ATE547114T1 - Flüssige zusammensetzungen von factor vii polypeptiden - Google Patents
Flüssige zusammensetzungen von factor vii polypeptidenInfo
- Publication number
- ATE547114T1 ATE547114T1 AT04738944T AT04738944T ATE547114T1 AT E547114 T1 ATE547114 T1 AT E547114T1 AT 04738944 T AT04738944 T AT 04738944T AT 04738944 T AT04738944 T AT 04738944T AT E547114 T1 ATE547114 T1 AT E547114T1
- Authority
- AT
- Austria
- Prior art keywords
- factor vii
- liquid compositions
- vii polypeptides
- iii
- ionic strength
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 229940012413 factor vii Drugs 0.000 title abstract 2
- 239000007788 liquid Substances 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 102100023804 Coagulation factor VII Human genes 0.000 abstract 1
- 108010023321 Factor VII Proteins 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 159000000003 magnesium salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300959 | 2003-06-25 | ||
| US48433403P | 2003-07-02 | 2003-07-02 | |
| PCT/DK2004/000181 WO2004082708A2 (en) | 2003-03-18 | 2004-03-18 | Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides |
| PCT/DK2004/000447 WO2004112828A1 (en) | 2003-06-25 | 2004-06-24 | Liquid composition of factor vii polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE547114T1 true ATE547114T1 (de) | 2012-03-15 |
Family
ID=36816398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04738944T ATE547114T1 (de) | 2003-06-25 | 2004-06-24 | Flüssige zusammensetzungen von factor vii polypeptiden |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20060183683A1 (de) |
| EP (1) | EP1641487B1 (de) |
| JP (1) | JP4658041B2 (de) |
| AT (1) | ATE547114T1 (de) |
| ES (1) | ES2382157T3 (de) |
| WO (1) | WO2004112828A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005002615A1 (en) * | 2003-07-01 | 2005-01-13 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical composition of factor vii polypeptides |
| CA2531988C (en) | 2003-08-05 | 2016-06-28 | Novo Nordisk A/S | Novel insulin derivatives |
| AU2012213951B2 (en) * | 2005-04-28 | 2014-10-16 | Novo Nordisk Health Care Ag | A closed container comprising an activated factor VII polypeptide, processes for the preparation of the same, and a kit and a method for use of the kit |
| CN101184474B (zh) * | 2005-04-28 | 2013-05-29 | 诺和诺德医疗保健公司 | 含有活化的凝血因子ⅶ多肽的密封容器,制备这种容器的方法,和试剂盒以及该试剂盒的使用方法 |
| US8097584B2 (en) | 2005-05-25 | 2012-01-17 | Novo Nordisk A/S | Stabilized formulations of insulin that comprise ethylenediamine |
| WO2006125762A1 (en) * | 2005-05-25 | 2006-11-30 | Novo Nordisk A/S | Stabilized polypeptide formulations |
| ES2371361T3 (es) | 2005-12-28 | 2011-12-30 | Novo Nordisk A/S | Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones. |
| CN104887620A (zh) | 2007-05-02 | 2015-09-09 | 诺沃—诺迪斯克保健股份有限公司 | 包括芳香族防腐剂和抗氧化剂的高浓度因子vii多肽制剂 |
| JP5552046B2 (ja) | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー/エス | インスリン誘導体を含有する薬学的製剤 |
| NL1034535C2 (nl) | 2007-10-17 | 2009-04-20 | Vanderlande Ind Nederland | Station voor het vanuit producthouders verzamelen van producten in verzamelhouders. |
| WO2009141418A1 (en) * | 2008-05-23 | 2009-11-26 | Novo Nordisk A/S | Formulations of peg-functionalised serine proteases with high concentrations of an aromatic preservative |
| EP2285401A1 (de) * | 2008-05-23 | 2011-02-23 | Novo Nordisk Health Care AG | Niederviskose zusammensetzungen mit einem pegylierten protein mit gla-domäne |
| JP4959005B2 (ja) | 2008-10-30 | 2012-06-20 | ノボ・ノルデイスク・エー/エス | 毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療 |
| US20120076779A1 (en) * | 2010-09-17 | 2012-03-29 | Baxter Healthcare S.A. | STABILIZATION OF IMMUNOGLOBULINS AND OTHER PROTEINS THROUGH AQUEOUS FORMULATIONS WITH SODIUM CHLORIDE AT WEAK ACIDIC TO NEUTRAL ph |
| DK2632478T3 (da) | 2010-10-27 | 2019-10-07 | Novo Nordisk As | Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller |
| US8883979B2 (en) | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
| EP2991672A1 (de) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Neuartiges verabreichungsschema |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| US12343383B2 (en) | 2019-07-12 | 2025-07-01 | Novo Nordisk A/S | High concentration insulin formulation |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US115590A (en) * | 1871-06-06 | Lfxlproxeixie | ||
| DE2916711A1 (de) * | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
| US4956386A (en) * | 1980-04-25 | 1990-09-11 | Gist-Brocades N.V. | Pharmaceutical compositions and process for their preparation |
| US4404132A (en) * | 1980-05-27 | 1983-09-13 | Cutter Laboratories, Inc. | Blood coagulation promoting product |
| CA1182748A (en) | 1980-11-21 | 1985-02-19 | Gerard Marx | Method for synthesizing procoagulant factor viii activity |
| US4495278A (en) * | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
| GR860984B (en) * | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| AU593042B2 (en) | 1985-11-26 | 1990-02-01 | Novo Nordisk Health Care Ag | Compositions and methods for the treatment of bleeding disorders |
| US5180583A (en) * | 1985-11-26 | 1993-01-19 | Hedner Ulla K E | Method for the treatment of bleeding disorders |
| US5595886A (en) * | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
| AU607927B2 (en) | 1986-06-24 | 1991-03-21 | Nordisk Gentofte A/S | A process for producing a coagulation active complex of factor viii fragments |
| JP2824430B2 (ja) | 1989-08-02 | 1998-11-11 | 財団法人化学及血清療法研究所 | 血液凝固第▲vii▼因子または活性型血液凝固第▲vii▼因子の調製方法 |
| DE4001451A1 (de) * | 1990-01-19 | 1991-08-01 | Octapharma Ag | Stabile injizierbare loesungen von faktor viii und faktor ix |
| US5788965A (en) | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
| US5833982A (en) | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
| WO1992015686A1 (en) | 1991-02-28 | 1992-09-17 | Zymogenetics, Inc. | Modified factor vii |
| AU2309692A (en) | 1991-07-03 | 1993-02-11 | Cryolife, Inc. | Method for stabilization of biomaterials |
| FR2684999A1 (fr) | 1991-12-16 | 1993-06-18 | Aquitaine Dev Transf Sanguine | Procede de fabrication d'un concentre de facteur vii active de haute purete essentiellement depourvu des facteurs vitamine k dependants et des facteurs viiic et viiicag. |
| JP3155797B2 (ja) | 1991-12-26 | 2001-04-16 | 株式会社日立製作所 | 過電圧自己保護型半導体装置、及び、それを使用した半導体回路 |
| CA2143125C (en) | 1992-08-27 | 2008-09-23 | Koenraad Mertens | Antibodies specific for a haemostatic protein, their use for isolating intact protein, haemostatic compositions devoid of proteolytic cleavage products of the protein |
| DK38293D0 (da) | 1993-03-31 | 1993-03-31 | Novo Nordisk As | Fremstilling af proteiner |
| SE9301581D0 (sv) | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Protein formulation |
| EP0699075B1 (de) | 1993-05-21 | 2001-12-12 | Zymogenetics, Inc. | MODIFIZIERTER FAKTOR VII zur Hemmung der vaskulären Restenosis und Thrombozytenablagerung |
| WO1995003332A1 (en) * | 1993-07-23 | 1995-02-02 | Baxter International Inc. | Activated human factor viii and method of preparation |
| US6277828B1 (en) * | 1993-08-20 | 2001-08-21 | Syntex (U.S.A.) Inc. | Pharmaceutical formulations of nerve growth factor |
| US5576291A (en) * | 1993-09-13 | 1996-11-19 | Baxter International Inc. | Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency |
| US5590109A (en) * | 1993-09-17 | 1996-12-31 | Matsushita Electric Industrial Co. | Disc apparatus |
| IL113010A (en) * | 1994-03-31 | 1999-10-28 | Pharmacia & Upjohn Ab | Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
| US6372716B1 (en) | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
| DE4435520A1 (de) * | 1994-10-04 | 1996-04-11 | Immuno Ag | Verfahren zur Trennung von rekombinantem pro-Faktor IX von rekombinantem Faktor IX |
| SE9403915D0 (sv) * | 1994-11-14 | 1994-11-14 | Annelie Almstedt | Process A |
| US5649959A (en) * | 1995-02-10 | 1997-07-22 | Sherwood Medical Company | Assembly for sealing a puncture in a vessel |
| US6255091B1 (en) | 1995-04-28 | 2001-07-03 | Axys Pharmaceuticals, Inc. | Potentiating metal mediated serine protease inhibitors with cobalt or zinc ions |
| DE19531637A1 (de) | 1995-08-28 | 1997-03-06 | Immuno Ag | Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung |
| DE19538715A1 (de) | 1995-10-18 | 1997-04-30 | Behringwerke Ag | Verfahren zur Reinigung von Faktor VII und aktiviertem Faktor VII |
| US5993795A (en) * | 1995-11-09 | 1999-11-30 | Takemoto Yushi Kabushiki Kaisha | Protein composition derived from sesame seed and use thereof |
| US6320029B1 (en) * | 1996-11-29 | 2001-11-20 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
| US5925738A (en) * | 1995-12-01 | 1999-07-20 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
| US5830852A (en) * | 1995-12-19 | 1998-11-03 | Cobra Therapeutics, Ltd. | Compositions for insulin-receptor mediated nucleic acid delivery |
| US5770700A (en) * | 1996-01-25 | 1998-06-23 | Genetics Institute, Inc. | Liquid factor IX formulations |
| US5927739A (en) * | 1996-10-07 | 1999-07-27 | Evling; Jens | Dual friction wheelchair hand rim |
| US5804420A (en) * | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| CZ298429B6 (cs) * | 1997-04-28 | 2007-10-03 | Eli Lilly And Company | Stabilní lyofilizovaný prostredek |
| US6310183B1 (en) * | 1997-09-10 | 2001-10-30 | Novo Nordisk A/S | Coagulation factor VIIa composition |
| AT409334B (de) | 1997-09-19 | 2002-07-25 | Immuno Ag | Pharmazeutisches präparat enthaltend vitamin k-abhängige einzelfaktoren |
| AT408613B (de) | 1998-06-17 | 2002-01-25 | Immuno Ag | Pharmazeutisches faktor vii-präparat |
| JP2002526557A (ja) | 1998-10-07 | 2002-08-20 | シグマ−アルドリッチ・カンパニー | トロンボプラスチン試薬ならびにそのような試薬の製造および使用方法 |
| DK1820516T3 (da) * | 1999-02-22 | 2013-10-28 | Univ Connecticut | Nye albuminfrie faktor VIII-præparater |
| US20010031721A1 (en) * | 1999-05-05 | 2001-10-18 | Chandra Webb | Highly concentrated, lyophilized, and liquid factor IX formulations |
| DE60024268T2 (de) | 1999-07-13 | 2006-08-03 | Biovitrum Ab | Zusammensetzungen mit stabilem faktor viii |
| US6586574B1 (en) * | 1999-08-17 | 2003-07-01 | Nn A/S | Stabilization of freeze-dried cake |
| DE60009926T2 (de) | 1999-08-17 | 2005-04-07 | Novo Nordisk Health Care Ag | Stabilisierung von gefriergetrocknetem kuchen |
| AU6875900A (en) * | 1999-09-08 | 2001-04-10 | Chugai Seiyaku Kabushiki Kaisha | Protein solution preparation and method of stabilizing the same |
| CA2739933A1 (en) | 2000-02-11 | 2001-08-16 | Bayer Healthcare Llc | Factor vii or viia-like molecules |
| EP1280548B1 (de) | 2000-05-03 | 2013-12-11 | Novo Nordisk Health Care AG | Subkutane Verabreichung des Koagulationsfaktor VII |
| JP4455802B2 (ja) * | 2000-05-03 | 2010-04-21 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | ヒト第vii凝固因子変異型 |
| JP2004505016A (ja) | 2000-05-10 | 2004-02-19 | ノボ ノルディスク アクティーゼルスカブ | 第VIIa因子及び第XIII因子を含んで成る医薬組成物 |
| WO2002022776A2 (en) | 2000-09-13 | 2002-03-21 | Novo Nordisk A/S | Human coagulation factor vii variants |
| BR0114373A (pt) * | 2000-10-02 | 2004-02-17 | Novo Nordisk As | Célula hospedeira eucariótica, métodos para a produção de fvii e de fviia ou de suas variantes, de uma proteìna dependente de vitamina k e de uma célula hospedeira eucariótica produtora de fvii ou de seu análogo, vetor recombinante, fvii e fviia recombinante ou suas variantes, e, proteìna dependente de vitamina k recombinante |
| DE50114021D1 (de) * | 2001-01-08 | 2008-07-24 | Csl Behring Gmbh | Stabilisierte Flüssigzubereitung der den Blutgerinnungsfaktor VII aktivierenden Protease oder ihres Proenzyms |
| US6825323B2 (en) * | 2001-01-10 | 2004-11-30 | The United States Of America As Represented By The Secretary Of The Army | Compositions for treatment of hemorrhaging with activated factor VIIa in combination with fibrinogen and methods of using same |
| GB0117879D0 (en) | 2001-07-21 | 2001-09-12 | Common Services Agency | Storage of liquid compositions |
| AU2002351755A1 (en) | 2001-12-21 | 2003-07-15 | Novo Nordisk A/S | Liquid composition of modified factor vii polypeptides |
| EP1458408B1 (de) | 2001-12-21 | 2009-04-15 | Novo Nordisk Health Care AG | Flüssige zusammensetzung aus faktor vii polypeptiden |
| KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
| WO2003092731A1 (en) | 2002-05-03 | 2003-11-13 | Novo Nordisk A/S | Stabilised solid compositions of modified factor vii |
| US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| CN1671410B (zh) | 2002-06-21 | 2010-05-12 | 诺和诺德医疗保健公司 | 因子ⅶ多肽的稳定化固体组合物 |
| US6933808B2 (en) | 2002-07-17 | 2005-08-23 | Qing Ma | Microelectromechanical apparatus and methods for surface acoustic wave switching |
| EP1422309A1 (de) | 2002-11-22 | 2004-05-26 | Siemens Aktiengesellschaft | Verwendung einer Sprühkompaktierungsanlage zur Erzeugung einer Schicht und Schichtsystem hergestellt mittels einer Sprühkompaktierungsanlage und Schichtsystem |
| AT501088A2 (de) | 2002-12-18 | 2006-06-15 | Bio Prod & Bio Eng Ag | Stabile therapeutische proteine |
| US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
-
2004
- 2004-06-24 EP EP04738944A patent/EP1641487B1/de not_active Expired - Lifetime
- 2004-06-24 JP JP2006515730A patent/JP4658041B2/ja not_active Expired - Fee Related
- 2004-06-24 AT AT04738944T patent/ATE547114T1/de active
- 2004-06-24 ES ES04738944T patent/ES2382157T3/es not_active Expired - Lifetime
- 2004-06-24 WO PCT/DK2004/000447 patent/WO2004112828A1/en not_active Ceased
-
2005
- 2005-12-15 US US11/304,429 patent/US20060183683A1/en not_active Abandoned
-
2008
- 2008-05-20 US US12/154,088 patent/US7790852B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004112828A1 (en) | 2004-12-29 |
| JP4658041B2 (ja) | 2011-03-23 |
| ES2382157T3 (es) | 2012-06-05 |
| US20060183683A1 (en) | 2006-08-17 |
| EP1641487B1 (de) | 2012-02-29 |
| JP2007508235A (ja) | 2007-04-05 |
| EP1641487A1 (de) | 2006-04-05 |
| US7790852B2 (en) | 2010-09-07 |
| US20080227715A1 (en) | 2008-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL162239A0 (en) | Liquid composition of factor vii polypeptides | |
| ATE547114T1 (de) | Flüssige zusammensetzungen von factor vii polypeptiden | |
| BR0215218A (pt) | Composição aquosa lìquida, método para a preparação da mesma, uso de uma composição, e, métodos para a inibição da coagulação do sangue em um indivìduo, e inibição de reações mediadas pelo fator de tecido em um indivìduo | |
| BR9714434A (pt) | Formulações de interferon liquidas estáveis | |
| MXPA03002218A (es) | Peptidos antimicrobianos y metodos de uso. | |
| BR0014486A (pt) | Composições farmacêuticas contendo polipeptìdeo lìquido estabilizado | |
| EA200501675A1 (ru) | Фармацевтическая композиция, содержащая лактат, и ее применение | |
| WO2005016365A3 (en) | Liquid, aqueous pharmaceutical composition of factor vii polypeptides | |
| ATE367429T1 (de) | Stabilisierte saure chlorbleichmittelzusammensetzung und verfahren zur anwendung | |
| BR0211404A (pt) | Aminas, ácidos, aminoácidos e tioéter ácidos substituìdos com perfluoroalquil | |
| ATE446313T1 (de) | Muteine von tränen-lipocalin | |
| DE60205234D1 (de) | 1,2,3,4-tetrahydroisochinolin-derivate als urotensin ii rezeptor-antagonisten | |
| BR0313970A (pt) | Composições pesticidas contendo ácidos dicarboxìlicos | |
| ATE527261T1 (de) | 7-aryl-3,9-diazabicycloä3.3.1ünon-6-en-derivate und ihre verwendung als renin-inhibitoren zur behandlung von bluthochdruck, herz-kreislauf- erkrankungen und nierenkrankheiten | |
| WO2003012050A3 (en) | Mitochondrial genome replenishment | |
| FI117284B (fi) | Materiaaliyhdistelmä veden puhdistamiseksi ja maaperien puhdistamiseksi | |
| BR0207826A (pt) | Composições pesticidas contendo ácido oxálico | |
| ATE505555T1 (de) | Fusionsproteine zur insektenbekämpfung | |
| ATE536886T1 (de) | Stabilisierte feste zusammensetzungen von modifizierter faktor vii | |
| MXPA04000428A (es) | Alimento que contiene proteina que comprende una enzima de entrelazamiento y un hidrocoloide. | |
| DE60239329D1 (de) | Verwendung von lanthankarbonat zur prävention von nierensteinleiden | |
| ATE294816T1 (de) | Neue, physiologisch aktive peptide und ihre verwendung. | |
| ATE349920T1 (de) | Stark saure metallisierte mischungen anorganischer säuren | |
| Janković et al. | Short catalytic peptides with tunable activity: Cys confers functionality and adaptability | |
| WO2003053855A3 (en) | Rapid high-throughput screen for detecting biological species in ballast water |