ATE550431T1 - Neues, für die dolichylphosphat-mannose-abhängige alpha-1,3-mannosyltransferase codierendes gen aus hansenula polymorpha und verfahren zur herstellung rekombinanter glykoproteine mit einem mutanten hansenula polymorpha-stamm, dem dieses gen fehlt - Google Patents

Neues, für die dolichylphosphat-mannose-abhängige alpha-1,3-mannosyltransferase codierendes gen aus hansenula polymorpha und verfahren zur herstellung rekombinanter glykoproteine mit einem mutanten hansenula polymorpha-stamm, dem dieses gen fehlt

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Publication number
ATE550431T1
ATE550431T1 AT06812236T AT06812236T ATE550431T1 AT E550431 T1 ATE550431 T1 AT E550431T1 AT 06812236 T AT06812236 T AT 06812236T AT 06812236 T AT06812236 T AT 06812236T AT E550431 T1 ATE550431 T1 AT E550431T1
Authority
AT
Austria
Prior art keywords
hansenula polymorpha
gene
mannosyltransferase
mannose
dolichylphosphate
Prior art date
Application number
AT06812236T
Other languages
English (en)
Inventor
Hyun Ah Kang
Jeong Seok Park
Moo Woong Kim
Eun Jung Kim
Hye Yun Moon
Doo Byoung Oh
Joo Hyung Heo
Sang Ki Rhee
Original Assignee
Korea Res Inst Of Bioscience
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Publication date
Application filed by Korea Res Inst Of Bioscience filed Critical Korea Res Inst Of Bioscience
Application granted granted Critical
Publication of ATE550431T1 publication Critical patent/ATE550431T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT06812236T 2005-10-27 2006-10-26 Neues, für die dolichylphosphat-mannose-abhängige alpha-1,3-mannosyltransferase codierendes gen aus hansenula polymorpha und verfahren zur herstellung rekombinanter glykoproteine mit einem mutanten hansenula polymorpha-stamm, dem dieses gen fehlt ATE550431T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020050101992A KR101105718B1 (ko) 2005-10-27 2005-10-27 돌리칠 포스페이트 만노스 의존알파-1,3-만노실트랜스퍼라제를 코딩하는 한세눌라폴리모르파 기원의 신규 유전자와 상기 유전자가 결손된한세눌라 폴리모르파 변이주를 이용한 재조합 당단백질생산 방법
PCT/KR2006/004395 WO2007049925A1 (en) 2005-10-27 2006-10-26 A novel hansenula polymorpha gene coding for dolichyl-phosphate-mannose dependent alpha-1,3-mannosyltransferase and process for the production of recombinant glycoproteins with hansenula polymorpha mutant strain deficient in the same gene

Publications (1)

Publication Number Publication Date
ATE550431T1 true ATE550431T1 (de) 2012-04-15

Family

ID=37967998

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06812236T ATE550431T1 (de) 2005-10-27 2006-10-26 Neues, für die dolichylphosphat-mannose-abhängige alpha-1,3-mannosyltransferase codierendes gen aus hansenula polymorpha und verfahren zur herstellung rekombinanter glykoproteine mit einem mutanten hansenula polymorpha-stamm, dem dieses gen fehlt

Country Status (6)

Country Link
US (2) US8187858B2 (de)
EP (1) EP1941042B1 (de)
JP (1) JP5134544B2 (de)
KR (1) KR101105718B1 (de)
AT (1) ATE550431T1 (de)
WO (1) WO2007049925A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2785836A4 (de) * 2011-11-30 2015-06-10 Battelle Memorial Institute Verbesserte herstellung von zitronensäure in aspergillus
US9206450B2 (en) 2011-11-30 2015-12-08 Battelle Memorial Institute Enhanced citric acid production in aspergillus with inactivated asparagine-linked glycosylation protein 3 (ALG3), and/or increased laeA expression
US9909152B2 (en) 2011-11-30 2018-03-06 Battelle Memorial Institute Enhanced itaconic acid production in Aspergillus with increased LaeA expression
DK2852610T3 (en) 2012-05-23 2018-09-03 Glykos Finland Oy PRODUCTION OF FUCOSYLED GLYCOPROTEIN
AU2015293949B2 (en) 2014-07-21 2019-07-25 Teknologian Tutkimuskeskus Vtt Oy Production of glycoproteins with mammalian-like N-glycans in filamentous fungi

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60032370T2 (de) 1999-08-19 2007-10-11 Kirin Beer K.K. Hefevarianten und verfahren zur herstellung von glykoprotein enthaltenden zuckerketten vom säugetiertyp
ATE440959T1 (de) 2000-06-28 2009-09-15 Glycofi Inc Verfahren für die herstellung modifizierter glykoproteine
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
EP2359685B1 (de) 2001-12-27 2013-12-04 GlycoFi, Inc. Verfahren für die rekombinante veränderung von kohlenhydratstrukturen des säugetiertyps
US7252933B2 (en) 2002-06-26 2007-08-07 Flanders Interuniversity Institute For Biotechnology Protein glycosylation modification in methylotrophic yeast
KR20040004089A (ko) 2002-06-29 2004-01-13 한국생명공학연구원 당외쇄 합성 결손 한세눌라 폴리모르파 변이주 및 그를이용한 재조합 당단백질의 제조 방법
KR100604994B1 (ko) 2004-01-30 2006-07-26 한국생명공학연구원 알파1,6-만노실트랜스퍼라제를 코딩하는 한세눌라폴리모르파 기원의 신규 유전자 및 상기 유전자가 결손된한세눌라 폴리모르파 변이주를 이용한 재조합 당단백질생산 방법

Also Published As

Publication number Publication date
KR20070045571A (ko) 2007-05-02
US8685671B2 (en) 2014-04-01
US20120202248A1 (en) 2012-08-09
US8187858B2 (en) 2012-05-29
US20100062485A1 (en) 2010-03-11
EP1941042B1 (de) 2012-03-21
WO2007049925A1 (en) 2007-05-03
EP1941042A1 (de) 2008-07-09
JP2009513131A (ja) 2009-04-02
JP5134544B2 (ja) 2013-01-30
EP1941042A4 (de) 2009-08-05
KR101105718B1 (ko) 2012-01-17

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