ATE359508T1 - Screening-verfahren unter verwendung von zebrafisch und der blut-hirn-schranke - Google Patents
Screening-verfahren unter verwendung von zebrafisch und der blut-hirn-schrankeInfo
- Publication number
- ATE359508T1 ATE359508T1 AT05708384T AT05708384T ATE359508T1 AT E359508 T1 ATE359508 T1 AT E359508T1 AT 05708384 T AT05708384 T AT 05708384T AT 05708384 T AT05708384 T AT 05708384T AT E359508 T1 ATE359508 T1 AT E359508T1
- Authority
- AT
- Austria
- Prior art keywords
- zebrafish
- blood
- brain barrier
- screening methods
- brain
- Prior art date
Links
- 241000252212 Danio rerio Species 0.000 title abstract 2
- 230000008499 blood brain barrier function Effects 0.000 title abstract 2
- 210000001218 blood-brain barrier Anatomy 0.000 title abstract 2
- 238000012216 screening Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 210000000133 brain stem Anatomy 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 241000251468 Actinopterygii Species 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0403490.6A GB0403490D0 (en) | 2004-02-17 | 2004-02-17 | Screening methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE359508T1 true ATE359508T1 (de) | 2007-05-15 |
Family
ID=32039873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05708384T ATE359508T1 (de) | 2004-02-17 | 2005-02-17 | Screening-verfahren unter verwendung von zebrafisch und der blut-hirn-schranke |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060193776A1 (de) |
| EP (1) | EP1644733B1 (de) |
| JP (1) | JP2007525665A (de) |
| AT (1) | ATE359508T1 (de) |
| AU (1) | AU2005215455A1 (de) |
| CA (1) | CA2556680A1 (de) |
| DE (1) | DE602005000874T2 (de) |
| ES (1) | ES2286794T3 (de) |
| GB (1) | GB0403490D0 (de) |
| WO (1) | WO2005080974A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7951989B2 (en) * | 1998-02-23 | 2011-05-31 | Phylonix Pharmaceuticals, Inc. | Methods of screening agents for activity using teleosts |
| WO1999042606A1 (en) | 1998-02-23 | 1999-08-26 | Phylonix Pharmaceuticals, Inc. | Methods of screening agents for activity using teleosts |
| US6656449B1 (en) | 1998-02-23 | 2003-12-02 | Phylonix Pharmaceuticals, Inc. | Methods of screening agents for activity using teleosts |
| US20060018833A1 (en) * | 2004-04-07 | 2006-01-26 | Randall Murphy | Method and system for screening compounds for muscular and/or neurological activity in animals |
| WO2010031794A1 (en) * | 2008-09-22 | 2010-03-25 | Entomopharm Aps | Screening methods employing insects with blood brain barrier |
| JP5733716B2 (ja) * | 2009-12-25 | 2015-06-10 | キヤノン株式会社 | 中枢神経系組織標識用組成物、中枢神経系組織の標識方法、及び中枢神経系組織標識用組成物を用いたスクリーニング方法 |
| EP2517732B1 (de) * | 2009-12-25 | 2016-09-21 | Canon Kabushiki Kaisha | Transnasale kennzeichnungszusammensetzung für gewebe des zentralen nervensystems |
| JP5888904B2 (ja) | 2011-02-16 | 2016-03-22 | 国立大学法人三重大学 | 中枢神経移行性評価用プローブ、中枢神経移行性評価方法、及び、中枢神経移行性評価用プローブを用いたスクリーニング方法 |
| CN102288750B (zh) * | 2011-08-12 | 2014-04-16 | 杭州环特生物科技有限公司 | 斑马鱼p-糖蛋白抑制剂筛选模型的建立方法及其应用 |
| US10143187B2 (en) | 2017-02-17 | 2018-12-04 | Denali Therapeutics Inc. | Transferrin receptor transgenic models |
| NZ756763A (en) | 2017-02-17 | 2023-04-28 | Denali Therapeutics Inc | Engineered transferrin receptor binding polypeptides |
| US10457717B2 (en) | 2017-02-17 | 2019-10-29 | Denali Therapeutics Inc. | Engineered polypeptides |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999042606A1 (en) * | 1998-02-23 | 1999-08-26 | Phylonix Pharmaceuticals, Inc. | Methods of screening agents for activity using teleosts |
-
2004
- 2004-02-17 GB GBGB0403490.6A patent/GB0403490D0/en not_active Ceased
-
2005
- 2005-02-17 AU AU2005215455A patent/AU2005215455A1/en not_active Abandoned
- 2005-02-17 ES ES05708384T patent/ES2286794T3/es not_active Expired - Lifetime
- 2005-02-17 CA CA002556680A patent/CA2556680A1/en not_active Abandoned
- 2005-02-17 WO PCT/GB2005/000583 patent/WO2005080974A1/en not_active Ceased
- 2005-02-17 DE DE602005000874T patent/DE602005000874T2/de not_active Revoked
- 2005-02-17 US US10/566,888 patent/US20060193776A1/en not_active Abandoned
- 2005-02-17 AT AT05708384T patent/ATE359508T1/de not_active IP Right Cessation
- 2005-02-17 JP JP2006552695A patent/JP2007525665A/ja active Pending
- 2005-02-17 EP EP05708384A patent/EP1644733B1/de not_active Revoked
Also Published As
| Publication number | Publication date |
|---|---|
| ES2286794T3 (es) | 2007-12-01 |
| WO2005080974A1 (en) | 2005-09-01 |
| AU2005215455A1 (en) | 2005-09-01 |
| GB0403490D0 (en) | 2004-03-24 |
| EP1644733B1 (de) | 2007-04-11 |
| CA2556680A1 (en) | 2005-09-01 |
| DE602005000874D1 (de) | 2007-05-24 |
| DE602005000874T2 (de) | 2008-01-17 |
| JP2007525665A (ja) | 2007-09-06 |
| EP1644733A1 (de) | 2006-04-12 |
| US20060193776A1 (en) | 2006-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |