ATE551315T1 - Verfahren zur herstellung von 6-ä3-(1-adamantyl)- 4-methoxyphenylü-2-naphtoesäure - Google Patents

Verfahren zur herstellung von 6-ä3-(1-adamantyl)- 4-methoxyphenylü-2-naphtoesäure

Info

Publication number: ATE551315T1
Authority: AT; Austria
Prior art keywords: adamantyl; methoxyphenyl; naphthoic acid; methoxyphenylü; producing
Prior art date: 2006-12-29

Application number

AT07858233T

Other languages

English (en)

Inventor

Ivars Kalvinsh

Aleksandrs Chernobrovijs

Vyacheslav Tribulovich

Vladimir Labeish

Original Assignee

Grindeks Jsc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-29

Filing date

2007-12-28

Publication date

2012-04-15

2007-12-28 Application filed by Grindeks Jsc filed Critical Grindeks Jsc

2007-12-28 Priority claimed from PCT/EP2007/064647 external-priority patent/WO2008080992A2/en

2012-04-15 Application granted granted Critical

2012-04-15 Publication of ATE551315T1 publication Critical patent/ATE551315T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 3
LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 abstract 3
XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 abstract 2
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
APQIUTYORBAGEZ-UHFFFAOYSA-N 1,1-dibromoethane Chemical compound CC(Br)Br APQIUTYORBAGEZ-UHFFFAOYSA-N 0.000 abstract 1
QQAMHHZQONQBFZ-UHFFFAOYSA-N 1-(5-bromo-2-methoxyphenyl)adamantane Chemical compound COC1=CC=C(Br)C=C1C1(C2)CC(C3)CC2CC3C1 QQAMHHZQONQBFZ-UHFFFAOYSA-N 0.000 abstract 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
238000006161 Suzuki-Miyaura coupling reaction Methods 0.000 abstract 1
FPZOBRFHRPQGAA-UHFFFAOYSA-N [3-(1-adamantyl)-4-methoxyphenyl]boronic acid Chemical compound COC1=CC=C(B(O)O)C=C1C1(C2)CC(C3)CC2CC3C1 FPZOBRFHRPQGAA-UHFFFAOYSA-N 0.000 abstract 1
150000001642 boronic acid derivatives Chemical class 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
229910052749 magnesium Inorganic materials 0.000 abstract 1
239000011777 magnesium Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 1
229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
235000013772 propylene glycol Nutrition 0.000 abstract 1
230000009466 transformation Effects 0.000 abstract 1
238000006478 transmetalation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT07858233T 2006-12-29 2007-12-28 Verfahren zur herstellung von 6-ä3-(1-adamantyl)- 4-methoxyphenylü-2-naphtoesäure ATE551315T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
LV066150		2006-12-29
PCT/EP2007/064647 WO2008080992A2 (en)	2006-12-28	2007-12-28	A process for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl-2-naphtoic acid

Publications (1)

Publication Number	Publication Date
ATE551315T1 true ATE551315T1 (de)	2012-04-15

Family

ID=42267084

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07858233T ATE551315T1 (de)	2006-12-29	2007-12-28	Verfahren zur herstellung von 6-ä3-(1-adamantyl)- 4-methoxyphenylü-2-naphtoesäure

Country Status (2)

Country	Link
US (1)	US20100160677A1 (de)
AT (1)	ATE551315T1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2018219437B2 (en)	2017-02-13	2023-03-02	Boehringer lngelheim Vetmedica GMBH	Liquid applicator for delivering vaccines
CN111333496B (zh) *	2020-05-02	2023-10-13	武汉诺安药业有限公司	一种阿达帕林的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3498995A (en) *	1966-07-25	1970-03-03	Bristol Myers Co	Isothiazole synthesis
LU85849A1 (fr) *	1985-04-11	1986-11-05	Cird	Derives benzonaphtaleniques,leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetiques
WO2005108338A1 (en) *	2004-05-03	2005-11-17	Auspex Pharmaceuticals	Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
ITMI20050550A1 (it) *	2005-04-01	2006-10-02	Dipharma Spa	Procedimento per la preparazione di adapalene

2007
- 2007-12-28 AT AT07858233T patent/ATE551315T1/de active
- 2007-12-28 US US12/448,670 patent/US20100160677A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20100160677A1 (en)	2010-06-24

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