ATE547410T1 - Verfahren zur herstellung von (s)-(+)-n-methyl-3- (1-naphthyloxy)-3-(2-thienyl)-propylamin mittels einer optisch aktiven methylhydroxylaminopropanolverbindung als zwischenprodukt - Google Patents

Verfahren zur herstellung von (s)-(+)-n-methyl-3- (1-naphthyloxy)-3-(2-thienyl)-propylamin mittels einer optisch aktiven methylhydroxylaminopropanolverbindung als zwischenprodukt

Info

Publication number
ATE547410T1
ATE547410T1 AT10156142T AT10156142T ATE547410T1 AT E547410 T1 ATE547410 T1 AT E547410T1 AT 10156142 T AT10156142 T AT 10156142T AT 10156142 T AT10156142 T AT 10156142T AT E547410 T1 ATE547410 T1 AT E547410T1
Authority
AT
Austria
Prior art keywords
methyl
naphthyloxy
thienyl
propylamin
producing
Prior art date
Application number
AT10156142T
Other languages
English (en)
Inventor
Bo-Feng Chen
Jinun-Ban Yeh
Weichyun Wong
Feng-Ju Lu
Original Assignee
Sci Pharmatech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sci Pharmatech Inc filed Critical Sci Pharmatech Inc
Application granted granted Critical
Publication of ATE547410T1 publication Critical patent/ATE547410T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT10156142T 2009-03-12 2010-03-10 Verfahren zur herstellung von (s)-(+)-n-methyl-3- (1-naphthyloxy)-3-(2-thienyl)-propylamin mittels einer optisch aktiven methylhydroxylaminopropanolverbindung als zwischenprodukt ATE547410T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/402,740 US8148549B2 (en) 2009-03-12 2009-03-12 Preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl) propylamine using optically active methylhydroxylaminopropanol compound as an intermediate
US12/718,289 US8614336B2 (en) 2009-03-12 2010-03-05 Process for preparing N-methyl-N-hydroxyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine derivative

Publications (1)

Publication Number Publication Date
ATE547410T1 true ATE547410T1 (de) 2012-03-15

Family

ID=42167649

Family Applications (1)

Application Number Title Priority Date Filing Date
AT10156142T ATE547410T1 (de) 2009-03-12 2010-03-10 Verfahren zur herstellung von (s)-(+)-n-methyl-3- (1-naphthyloxy)-3-(2-thienyl)-propylamin mittels einer optisch aktiven methylhydroxylaminopropanolverbindung als zwischenprodukt

Country Status (5)

Country Link
US (2) US8148549B2 (de)
EP (1) EP2228372B1 (de)
JP (1) JP5143167B2 (de)
AT (1) ATE547410T1 (de)
ES (1) ES2382604T3 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8148549B2 (en) * 2009-03-12 2012-04-03 Sci Pharmtech, Inc. Preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl) propylamine using optically active methylhydroxylaminopropanol compound as an intermediate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956388A (en) * 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
DE10207586A1 (de) * 2002-02-22 2003-09-11 Degussa Herstellung von N-Methyl-3-hydroxy-3-(2-thienyl)propanamin über neue carbamatgruppenhaltige Thiophenderivate als Zwischenprodukte
JP2007523213A (ja) * 2004-12-23 2007-08-16 テバ ファーマシューティカル インダストリーズ リミティド 医薬的に許容できるデュロキセチンの塩及びその中間体の調製方法
US7538232B2 (en) * 2006-01-19 2009-05-26 Eli Lilly And Company Process for the asymmetric synthesis of duloxetine
EP2114912B1 (de) * 2006-12-22 2012-04-04 Synthon B.V. Verfahren zur herstellung von duloxetin und verwandten verbindungen
US7829731B2 (en) * 2007-10-29 2010-11-09 Sci Pharmtech, Inc. Methylhydroxylaminopropanol derivative and its use as intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-OL
US8148549B2 (en) * 2009-03-12 2012-04-03 Sci Pharmtech, Inc. Preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl) propylamine using optically active methylhydroxylaminopropanol compound as an intermediate

Also Published As

Publication number Publication date
US20100234620A1 (en) 2010-09-16
EP2228372B1 (de) 2012-02-29
EP2228372A1 (de) 2010-09-15
JP5143167B2 (ja) 2013-02-13
ES2382604T3 (es) 2012-06-11
US8148549B2 (en) 2012-04-03
US8614336B2 (en) 2013-12-24
JP2010215623A (ja) 2010-09-30
US20100234619A1 (en) 2010-09-16

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