US20070037758A1 (en) 2007-02-15
EP1165578A4 (de) 2002-08-28
WO2000056267A8 (en) 2001-05-17
US6673907B2 (en) 2004-01-06
WO2000056267A2 (en) 2000-09-28
US20050004048A1 (en) 2005-01-06
AU5095800A (en) 2000-10-09
US20020137694A1 (en) 2002-09-26
WO2000056267A3 (en) 2001-02-22
AU778910B2 (en) 2004-12-23
US7109177B2 (en) 2006-09-19
EP1165578A2 (de) 2002-01-02
EP1165578B1 (de) 2012-02-22
US7557090B2 (en) 2009-07-07
CA2366681A1 (en) 2000-09-28

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