ATE419340T1 - Neue carbonylreduktase, deren gen sowie verfahren zur verwendung davon - Google Patents
Neue carbonylreduktase, deren gen sowie verfahren zur verwendung davonInfo
- Publication number
- ATE419340T1 ATE419340T1 AT05767288T AT05767288T ATE419340T1 AT E419340 T1 ATE419340 T1 AT E419340T1 AT 05767288 T AT05767288 T AT 05767288T AT 05767288 T AT05767288 T AT 05767288T AT E419340 T1 ATE419340 T1 AT E419340T1
- Authority
- AT
- Austria
- Prior art keywords
- polypeptide
- butoxycarbonylamino
- chloro
- tert
- phenyl
- Prior art date
Links
- 102000005751 Alcohol Oxidoreductases Human genes 0.000 title 1
- 108010031132 Alcohol Oxidoreductases Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- GFGQSTIUFXHAJS-STQMWFEESA-N tert-butyl n-[(2s,3r)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@H]([C@@H](O)CCl)CC1=CC=CC=C1 GFGQSTIUFXHAJS-STQMWFEESA-N 0.000 abstract 3
- 241001112159 Ogataea Species 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- JAKDNFBATYIEIE-LBPRGKRZSA-N tert-butyl n-[(2s)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@H](C(=O)CCl)CC1=CC=CC=C1 JAKDNFBATYIEIE-LBPRGKRZSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004231226 | 2004-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE419340T1 true ATE419340T1 (de) | 2009-01-15 |
Family
ID=35787086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05767288T ATE419340T1 (de) | 2004-08-06 | 2005-08-01 | Neue carbonylreduktase, deren gen sowie verfahren zur verwendung davon |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7794993B2 (de) |
| EP (1) | EP1792986B1 (de) |
| JP (1) | JP4746548B2 (de) |
| KR (1) | KR20070050461A (de) |
| CN (1) | CN1993464B (de) |
| AT (1) | ATE419340T1 (de) |
| DE (1) | DE602005012127D1 (de) |
| ES (1) | ES2317277T3 (de) |
| WO (1) | WO2006013801A1 (de) |
| ZA (1) | ZA200701856B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT501928B1 (de) * | 2004-10-27 | 2010-09-15 | Iep Gmbh | Verfahren zur herstellung von chiralen alkoholen |
| JP5261172B2 (ja) | 2006-03-31 | 2013-08-14 | 株式会社カネカ | エリスロ又はスレオ−２−アミノ−３−ヒドロキシプロピオン酸エステルの製造方法、新規カルボニル還元酵素、その遺伝子、ベクター、形質転換体、およびそれらを利用した光学活性アルコールの製造方法 |
| GB0619240D0 (en) * | 2006-09-29 | 2006-11-08 | Almac Sciences Ltd | Reduction of alpha-halo ketones |
| SI2404994T1 (sl) * | 2007-12-27 | 2013-10-30 | Otsuka Pharmaceutical Co., Ltd. | Encim, povezan s sintezo ekvola |
| SG177331A1 (en) | 2009-06-22 | 2012-02-28 | Codexis Inc | Ketoreductase-mediated stereoselective route to alpha chloroalcohols |
| WO2011100265A2 (en) | 2010-02-10 | 2011-08-18 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
| EP2639216B1 (de) | 2010-11-09 | 2018-07-11 | Kaneka Corporation | Halogenierte indenone und verfahren zur herstellung optisch aktiver indanone oder optisch aktiver indanole unter verwendung dieser |
| CN102732579A (zh) * | 2011-04-01 | 2012-10-17 | 浙江九洲药业股份有限公司 | 一种微生物转化制备(3s)-3-(叔丁氧羰基)氨基-1-氯-4-苯基-(2r)-丁醇的方法 |
| CN103695443B (zh) * | 2014-01-12 | 2015-12-09 | 中国科学院成都生物研究所 | 一种新型羰基还原酶、其基因及应用 |
| CN103740668B (zh) * | 2014-01-17 | 2016-02-10 | 江苏八巨药业有限公司 | 一种提高葡萄糖脱氢酶释放量的方法 |
| CN105821013B (zh) * | 2016-04-05 | 2019-05-03 | 华东理工大学 | 羰基还原酶及其在制备手性n-保护-羟基氮杂环中的应用 |
| CN110387361A (zh) * | 2019-08-12 | 2019-10-29 | 天津迪沙医药技术开发有限公司 | 一种醛酮还原酶及其应用 |
| US12473578B2 (en) * | 2019-11-22 | 2025-11-18 | Ube Corporation | Carbonyl reductase, nucleic acid encoding same, and method for producing optically active compound using same |
| CN111662889B (zh) * | 2020-07-07 | 2022-03-04 | 南京朗恩生物科技有限公司 | 一种用于生产达芦那韦中间体的酮还原酶突变体 |
| CN111690696B (zh) * | 2020-07-07 | 2021-12-31 | 南京朗恩生物科技有限公司 | 一种生物催化制备达芦那韦中间体的方法 |
| CN111635893A (zh) * | 2020-07-07 | 2020-09-08 | 南京朗恩生物科技有限公司 | 一种酮还原酶及其在达芦那韦中间体生产中的应用 |
| CN113249348B (zh) * | 2021-05-19 | 2023-06-23 | 华东理工大学 | 羰基还原酶、其基因、含有该基因的重组表达转化体及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE519261C2 (sv) | 2001-07-17 | 2003-02-04 | Sca Hygiene Prod Ab | Absorberande alster |
| JP4270918B2 (ja) | 2002-03-19 | 2009-06-03 | 三菱化学株式会社 | 新規カルボニル還元酵素及びこれをコードする遺伝子、ならびにこれらを利用した光学活性アルコールの製造方法 |
| DE60323215D1 (de) | 2002-03-19 | 2008-10-09 | Mitsubishi Chem Corp | Neue carbonylreduktase, diese codierendes gen und verfahren zur produktion optisch-aktiver alkohole damit |
| JP2004254554A (ja) | 2003-02-25 | 2004-09-16 | Mitsubishi Chemicals Corp | 光学活性２−メトキシ−１−（４−トリフルオロメチル−フェニル）エタノールの製造方法 |
-
2005
- 2005-08-01 WO PCT/JP2005/014006 patent/WO2006013801A1/ja not_active Ceased
- 2005-08-01 US US11/659,481 patent/US7794993B2/en not_active Expired - Fee Related
- 2005-08-01 KR KR1020077005277A patent/KR20070050461A/ko not_active Withdrawn
- 2005-08-01 DE DE602005012127T patent/DE602005012127D1/de not_active Expired - Lifetime
- 2005-08-01 JP JP2006531447A patent/JP4746548B2/ja not_active Expired - Fee Related
- 2005-08-01 CN CN2005800266432A patent/CN1993464B/zh not_active Expired - Fee Related
- 2005-08-01 AT AT05767288T patent/ATE419340T1/de active
- 2005-08-01 EP EP05767288A patent/EP1792986B1/de not_active Expired - Lifetime
- 2005-08-01 ZA ZA200701856A patent/ZA200701856B/en unknown
- 2005-08-01 ES ES05767288T patent/ES2317277T3/es not_active Expired - Lifetime
-
2010
- 2010-07-20 US US12/840,026 patent/US7915022B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005012127D1 (de) | 2009-02-12 |
| US20080261281A1 (en) | 2008-10-23 |
| JP4746548B2 (ja) | 2011-08-10 |
| US7794993B2 (en) | 2010-09-14 |
| EP1792986A4 (de) | 2007-09-12 |
| US20100317075A1 (en) | 2010-12-16 |
| WO2006013801A1 (ja) | 2006-02-09 |
| EP1792986A1 (de) | 2007-06-06 |
| JPWO2006013801A1 (ja) | 2008-05-01 |
| US7915022B2 (en) | 2011-03-29 |
| ES2317277T3 (es) | 2009-04-16 |
| EP1792986B1 (de) | 2008-12-31 |
| ZA200701856B (en) | 2008-07-30 |
| CN1993464B (zh) | 2011-12-28 |
| KR20070050461A (ko) | 2007-05-15 |
| CN1993464A (zh) | 2007-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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