ATE551366T1 - Hybride mensch/nagetier igg antikörper gegen cd3 und verfahren zur dessen herstellung - Google Patents

Hybride mensch/nagetier igg antikörper gegen cd3 und verfahren zur dessen herstellung

Info

Publication number
ATE551366T1
ATE551366T1 AT99934931T AT99934931T ATE551366T1 AT E551366 T1 ATE551366 T1 AT E551366T1 AT 99934931 T AT99934931 T AT 99934931T AT 99934931 T AT99934931 T AT 99934931T AT E551366 T1 ATE551366 T1 AT E551366T1
Authority
AT
Austria
Prior art keywords
ser
asp
pro
rodent
phe
Prior art date
Application number
AT99934931T
Other languages
English (en)
Inventor
Herman Waldmann
Mark Frewin
Original Assignee
Btg Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Btg Int Ltd filed Critical Btg Int Ltd
Application granted granted Critical
Publication of ATE551366T1 publication Critical patent/ATE551366T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT99934931T 1998-07-21 1999-07-21 Hybride mensch/nagetier igg antikörper gegen cd3 und verfahren zur dessen herstellung ATE551366T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9815909.8A GB9815909D0 (en) 1998-07-21 1998-07-21 Antibody preparation
PCT/GB1999/002380 WO2000005268A1 (en) 1998-07-21 1999-07-21 Hybrid human/rodent igg antibody to cd3, and methods of its construction

Publications (1)

Publication Number Publication Date
ATE551366T1 true ATE551366T1 (de) 2012-04-15

Family

ID=10835937

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99934931T ATE551366T1 (de) 1998-07-21 1999-07-21 Hybride mensch/nagetier igg antikörper gegen cd3 und verfahren zur dessen herstellung

Country Status (16)

Country Link
US (4) US20020131968A1 (de)
EP (2) EP1098909B1 (de)
JP (1) JP4629228B2 (de)
KR (1) KR100629017B1 (de)
AT (1) ATE551366T1 (de)
AU (1) AU766486B2 (de)
CA (1) CA2334047C (de)
CY (1) CY1113296T1 (de)
DK (1) DK1098909T3 (de)
ES (1) ES2384319T3 (de)
GB (1) GB9815909D0 (de)
NZ (1) NZ509074A (de)
PT (1) PT1098909E (de)
RU (1) RU2244720C2 (de)
WO (1) WO2000005268A1 (de)
ZA (1) ZA200100478B (de)

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CA2334047C (en) 2015-11-24
US7994289B2 (en) 2011-08-09
GB9815909D0 (en) 1998-09-16
CY1113296T1 (el) 2016-04-13
US7993641B2 (en) 2011-08-09
US20070092516A1 (en) 2007-04-26
EP2388275A2 (de) 2011-11-23
RU2244720C2 (ru) 2005-01-20
ES2384319T3 (es) 2012-07-03
JP2002521022A (ja) 2002-07-16
AU766486B2 (en) 2003-10-16
DK1098909T3 (da) 2012-06-25
US20040006216A1 (en) 2004-01-08
NZ509074A (en) 2003-09-26
EP1098909B1 (de) 2012-03-28
AU5055299A (en) 2000-02-14
PT1098909E (pt) 2012-06-25
JP4629228B2 (ja) 2011-02-09
CA2334047A1 (en) 2000-02-03
KR20010082010A (ko) 2001-08-29
US20020131968A1 (en) 2002-09-19
WO2000005268A1 (en) 2000-02-03
US20110282037A1 (en) 2011-11-17
KR100629017B1 (ko) 2006-09-26
EP1098909A1 (de) 2001-05-16
EP2388275A3 (de) 2013-04-03
ZA200100478B (en) 2001-07-30

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