ATE551363T1 - Verwendung von antikörper gegen interleukin-4 rezeptor und deren zusammensetzungen - Google Patents
Verwendung von antikörper gegen interleukin-4 rezeptor und deren zusammensetzungenInfo
- Publication number
- ATE551363T1 ATE551363T1 AT01952133T AT01952133T ATE551363T1 AT E551363 T1 ATE551363 T1 AT E551363T1 AT 01952133 T AT01952133 T AT 01952133T AT 01952133 T AT01952133 T AT 01952133T AT E551363 T1 ATE551363 T1 AT E551363T1
- Authority
- AT
- Austria
- Prior art keywords
- antibodies
- interleukin
- receptor
- compositions
- bind
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57980800A | 2000-05-26 | 2000-05-26 | |
| US66534300A | 2000-09-19 | 2000-09-19 | |
| US09/785,934 US20020002132A1 (en) | 2000-05-26 | 2001-02-15 | Use of interleukin-4 antagonists and compositions thereof |
| US84781601A | 2001-05-01 | 2001-05-01 | |
| PCT/US2001/017094 WO2001092340A2 (en) | 2000-05-26 | 2001-05-25 | Use of interleukin-4 antagonists and compositions thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE551363T1 true ATE551363T1 (de) | 2012-04-15 |
Family
ID=27504940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01952133T ATE551363T1 (de) | 2000-05-26 | 2001-05-25 | Verwendung von antikörper gegen interleukin-4 rezeptor und deren zusammensetzungen |
Country Status (12)
| Country | Link |
|---|---|
| US (8) | US7186809B2 (de) |
| EP (4) | EP2990420B1 (de) |
| AT (1) | ATE551363T1 (de) |
| AU (1) | AU2001272925A1 (de) |
| CA (1) | CA2409267C (de) |
| CY (1) | CY1118951T1 (de) |
| DE (1) | DE16192152T1 (de) |
| DK (1) | DK2990420T3 (de) |
| ES (3) | ES2382891T3 (de) |
| MX (1) | MXPA02011682A (de) |
| PT (1) | PT2990420T (de) |
| WO (1) | WO2001092340A2 (de) |
Families Citing this family (108)
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| ES2277460T3 (es) | 1998-12-14 | 2007-07-01 | Genetics Institute, Llc | Cadena del receptor de la citoquina. |
| US7553487B2 (en) | 1998-12-14 | 2009-06-30 | Genetics Institute, Llc | Method and compositions for treating asthma |
| DE16192152T1 (de) | 2000-05-26 | 2020-08-06 | Immunex Corporation | Verwendung von interleukin-4 rezeptor (il-4r) antikörpern und zusammensetzungen davon |
| WO2003092610A2 (en) | 2002-05-01 | 2003-11-13 | Regeneron Pharmaceuticals, Inc. | Methods of using cytokine antagonists to treat hiv infection and aids |
| US20070104710A1 (en) * | 2002-06-28 | 2007-05-10 | Domants Limited | Ligand that has binding specificity for IL-4 and/or IL-13 |
| US20110223168A1 (en) * | 2002-12-27 | 2011-09-15 | Greg Winter | Ligand that has binding specificity for il-4 and/or il-13 |
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| GEP20104991B (en) | 2003-11-07 | 2010-05-25 | Immunex Corp | Antibodies that bind interleukin-4 receptor |
| NZ548821A (en) * | 2004-02-06 | 2009-12-24 | Univ Massachusetts | Antibodies against clostridium difficile toxins and uses thereof |
| US8618054B2 (en) | 2004-05-05 | 2013-12-31 | Valorisation-Rechereche Société en Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
| AR049390A1 (es) | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
| US7501121B2 (en) | 2004-06-17 | 2009-03-10 | Wyeth | IL-13 binding agents |
| EP2366786A3 (de) * | 2005-05-05 | 2012-08-29 | VALORISATION HSJ, Société en Commandite | Zytokin-Rezeptormodulatoren und Verwendung davon |
| GB0510790D0 (en) | 2005-05-26 | 2005-06-29 | Syngenta Crop Protection Ag | Anti-CD16 binding molecules |
| US20070009479A1 (en) * | 2005-06-17 | 2007-01-11 | Aerovance, Inc. | Methods for treating dermatitis using mutant human IL-4 compositions |
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| WO2008054606A2 (en) * | 2006-10-02 | 2008-05-08 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human il-4 receptor |
| JP5588866B2 (ja) | 2007-08-10 | 2014-09-10 | メダレックス エル.エル.シー. | Hco32およびhco27、ならびに関連実施例 |
| MX2010002683A (es) | 2007-09-14 | 2010-03-26 | Amgen Inc | Poblaciones de anticuerpos homogeneos. |
| US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
| RU2490278C2 (ru) * | 2007-12-21 | 2013-08-20 | Медиммун Лимитед | ЭЛЕМЕНТ, СВЯЗЫВАЮЩИЙСЯ С α-РЕЦЕПТОРОМ ИНТЕРЛЕЙКИНА-4 (IL-4Rα)-173 |
| US20110008326A1 (en) * | 2008-04-02 | 2011-01-13 | Oliver Hill | Binding agents directed against il-4 receptor for the treatment of tumors, inflammatory and immunological disorders |
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| WO2011106779A1 (en) * | 2010-02-26 | 2011-09-01 | Aerovance Inc. | Use of modified il-4 mutien receptor antagonists to treat dermatitis |
| PL2624865T3 (pl) | 2010-10-06 | 2018-11-30 | Regeneron Pharmaceuticals, Inc. | Stabilizowane preparaty zawierające przeciwciała przeciwko receptorowi interleukiny-4 (IL-4R) |
| CN103930444B (zh) | 2011-09-16 | 2020-08-04 | 瑞泽恩制药公司 | 用前蛋白转化酶枯草溶菌素-9(PCSK9)抑制剂降低脂蛋白(a)水平的方法 |
| EP2596802A1 (de) | 2011-11-23 | 2013-05-29 | PLS-Design GmbH | Pharmazeutische Zusammensetzung zur Behandlung allergischer Reaktionen |
| WO2014031610A1 (en) | 2012-08-21 | 2014-02-27 | Sanofi | Methods for treating or preventing asthma by administering an il-4r antagonist |
| HRP20181227T1 (hr) | 2012-09-07 | 2018-10-05 | Regeneron Pharmaceuticals, Inc. | Metode za liječenje atopijskog dermatitisa primjenom antagonista il-4r |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| CN103289962B (zh) * | 2012-12-07 | 2015-03-18 | 天津三箭生物技术有限公司 | 小鼠抗人cd23单克隆抗体及分泌该单克隆抗体的杂交瘤细胞株 |
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| TWI755763B (zh) | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法 |
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| US10156562B2 (en) | 2014-05-16 | 2018-12-18 | Amgen Inc. | Assay for detecting Th1 and Th2 cell populations |
| WO2016023916A1 (en) | 2014-08-12 | 2016-02-18 | Kymab Limited | Treatment of disease using ligand binding to targets of interest |
| EP3194446B1 (de) | 2014-09-18 | 2022-10-26 | Cedars-Sinai Medical Center | Zusammensetzungen und verfahren zur behandlung von fibrose |
| WO2016071701A1 (en) | 2014-11-07 | 2016-05-12 | Kymab Limited | Treatment of disease using ligand binding to targets of interest |
| US10066017B2 (en) | 2014-11-14 | 2018-09-04 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| WO2017102920A1 (en) | 2015-12-18 | 2017-06-22 | Intervet International B.V. | Caninized human antibodies to human and canine il-4r alpha |
| MA44238B1 (fr) | 2016-02-19 | 2024-07-31 | Regeneron Pharmaceuticals, Inc. | Procédés d'augmentation de l'efficacité d'un vaccin par administration d'un antagoniste d'il-4r |
| CN107474134B (zh) | 2016-06-08 | 2021-07-27 | 苏州康乃德生物医药有限公司 | 用于结合白细胞介素4受体的抗体 |
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-
2001
- 2001-05-25 DE DE16192152.3T patent/DE16192152T1/de active Pending
- 2001-05-25 EP EP15168899.1A patent/EP2990420B1/de not_active Revoked
- 2001-05-25 ES ES01952133T patent/ES2382891T3/es not_active Expired - Lifetime
- 2001-05-25 AU AU2001272925A patent/AU2001272925A1/en not_active Abandoned
- 2001-05-25 PT PT151688991T patent/PT2990420T/pt unknown
- 2001-05-25 CA CA2409267A patent/CA2409267C/en not_active Expired - Lifetime
- 2001-05-25 EP EP16192152.3A patent/EP3190126A1/de not_active Ceased
- 2001-05-25 MX MXPA02011682A patent/MXPA02011682A/es active IP Right Grant
- 2001-05-25 ES ES15168899.1T patent/ES2614260T3/es not_active Expired - Lifetime
- 2001-05-25 EP EP10185626.8A patent/EP2292665B1/de not_active Revoked
- 2001-05-25 EP EP01952133A patent/EP1283851B1/de not_active Expired - Lifetime
- 2001-05-25 ES ES10185626.8T patent/ES2549767T3/es not_active Expired - Lifetime
- 2001-05-25 WO PCT/US2001/017094 patent/WO2001092340A2/en not_active Ceased
- 2001-05-25 DK DK15168899.1T patent/DK2990420T3/en active
- 2001-05-25 AT AT01952133T patent/ATE551363T1/de active
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2002
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2006
- 2006-10-27 US US11/588,696 patent/US7465450B2/en not_active Expired - Fee Related
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2008
- 2008-11-13 US US12/291,702 patent/US20090104662A1/en not_active Abandoned
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2010
- 2010-07-01 US US12/829,231 patent/US8679487B2/en not_active Expired - Lifetime
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2014
- 2014-02-07 US US14/175,943 patent/US9587026B2/en not_active Expired - Fee Related
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2017
- 2017-01-24 US US15/414,447 patent/US20170137526A1/en not_active Abandoned
- 2017-02-21 CY CY20171100233T patent/CY1118951T1/el unknown
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2018
- 2018-02-09 US US15/893,101 patent/US20180171016A1/en not_active Abandoned
- 2018-10-04 US US16/151,781 patent/US20190023798A1/en not_active Abandoned
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| CA2409267C (en) | 2017-02-28 |
| US8679487B2 (en) | 2014-03-25 |
| WO2001092340A2 (en) | 2001-12-06 |
| ES2614260T3 (es) | 2017-05-30 |
| CA2409267A1 (en) | 2001-12-06 |
| DK2990420T3 (en) | 2017-04-03 |
| EP1283851B1 (de) | 2012-03-28 |
| US20070041976A1 (en) | 2007-02-22 |
| EP2292665B1 (de) | 2015-07-08 |
| ES2549767T3 (es) | 2015-11-02 |
| MXPA02011682A (es) | 2003-05-14 |
| ES2382891T3 (es) | 2012-06-14 |
| US20170137526A1 (en) | 2017-05-18 |
| US20090104662A1 (en) | 2009-04-23 |
| DE16192152T1 (de) | 2020-08-06 |
| EP2292665A1 (de) | 2011-03-09 |
| US20110002913A1 (en) | 2011-01-06 |
| US20030124121A1 (en) | 2003-07-03 |
| US9587026B2 (en) | 2017-03-07 |
| EP2990420A1 (de) | 2016-03-02 |
| US20140154267A1 (en) | 2014-06-05 |
| US7465450B2 (en) | 2008-12-16 |
| AU2001272925A1 (en) | 2001-12-11 |
| EP2990420B1 (de) | 2016-12-21 |
| US7186809B2 (en) | 2007-03-06 |
| EP1283851A2 (de) | 2003-02-19 |
| WO2001092340A3 (en) | 2002-04-25 |
| CY1118951T1 (el) | 2018-01-10 |
| EP3190126A1 (de) | 2017-07-12 |
| US20190023798A1 (en) | 2019-01-24 |
| US20180171016A1 (en) | 2018-06-21 |
| PT2990420T (pt) | 2017-03-16 |
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