ATE549417T1 - Diagnoseverfahren für osteoarthritis - Google Patents
Diagnoseverfahren für osteoarthritisInfo
- Publication number
- ATE549417T1 ATE549417T1 AT07816051T AT07816051T ATE549417T1 AT E549417 T1 ATE549417 T1 AT E549417T1 AT 07816051 T AT07816051 T AT 07816051T AT 07816051 T AT07816051 T AT 07816051T AT E549417 T1 ATE549417 T1 AT E549417T1
- Authority
- AT
- Austria
- Prior art keywords
- osteoarthritis
- risk
- subject
- cellular level
- nuclear
- Prior art date
Links
- 201000008482 osteoarthritis Diseases 0.000 title abstract 7
- 238000002405 diagnostic procedure Methods 0.000 title 1
- 230000001413 cellular effect Effects 0.000 abstract 3
- 102000016670 prohibitin Human genes 0.000 abstract 3
- 108010028138 prohibitin Proteins 0.000 abstract 3
- 239000000523 sample Substances 0.000 abstract 3
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 239000013068 control sample Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 101001129610 Homo sapiens Prohibitin 1 Proteins 0.000 abstract 1
- 102100031169 Prohibitin 1 Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004942 nuclear accumulation Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
- G01N2333/4704—Inhibitors; Supressors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
- G01N2333/4706—Regulators; Modulating activity stimulating, promoting or activating activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85407706P | 2006-10-25 | 2006-10-25 | |
| PCT/CA2007/001901 WO2008049225A1 (en) | 2006-10-25 | 2007-10-25 | Methods for diagnosing osteoarthritis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE549417T1 true ATE549417T1 (de) | 2012-03-15 |
Family
ID=39324072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07816051T ATE549417T1 (de) | 2006-10-25 | 2007-10-25 | Diagnoseverfahren für osteoarthritis |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20100028882A1 (de) |
| EP (1) | EP2089546B1 (de) |
| AT (1) | ATE549417T1 (de) |
| AU (1) | AU2007308715B2 (de) |
| CA (1) | CA2703124C (de) |
| ES (1) | ES2386916T3 (de) |
| WO (1) | WO2008049225A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007308715B2 (en) | 2006-10-25 | 2011-06-23 | Chu Sainte Justine | Methods for diagnosing osteoarthritis |
| EP2391889A4 (de) | 2009-02-02 | 2012-11-21 | Nestec Sa | Verfahren zur diagnose von bevorstehendem gelenkversagen |
| WO2013053065A1 (en) * | 2011-10-14 | 2013-04-18 | Hôpital Ste-Justine | Methods and kits for diagnosing and/or prognosing osteoarthritis |
| EP3071685A4 (de) | 2013-11-21 | 2017-07-05 | Memorial Sloan Kettering Cancer Center | Spezifikation von funktionellen kranialen placoden-derivaten aus menschlichen pluripotenten stammzellen |
| CN115992240A (zh) * | 2022-10-28 | 2023-04-21 | 中山大学附属第三医院 | E2f转录因子2作为治疗靶点在制备预防和/或治疗多发性骨髓瘤的药物中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05271294A (ja) | 1992-01-24 | 1993-10-19 | Japan Found Cancer Res | ヒトプロヒビチンおよびそれをコードするdna |
| US6127158A (en) | 1994-12-07 | 2000-10-03 | President And Fellows Of Harvard College | Ubiquitin conjugating enzymes |
| WO2002048310A2 (en) | 2000-12-15 | 2002-06-20 | Genetics Institute, Llc | Methods and compositions for diagnosing and treating rheumatoid arthritis |
| WO2005029091A2 (en) * | 2003-09-15 | 2005-03-31 | Oklahoma Medical Research Foundation | Method of using cytokine assays to diagnose, treat, and evaluate inflammatory and autoimmune diseases |
| US20090203547A1 (en) | 2005-02-18 | 2009-08-13 | Albert Banes | Gene and Cognate Protein Profiles and Methods to Determine Connective Tissue Markers in Normal and Pathologic Conditions |
| EP1941057A4 (de) | 2005-10-07 | 2009-11-11 | Baylor Res Inst | Diagnose des systemischen ausbruchs juveniler idiopathischer arthritis über blutleukozyten-mikroarrayanalyse |
| AU2007308715B2 (en) | 2006-10-25 | 2011-06-23 | Chu Sainte Justine | Methods for diagnosing osteoarthritis |
| CN103035712B (zh) | 2011-10-09 | 2015-10-14 | 中国科学院微电子研究所 | 半导体器件及其制造方法 |
| WO2013053065A1 (en) | 2011-10-14 | 2013-04-18 | Hôpital Ste-Justine | Methods and kits for diagnosing and/or prognosing osteoarthritis |
-
2007
- 2007-10-25 AU AU2007308715A patent/AU2007308715B2/en active Active
- 2007-10-25 AT AT07816051T patent/ATE549417T1/de active
- 2007-10-25 CA CA2703124A patent/CA2703124C/en active Active
- 2007-10-25 WO PCT/CA2007/001901 patent/WO2008049225A1/en not_active Ceased
- 2007-10-25 US US12/447,152 patent/US20100028882A1/en not_active Abandoned
- 2007-10-25 ES ES07816051T patent/ES2386916T3/es active Active
- 2007-10-25 EP EP07816051A patent/EP2089546B1/de active Active
-
2014
- 2014-12-12 US US14/568,444 patent/US20150153362A1/en not_active Abandoned
-
2016
- 2016-05-19 US US15/158,689 patent/US10324095B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2089546B1 (de) | 2012-03-14 |
| WO2008049225A8 (en) | 2008-07-03 |
| ES2386916T3 (es) | 2012-09-05 |
| EP2089546A4 (de) | 2010-03-03 |
| US10324095B2 (en) | 2019-06-18 |
| WO2008049225A1 (en) | 2008-05-02 |
| US20160299155A1 (en) | 2016-10-13 |
| CA2703124A1 (en) | 2008-05-02 |
| EP2089546A1 (de) | 2009-08-19 |
| US20100028882A1 (en) | 2010-02-04 |
| US20150153362A1 (en) | 2015-06-04 |
| AU2007308715A1 (en) | 2008-05-02 |
| CA2703124C (en) | 2017-06-13 |
| AU2007308715B2 (en) | 2011-06-23 |
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