ATE419340T1 - Neue carbonylreduktase, deren gen sowie verfahren zur verwendung davon - Google Patents
Neue carbonylreduktase, deren gen sowie verfahren zur verwendung davonInfo
- Publication number
- ATE419340T1 ATE419340T1 AT05767288T AT05767288T ATE419340T1 AT E419340 T1 ATE419340 T1 AT E419340T1 AT 05767288 T AT05767288 T AT 05767288T AT 05767288 T AT05767288 T AT 05767288T AT E419340 T1 ATE419340 T1 AT E419340T1
- Authority
- AT
- Austria
- Prior art keywords
- polypeptide
- butoxycarbonylamino
- chloro
- tert
- phenyl
- Prior art date
Links
- 102000005751 Alcohol Oxidoreductases Human genes 0.000 title 1
- 108010031132 Alcohol Oxidoreductases Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- GFGQSTIUFXHAJS-STQMWFEESA-N tert-butyl n-[(2s,3r)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@H]([C@@H](O)CCl)CC1=CC=CC=C1 GFGQSTIUFXHAJS-STQMWFEESA-N 0.000 abstract 3
- 241001112159 Ogataea Species 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- JAKDNFBATYIEIE-LBPRGKRZSA-N tert-butyl n-[(2s)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@H](C(=O)CCl)CC1=CC=CC=C1 JAKDNFBATYIEIE-LBPRGKRZSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004231226 | 2004-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE419340T1 true ATE419340T1 (de) | 2009-01-15 |
Family
ID=35787086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05767288T ATE419340T1 (de) | 2004-08-06 | 2005-08-01 | Neue carbonylreduktase, deren gen sowie verfahren zur verwendung davon |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7794993B2 (de) |
| EP (1) | EP1792986B1 (de) |
| JP (1) | JP4746548B2 (de) |
| KR (1) | KR20070050461A (de) |
| CN (1) | CN1993464B (de) |
| AT (1) | ATE419340T1 (de) |
| DE (1) | DE602005012127D1 (de) |
| ES (1) | ES2317277T3 (de) |
| WO (1) | WO2006013801A1 (de) |
| ZA (1) | ZA200701856B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT501928B1 (de) * | 2004-10-27 | 2010-09-15 | Iep Gmbh | Verfahren zur herstellung von chiralen alkoholen |
| ATE529507T1 (de) | 2006-03-31 | 2011-11-15 | Kaneka Corp | Verfahren zur produktion von erythro- oder threo- 2-amino-3-hydroxypropionsäureester, neuartige carbonylreduktase, gen für die reduktase, vektor, transformante und verfahren zur produktion von optisch aktivem alkohol unter verwendung dieser |
| GB0619240D0 (en) * | 2006-09-29 | 2006-11-08 | Almac Sciences Ltd | Reduction of alpha-halo ketones |
| KR101543501B1 (ko) | 2007-12-27 | 2015-08-11 | 오츠카 세이야쿠 가부시키가이샤 | 에쿠올 합성에 관여하는 효소 |
| EP2446025B1 (de) | 2009-06-22 | 2018-08-08 | Codexis, Inc. | Ketoreduktase-vermittelter stereoselektiver pfad zu alpha-chloralkoholen |
| WO2011100265A2 (en) | 2010-02-10 | 2011-08-18 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
| WO2012063843A1 (ja) | 2010-11-09 | 2012-05-18 | 株式会社カネカ | ハロゲン化インデノン類及びそれを用いた光学活性インダノン類又は光学活性インダノール類の製造方法 |
| CN102732579A (zh) * | 2011-04-01 | 2012-10-17 | 浙江九洲药业股份有限公司 | 一种微生物转化制备(3s)-3-(叔丁氧羰基)氨基-1-氯-4-苯基-(2r)-丁醇的方法 |
| CN103695443B (zh) * | 2014-01-12 | 2015-12-09 | 中国科学院成都生物研究所 | 一种新型羰基还原酶、其基因及应用 |
| CN103740668B (zh) * | 2014-01-17 | 2016-02-10 | 江苏八巨药业有限公司 | 一种提高葡萄糖脱氢酶释放量的方法 |
| CN105821013B (zh) * | 2016-04-05 | 2019-05-03 | 华东理工大学 | 羰基还原酶及其在制备手性n-保护-羟基氮杂环中的应用 |
| CN110387361A (zh) * | 2019-08-12 | 2019-10-29 | 天津迪沙医药技术开发有限公司 | 一种醛酮还原酶及其应用 |
| WO2021100848A1 (ja) * | 2019-11-22 | 2021-05-27 | 株式会社エーピーアイ コーポレーション | カルボニル還元酵素、これをコードする核酸、及びこれらを利用した光学活性化合物の製造方法 |
| CN111662889B (zh) * | 2020-07-07 | 2022-03-04 | 南京朗恩生物科技有限公司 | 一种用于生产达芦那韦中间体的酮还原酶突变体 |
| CN111635893A (zh) * | 2020-07-07 | 2020-09-08 | 南京朗恩生物科技有限公司 | 一种酮还原酶及其在达芦那韦中间体生产中的应用 |
| CN111690696B (zh) * | 2020-07-07 | 2021-12-31 | 南京朗恩生物科技有限公司 | 一种生物催化制备达芦那韦中间体的方法 |
| CN113249348B (zh) * | 2021-05-19 | 2023-06-23 | 华东理工大学 | 羰基还原酶、其基因、含有该基因的重组表达转化体及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE519261C2 (sv) | 2001-07-17 | 2003-02-04 | Sca Hygiene Prod Ab | Absorberande alster |
| JP4270918B2 (ja) | 2002-03-19 | 2009-06-03 | 三菱化学株式会社 | 新規カルボニル還元酵素及びこれをコードする遺伝子、ならびにこれらを利用した光学活性アルコールの製造方法 |
| CN1322129C (zh) * | 2002-03-19 | 2007-06-20 | 三菱化学株式会社 | 新型羰基还原酶及其编码基因、以及利用它们制备光学活性醇的方法 |
| JP2004254554A (ja) * | 2003-02-25 | 2004-09-16 | Mitsubishi Chemicals Corp | 光学活性２−メトキシ−１−（４−トリフルオロメチル−フェニル）エタノールの製造方法 |
-
2005
- 2005-08-01 KR KR1020077005277A patent/KR20070050461A/ko not_active Withdrawn
- 2005-08-01 WO PCT/JP2005/014006 patent/WO2006013801A1/ja not_active Ceased
- 2005-08-01 DE DE602005012127T patent/DE602005012127D1/de not_active Expired - Lifetime
- 2005-08-01 JP JP2006531447A patent/JP4746548B2/ja not_active Expired - Fee Related
- 2005-08-01 CN CN2005800266432A patent/CN1993464B/zh not_active Expired - Fee Related
- 2005-08-01 ZA ZA200701856A patent/ZA200701856B/en unknown
- 2005-08-01 AT AT05767288T patent/ATE419340T1/de active
- 2005-08-01 ES ES05767288T patent/ES2317277T3/es not_active Expired - Lifetime
- 2005-08-01 US US11/659,481 patent/US7794993B2/en not_active Expired - Fee Related
- 2005-08-01 EP EP05767288A patent/EP1792986B1/de not_active Expired - Lifetime
-
2010
- 2010-07-20 US US12/840,026 patent/US7915022B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1993464A (zh) | 2007-07-04 |
| JPWO2006013801A1 (ja) | 2008-05-01 |
| CN1993464B (zh) | 2011-12-28 |
| WO2006013801A1 (ja) | 2006-02-09 |
| US7915022B2 (en) | 2011-03-29 |
| US20080261281A1 (en) | 2008-10-23 |
| US7794993B2 (en) | 2010-09-14 |
| JP4746548B2 (ja) | 2011-08-10 |
| US20100317075A1 (en) | 2010-12-16 |
| EP1792986A4 (de) | 2007-09-12 |
| ES2317277T3 (es) | 2009-04-16 |
| EP1792986B1 (de) | 2008-12-31 |
| DE602005012127D1 (de) | 2009-02-12 |
| ZA200701856B (en) | 2008-07-30 |
| KR20070050461A (ko) | 2007-05-15 |
| EP1792986A1 (de) | 2007-06-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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