ATE550346T1 - Synthese von n-än-(3,3-dimethylbutyl)-l-alpha- aspartylü - l-phenylalanin-1-methylester unter verwendung von 3,3- dimethylbutyraldehyddimethylacetal als vorläufer - Google Patents

Synthese von n-än-(3,3-dimethylbutyl)-l-alpha- aspartylü - l-phenylalanin-1-methylester unter verwendung von 3,3- dimethylbutyraldehyddimethylacetal als vorläufer

Info

Publication number
ATE550346T1
ATE550346T1 AT04751149T AT04751149T ATE550346T1 AT E550346 T1 ATE550346 T1 AT E550346T1 AT 04751149 T AT04751149 T AT 04751149T AT 04751149 T AT04751149 T AT 04751149T AT E550346 T1 ATE550346 T1 AT E550346T1
Authority
AT
Austria
Prior art keywords
dimethylbutyl
phenylalanine
methyl ester
dimethylbutyraldehyde
synthesis
Prior art date
Application number
AT04751149T
Other languages
English (en)
Inventor
Indra Prakash
Kenneth Furlong
Handley Jackson
Original Assignee
Nutrasweet Property Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Property Holdings Inc filed Critical Nutrasweet Property Holdings Inc
Application granted granted Critical
Publication of ATE550346T1 publication Critical patent/ATE550346T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Seasonings (AREA)
AT04751149T 2003-05-06 2004-04-30 Synthese von n-än-(3,3-dimethylbutyl)-l-alpha- aspartylü - l-phenylalanin-1-methylester unter verwendung von 3,3- dimethylbutyraldehyddimethylacetal als vorläufer ATE550346T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46807603P 2003-05-06 2003-05-06
PCT/US2004/013625 WO2004101604A2 (en) 2003-05-06 2004-04-30 SYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING 3,3-DIMETHYLBUTYRALDEHYDE PRECURSORS

Publications (1)

Publication Number Publication Date
ATE550346T1 true ATE550346T1 (de) 2012-04-15

Family

ID=33452184

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04751149T ATE550346T1 (de) 2003-05-06 2004-04-30 Synthese von n-än-(3,3-dimethylbutyl)-l-alpha- aspartylü - l-phenylalanin-1-methylester unter verwendung von 3,3- dimethylbutyraldehyddimethylacetal als vorläufer

Country Status (7)

Country Link
US (3) US7288670B2 (de)
EP (2) EP2138506A3 (de)
JP (2) JP4602982B2 (de)
KR (3) KR101108256B1 (de)
CN (4) CN101565451B (de)
AT (1) ATE550346T1 (de)
WO (1) WO2004101604A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101775066B (zh) * 2010-01-29 2012-05-02 常茂生物化学工程股份有限公司 一种合成纽甜的方法
CN102295541B (zh) * 2011-08-16 2013-04-17 济南诚汇双达化工有限公司 一种3，3-二甲基丁醛的制备方法
CN104045688B (zh) * 2014-06-18 2016-09-14 山东诚汇双达药业有限公司 一种纽甜的合成方法
CN105504006B (zh) * 2016-01-28 2019-01-04 柳玉荣 一种提高纽甜质量的合成方法
CN105541965B (zh) * 2016-01-28 2019-01-18 柳玉荣 一种提高纽甜得率的合成方法
CN110467648B (zh) * 2019-07-24 2021-12-21 江苏理工学院 一种去除纽甜异味的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1038102A (en) 1911-12-09 1912-09-10 Farbenfab Vorm Bayer F & Co 2-alkoxy-5-monosubstituted barbituric acids.
FR2697844B1 (fr) * 1992-11-12 1995-01-27 Claude Nofre Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation.
FR2719590B1 (fr) 1994-05-09 1996-07-26 Claude Nofre Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.
US5728862A (en) * 1997-01-29 1998-03-17 The Nutrasweet Company Method for preparing and purifying an N-alkylated aspartame derivative
RU2179979C1 (ru) * 1998-04-09 2002-02-27 Адзиномото Ко., Инк. Сложноэфирные производные аспартилдипептидов и подслащивающие вещества
US5905175A (en) * 1998-05-20 1999-05-18 The Nutrasweet Company Synthesis and purification of 3,3-dimethylbutyraldehyde via oxidation of 1-chloro-3,3-dimethylbutane with dimethyl sulfoxide
NL1010063C2 (nl) 1998-09-10 2000-03-13 Holland Sweetener Co Werkwijze voor de bereiding van neotaam.
AU1832500A (en) * 1998-11-25 2000-06-19 Nutrasweet Company, The Purification of N-(N-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methyl ester via crystallization
US6573409B1 (en) * 1999-07-02 2003-06-03 The Nutrasweet Company Process for the preparation of 3,3-dimethylbutanal
ES2233644T3 (es) * 2000-05-18 2005-06-16 The Nutrasweet Company Sintesis de n-(n-3,3 -dimetilbutil) -l-alfa aspartil)-l- fenilalanina 1- metil ester por utilizacion de precursores de l-alfa-aspartatil-l.-fenilalanina 1-metil ester.
US6720446B2 (en) * 2001-11-05 2004-04-13 The Nutrasweet Company Catalyst modification to enhance neotame production

Also Published As

Publication number Publication date
CN1784418A (zh) 2006-06-07
US20100222608A1 (en) 2010-09-02
JP2007529419A (ja) 2007-10-25
CN101565449A (zh) 2009-10-28
CN101565451B (zh) 2013-03-27
US20040236140A1 (en) 2004-11-25
JP4602982B2 (ja) 2010-12-22
KR20110126191A (ko) 2011-11-22
CN101565450A (zh) 2009-10-28
US7288670B2 (en) 2007-10-30
EP2138506A3 (de) 2010-04-21
KR101108256B1 (ko) 2012-01-31
CN101565451A (zh) 2009-10-28
CN100482681C (zh) 2009-04-29
JP2011026323A (ja) 2011-02-10
US8034969B2 (en) 2011-10-11
EP1620458A2 (de) 2006-02-01
EP1620458B1 (de) 2012-03-21
EP2138506A2 (de) 2009-12-30
CN101565449B (zh) 2012-05-30
KR20060013385A (ko) 2006-02-09
US20080045744A1 (en) 2008-02-21
KR101127519B1 (ko) 2012-03-22
WO2004101604A2 (en) 2004-11-25
KR20110060969A (ko) 2011-06-08
WO2004101604A3 (en) 2005-03-31

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