BRPI0905687A2 - "composto da fórmula i ou i', composição farmacêutica, método de tratamento de um paciente com uma doença, uso do composto" - Google Patents

"composto da fórmula i ou i', composição farmacêutica, método de tratamento de um paciente com uma doença, uso do composto"

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Publication number
BRPI0905687A2
BRPI0905687A2 BRPI0905687-4A BRPI0905687A BRPI0905687A2 BR PI0905687 A2 BRPI0905687 A2 BR PI0905687A2 BR PI0905687 A BRPI0905687 A BR PI0905687A BR PI0905687 A2 BRPI0905687 A2 BR PI0905687A2
Authority
BR
Brazil
Prior art keywords
compound
disease
patient
treating
formula
Prior art date
Application number
BRPI0905687-4A
Other languages
English (en)
Inventor
Winssinger
Nicolas
Barluenga
Sofia
Karplus
Martin
Original Assignee
Univ Strasbourg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Strasbourg filed Critical Univ Strasbourg
Publication of BRPI0905687A2 publication Critical patent/BRPI0905687A2/pt
Publication of BRPI0905687A8 publication Critical patent/BRPI0905687A8/pt

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    • A61K31/365—Lactones
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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BRPI0905687A 2008-01-15 2009-01-15 composto da fórmula i ou i', composição farmacêutica, método de tratamento de um paciente com uma doença, uso do composto BRPI0905687A8 (pt)

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FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
CN107011311A (zh) * 2010-10-22 2017-08-04 斯特拉斯堡大学 用于治疗HSP90相关病状的Pochoxime缀合物
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
CN105473133A (zh) 2013-04-30 2016-04-06 欧缇托匹克公司 干粉制剂及使用方法
WO2016196256A2 (en) 2015-06-04 2016-12-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones
CA3076353A1 (en) 2017-09-22 2019-03-28 Otitopic Inc. Dry powder compositions with magnesium stearate
US10786456B2 (en) 2017-09-22 2020-09-29 Otitopic Inc. Inhaled aspirin and magnesium to treat inflammation
KR102059808B1 (ko) 2018-06-11 2019-12-27 주식회사 티맥스오에스 컨테이너 기반 통합 관리 시스템
JP6849729B2 (ja) * 2019-04-15 2021-03-24 キヤノン株式会社 モータ制御装置、シート搬送装置及び画像形成装置
CN110464717B (zh) * 2019-09-23 2022-02-18 张建国 一种2,4-二羟基苯甲酸在制备降低血糖的药物的应用
CN119424412A (zh) * 2024-12-04 2025-02-14 中国药科大学 以prdx1作为药物靶标的天然抑制剂在制备抗乳腺癌药物中的应用

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ES2149468T3 (es) * 1995-04-26 2000-11-01 Kyowa Hakko Kogyo Kk Derivados de radicicol.
NZ331062A (en) * 1996-10-25 2000-05-26 Kyowa Hakko Kogyo Company Ltd Radicicol derivatives or pharmacologically acceptable salts which show tyrosine kinase inhibition activity and have antitumor effects
US6887853B2 (en) 2000-06-29 2005-05-03 The Trustees Of Boston University Use of geldanamycin and related compounds for treatment of fibrogenic disorders
ATE328888T1 (de) * 2000-08-25 2006-06-15 Sloan Kettering Inst Cancer Radicicol und monocillin und ihre analogen und ihre anwendungen
US20060177416A1 (en) * 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
RU2312863C2 (ru) * 2002-04-17 2007-12-20 Тайсо Фармасьютикал Ко., Лтд. Тоник для роста волос
US20050002996A1 (en) * 2003-07-02 2005-01-06 Milan Sojka Sustained release compositions and controlled delivery method
US7781485B2 (en) 2004-11-09 2010-08-24 Kyowa Hakko Kirin Co., Ltd. Hsp90 family protein inhibitors
WO2008150302A1 (en) * 2007-06-04 2008-12-11 Nexgenix Pharmaceuticals Treatment of neurofibromatosis with radicicol and its derivatives
WO2007143629A1 (en) 2006-06-02 2007-12-13 Nexgenix Pharmaceuticals Treatment of neurofibromatosis with inhibitors of a signal transduction pathway
JP5465006B2 (ja) * 2006-08-11 2014-04-09 ユニベルシテ・ドウ・ストラスブール キナーゼおよびｈｓｐ９０の阻害剤として有用な大環状化合物
JP2011510017A (ja) 2008-01-15 2011-03-31 ユニベルシテ・ドウ・ストラスブール 治療薬として有用なレゾルシン酸ラクトンの合成

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CA2755876C (en) 2017-04-18
MX376743B (es) 2025-03-07
KR101835252B1 (ko) 2018-03-06
CA2755876A1 (en) 2009-07-23
US10239856B2 (en) 2019-03-26
KR20160112016A (ko) 2016-09-27
WO2009091921A1 (en) 2009-07-23
JP6159350B2 (ja) 2017-07-05
KR20160017105A (ko) 2016-02-15
JP2015110624A (ja) 2015-06-18
BRPI0905687A8 (pt) 2019-05-21
CN101990399B (zh) 2016-05-04
CN101990399A (zh) 2011-03-23
EP2242359B1 (en) 2016-06-01
KR20110003468A (ko) 2011-01-12
KR101835253B1 (ko) 2018-03-06
US9051302B2 (en) 2015-06-09
AU2009206097A1 (en) 2009-07-23
MX2010007755A (es) 2010-12-21
IL207049A (en) 2015-01-29
US20160075677A1 (en) 2016-03-17
ES2587390T3 (es) 2016-10-24
JP2011510017A (ja) 2011-03-31
AU2009206097B2 (en) 2014-08-14
IL207049A0 (en) 2010-12-30
KR20160112015A (ko) 2016-09-27
EP2242359A4 (en) 2011-11-09
RU2534527C2 (ru) 2014-11-27
US20110217335A1 (en) 2011-09-08
EP2242359A1 (en) 2010-10-27
RU2010133979A (ru) 2012-02-27
US20190359585A1 (en) 2019-11-28

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