DK2094841T3 - Fremgangsmåde til fremstilling af pravastatin - Google Patents

Fremgangsmåde til fremstilling af pravastatin

Info

Publication number
DK2094841T3
DK2094841T3 DK07848031.6T DK07848031T DK2094841T3 DK 2094841 T3 DK2094841 T3 DK 2094841T3 DK 07848031 T DK07848031 T DK 07848031T DK 2094841 T3 DK2094841 T3 DK 2094841T3
Authority
DK
Denmark
Prior art keywords
pravastatin
seq
provides
present
preparation
Prior art date
Application number
DK07848031.6T
Other languages
English (en)
Inventor
Paul Klaassen
Adrianus Wilhelmus Hermanus Vollebregt
Den Berg Marco Alexander Van
Marcus Hans
Der Laan Jan Metske Van
Original Assignee
Dsm Sinochem Pharm Nl Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Sinochem Pharm Nl Bv filed Critical Dsm Sinochem Pharm Nl Bv
Application granted granted Critical
Publication of DK2094841T3 publication Critical patent/DK2094841T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK07848031.6T 2006-12-13 2007-12-11 Fremgangsmåde til fremstilling af pravastatin DK2094841T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06126046 2006-12-13
PCT/EP2007/063638 WO2008071673A1 (en) 2006-12-13 2007-12-11 Process for preparing pravastatin

Publications (1)

Publication Number Publication Date
DK2094841T3 true DK2094841T3 (da) 2012-05-29

Family

ID=37831718

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07848031.6T DK2094841T3 (da) 2006-12-13 2007-12-11 Fremgangsmåde til fremstilling af pravastatin

Country Status (7)

Country Link
US (1) US20100217032A1 (da)
EP (1) EP2094841B1 (da)
JP (1) JP2010512733A (da)
CN (1) CN101558152B (da)
AT (1) ATE549399T1 (da)
DK (1) DK2094841T3 (da)
WO (1) WO2008071673A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101401468B1 (ko) * 2011-11-15 2014-05-30 전남대학교산학협력단 박테리아 시토크롬 ｐ450을 이용한 아토르바스타틴으로부터 대사산물의 신규한 생산방법 및 이를 위한 조성물
WO2021207265A1 (en) * 2020-04-08 2021-10-14 Zymergen Inc. High-throughput automated strain library generator

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990010010A1 (en) * 1989-02-28 1990-09-07 Sawao Murao New substance trehalostatin and production thereof
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
DE69839248T2 (de) * 1997-08-07 2009-04-02 Kyowa Hakko Kogyo Co., Ltd. VERFAHREN FÜR DIE HERSTELLUNG VON INHIBITOREN DER HMG-CoA-REDUKTASE.
HK1040419B (en) * 1999-01-20 2007-12-14 协和发酵工业株式会社 Process for producing hmg-coa reductase inhibitors
CZ20012728A3 (cs) * 1999-01-29 2002-02-13 Kyowa Hakko Kogyo Co., Ltd. Způsob výroby inhibitorů HMG-CoA reduktasy
RU2003131338A (ru) * 2001-03-27 2005-02-10 Рэнбакси Лабораториз Лимитед (In) Стабильная фармацевтическая композиция на основе правастатина
JPWO2002099109A1 (ja) * 2001-06-01 2004-09-16 メルシャン株式会社 新規なポリペプチド、そのポリペプチドをコードするｄｎａおよびそれらの用途
AU2002365070A1 (en) * 2001-08-03 2003-06-30 Diversa Corporation P450 enzymes, nucleic acids encoding them and methods of making and using them
US6884608B2 (en) * 2001-12-26 2005-04-26 Bristol-Myers Squibb Company Compositions and methods for hydroxylating epothilones
JP3957053B2 (ja) * 2002-02-06 2007-08-08 株式会社Ａｄｅｋａ 新規な微生物及びプラバスタチンの製造方法
JP2005531297A (ja) * 2002-03-12 2005-10-20 ユーエス スモークレス タバコ カンパニー タバコ由来シトクロムｐ４５０遺伝子のクローニング
AU2003219947A1 (en) * 2003-02-26 2004-09-28 Bristol-Myers Squibb Company Compositions and methods for hydroxylating epothilones
CN1243823C (zh) 2004-05-31 2006-03-01 江南大学 一种拟无枝酸菌及其生物转化洛伐他汀为无锡他汀的技术
KR100934944B1 (ko) * 2004-10-04 2010-01-06 주식회사 핸슨바이오텍 세베키아 베니하나의 신규 사이토크롬 p450 하이드록실레이즈
WO2006051729A1 (ja) * 2004-11-10 2006-05-18 Marine Biotechnology Institute Co., Ltd. P450遺伝子の単離法
TWI307360B (en) * 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability

Also Published As

Publication number Publication date
JP2010512733A (ja) 2010-04-30
CN101558152A (zh) 2009-10-14
EP2094841B1 (en) 2012-03-14
EP2094841A1 (en) 2009-09-02
ATE549399T1 (de) 2012-03-15
US20100217032A1 (en) 2010-08-26
CN101558152B (zh) 2013-07-10
WO2008071673A1 (en) 2008-06-19

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