|
EP2612854B1
(de)
|
2005-10-25 |
2015-04-29 |
Shionogi&Co., Ltd. |
Aminothiazolidin- und Aminotetrahydrothiazepin-Derivate als BACE 1-Inhibitoren
|
|
AU2006320374B2
(en)
|
2005-12-02 |
2012-08-30 |
Isis Pharmaceuticals, Inc. |
Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
|
|
DK3219705T3
(da)
|
2005-12-28 |
2020-04-14 |
Vertex Pharma |
Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
|
|
WO2007128568A1
(en)
|
2006-05-10 |
2007-11-15 |
Novartis Ag |
Bicyclic derivatives as cetp inhibitors
|
|
GB0609268D0
(en)
*
|
2006-05-10 |
2006-06-21 |
Novartis Ag |
Organic compounds
|
|
BRPI0711447A2
(pt)
*
|
2006-05-11 |
2011-11-08 |
Novartis Ag |
compostos orgánicos
|
|
US7750019B2
(en)
|
2006-08-11 |
2010-07-06 |
Kowa Company, Ltd. |
Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same
|
|
US7790737B2
(en)
|
2007-03-13 |
2010-09-07 |
Kowa Company, Ltd. |
Substituted pyrimidine compounds and their utility as CETP inhibitors
|
|
MX2009010050A
(es)
*
|
2007-03-23 |
2009-10-12 |
Amgen Inc |
Derivados de quinolina o quinoxalina 3-sustituidos y su uso como inhibidores de fosfotidilinositol 3-cinasa (p13k).
|
|
MX2009010962A
(es)
|
2007-04-13 |
2009-12-16 |
Kowa Co |
Compuesto pirimidina novedoso que tiene estructura de dibencilamina y medicamento que comprende el mismo.
|
|
WO2008133273A1
(ja)
|
2007-04-24 |
2008-11-06 |
Shionogi & Co., Ltd. |
アルツハイマー症治療用医薬組成物
|
|
TW200902526A
(en)
*
|
2007-04-24 |
2009-01-16 |
Shionogi & Amp Co Ltd |
Aminodihydrothiazin derivative substituted with a cyclic group
|
|
EP2025674A1
(de)
|
2007-08-15 |
2009-02-18 |
sanofi-aventis |
Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
AR069165A1
(es)
|
2007-11-05 |
2010-01-06 |
Novartis Ag |
Derivados de 4-bencilamino-1-carboxacilpiperidina como inhibidores de cetp utiles para el tratamiento de hiperlipidemia
|
|
PT2404901E
(pt)
|
2007-12-03 |
2013-08-29 |
Novartis Ag |
Derivados de 4-benzilamino-pirrolidina 1,2-dissubstituídos como inibidores de cetp úteis para o tratamento de doenças tais como a hiperlipidemia ou a arteriosclerose
|
|
EP2231641B1
(de)
|
2007-12-21 |
2016-06-01 |
UCB Biopharma SPRL |
Chinoxalin- und chinolinderivate als kinasehemmer
|
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
|
CA2711558C
(en)
|
2008-01-04 |
2016-12-13 |
Intellikine, Inc. |
Phosphatidyl inositol-3 kinase inhibiting compounds
|
|
WO2009151098A1
(ja)
*
|
2008-06-13 |
2009-12-17 |
塩野義製薬株式会社 |
βセクレターゼ阻害作用を有する含硫黄複素環誘導体
|
|
WO2010030704A2
(en)
|
2008-09-10 |
2010-03-18 |
Achaogen, Inc. |
Antibacterial aminoglycoside analogs
|
|
WO2010030690A1
(en)
|
2008-09-10 |
2010-03-18 |
Isis Pharmaceuticals, Inc. |
Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
|
|
WO2010042851A1
(en)
|
2008-10-09 |
2010-04-15 |
Achaogen, Inc. |
Antibacterial aminoglycoside analogs
|
|
WO2010042850A1
(en)
|
2008-10-09 |
2010-04-15 |
Achaogen, Inc. |
Antibacterial aminoglycoside analogs
|
|
JPWO2010047372A1
(ja)
*
|
2008-10-22 |
2012-03-22 |
塩野義製薬株式会社 |
Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体
|
|
US8314239B2
(en)
|
2008-10-23 |
2012-11-20 |
Vertex Pharmaceutical Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
TWI465449B
(zh)
|
2008-10-23 |
2014-12-21 |
Vertex Pharma |
囊腫性纖維化跨膜傳導調節因子之調控因子
|
|
EP2396315B1
(de)
*
|
2009-02-13 |
2016-08-31 |
UCB Biopharma SPRL |
Chinolin-derivate als pi3k-kinase-inhibitoren
|
|
SG176628A1
(en)
|
2009-06-05 |
2012-01-30 |
Link Medicine Corp |
Aminopyrrolidinone derivatives and uses thereof
|
|
EP2845856A1
(de)
|
2009-06-29 |
2015-03-11 |
Incyte Corporation |
Pyrimidone als PI3K-Hemmer
|
|
CA2777107A1
(en)
|
2009-10-09 |
2011-04-14 |
Achaogen, Inc. |
Antibacterial aminoglycoside analogs
|
|
UA110467C2
(uk)
|
2009-12-11 |
2016-01-12 |
Шионогі Енд Ко., Лтд. |
Похідні оксазину
|
|
WO2011075630A1
(en)
*
|
2009-12-18 |
2011-06-23 |
Incyte Corporation |
Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors
|
|
US8759359B2
(en)
*
|
2009-12-18 |
2014-06-24 |
Incyte Corporation |
Substituted heteroaryl fused derivatives as PI3K inhibitors
|
|
EP2558463A1
(de)
|
2010-04-14 |
2013-02-20 |
Incyte Corporation |
Kondensierte derivate als i3-hemmer
|
|
US8450350B2
(en)
|
2010-05-05 |
2013-05-28 |
Infinity Pharmaceuticals, Inc. |
Triazoles as inhibitors of fatty acid synthase
|
|
WO2011140190A1
(en)
|
2010-05-05 |
2011-11-10 |
Infinity Pharmaceuticals |
Tetrazolones as inhibitors of fatty acid synthase
|
|
AU2011255218B2
(en)
|
2010-05-21 |
2015-03-12 |
Infinity Pharmaceuticals, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
|
US8933024B2
(en)
|
2010-06-18 |
2015-01-13 |
Sanofi |
Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
|
|
WO2011163195A1
(en)
|
2010-06-21 |
2011-12-29 |
Incyte Corporation |
Fused pyrrole derivatives as pi3k inhibitors
|
|
CA2804924C
(en)
|
2010-07-09 |
2016-06-28 |
Daiichi Sankyo Company, Limited |
Substituted pyridine compound
|
|
BR112013000925A2
(pt)
|
2010-07-15 |
2020-12-01 |
Bayer Intellectual Property Gmbh |
compostos heterocíclicos como pesticidas
|
|
WO2012037204A1
(en)
*
|
2010-09-14 |
2012-03-22 |
Exelixis, Inc. |
Inhibitors of pi3k-delta and methods of their use and manufacture
|
|
EP2634188A4
(de)
|
2010-10-29 |
2014-05-07 |
Shionogi & Co |
Kondensiertes aminodihydropyrimidinderivat
|
|
CN103261199A
(zh)
|
2010-10-29 |
2013-08-21 |
盐野义制药株式会社 |
萘啶衍生物
|
|
CN103282370A
(zh)
|
2010-11-17 |
2013-09-04 |
尔察祯有限公司 |
抗菌氨基糖苷类类似物
|
|
TW201249844A
(en)
|
2010-12-20 |
2012-12-16 |
Incyte Corp |
N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors
|
|
WO2012088266A2
(en)
|
2010-12-22 |
2012-06-28 |
Incyte Corporation |
Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
|
|
AU2012205669B2
(en)
|
2011-01-10 |
2015-08-20 |
Infinity Pharmaceuticals Inc. |
Processes for preparing isoquinolinones and solid forms of isoquinolinones
|
|
EP2683704B1
(de)
|
2011-03-08 |
2014-12-17 |
Sanofi |
Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
WO2012120056A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
WO2012120054A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
US8710050B2
(en)
|
2011-03-08 |
2014-04-29 |
Sanofi |
Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
|
|
EP2766349B1
(de)
|
2011-03-08 |
2016-06-01 |
Sanofi |
Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
WO2012125629A1
(en)
|
2011-03-14 |
2012-09-20 |
Incyte Corporation |
Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
|
|
GB201104267D0
(en)
|
2011-03-14 |
2011-04-27 |
Cancer Rec Tech Ltd |
Pyrrolopyridineamino derivatives
|
|
US9126948B2
(en)
|
2011-03-25 |
2015-09-08 |
Incyte Holdings Corporation |
Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
|
|
WO2012147763A1
(ja)
|
2011-04-26 |
2012-11-01 |
塩野義製薬株式会社 |
オキサジン誘導体およびそれを含有するbace1阻害剤
|
|
PL2729142T3
(pl)
|
2011-07-08 |
2018-10-31 |
Novartis Ag |
Sposób leczenia miażdżycy tętnic u osobników z wysokim poziomem triglicerydów
|
|
US9056877B2
(en)
|
2011-07-19 |
2015-06-16 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
EP2751093A1
(de)
|
2011-08-29 |
2014-07-09 |
Infinity Pharmaceuticals, Inc. |
Heterocyclische verbindungen und ihre verwendung
|
|
UA121539C2
(uk)
|
2011-09-02 |
2020-06-25 |
Інсайт Холдинґс Корпорейшн |
Гетероцикліламіни як інгібітори рі3к
|
|
JP6140168B2
(ja)
*
|
2011-09-27 |
2017-05-31 |
ドクター レディズ ラボラトリーズ リミテッド |
アテローム性動脈硬化症の処置のために有用なコレステリルエステル転送タンパク質(cetp)インヒビターとしての5−ベンジルアミノメチル−6−アミノピラゾロ[3,4−b]ピリジン誘導体
|
|
WO2013103150A1
(ja)
|
2012-01-06 |
2013-07-11 |
第一三共株式会社 |
置換ピリジン化合物の酸付加塩
|
|
AR090548A1
(es)
|
2012-04-02 |
2014-11-19 |
Incyte Corp |
Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
|
|
SI3459942T1
(sl)
|
2012-04-24 |
2021-05-31 |
Vertex Pharmaceuticals Incorporated |
Inhibitorji DNA-PK
|
|
LT3495367T
(lt)
|
2012-06-13 |
2021-02-25 |
Incyte Holdings Corporation |
Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai
|
|
US8828998B2
(en)
|
2012-06-25 |
2014-09-09 |
Infinity Pharmaceuticals, Inc. |
Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
|
|
JPWO2014017569A1
(ja)
*
|
2012-07-26 |
2016-07-11 |
興和株式会社 |
血中ldlを低下させるための医薬
|
|
WO2014026125A1
(en)
|
2012-08-10 |
2014-02-13 |
Incyte Corporation |
Pyrazine derivatives as fgfr inhibitors
|
|
GB201216018D0
(en)
|
2012-09-07 |
2012-10-24 |
Cancer Rec Tech Ltd |
Pharmacologically active compounds
|
|
EP2912035A4
(de)
|
2012-10-24 |
2016-06-15 |
Shionogi & Co |
Dihydrooxazin- oder oxazepinderivate mit bace1-hemmender wirkung
|
|
KR102229478B1
(ko)
|
2012-11-01 |
2021-03-18 |
인피니티 파마슈티칼스, 인코포레이티드 |
Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료
|
|
US9266892B2
(en)
|
2012-12-19 |
2016-02-23 |
Incyte Holdings Corporation |
Fused pyrazoles as FGFR inhibitors
|
|
HUE041544T2
(hu)
|
2013-03-12 |
2019-05-28 |
Vertex Pharma |
DNS-PK inhibitorok
|
|
US9481667B2
(en)
|
2013-03-15 |
2016-11-01 |
Infinity Pharmaceuticals, Inc. |
Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
|
|
LT2986610T
(lt)
|
2013-04-19 |
2018-04-10 |
Incyte Holdings Corporation |
Bicikliniai heterociklai, kaip fgfr inhibitoriai
|
|
GB201314452D0
(en)
|
2013-08-13 |
2013-09-25 |
Ostara Biomedical Ltd |
Embryo implantation
|
|
PT3424920T
(pt)
|
2013-10-17 |
2020-07-07 |
Vertex Pharma |
Co-cristais de (s)-n-metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il)amino)propan-2-il)quinolina-4-carboxamida e derivados deuterados dos mesmos como inibidores de adn-pk
|
|
US20150320755A1
(en)
|
2014-04-16 |
2015-11-12 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
|
US10077277B2
(en)
|
2014-06-11 |
2018-09-18 |
Incyte Corporation |
Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
|
|
GB201415569D0
(en)
|
2014-09-03 |
2014-10-15 |
C4X Discovery Ltd |
Therapeutic Compounds
|
|
CN107250113B
(zh)
|
2014-10-07 |
2019-03-29 |
弗特克斯药品有限公司 |
囊性纤维化跨膜传导调节蛋白的调节剂的共晶
|
|
US10851105B2
(en)
|
2014-10-22 |
2020-12-01 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
|
GB201501302D0
(en)
|
2015-01-27 |
2015-03-11 |
Ostara Biomedical Ltd |
Embryo implantation
|
|
WO2016134294A1
(en)
|
2015-02-20 |
2016-08-25 |
Incyte Corporation |
Bicyclic heterocycles as fgfr4 inhibitors
|
|
SG11201706287PA
(en)
|
2015-02-20 |
2017-09-28 |
Incyte Corp |
Bicyclic heterocycles as fgfr inhibitors
|
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
|
UA122332C2
(uk)
|
2015-02-27 |
2020-10-26 |
Інсайт Корпорейшн |
Солі інгібітора pi3k і способи їх отримання
|
|
EP3932914A1
(de)
|
2015-03-13 |
2022-01-05 |
Valo Health, Inc. |
Alpha-cinnamid-verbindungen und zusammensetzungen als hdac8-inhibitoren
|
|
WO2016183063A1
(en)
|
2015-05-11 |
2016-11-17 |
Incyte Corporation |
Crystalline forms of a pi3k inhibitor
|
|
WO2016183060A1
(en)
|
2015-05-11 |
2016-11-17 |
Incyte Corporation |
Process for the synthesis of a phosphoinositide 3-kinase inhibitor
|
|
GB201517523D0
(en)
|
2015-10-05 |
2015-11-18 |
Ostara Biomedical Ltd |
Methods and compositions for managing reproduction
|
|
TWI728017B
(zh)
|
2015-12-15 |
2021-05-21 |
瑞典商阿斯特捷利康公司 |
異吲哚化合物、包含其之醫藥組成物及其用途
|
|
GB201601703D0
(en)
|
2016-01-29 |
2016-03-16 |
C4X Discovery Ltd |
Therapeutic compounds
|
|
MX391135B
(es)
|
2016-06-24 |
2025-03-21 |
Infinity Pharmaceuticals Inc |
Terapias de combinacion.
|
|
MX2019000536A
(es)
|
2016-07-14 |
2019-04-01 |
Pfizer |
Nuevas pirimidinas carboxamidas como inhibidores de enzima vanina-1.
|
|
ES2846833T3
(es)
|
2016-07-18 |
2021-07-29 |
Janssen Pharmaceutica Nv |
Ligandos de obtención de imágenes de tau por PET
|
|
JP2019529475A
(ja)
|
2016-09-27 |
2019-10-17 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Dna損傷剤とdna−pk阻害剤との組合せ物を使用する、がんを処置するための方法
|
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
|
EP3638661A1
(de)
|
2017-06-14 |
2020-04-22 |
Astrazeneca AB |
Als ror-gamma-modulatoren verwendbare 2,3-dihydroisoindol-1-carboxamide
|
|
MX2020011718A
(es)
|
2018-05-04 |
2021-02-15 |
Incyte Corp |
Formas solidas de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr) y procesos para prepararlas.
|
|
ES3061844T3
(en)
|
2018-05-04 |
2026-04-07 |
Incyte Corp |
Salts of an fgfr inhibitor
|
|
MX2020012826A
(es)
|
2018-06-01 |
2021-03-09 |
Incyte Corp |
Regimen de dosificacion para el tratamiento de trastornos relacionados con fosfatidilinositol 3-cinasas (pi3k).
|
|
US11628162B2
(en)
|
2019-03-08 |
2023-04-18 |
Incyte Corporation |
Methods of treating cancer with an FGFR inhibitor
|
|
US11591329B2
(en)
|
2019-07-09 |
2023-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
US12122767B2
(en)
|
2019-10-01 |
2024-10-22 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
TWI891666B
(zh)
|
2019-10-14 |
2025-08-01 |
美商英塞特公司 |
作為fgfr抑制劑之雙環雜環
|
|
US11566028B2
(en)
|
2019-10-16 |
2023-01-31 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
CA3163875A1
(en)
|
2019-12-04 |
2021-06-10 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
|
WO2021113462A1
(en)
|
2019-12-04 |
2021-06-10 |
Incyte Corporation |
Derivatives of an fgfr inhibitor
|
|
MX2022006865A
(es)
|
2019-12-06 |
2022-07-11 |
Vertex Pharma |
Tetrahidrofuranos sustituidos como moduladores de canales de sodio.
|
|
US12012409B2
(en)
|
2020-01-15 |
2024-06-18 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
CA3200234A1
(en)
|
2020-11-25 |
2022-06-02 |
Daryl C. Drummond |
Lipid nanoparticles for delivery of nucleic acids, and related methods of use
|
|
TW202304459A
(zh)
|
2021-04-12 |
2023-02-01 |
美商英塞特公司 |
包含fgfr抑制劑及nectin-4靶向劑之組合療法
|
|
CN117794920A
(zh)
|
2021-06-04 |
2024-03-29 |
沃泰克斯药物股份有限公司 |
N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂
|
|
JP2024522189A
(ja)
|
2021-06-09 |
2024-06-11 |
インサイト・コーポレイション |
Fgfr阻害剤としての三環式ヘテロ環
|
|
EP4352060A1
(de)
|
2021-06-09 |
2024-04-17 |
Incyte Corporation |
Tricyclische heterocyclen als fgfr-inhibitoren
|
|
EP4531819A2
(de)
|
2022-05-25 |
2025-04-09 |
Akagera Medicines, Inc. |
Lipidnanopartikel zur abgabe von nukleinsäuren und verfahren zur verwendung davon
|
|
CN117105798A
(zh)
*
|
2023-08-10 |
2023-11-24 |
妆莱(广州)生物研究有限公司 |
一种壬二酰胺mea的制备方法
|