ES2158093T3 - Compuesto del 9-desoxotaxano. - Google Patents

Compuesto del 9-desoxotaxano.

Info

Publication number
ES2158093T3
ES2158093T3 ES95912007T ES95912007T ES2158093T3 ES 2158093 T3 ES2158093 T3 ES 2158093T3 ES 95912007 T ES95912007 T ES 95912007T ES 95912007 T ES95912007 T ES 95912007T ES 2158093 T3 ES2158093 T3 ES 2158093T3
Authority
ES
Spain
Prior art keywords
deoxotaxan
composite
compounds
taxol
oxygenated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95912007T
Other languages
English (en)
Inventor
Larry L Klein
Clinton M Yeung
Leping Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2158093T3 publication Critical patent/ES2158093T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

COMPUESTOS QUE TIENEN LA FORMULA (I), EN DONDE -OR 1 COMPRENDE ALCANOILO O LA CADENA LATERAL C-13 DE PACLITAXEL; R{SUP,2}, R{SUP,3} Y R{SUP,6} PUEDEN SER OXIGENADOS O HIDROGENO EN VARIAS COMBINACIONES; Y R{SUP,4} Y R{SUP,5} SON GRUPOS ACILO, ASI COMO UN PROCESO PARA LA PREPARACION DE LOS MISMOS, COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS ANTERIORES COMPUESTOS, Y UN METODO PARA SU USO EN EL INHIBICION DEL CRECIMIENTO TUMORAL.
ES95912007T 1994-03-09 1995-03-01 Compuesto del 9-desoxotaxano. Expired - Lifetime ES2158093T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/208,509 US5440056A (en) 1992-04-17 1994-03-09 9-deoxotaxane compounds

Publications (1)

Publication Number Publication Date
ES2158093T3 true ES2158093T3 (es) 2001-09-01

Family

ID=22774850

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95912007T Expired - Lifetime ES2158093T3 (es) 1994-03-09 1995-03-01 Compuesto del 9-desoxotaxano.

Country Status (15)

Country Link
US (2) US5440056A (es)
EP (1) EP0749432B1 (es)
JP (1) JPH09511235A (es)
KR (1) KR970701708A (es)
AT (1) ATE201019T1 (es)
AU (1) AU688946B2 (es)
CA (1) CA2182103A1 (es)
DE (1) DE69520880T2 (es)
DK (1) DK0749432T3 (es)
ES (1) ES2158093T3 (es)
GR (1) GR3036286T3 (es)
IL (1) IL112880A0 (es)
PH (1) PH31271A (es)
PT (1) PT749432E (es)
WO (1) WO1995024402A1 (es)

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US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
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US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US6339164B1 (en) 1993-01-29 2002-01-15 Florida State University C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6710191B2 (en) 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
US6066747A (en) * 1993-03-05 2000-05-23 Florida State University Process for the preparation of 9-desoxotaxanes
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US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
AU724499B2 (en) 1996-05-06 2000-09-21 Florida State University 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
US8137684B2 (en) * 1996-10-01 2012-03-20 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US6111144A (en) 1997-08-21 2000-08-29 Florida State University Method for the synthesis of a taxane intermediate
US20050222246A1 (en) * 1999-04-14 2005-10-06 Li Chiang J Beta-lapachone is a broad spectrum anti-cancer agent
US20050192360A1 (en) * 1999-04-14 2005-09-01 Li Chiang J. Method of treatment of pancreatic cancer
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US20050197405A1 (en) * 2000-11-07 2005-09-08 Li Chiang J. Treatment of hematologic tumors and cancers with beta-lapachone, a broad spectrum anti-cancer agent
US7070797B2 (en) * 2000-11-07 2006-07-04 Dana Farber Cancer Institute, Inc. Method of treating hematologic tumors and cancers
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CA2440935A1 (en) 2001-03-13 2002-09-19 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
DE60220519T2 (de) * 2001-04-20 2007-09-27 The University Of British Columbia, Vancouver Mizellares arzneistoffverabreichungssystem für hydrophobe arzneistoffe
WO2003026581A2 (en) * 2001-09-26 2003-04-03 Intermune, Inc. Pharmaceutical compositions and methods for treating cancer
US20030216758A1 (en) * 2001-12-28 2003-11-20 Angiotech Pharmaceuticals, Inc. Coated surgical patches
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US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
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US20050187288A1 (en) * 2004-02-20 2005-08-25 Chiang Li Beta-lapachone and methods of treating cancer
US20050192247A1 (en) * 2004-02-23 2005-09-01 Li Chiang J. Method of treating cancers
US7846940B2 (en) * 2004-03-31 2010-12-07 Cordis Corporation Solution formulations of sirolimus and its analogs for CAD treatment
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
US8003122B2 (en) * 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
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US20060135468A1 (en) 2004-09-02 2006-06-22 Bionaut Pharmaceuticals, Inc. Treatment of refractory cancers using NA+/K+ ATPase inhibitors
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US20070073385A1 (en) * 2005-09-20 2007-03-29 Cook Incorporated Eluting, implantable medical device
US7919108B2 (en) * 2006-03-10 2011-04-05 Cook Incorporated Taxane coatings for implantable medical devices
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US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5416225A (en) * 1992-03-30 1995-05-16 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol
CA2130578A1 (en) * 1992-04-17 1993-10-28 Geewananda P. Gunawardana Taxol derivatives
IL108316A (en) * 1993-01-15 2006-10-31 Univ Florida State C10 taxane derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DK0749432T3 (da) 2001-07-30
MX9603891A (es) 1997-07-31
ATE201019T1 (de) 2001-05-15
CA2182103A1 (en) 1995-09-14
US5440056A (en) 1995-08-08
DE69520880D1 (de) 2001-06-13
PH31271A (en) 1998-06-18
IL112880A0 (en) 1995-06-29
AU688946B2 (en) 1998-03-19
AU3104795A (en) 1995-09-25
WO1995024402A1 (en) 1995-09-14
DE69520880T2 (de) 2001-12-20
PT749432E (pt) 2001-09-28
EP0749432B1 (en) 2001-05-09
KR970701708A (ko) 1997-04-12
GR3036286T3 (en) 2001-10-31
EP0749432A1 (en) 1996-12-27
US5616740A (en) 1997-04-01
JPH09511235A (ja) 1997-11-11

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