ATE551358T1 - Verfahren und zusammensetzungen zur modulierung des hepatozytenwachstums, der differenzierung von plasmazellen oder der aktivität von t-zellen durch modulierung der aktivität von xbp-1 - Google Patents

Verfahren und zusammensetzungen zur modulierung des hepatozytenwachstums, der differenzierung von plasmazellen oder der aktivität von t-zellen durch modulierung der aktivität von xbp-1

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Publication number
ATE551358T1
ATE551358T1 AT05013817T AT05013817T ATE551358T1 AT E551358 T1 ATE551358 T1 AT E551358T1 AT 05013817 T AT05013817 T AT 05013817T AT 05013817 T AT05013817 T AT 05013817T AT E551358 T1 ATE551358 T1 AT E551358T1
Authority
AT
Austria
Prior art keywords
activity
xbp
methods
modulating
hepatocyte growth
Prior art date
Application number
AT05013817T
Other languages
English (en)
Inventor
Laurie H Glimcher
Andreas M Reimold
Original Assignee
Harvard College
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Publication date
Application filed by Harvard College filed Critical Harvard College
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Publication of ATE551358T1 publication Critical patent/ATE551358T1/de

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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
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  • Zoology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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AT05013817T 1999-12-30 2000-12-29 Verfahren und zusammensetzungen zur modulierung des hepatozytenwachstums, der differenzierung von plasmazellen oder der aktivität von t-zellen durch modulierung der aktivität von xbp-1 ATE551358T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17393199P 1999-12-30 1999-12-30

Publications (1)

Publication Number Publication Date
ATE551358T1 true ATE551358T1 (de) 2012-04-15

Family

ID=22634110

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05013817T ATE551358T1 (de) 1999-12-30 2000-12-29 Verfahren und zusammensetzungen zur modulierung des hepatozytenwachstums, der differenzierung von plasmazellen oder der aktivität von t-zellen durch modulierung der aktivität von xbp-1
AT00988444T ATE361934T1 (de) 1999-12-30 2000-12-29 Verfahren zur modulierung der aktivität von th2- zellen durch modulierung der aktivität von xbp-1

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT00988444T ATE361934T1 (de) 1999-12-30 2000-12-29 Verfahren zur modulierung der aktivität von th2- zellen durch modulierung der aktivität von xbp-1

Country Status (12)

Country Link
US (3) US6632608B2 (de)
EP (2) EP1626056B1 (de)
JP (1) JP2003518942A (de)
AT (2) ATE551358T1 (de)
AU (3) AU784883B2 (de)
CA (1) CA2396062C (de)
DE (1) DE60034817T2 (de)
DK (1) DK1254169T3 (de)
ES (1) ES2283340T3 (de)
MX (1) MXPA02006433A (de)
PT (1) PT1254169E (de)
WO (1) WO2001049717A2 (de)

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US7666587B2 (en) * 2002-04-12 2010-02-23 New York University Method of screening test substances for treating or preventing a disease mediated by plasma cells
AU2003243443B2 (en) * 2002-06-21 2008-11-06 Centocor, Inc. Method for generating monoclonal antibodies
WO2004020610A2 (en) * 2002-08-30 2004-03-11 President And Fellows Of Harvard College Methods and compositions for modulating xbp-1 activity
JP4890269B2 (ja) * 2004-02-12 2012-03-07 ウォルター アンド エリザ ホール インスティテュート オブ メディカル リサーチ Ｂｌｉｍｐ１およびレポーター分子を共発現する改変細胞およびその使用方法
WO2006031930A2 (en) * 2004-09-15 2006-03-23 The President And Fellows Of Harvard College Modulation of xbp-1 activity for treatment of metabolic disorders
US20060063187A1 (en) * 2004-09-15 2006-03-23 Hotamisligil Gokhan S Modulation of XBP-1 activity for treatment of metabolic disorders
SG166788A1 (en) * 2005-10-28 2010-12-29 Centocor Inc Use of b cell expansion agents in generating antibodies
AU2007221966A1 (en) * 2006-12-08 2008-06-26 Centenary Institute Of Cancer Medicine And Cell Biology Assay for response to proteasome inhibitors
US8227184B2 (en) * 2008-01-14 2012-07-24 President And Fellows Of Harvard College Methods for modulating de novo hepatic lipogenesis by modulating XBP-1 activity
EP2391372A4 (de) * 2009-01-30 2013-07-03 Bayer Healthcare Llc Verfahren zur behandlung von östrogenrezeptor-positivem tumor mittels hemmung des x-box-bindenden proteins 1
WO2012109238A2 (en) 2011-02-07 2012-08-16 President And Fellows Of Harvard College Methods for increasing immune responses using agents that directly bind to and activate ire-1
WO2013134774A1 (en) 2012-03-09 2013-09-12 Cornell University Modulation of breast cancer growth by modulation of xbp1 activity
US9957506B2 (en) 2013-09-25 2018-05-01 Cornell University Compounds for inducing anti-tumor immunity and methods thereof
KR101864410B1 (ko) * 2016-01-21 2018-06-05 한국화학연구원 3차원 간세포 배양 유닛, 간독성 평가 시스템 및 이를 이용한 간독성 평가 방법
US10392367B2 (en) 2017-06-01 2019-08-27 Quentis Therapeutics, Inc. IRE1 small molecule inhibitors
JP7126084B2 (ja) 2017-06-01 2022-08-26 コーネル ユニバーシティー Ｉｒｅ１小分子阻害薬
WO2020011909A1 (en) * 2018-07-11 2020-01-16 Secarna Pharmaceuticals Gmbh & Co. Kg Nucleic acid polymers inhibiting the expression of xbp1

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US7358415B2 (en) 2008-04-15
US6632608B2 (en) 2003-10-14
WO2001049717A2 (en) 2001-07-12
AU2006202243B2 (en) 2010-06-03
ATE361934T1 (de) 2007-06-15
MXPA02006433A (es) 2002-11-29
DK1254169T3 (da) 2007-08-06
CA2396062C (en) 2009-11-17
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EP1626056B1 (de) 2012-03-28
EP1626056A2 (de) 2006-02-15
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