ATE549399T1 - Verfahren zur herstellung von pravastatin - Google Patents

Verfahren zur herstellung von pravastatin

Info

Publication number
ATE549399T1
ATE549399T1 AT07848031T AT07848031T ATE549399T1 AT E549399 T1 ATE549399 T1 AT E549399T1 AT 07848031 T AT07848031 T AT 07848031T AT 07848031 T AT07848031 T AT 07848031T AT E549399 T1 ATE549399 T1 AT E549399T1
Authority
AT
Austria
Prior art keywords
pravastatin
seq
provides
present
producing
Prior art date
Application number
AT07848031T
Other languages
English (en)
Inventor
Paul Klaassen
Adrianus Wilhelmus Hermanus Vollebregt
Den Berg Marco Alexander Van
Marcus Hans
Der Laan Jan Metske Van
Original Assignee
Dsm Sinochem Pharm Nl Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Sinochem Pharm Nl Bv filed Critical Dsm Sinochem Pharm Nl Bv
Application granted granted Critical
Publication of ATE549399T1 publication Critical patent/ATE549399T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT07848031T 2006-12-13 2007-12-11 Verfahren zur herstellung von pravastatin ATE549399T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06126046 2006-12-13
PCT/EP2007/063638 WO2008071673A1 (en) 2006-12-13 2007-12-11 Process for preparing pravastatin

Publications (1)

Publication Number Publication Date
ATE549399T1 true ATE549399T1 (de) 2012-03-15

Family

ID=37831718

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07848031T ATE549399T1 (de) 2006-12-13 2007-12-11 Verfahren zur herstellung von pravastatin

Country Status (7)

Country Link
US (1) US20100217032A1 (de)
EP (1) EP2094841B1 (de)
JP (1) JP2010512733A (de)
CN (1) CN101558152B (de)
AT (1) ATE549399T1 (de)
DK (1) DK2094841T3 (de)
WO (1) WO2008071673A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101401468B1 (ko) * 2011-11-15 2014-05-30 전남대학교산학협력단 박테리아 시토크롬 ｐ450을 이용한 아토르바스타틴으로부터 대사산물의 신규한 생산방법 및 이를 위한 조성물
WO2021207265A1 (en) * 2020-04-08 2021-10-14 Zymergen Inc. High-throughput automated strain library generator

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0414914B1 (de) 1989-02-28 1994-05-11 Suntory Limited Trehalostatin und seine herstellung
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
WO1999007872A1 (en) * 1997-08-07 1999-02-18 Kyowa Hakko Kogyo Co., Ltd. PROCESS FOR THE PREPARATION OF HMG-CoA REDUCTASE INHIBITORS
KR100633867B1 (ko) * 1999-01-20 2006-10-16 교와 핫꼬 고교 가부시끼가이샤 히드록시메틸글루타릴 코에이 환원효소 저해제의 제조방법
CZ20012728A3 (cs) * 1999-01-29 2002-02-13 Kyowa Hakko Kogyo Co., Ltd. Způsob výroby inhibitorů HMG-CoA reduktasy
NZ528543A (en) * 2001-03-27 2005-07-29 Ranbaxy Lab Ltd A stable pharmaceutical composition of pravastatin and a carrier
WO2002099109A1 (en) * 2001-06-01 2002-12-12 Mercian Corporation Novel polypeptide, dna encoding the polypeptide and use thereof
AU2002365070A1 (en) * 2001-08-03 2003-06-30 Diversa Corporation P450 enzymes, nucleic acids encoding them and methods of making and using them
US6884608B2 (en) * 2001-12-26 2005-04-26 Bristol-Myers Squibb Company Compositions and methods for hydroxylating epothilones
JP3957053B2 (ja) * 2002-02-06 2007-08-08 株式会社Ａｄｅｋａ 新規な微生物及びプラバスタチンの製造方法
MXPA04008785A (es) * 2002-03-12 2005-09-30 Us Smokeless Tobacco Co Clonacion de genes p450 de citocromos de nicotiana.
WO2004078978A1 (en) * 2003-02-26 2004-09-16 Bristol-Myers Squibb Company Compositions and methods for hydroxylating epothilones
CN1243823C (zh) 2004-05-31 2006-03-01 江南大学 一种拟无枝酸菌及其生物转化洛伐他汀为无锡他汀的技术
KR100934944B1 (ko) * 2004-10-04 2010-01-06 주식회사 핸슨바이오텍 세베키아 베니하나의 신규 사이토크롬 p450 하이드록실레이즈
US20080220419A1 (en) * 2004-11-10 2008-09-11 Marine Biotechnology Institute Co., Ltd. Method of Isolating P450 Gene
TWI307360B (en) * 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability

Also Published As

Publication number Publication date
DK2094841T3 (da) 2012-05-29
EP2094841A1 (de) 2009-09-02
WO2008071673A1 (en) 2008-06-19
EP2094841B1 (de) 2012-03-14
JP2010512733A (ja) 2010-04-30
CN101558152B (zh) 2013-07-10
US20100217032A1 (en) 2010-08-26
CN101558152A (zh) 2009-10-14

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