ATE549323T1 - Prophylaktisches und/oder therapeutisches mittel gegen hyperlipidemie - Google Patents

Prophylaktisches und/oder therapeutisches mittel gegen hyperlipidemie

Info

Publication number: ATE549323T1
Authority: AT; Austria
Prior art keywords: prophylactic; solvate; salt; therapeutic agent; hyperlipidemia
Prior art date: 2007-03-29

Application number

AT08720655T

Other languages

English (en)

Inventor

Toshiaki Takizawa

Noriyuki Inoue

Katsutoshi Miyosawa

Original Assignee

Kowa Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-29

Filing date

2008-03-28

Publication date

2012-03-15

2008-03-28 Application filed by Kowa Co filed Critical Kowa Co

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE549323T1 publication Critical patent/ATE549323T1/de

Links

208000031226 Hyperlipidaemia Diseases 0.000 title abstract 2
230000000069 prophylactic effect Effects 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
229940124597 therapeutic agent Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 4
239000012453 solvate Substances 0.000 abstract 4
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 abstract 2
229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 2
208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
206010045261 Type IIa hyperlipidaemia Diseases 0.000 abstract 1
201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 abstract 1
229960002797 pitavastatin Drugs 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT08720655T 2007-03-29 2008-03-28 Prophylaktisches und/oder therapeutisches mittel gegen hyperlipidemie ATE549323T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2007087081		2007-03-29
PCT/JP2008/000788 WO2008120472A1 (ja)	2007-03-29	2008-03-28	高脂血症の予防及び／又は治療剤

Publications (1)

Publication Number	Publication Date
ATE549323T1 true ATE549323T1 (de)	2012-03-15

Family

ID=39808058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08720655T ATE549323T1 (de)	2007-03-29	2008-03-28	Prophylaktisches und/oder therapeutisches mittel gegen hyperlipidemie

Country Status (11)

Country	Link
US (1)	US8426455B2 (de)
EP (2)	EP2433932A1 (de)
JP (1)	JP5275975B2 (de)
KR (1)	KR101420319B1 (de)
CN (1)	CN101627021B (de)
AT (1)	ATE549323T1 (de)
CA (1)	CA2680407C (de)
ES (1)	ES2380752T3 (de)
PT (1)	PT2141155E (de)
TW (1)	TWI407955B (de)
WO (1)	WO2008120472A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5679458B2 (ja) *	2009-09-28	2015-03-04	興和株式会社	内臓脂肪重量の低下剤
CN102977085B (zh) *	2011-10-27	2015-07-29	四川大学	2-芳基-苯并[d]噁唑、2-芳基-苯并[d]噻唑衍生物及其制备方法和用途
TWI598098B (zh) *	2012-09-27	2017-09-11	興和股份有限公司	脂質異常症治療劑
CN110327331B (zh) *	2013-08-28	2022-04-26	兴和株式会社	血脂异常症治疗剂
PT3275438T (pt)	2016-07-29	2021-01-25	Kowa Co	Métodos de prevenção de eventos cardiovasculares em populações dislipidémicas de risco residual
JPWO2019004453A1 (ja)	2017-06-30	2020-04-30	興和株式会社	医薬品
WO2019004466A1 (ja) *	2017-06-30	2019-01-03	興和株式会社	医薬
KR20200024165A (ko) *	2017-06-30	2020-03-06	교와 가부시키가이샤	의약 조성물
CA3085951C (en)	2017-12-21	2022-10-11	Kowa Company, Ltd.	Methods of treatment of hypertriglyceridemia
US11446282B2 (en)	2017-12-21	2022-09-20	Kowa Company, Ltd.	Methods of treating mixed dyslipidemia and hypertriglycertdemia
JP7356968B2 (ja) *	2018-05-08	2023-10-05	国立大学法人岡山大学	心血管疾患に有用な医薬
WO2020138405A1 (ja)	2018-12-27	2020-07-02	興和株式会社	医薬品
EP3903780A4 (de) *	2018-12-27	2023-01-18	Kowa Company, Ltd.	Medizinprodukt
KR102289381B1 (ko)	2020-03-17	2021-08-17	주식회사 대웅테라퓨틱스	당뇨치료제 및 고지혈증 치료제를 포함하는 약학적 조성물

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4444784A (en)	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
MX7065E (es)	1980-06-06	1987-04-10	Sankyo Co	Un procedimiento microbiologico para preparar derivados de ml-236b
JP2569746B2 (ja)	1987-08-20	1997-01-08	日産化学工業株式会社	キノリン系メバロノラクトン類
US5177080A (en)	1990-12-14	1993-01-05	Bayer Aktiengesellschaft	Substituted pyridyl-dihydroxy-heptenoic acid and its salts
DE19858789A1 (de)	1998-12-18	2000-06-21	Bayer Ag	Kombination von Cerivastatin und Fibraten
BR0009650A (pt)	1999-04-09	2002-01-02	Meiji Seika Kaisha	Composto, composição farmacêutica, processos para inibir a secreção de uma lipoproteìna contendo apolipoproteìna b, para inibir a biossìntese de triglicerìdeos e para prevenir ou tratar hiperlipidemia, doenças arterioscleróticas e pancreatite, e, uso do composto
EP1414496B1 (de) *	2001-08-07	2010-10-20	Galephar M/F	Zusammensetzung enthaltend eine kombination aus einem ppar-alpha, pravastatin und polyglykolisiertem glyzerid
DE10200138A1 (de) *	2002-01-04	2003-07-17	Karl Winkler	Kombination von einem PPAR-Agonisten mit PPAR-alpha Aktivität mit einem Induktor des LDL-Rezeptors
WO2003088962A1 (en) *	2002-04-16	2003-10-30	Merck & Co., Inc.	Combination therapy using a ppar alpha/gamma agonist
HRP20110009T1 (hr)	2003-09-03	2011-03-31	Kowa Co.	Spoj kojim se aktivira ppar i farmaceutski pripravak koji ga sadrži
EP1714648A4 (de)	2004-02-09	2010-05-26	Aska Pharm Co Ltd	Kombinationsarzneimittel
EP1852426B1 (de) *	2005-02-23	2013-11-13	Kowa Company, Ltd.	Verfahren zur herstellung einer optisch aktiven ppar-aktivierenden verbindung und zwischenprodukt davon
JPWO2006090756A1 (ja)	2005-02-25	2008-07-24	杏林製薬株式会社	脂質代謝異常、肥満および糖尿病の新規な予防または治療剤およびそのための使用
AR054368A1 (es)	2005-06-01	2007-06-20	Takeda Pharmaceutical	Metodo para tratar hiperlipidemia

2008
- 2008-03-20 TW TW097109834A patent/TWI407955B/zh not_active IP Right Cessation
- 2008-03-28 EP EP11195053A patent/EP2433932A1/de not_active Withdrawn
- 2008-03-28 CA CA2680407A patent/CA2680407C/en not_active Expired - Fee Related
- 2008-03-28 JP JP2009507415A patent/JP5275975B2/ja not_active Expired - Fee Related
- 2008-03-28 CN CN2008800033811A patent/CN101627021B/zh active Active
- 2008-03-28 AT AT08720655T patent/ATE549323T1/de active
- 2008-03-28 PT PT08720655T patent/PT2141155E/pt unknown
- 2008-03-28 US US12/593,356 patent/US8426455B2/en not_active Expired - Fee Related
- 2008-03-28 EP EP08720655A patent/EP2141155B1/de not_active Not-in-force
- 2008-03-28 WO PCT/JP2008/000788 patent/WO2008120472A1/ja not_active Ceased
- 2008-03-28 ES ES08720655T patent/ES2380752T3/es active Active
- 2008-03-28 KR KR1020097018191A patent/KR101420319B1/ko active Active

Also Published As

Publication number	Publication date
EP2141155A4 (de)	2010-05-19
CA2680407C (en)	2015-04-21
EP2141155A1 (de)	2010-01-06
KR20090129994A (ko)	2009-12-17
TWI407955B (zh)	2013-09-11
WO2008120472A1 (ja)	2008-10-09
EP2141155B1 (de)	2012-03-14
TW200838510A (en)	2008-10-01
US8426455B2 (en)	2013-04-23
PT2141155E (pt)	2012-05-23
HK1138277A1 (en)	2010-08-20
US20100069433A1 (en)	2010-03-18
JP5275975B2 (ja)	2013-08-28
CN101627021A (zh)	2010-01-13
ES2380752T3 (es)	2012-05-18
EP2433932A1 (de)	2012-03-28
JPWO2008120472A1 (ja)	2010-07-15
CA2680407A1 (en)	2008-10-09
KR101420319B1 (ko)	2014-07-16
CN101627021B (zh)	2012-11-28

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