ATE549021T1 - Kombinationstherapien zur behandlung von morbus alzheimer mit dimebon und donepezil - Google Patents
Kombinationstherapien zur behandlung von morbus alzheimer mit dimebon und donepezilInfo
- Publication number
- ATE549021T1 ATE549021T1 AT07867284T AT07867284T ATE549021T1 AT E549021 T1 ATE549021 T1 AT E549021T1 AT 07867284 T AT07867284 T AT 07867284T AT 07867284 T AT07867284 T AT 07867284T AT E549021 T1 ATE549021 T1 AT E549021T1
- Authority
- AT
- Austria
- Prior art keywords
- alzheimer
- disease
- dimebon
- combination therapies
- donepezil
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 3
- 238000002648 combination therapy Methods 0.000 title abstract 2
- JNODQFNWMXFMEV-UHFFFAOYSA-N latrepirdine Chemical compound C1N(C)CCC2=C1C1=CC(C)=CC=C1N2CCC1=CC=C(C)N=C1 JNODQFNWMXFMEV-UHFFFAOYSA-N 0.000 title abstract 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 title 2
- 229960003530 donepezil Drugs 0.000 title 1
- RDMFHRSPDKWERA-UHFFFAOYSA-N 5H-Pyrido[4,3-b]indole Chemical class C1=NC=C2C3=CC=CC=C3NC2=C1 RDMFHRSPDKWERA-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85486606P | 2006-10-27 | 2006-10-27 | |
| PCT/US2007/022645 WO2008051599A2 (en) | 2006-10-27 | 2007-10-26 | Combination therapies for treating alzheimer's disease using i. a. dimebon and dolepezil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE549021T1 true ATE549021T1 (de) | 2012-03-15 |
Family
ID=39315586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07867284T ATE549021T1 (de) | 2006-10-27 | 2007-10-26 | Kombinationstherapien zur behandlung von morbus alzheimer mit dimebon und donepezil |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100152108A1 (de) |
| EP (2) | EP2420235A1 (de) |
| JP (1) | JP2010507672A (de) |
| KR (1) | KR20090087009A (de) |
| CN (1) | CN101631547A (de) |
| AT (1) | ATE549021T1 (de) |
| AU (1) | AU2007309390A1 (de) |
| BR (1) | BRPI0718437A2 (de) |
| CA (1) | CA2667553A1 (de) |
| IL (2) | IL198405A0 (de) |
| MX (1) | MX2009004516A (de) |
| NO (1) | NO20092051L (de) |
| RU (1) | RU2009120048A (de) |
| SG (1) | SG178000A1 (de) |
| WO (1) | WO2008051599A2 (de) |
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| AU2008302751A1 (en) | 2007-09-20 | 2009-03-26 | D2E, Llc | Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use |
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| RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
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| JP2013504580A (ja) * | 2009-09-11 | 2013-02-07 | スノヴィオン ファーマシューティカルズ インコーポレイテッド | ヒスタミンｈ３インバースアゴニストおよびアンタゴニストとその使用方法 |
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| EP2533645B1 (de) | 2010-02-09 | 2016-07-27 | The Johns Hopkins University | Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen |
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| WO2012122405A2 (en) * | 2011-03-08 | 2012-09-13 | The Trustees Of Columbia University In The City Of New York | Screening assays using stem cells and stem cell-derived neurons from mouse models of alzheimer's disease |
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| US10966989B2 (en) | 2019-04-12 | 2021-04-06 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating mental, behavioral, cognitive disorders |
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| US11744833B2 (en) | 2019-04-12 | 2023-09-05 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of insomnia |
| US11690849B2 (en) | 2019-04-12 | 2023-07-04 | LA PharmaTech Inc. | Method of treating dementia |
| US11938139B2 (en) | 2019-04-12 | 2024-03-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders |
| KR20220008824A (ko) | 2019-04-17 | 2022-01-21 | 컴퍼스 패쓰파인더 리미티드 | 실로시빈으로 불안 장애, 두통 장애 및 섭식 장애를 치료하는 방법 |
| EP3973586A4 (de) * | 2019-05-21 | 2023-01-11 | La Pharma Tech Inc. | Neuartige pharmazeutische zusammensetzungen und verfahren zur behandlung von mentalen, verhaltensbezogen, kognitiven störungen |
| IL297861A (en) | 2020-05-08 | 2023-01-01 | Psilera Inc | Novel compositions of matter and pharmaceutical compositions |
| BR112022025306A2 (pt) * | 2020-06-12 | 2023-02-28 | Beckley Psytech Ltd | Composição compreendendo um sal benzoato de 5-metóxin, n-dimetiltriptamina |
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| DK4452267T3 (da) * | 2021-12-23 | 2025-05-26 | Cilcare Dev | 4-phenyl-tetrahydropyridinderivater til behandling af hørelidelser |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR8204M (de) | 1967-12-08 | 1970-09-14 | ||
| DE1952800C3 (de) | 1969-10-20 | 1974-04-18 | Nautschno-Issledowatelskij Institut Farmakologii I Chimioterapii, Moskau | 3,6-Dimethyl-l,2,3,4,4a,9a-hexahydro-gamma-carbolin-dihydrochlorid |
| US3718657A (en) | 1970-12-03 | 1973-02-27 | Abbott Lab | Certain-2-substituted-1,2,3,4-tetrahydro-beta or gamma carbolines |
| IL74497A (en) | 1985-03-05 | 1990-02-09 | Proterra Ag | Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives |
| US4663318A (en) | 1986-01-15 | 1987-05-05 | Bonnie Davis | Method of treating Alzheimer's disease |
| NL195004C (nl) | 1987-03-04 | 2003-11-04 | Novartis Ag | Fenylcarbamaat bevattend farmaceutisch preparaat. |
| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| DE10299048I2 (de) | 1989-04-14 | 2006-07-13 | Merz Pharma Gmbh & Co Kgaa | Verwendung von Adamantan-Derivaten zur Pr{vention und Behandlung der cerebralen Isch{mie |
| US5614560A (en) | 1991-04-04 | 1997-03-25 | Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| RU2106864C1 (ru) * | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
| WO1997046526A1 (en) | 1996-06-07 | 1997-12-11 | Eisai Co., Ltd. | Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production |
| TW513409B (en) | 1996-06-07 | 2002-12-11 | Eisai Co Ltd | Polymorphs of donepezil hydrochloride |
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| JPH10259126A (ja) * | 1997-01-17 | 1998-09-29 | Takeda Chem Ind Ltd | アルツハイマー病治療・予防剤 |
| WO1999029668A1 (en) | 1997-12-05 | 1999-06-17 | Eisai Co., Ltd. | Donepezil polycrystals and process for producing the same |
| US6372760B1 (en) | 1999-03-31 | 2002-04-16 | Eisai Co., Ltd. | Stabilized composition comprising antidementia medicament |
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| CN100339070C (zh) * | 2002-10-24 | 2007-09-26 | 莫茨药物股份两合公司 | 包含1－氨基环己烷衍生物类和乙酰胆碱酯酶抑制剂类的药物组合物 |
| BRPI0411451A (pt) * | 2003-06-16 | 2006-07-18 | Allergan Inc | formas de dosagens orais de memantina |
| RU2283108C2 (ru) | 2003-12-08 | 2006-09-10 | Сергей Олегович Бачурин | ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| JP5180816B2 (ja) * | 2005-04-04 | 2013-04-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経変性疾患および認知症のためのジヒドロピリジン化合物 |
-
2007
- 2007-10-26 EP EP11181674A patent/EP2420235A1/de not_active Withdrawn
- 2007-10-26 US US12/447,448 patent/US20100152108A1/en not_active Abandoned
- 2007-10-26 AT AT07867284T patent/ATE549021T1/de active
- 2007-10-26 BR BRPI0718437-9A2A patent/BRPI0718437A2/pt not_active Application Discontinuation
- 2007-10-26 KR KR1020097010803A patent/KR20090087009A/ko not_active Withdrawn
- 2007-10-26 MX MX2009004516A patent/MX2009004516A/es not_active Application Discontinuation
- 2007-10-26 RU RU2009120048/15A patent/RU2009120048A/ru not_active Application Discontinuation
- 2007-10-26 EP EP07867284A patent/EP2086538B1/de not_active Not-in-force
- 2007-10-26 AU AU2007309390A patent/AU2007309390A1/en not_active Abandoned
- 2007-10-26 CN CN200780048266A patent/CN101631547A/zh active Pending
- 2007-10-26 CA CA002667553A patent/CA2667553A1/en not_active Abandoned
- 2007-10-26 JP JP2009534657A patent/JP2010507672A/ja active Pending
- 2007-10-26 SG SG2012004289A patent/SG178000A1/en unknown
- 2007-10-26 WO PCT/US2007/022645 patent/WO2008051599A2/en not_active Ceased
-
2009
- 2009-04-26 IL IL198405A patent/IL198405A0/en unknown
- 2009-05-26 NO NO20092051A patent/NO20092051L/no not_active Application Discontinuation
-
2012
- 2012-05-10 IL IL219709A patent/IL219709A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0718437A2 (pt) | 2013-11-19 |
| RU2009120048A (ru) | 2010-12-10 |
| AU2007309390A1 (en) | 2008-05-02 |
| JP2010507672A (ja) | 2010-03-11 |
| US20100152108A1 (en) | 2010-06-17 |
| IL198405A0 (en) | 2010-02-17 |
| IL219709A0 (en) | 2012-06-28 |
| EP2086538B1 (de) | 2012-03-14 |
| NO20092051L (no) | 2009-07-22 |
| WO2008051599A3 (en) | 2008-07-24 |
| EP2086538A2 (de) | 2009-08-12 |
| SG178000A1 (en) | 2012-02-28 |
| CN101631547A (zh) | 2010-01-20 |
| EP2420235A1 (de) | 2012-02-22 |
| CA2667553A1 (en) | 2008-05-02 |
| WO2008051599A2 (en) | 2008-05-02 |
| KR20090087009A (ko) | 2009-08-14 |
| MX2009004516A (es) | 2009-08-12 |
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