ATE339210T1 - Verfahren zum identifizieren von inhibitoren der methioninaminopeptidasen - Google Patents

Verfahren zum identifizieren von inhibitoren der methioninaminopeptidasen

Info

Publication number
ATE339210T1
ATE339210T1 AT00984526T AT00984526T ATE339210T1 AT E339210 T1 ATE339210 T1 AT E339210T1 AT 00984526 T AT00984526 T AT 00984526T AT 00984526 T AT00984526 T AT 00984526T AT E339210 T1 ATE339210 T1 AT E339210T1
Authority
AT
Austria
Prior art keywords
map
peptide
methods
detection moiety
methionineminopeptidases
Prior art date
Application number
AT00984526T
Other languages
English (en)
Inventor
Yie-Hwa Chang
Original Assignee
Univ Saint Louis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Saint Louis filed Critical Univ Saint Louis
Application granted granted Critical
Publication of ATE339210T1 publication Critical patent/ATE339210T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00984526T 1999-10-14 2000-10-12 Verfahren zum identifizieren von inhibitoren der methioninaminopeptidasen ATE339210T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/418,135 US6261794B1 (en) 1999-10-14 1999-10-14 Methods for identifying inhibitors of methionine aminopeptidases

Publications (1)

Publication Number Publication Date
ATE339210T1 true ATE339210T1 (de) 2006-10-15

Family

ID=23656861

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00984526T ATE339210T1 (de) 1999-10-14 2000-10-12 Verfahren zum identifizieren von inhibitoren der methioninaminopeptidasen

Country Status (8)

Country Link
US (2) US6261794B1 (de)
EP (1) EP1221954B1 (de)
JP (1) JP3727269B2 (de)
AT (1) ATE339210T1 (de)
AU (1) AU2113001A (de)
CA (1) CA2387126A1 (de)
DE (1) DE60030744T2 (de)
WO (1) WO2001027242A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002081415A2 (en) * 2001-04-03 2002-10-17 Smithkline Beecham Corporation Method for inhibiting metap2
US20020182701A1 (en) * 2001-08-30 2002-12-05 Saint Louis University Dominant negative variants of methionine aminopeptidase 2 (MetAP2) and clinical uses thereof
US20050222212A1 (en) * 2002-03-27 2005-10-06 Marino Joseph P Compounds and methods
US7195884B2 (en) * 2002-07-19 2007-03-27 Promega Corp. Methods and kits for transferases
CA2518465A1 (en) 2003-03-25 2004-10-14 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
JP2007511467A (ja) 2003-05-14 2007-05-10 タケダ サン ディエゴ インコーポレイテッド ジペプチジルペプチダーゼインヒビター
KR20060041309A (ko) * 2003-08-13 2006-05-11 다케다 야쿠힌 고교 가부시키가이샤 ４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
EP1699777B1 (de) 2003-09-08 2012-12-12 Takeda Pharmaceutical Company Limited Dipeptidylpeptidase-hemmer
NZ548166A (en) * 2003-12-01 2010-06-25 Meiji Dairies Corp Peptide inhibiting angiontensin converting enzyme
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
UA85871C2 (uk) 2004-03-15 2009-03-10 Такеда Фармасьютікал Компані Лімітед Інгібітори дипептидилпептидази
US7109015B2 (en) * 2004-03-29 2006-09-19 Academia Sinica Removal of N-terminal methionine from proteins by engineered methionine aminopeptidase
US7687638B2 (en) 2004-06-04 2010-03-30 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
JP2008524331A (ja) * 2004-12-21 2008-07-10 武田薬品工業株式会社 ジペプチジルペプチダーゼ阻害剤
AU2006239560B2 (en) * 2005-04-28 2010-03-25 Unilever Plc Peptides having an ace inhibiting effect
MY147393A (en) 2005-09-14 2012-11-30 Takeda Pharmaceutical Administration of dipeptidyl peptidase inhibitors
PE20070622A1 (es) * 2005-09-14 2007-08-22 Takeda Pharmaceutical Administracion de inhibidores de dipeptidil peptidasa
CA2622642C (en) 2005-09-16 2013-12-31 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7740691B2 (en) * 2006-01-10 2010-06-22 Edwin W. Cash Gas treating method and apparatus
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
MX2009002772A (es) * 2006-09-13 2009-05-28 Takeda Pharmaceutical Uso de 2-6-(3-amino-piperidin-1-il)-3-metil-2,4-dioxo-3,4-dihidro- 2h-pirimidin-1-ilmetil-4-fluoro-benzonitrilo.
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
US20100144140A1 (en) * 2008-12-10 2010-06-10 Novellus Systems, Inc. Methods for depositing tungsten films having low resistivity for gapfill applications
WO2013125622A1 (ja) * 2012-02-22 2013-08-29 森永乳業株式会社 ジペプチジルペプチダーゼ－ｉｖ阻害剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5255593A (en) * 1975-10-30 1977-05-07 Ajinomoto Kk Measuring method of enzyme activity
NL7607684A (nl) * 1976-07-12 1978-01-16 Akzo Nv Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan.
US5268164A (en) * 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
NL9401886A (nl) * 1994-05-27 1996-01-02 Dsm Nv Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijgeven van de actieve stof.
CA2194014C (en) * 1994-06-17 2009-10-06 Trobe University (La) Biological control of insects
US5888796A (en) 1996-01-31 1999-03-30 St. Louis University Clone of a nucleotide sequence encoding a protein having two functions
EA200000408A1 (ru) * 1997-10-10 2000-12-25 Сайтовиэ, Инк. Новые флуоресцентные сигнальные молекулы и их применение, в том числе, в анализах каспаз
AU755387B2 (en) * 1997-12-16 2002-12-12 Japan Tobacco Inc. Polypeptides having aminopeptidase activity and nucleic acids encoding same
US6136604A (en) * 1999-10-27 2000-10-24 Isis Pharmaceuticals Inc. Antisense inhibition of methionine aminopeptidase 2 expression

Also Published As

Publication number Publication date
WO2001027242A3 (en) 2001-12-20
JP2003511063A (ja) 2003-03-25
WO2001027242A2 (en) 2001-04-19
EP1221954A2 (de) 2002-07-17
JP3727269B2 (ja) 2005-12-14
EP1221954A4 (de) 2002-11-27
DE60030744D1 (de) 2006-10-26
US6261794B1 (en) 2001-07-17
EP1221954B1 (de) 2006-09-13
CA2387126A1 (en) 2001-04-19
DE60030744T2 (de) 2007-09-20
US20010047078A1 (en) 2001-11-29
AU2113001A (en) 2001-04-23
US6593454B2 (en) 2003-07-15

Similar Documents

Publication Publication Date Title
ATE339210T1 (de) Verfahren zum identifizieren von inhibitoren der methioninaminopeptidasen
AU6162999A (en) Apoptosis marker antibodies and methods of use
ATE498838T1 (de) Elektronische verfahren und vorrichtung zum nachweis von analyten
DE69114499D1 (de) Verfahren zur verstärkung des emissionssignals einer lumineszierenden verbindung.
ATE271691T1 (de) Verfahren zum nachweis der effektivität einer krebstherapie
ATE431427T1 (de) Verbessertes verfahren zum nachweis von atp
DE60321961D1 (de) Verfahren zum genmutationsnachweis
DE69828682D1 (de) Nanomolare, non-peptidische inhibitoren von cathepsin d
ES2162277T3 (es) Sustratos e inhibidores de enzimas proteoliticos.
DE69842003D1 (de) Verfahren zum nachweis eines fibringerinnsels
ATE426858T1 (de) System und verfahren zum erkennen von bísartigem code
ATE241380T1 (de) Modulierung der gefässepermeabilität mittels tie2 rezeptoraktivatoren
EP1298205A4 (de) Neuartige lipase
DE60310012D1 (de) Verfahren, Assay und Kit zur Quantifizierung von HIV-Proteasehemmer
AU2126400A (en) Detection of small molecules by use of a piezoelectric sensor
DE3680978D1 (de) Verfahren zur bestimmung von proteaseinhibitoren.
ATE211719T1 (de) Korrosionsinhibitoren enthaltender injektionszement
ATE550663T1 (de) Verfahren zur detektion von modulatoren der asparaginylhydroxylase
DE502004010751D1 (de) Verfahren und vorrichtung zum magnetronsputtern
WO2002038799A3 (en) Detection of proteases and screening for protease inhibitors
ATE455862T1 (de) Verbesserter rezeptornachweis
DE60114443D1 (de) Verfahren zur identifizierung von listeria-monozytogenen und kulturmedium
ATE346957T1 (de) Verfahren zum nachweis von chloralhydrat in dichloressigsäure
ATE288081T1 (de) Verfahren zum selektieren von inhibitoren für enzyme
ATE247831T1 (de) Verfahren zum nachweis von autoimmun-pathologien

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties