ATE550663T1 - Verfahren zur detektion von modulatoren der asparaginylhydroxylase - Google Patents
Verfahren zur detektion von modulatoren der asparaginylhydroxylaseInfo
- Publication number
- ATE550663T1 ATE550663T1 AT03730330T AT03730330T ATE550663T1 AT E550663 T1 ATE550663 T1 AT E550663T1 AT 03730330 T AT03730330 T AT 03730330T AT 03730330 T AT03730330 T AT 03730330T AT E550663 T1 ATE550663 T1 AT E550663T1
- Authority
- AT
- Austria
- Prior art keywords
- detecting
- substrate
- asparaginyl hydroxylase
- hif
- modulators
- Prior art date
Links
- 102000008109 Mixed Function Oxygenases Human genes 0.000 title abstract 3
- 108010074633 Mixed Function Oxygenases Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000758 substrate Substances 0.000 abstract 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 2
- 229960001230 asparagine Drugs 0.000 abstract 2
- 235000009582 asparagine Nutrition 0.000 abstract 2
- 230000033444 hydroxylation Effects 0.000 abstract 2
- 238000005805 hydroxylation reaction Methods 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000007954 hypoxia Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0211920.4A GB0211920D0 (en) | 2002-05-23 | 2002-05-23 | Assay |
| PCT/GB2003/002257 WO2003100438A1 (en) | 2002-05-23 | 2003-05-23 | Assays for modulators of asparaginyl hydroxylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE550663T1 true ATE550663T1 (de) | 2012-04-15 |
Family
ID=9937298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03730330T ATE550663T1 (de) | 2002-05-23 | 2003-05-23 | Verfahren zur detektion von modulatoren der asparaginylhydroxylase |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7544480B2 (de) |
| EP (1) | EP1506409B1 (de) |
| JP (1) | JP4445851B2 (de) |
| AT (1) | ATE550663T1 (de) |
| AU (2) | AU2003241012A1 (de) |
| CA (1) | CA2487303A1 (de) |
| GB (1) | GB0211920D0 (de) |
| IL (1) | IL165325A0 (de) |
| MX (1) | MXPA04011627A (de) |
| WO (1) | WO2003100438A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR773801A0 (en) * | 2001-09-18 | 2001-10-11 | Adelaide Research & Innovation Pty Ltd | Asparagine hydroxylation of the cad domain of a hif protein |
| EP1700921A3 (de) * | 2002-05-27 | 2006-09-20 | Bayer HealthCare AG | Regulation einer humanen Asparaginhydroxylase |
| US8124582B2 (en) * | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| WO2005093411A2 (en) * | 2004-03-26 | 2005-10-06 | Isis Innovation Limited | Assays for identifying modulators of the hydroxylation of ankyrin repeat proteins by 2-oxoglutarate dependent oxigenase and methods of using the same |
| MX2007016160A (es) * | 2005-06-15 | 2008-03-07 | Fibrogen Inc | Uso de moduladoers de hif-1 alfa para el tratamiento contra el cancer. |
| KR100759389B1 (ko) * | 2005-10-10 | 2007-09-19 | 한국생명공학연구원 | 803번 아스파라진 잔기가 수화된 HIF-1α를 특이적으로인식하는 단일클론항체 및 항원 펩티드 |
| KR100860060B1 (ko) | 2006-10-12 | 2008-09-24 | 한국과학기술연구원 | HIF-1α C-말단 펩타이드와 CBP 또는 p300단백질과의 결합을 정량분석하는 방법 및 상기 방법을이용한 단백질 복합체 형성을 저해하는 억제제의 스크리닝방법 |
| US8962530B2 (en) * | 2007-06-27 | 2015-02-24 | Regents Of The University Of Colorado | Inflammatory bowel disease therapies |
| WO2010033879A2 (en) * | 2008-09-18 | 2010-03-25 | New York University | Inhibiting interaction between hif-1a and p300/cbp with hydrogen bond surrogate-based helices |
| US20140205681A1 (en) | 2013-01-19 | 2014-07-24 | New York University | HYDROGEN-BOND SURROGATE PEPTIDES AND PEPTIDOMIMETICS FOR p53 REACTIVATION |
| JP7739078B2 (ja) * | 2021-07-29 | 2025-09-16 | キヤノン株式会社 | 現像装置 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE383877T1 (de) | 1999-06-04 | 2008-02-15 | Dana Farber Cancer Inst Inc | Identifikation von stoffen, die transkriptionelle antworten auf hypoxia modifizieren |
| AUPR773801A0 (en) | 2001-09-18 | 2001-10-11 | Adelaide Research & Innovation Pty Ltd | Asparagine hydroxylation of the cad domain of a hif protein |
| EP1700921A3 (de) * | 2002-05-27 | 2006-09-20 | Bayer HealthCare AG | Regulation einer humanen Asparaginhydroxylase |
-
2002
- 2002-05-23 GB GBGB0211920.4A patent/GB0211920D0/en not_active Ceased
-
2003
- 2003-05-23 WO PCT/GB2003/002257 patent/WO2003100438A1/en not_active Ceased
- 2003-05-23 US US10/515,419 patent/US7544480B2/en not_active Expired - Fee Related
- 2003-05-23 JP JP2004507844A patent/JP4445851B2/ja not_active Expired - Fee Related
- 2003-05-23 CA CA002487303A patent/CA2487303A1/en not_active Abandoned
- 2003-05-23 EP EP03730330A patent/EP1506409B1/de not_active Expired - Lifetime
- 2003-05-23 AT AT03730330T patent/ATE550663T1/de active
- 2003-05-23 AU AU2003241012A patent/AU2003241012A1/en not_active Abandoned
- 2003-05-23 MX MXPA04011627A patent/MXPA04011627A/es active IP Right Grant
- 2003-05-23 IL IL16532503A patent/IL165325A0/xx unknown
-
2009
- 2009-04-30 US US12/433,607 patent/US20090286858A1/en not_active Abandoned
- 2009-08-19 AU AU2009210390A patent/AU2009210390A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20050244915A1 (en) | 2005-11-03 |
| JP2005526515A (ja) | 2005-09-08 |
| IL165325A0 (en) | 2006-01-15 |
| WO2003100438A1 (en) | 2003-12-04 |
| EP1506409A1 (de) | 2005-02-16 |
| US20090286858A1 (en) | 2009-11-19 |
| EP1506409B1 (de) | 2012-03-21 |
| MXPA04011627A (es) | 2005-03-31 |
| JP4445851B2 (ja) | 2010-04-07 |
| AU2009210390A1 (en) | 2009-09-10 |
| GB0211920D0 (en) | 2002-07-03 |
| CA2487303A1 (en) | 2003-12-04 |
| US7544480B2 (en) | 2009-06-09 |
| AU2003241012A1 (en) | 2003-12-12 |
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