ATE445601T1 - Verfahren zur herstellung von carvedilol und seinen enantiomeren - Google Patents
Verfahren zur herstellung von carvedilol und seinen enantiomerenInfo
- Publication number
- ATE445601T1 ATE445601T1 AT05815876T AT05815876T ATE445601T1 AT E445601 T1 ATE445601 T1 AT E445601T1 AT 05815876 T AT05815876 T AT 05815876T AT 05815876 T AT05815876 T AT 05815876T AT E445601 T1 ATE445601 T1 AT E445601T1
- Authority
- AT
- Austria
- Prior art keywords
- enantiomers
- carvedilol
- producing
- preparation
- relates
- Prior art date
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title abstract 4
- NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 title abstract 3
- 229960004195 carvedilol Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000007810 chemical reaction solvent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106438 | 2004-12-09 | ||
| PCT/EP2005/056469 WO2006061364A1 (en) | 2004-12-09 | 2005-12-05 | Process for the preparation of carvedilol and its enantiomers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE445601T1 true ATE445601T1 (de) | 2009-10-15 |
Family
ID=35985349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05815876T ATE445601T1 (de) | 2004-12-09 | 2005-12-05 | Verfahren zur herstellung von carvedilol und seinen enantiomeren |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20090005429A1 (de) |
| EP (1) | EP1838670B1 (de) |
| JP (1) | JP2008523025A (de) |
| CN (1) | CN100591668C (de) |
| AT (1) | ATE445601T1 (de) |
| CA (1) | CA2589699A1 (de) |
| CY (1) | CY1110688T1 (de) |
| DE (1) | DE602005017194D1 (de) |
| DK (1) | DK1838670T3 (de) |
| ES (1) | ES2333537T3 (de) |
| HR (1) | HRP20100023T1 (de) |
| IL (1) | IL183449A0 (de) |
| PL (1) | PL1838670T3 (de) |
| PT (1) | PT1838670E (de) |
| SI (1) | SI1838670T1 (de) |
| WO (1) | WO2006061364A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004501191A (ja) | 2000-06-28 | 2004-01-15 | テバ ファーマシューティカル インダストリーズ リミティド | カルベジロール |
| MXPA04006909A (es) | 2002-01-15 | 2005-04-19 | Teva Pharma | Solidos cristalinos de carvedilol y procesos para su preparacion. |
| KR100746455B1 (ko) * | 2006-02-23 | 2007-08-03 | 안국약품 주식회사 | 고광학순도의 키랄 카베딜롤의 제조방법 |
| WO2008002683A2 (en) | 2006-06-28 | 2008-01-03 | Teva Pharmaceutical Industries Ltd. | Polymorphous forms of carvedilol phosphate |
| CN102190613B (zh) * | 2010-03-14 | 2014-06-25 | 浙江华海药业股份有限公司 | 一种卡维地洛的制备方法 |
| JP6018041B2 (ja) | 2010-03-23 | 2016-11-02 | シガ・テクノロジーズ・インコーポレーテッド | Ｓｔ−２４６の多形型および調製方法 |
| WO2015031914A1 (en) * | 2013-08-30 | 2015-03-05 | Uti Limited Partnership | Store overload-induced calcium release inhibitors and methods for producing and using the same |
| CN104592096A (zh) * | 2014-12-24 | 2015-05-06 | 江苏苏南药业实业有限公司 | 一种s-卡维地洛的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3319027A1 (de) * | 1983-05-26 | 1984-11-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten |
| EP0893440A1 (de) * | 1997-07-22 | 1999-01-27 | Roche Diagnostics GmbH | Eine thermodynamisch stabile Modifikation von 1-(4-Carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]- 2-propanole, Verfahren zu ihrer Herstellung und ihre enthaltende Arznemittel |
| JP2004501191A (ja) * | 2000-06-28 | 2004-01-15 | テバ ファーマシューティカル インダストリーズ リミティド | カルベジロール |
-
2005
- 2005-12-05 CA CA002589699A patent/CA2589699A1/en not_active Abandoned
- 2005-12-05 SI SI200530863T patent/SI1838670T1/sl unknown
- 2005-12-05 JP JP2007544890A patent/JP2008523025A/ja active Pending
- 2005-12-05 AT AT05815876T patent/ATE445601T1/de active
- 2005-12-05 ES ES05815876T patent/ES2333537T3/es not_active Expired - Lifetime
- 2005-12-05 DK DK05815876.7T patent/DK1838670T3/da active
- 2005-12-05 US US11/720,110 patent/US20090005429A1/en not_active Abandoned
- 2005-12-05 PL PL05815876T patent/PL1838670T3/pl unknown
- 2005-12-05 CN CN200580042214A patent/CN100591668C/zh not_active Expired - Fee Related
- 2005-12-05 PT PT05815876T patent/PT1838670E/pt unknown
- 2005-12-05 DE DE602005017194T patent/DE602005017194D1/de not_active Expired - Lifetime
- 2005-12-05 WO PCT/EP2005/056469 patent/WO2006061364A1/en not_active Ceased
- 2005-12-05 HR HR20100023T patent/HRP20100023T1/hr unknown
- 2005-12-05 EP EP05815876A patent/EP1838670B1/de not_active Expired - Lifetime
-
2007
- 2007-05-28 IL IL183449A patent/IL183449A0/en unknown
-
2009
- 2009-12-08 CY CY20091101281T patent/CY1110688T1/el unknown
-
2011
- 2011-10-27 US US13/282,868 patent/US20120041044A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2333537T3 (es) | 2010-02-23 |
| US20120041044A1 (en) | 2012-02-16 |
| JP2008523025A (ja) | 2008-07-03 |
| DK1838670T3 (da) | 2010-03-01 |
| DE602005017194D1 (de) | 2009-11-26 |
| CN101072753A (zh) | 2007-11-14 |
| CA2589699A1 (en) | 2006-06-15 |
| EP1838670A1 (de) | 2007-10-03 |
| SI1838670T1 (sl) | 2010-04-30 |
| HRP20100023T1 (hr) | 2010-02-28 |
| CY1110688T1 (el) | 2015-06-10 |
| PL1838670T3 (pl) | 2010-03-31 |
| CN100591668C (zh) | 2010-02-24 |
| PT1838670E (pt) | 2009-12-18 |
| WO2006061364A1 (en) | 2006-06-15 |
| IL183449A0 (en) | 2007-09-20 |
| EP1838670B1 (de) | 2009-10-14 |
| US20090005429A1 (en) | 2009-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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