ATE549399T1 - Verfahren zur herstellung von pravastatin - Google Patents

Verfahren zur herstellung von pravastatin

Info

Publication number: ATE549399T1
Authority: AT; Austria
Prior art keywords: pravastatin; seq; provides; present; producing
Prior art date: 2006-12-13

Application number

AT07848031T

Other languages

English (en)

Inventor

Paul Klaassen

Adrianus Wilhelmus Hermanus Vollebregt

Den Berg Marco Alexander Van

Marcus Hans

Der Laan Jan Metske Van

Original Assignee

Dsm Sinochem Pharm Nl Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-13

Filing date

2007-12-11

Publication date

2012-03-15

2007-12-11 Application filed by Dsm Sinochem Pharm Nl Bv filed Critical Dsm Sinochem Pharm Nl Bv

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE549399T1 publication Critical patent/ATE549399T1/de

Links

TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 title abstract 4
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title abstract 4
229960002965 pravastatin Drugs 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title abstract 2
229920001184 polypeptide Polymers 0.000 abstract 3
102000004196 processed proteins & peptides Human genes 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
108091033319 polynucleotide Proteins 0.000 abstract 2
102000040430 polynucleotide Human genes 0.000 abstract 2
239000002157 polynucleotide Substances 0.000 abstract 2
VGMFHMLQOYWYHN-UHFFFAOYSA-N Compactin Natural products OCC1OC(OC2C(O)C(O)C(CO)OC2Oc3cc(O)c4C(=O)C(=COc4c3)c5ccc(O)c(O)c5)C(O)C(O)C1O VGMFHMLQOYWYHN-UHFFFAOYSA-N 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
AJLFOPYRIVGYMJ-UHFFFAOYSA-N SJ000287055 Natural products C12C(OC(=O)C(C)CC)CCC=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 AJLFOPYRIVGYMJ-UHFFFAOYSA-N 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 abstract 1
BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT07848031T 2006-12-13 2007-12-11 Verfahren zur herstellung von pravastatin ATE549399T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06126046		2006-12-13
PCT/EP2007/063638 WO2008071673A1 (en)	2006-12-13	2007-12-11	Process for preparing pravastatin

Publications (1)

Publication Number	Publication Date
ATE549399T1 true ATE549399T1 (de)	2012-03-15

Family

ID=37831718

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07848031T ATE549399T1 (de)	2006-12-13	2007-12-11	Verfahren zur herstellung von pravastatin

Country Status (7)

Country	Link
US (1)	US20100217032A1 (de)
EP (1)	EP2094841B1 (de)
JP (1)	JP2010512733A (de)
CN (1)	CN101558152B (de)
AT (1)	ATE549399T1 (de)
DK (1)	DK2094841T3 (de)
WO (1)	WO2008071673A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101401468B1 (ko) *	2011-11-15	2014-05-30	전남대학교산학협력단	박테리아 시토크롬 ｐ450을 이용한 아토르바스타틴으로부터 대사산물의 신규한 생산방법 및 이를 위한 조성물
WO2021207265A1 (en) *	2020-04-08	2021-10-14	Zymergen Inc.	High-throughput automated strain library generator

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0414914B1 (de) *	1989-02-28	1994-05-11	Suntory Limited	Trehalostatin und seine herstellung
US5942423A (en) *	1995-06-07	1999-08-24	Massachusetts Institute Of Technology	Conversion of compactin to pravastatin by actinomadura
KR100433888B1 (ko) *	1997-08-07	2004-06-04	교와 핫꼬 고교 가부시끼가이샤	ＨＭＧ-ＣｏＡ 환원효소 저해제의 제조법
ATE360703T1 (de) *	1999-01-20	2007-05-15	Kyowa Hakko Kogyo Kk	Verfahren zur herstellung von hemmern der hmg-coa reduktase
EP1148122B1 (de) *	1999-01-29	2009-09-02	Kyowa Hakko Bio Co., Ltd.	Verfahren zur herstellung eines hmg-coa reduktase hemmers
MXPA03008837A (es) *	2001-03-27	2004-05-05	Ranbaxy Lab Ltd	Una composicion farmaceutica estable de pravastatina.
JPWO2002099109A1 (ja) *	2001-06-01	2004-09-16	メルシャン株式会社	新規なポリペプチド、そのポリペプチドをコードするｄｎａおよびそれらの用途
JP2005512532A (ja) *	2001-08-03	2005-05-12	ディヴァーサコーポレイション	Ｐ４５０酵素、それらをコードした核酸及びそれらの作製と使用
US6884608B2 (en) *	2001-12-26	2005-04-26	Bristol-Myers Squibb Company	Compositions and methods for hydroxylating epothilones
JP3957053B2 (ja) *	2002-02-06	2007-08-08	株式会社Ａｄｅｋａ	新規な微生物及びプラバスタチンの製造方法
CA2477452A1 (en) *	2002-03-12	2003-09-25	U.S. Smokeless Tobacco Company	Cloning of cytochrome p450 genes from nicotiana
WO2004078978A1 (en) *	2003-02-26	2004-09-16	Bristol-Myers Squibb Company	Compositions and methods for hydroxylating epothilones
CN1243823C (zh)	2004-05-31	2006-03-01	江南大学	一种拟无枝酸菌及其生物转化洛伐他汀为无锡他汀的技术
KR100934944B1 (ko) *	2004-10-04	2010-01-06	주식회사 핸슨바이오텍	세베키아 베니하나의 신규 사이토크롬 p450 하이드록실레이즈
WO2006051729A1 (ja) *	2004-11-10	2006-05-18	Marine Biotechnology Institute Co., Ltd.	P450遺伝子の単離法
TWI307360B (en) *	2004-12-03	2009-03-11	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Process for constructing strain having compactin hydroxylation ability

2007
- 2007-12-11 JP JP2009540741A patent/JP2010512733A/ja active Pending
- 2007-12-11 CN CN2007800462704A patent/CN101558152B/zh not_active Expired - Fee Related
- 2007-12-11 EP EP07848031A patent/EP2094841B1/de not_active Not-in-force
- 2007-12-11 WO PCT/EP2007/063638 patent/WO2008071673A1/en not_active Ceased
- 2007-12-11 US US12/518,713 patent/US20100217032A1/en not_active Abandoned
- 2007-12-11 AT AT07848031T patent/ATE549399T1/de active
- 2007-12-11 DK DK07848031.6T patent/DK2094841T3/da active

Also Published As

Publication number	Publication date
JP2010512733A (ja)	2010-04-30
CN101558152A (zh)	2009-10-14
DK2094841T3 (da)	2012-05-29
EP2094841A1 (de)	2009-09-02
US20100217032A1 (en)	2010-08-26
EP2094841B1 (de)	2012-03-14
CN101558152B (zh)	2013-07-10
WO2008071673A1 (en)	2008-06-19

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