ATE553122T1 - Antiangiogene methoden und zusammensetzungen - Google Patents
Antiangiogene methoden und zusammensetzungenInfo
- Publication number
- ATE553122T1 ATE553122T1 AT06736663T AT06736663T ATE553122T1 AT E553122 T1 ATE553122 T1 AT E553122T1 AT 06736663 T AT06736663 T AT 06736663T AT 06736663 T AT06736663 T AT 06736663T AT E553122 T1 ATE553122 T1 AT E553122T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- compositions
- antiangiogenic
- pedf
- retinopathies
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000001772 anti-angiogenic effect Effects 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010029113 Neovascularisation Diseases 0.000 abstract 1
- 102100035846 Pigment epithelium-derived factor Human genes 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 101710185494 Zinc finger protein Proteins 0.000 abstract 1
- 102100023597 Zinc finger protein 816 Human genes 0.000 abstract 1
- 210000000981 epithelium Anatomy 0.000 abstract 1
- 208000002780 macular degeneration Diseases 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 230000014399 negative regulation of angiogenesis Effects 0.000 abstract 1
- 239000000049 pigment Substances 0.000 abstract 1
- 108090000102 pigment epithelium-derived factor Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65722405P | 2005-02-28 | 2005-02-28 | |
| US67758405P | 2005-05-03 | 2005-05-03 | |
| US71532605P | 2005-09-08 | 2005-09-08 | |
| PCT/US2006/007382 WO2006094106A2 (en) | 2005-02-28 | 2006-02-28 | Anti-angiogenic methods and compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE553122T1 true ATE553122T1 (de) | 2012-04-15 |
Family
ID=36829867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06736663T ATE553122T1 (de) | 2005-02-28 | 2006-02-28 | Antiangiogene methoden und zusammensetzungen |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US7358085B2 (de) |
| EP (2) | EP2314614B1 (de) |
| JP (1) | JP4988606B2 (de) |
| AT (1) | ATE553122T1 (de) |
| CA (1) | CA2599004C (de) |
| WO (1) | WO2006094106A2 (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| US8071134B2 (en) * | 2003-09-15 | 2011-12-06 | Ordway Research Institute, Inc. | Thyroid hormone analogs and methods of use |
| CA2539288C (en) | 2003-09-15 | 2015-05-12 | Shaker A. Mousa | Thyroid hormone analogs and methods of use |
| US9198887B2 (en) | 2003-09-15 | 2015-12-01 | Nanopharmaceuticals Llc | Thyroid hormone analogs and methods of use |
| US8668926B1 (en) | 2003-09-15 | 2014-03-11 | Shaker A. Mousa | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof |
| CA2613889A1 (en) * | 2005-06-08 | 2006-12-14 | Centocor, Inc. | A cellular therapy for ocular degeneration |
| US10130686B2 (en) | 2005-09-15 | 2018-11-20 | Nanopharmaceuticals Llc | Method and composition of thyroid hormone analogues and nanoformulations thereof for treating inflammatory disorders |
| US9498536B2 (en) | 2005-09-15 | 2016-11-22 | Nanopharmaceuticals Llc | Method and composition of thyroid hormone analogues and nanoformulations thereof for treating anti-inflammatory disorders |
| US20100209382A1 (en) | 2005-09-16 | 2010-08-19 | Ordway Research Institute, Inc. | Polyphenol Conjugates as RGD-Binding Compounds and Methods of Use |
| WO2007127408A2 (en) * | 2006-04-28 | 2007-11-08 | Tulane University Health Sciences Center | Methods for treating diabetes |
| CA2657308C (en) * | 2006-07-12 | 2017-06-27 | Angioblast Systems, Inc. | Treatment of excessive neovascularization |
| US8319471B2 (en) | 2006-12-06 | 2012-11-27 | Solaredge, Ltd. | Battery power delivery module |
| ES2535005T3 (es) * | 2006-12-22 | 2015-05-04 | Nanopharmaceuticals Llc | Formulaciones de nanopartículas y de polímeros para análogos, antagonistas y formulaciones de la hormona tiroidea, y usos de los mismos |
| CN101883850B (zh) | 2007-07-12 | 2014-11-12 | 桑格摩生物科学股份有限公司 | 用于失活α-1,6岩藻糖基转移酶(FUT8)基因表达的方法和组合物 |
| EP2182981B1 (de) * | 2007-08-02 | 2013-01-09 | Gilead Biologics, Inc. | Verfahren und zusammensetzungen zur behandlung und diagnose von fibrose |
| EP2250184A4 (de) * | 2008-02-08 | 2011-05-04 | Sangamo Biosciences Inc | Behandlung chronischer schmerzen mit zinkfingerproteinen |
| KR101673566B1 (ko) | 2008-10-29 | 2016-11-07 | 상가모 바이오사이언스 인코포레이티드 | 글루타민 신테타제 유전자 발현을 불활성화시키기 위한 방법 및 조성물 |
| WO2010075332A1 (en) * | 2008-12-23 | 2010-07-01 | Charitable Leadership Foundation | Small molecule ligands of the integrin rgd recognition site and methods of use |
| WO2010080769A2 (en) | 2009-01-06 | 2010-07-15 | Arresto Biosciences, Inc. | Chemotherapeutic methods and compositions |
| KR20110140121A (ko) * | 2009-02-06 | 2011-12-30 | 길리아드 바이오로직스, 인크. | 혈관신생의 치료를 위한 방법 및 조성물 |
| US8871905B2 (en) * | 2009-03-20 | 2014-10-28 | Sangamo Biosciences, Inc. | Modification of CXCR4 using engineered zinc finger proteins |
| US9180107B2 (en) * | 2009-03-31 | 2015-11-10 | Nanopharmaceuticals Llc | Combination treatment of cancer with cetuximab and tetrac |
| CA2765792C (en) * | 2009-06-17 | 2017-03-28 | Nanopharmaceuticals Llc | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof |
| JP2013502437A (ja) * | 2009-08-21 | 2013-01-24 | ギリアド バイオロジクス,インク. | 治療方法及び組成物 |
| CN102713601A (zh) * | 2009-08-21 | 2012-10-03 | 吉联亚生物科技有限公司 | 体外筛选试验 |
| AU2010283997B2 (en) * | 2009-08-21 | 2015-04-09 | Gilead Biologics, Inc. | Methods and compositions for treatment of pulmonary fibrotic disorders |
| JP2013502226A (ja) * | 2009-08-21 | 2013-01-24 | ギリアド バイオロジクス,インク. | リシル酸化酵素及びloxl2由来の触媒ドメイン |
| WO2011022670A1 (en) * | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vivo screening assays |
| JP2013509874A (ja) * | 2009-11-04 | 2013-03-21 | エラスムス ユニバーシティ メディカル センター ロッテルダム | 新脈管形成を調節する為の新規化合物及びこれらの化合物を使用する処置方法 |
| KR20130008021A (ko) | 2010-02-04 | 2013-01-21 | 길리아드 바이오로직스, 인크. | 리실 산화효소-유사 2 (loxl2)에 결합하는 항체, 및 그를 위한 사용 방법 |
| ES2562421T3 (es) | 2010-10-12 | 2016-03-04 | The Children's Hospital Of Philadelphia | Métodos y composiciones para tratar la hemofilia B |
| US8802240B2 (en) | 2011-01-06 | 2014-08-12 | Nanopharmaceuticals Llc | Uses of formulations of thyroid hormone analogs and nanoparticulate forms thereof to increase chemosensitivity and radiosensitivity in tumor or cancer cells |
| US20120239681A1 (en) | 2011-03-14 | 2012-09-20 | Splunk Inc. | Scalable interactive display of distributed data |
| WO2013016434A1 (en) * | 2011-07-27 | 2013-01-31 | The Board Institute, Inc. | Compositions and methods of treating head and neck cancer |
| EP2820127B1 (de) * | 2012-02-28 | 2018-09-26 | Sigma Aldrich Co. LLC | Gezielte histonacetylierung |
| CN104204225A (zh) * | 2012-02-29 | 2014-12-10 | 桑格摩生物科学股份有限公司 | 治疗亨廷顿氏病的方法和组合物 |
| US9650648B2 (en) | 2012-08-29 | 2017-05-16 | Sangamo Biosciences, Inc. | Methods and compositions for treatment of a genetic condition |
| US9941813B2 (en) | 2013-03-14 | 2018-04-10 | Solaredge Technologies Ltd. | High frequency multi-level inverter |
| AU2015231353B2 (en) | 2014-03-18 | 2020-11-05 | Sangamo Therapeutics, Inc. | Methods and compositions for regulation of zinc finger protein expression |
| US9318974B2 (en) | 2014-03-26 | 2016-04-19 | Solaredge Technologies Ltd. | Multi-level inverter with flying capacitor topology |
| JP7074749B2 (ja) | 2016-06-07 | 2022-05-24 | ナノファーマシューティカルズ エルエルシー | αvβ3インテグリン甲状腺アンタゴニストにコンジュゲートした非開裂性ポリマー |
| AU2018375192B2 (en) | 2017-12-01 | 2023-11-09 | Encoded Therapeutics, Inc. | Engineered DNA binding proteins |
| US10328043B1 (en) | 2018-04-11 | 2019-06-25 | Nanopharmaceuticals, Llc. | Composition and method for dual targeting in treatment of neuroendocrine tumors |
| US11351137B2 (en) | 2018-04-11 | 2022-06-07 | Nanopharmaceuticals Llc | Composition and method for dual targeting in treatment of neuroendocrine tumors |
| BR112021024055A2 (pt) | 2019-05-29 | 2022-02-08 | Encoded Therapeutics Inc | Composições e métodos para a regulação seletiva de gene |
| US10961204B1 (en) | 2020-04-29 | 2021-03-30 | Nanopharmaceuticals Llc | Composition of scalable thyrointegrin antagonists with improved blood brain barrier penetration and retention into brain tumors |
| KR102766359B1 (ko) * | 2021-04-07 | 2025-02-14 | (주)리젠이노팜 | 세포 투과성 펩타이드 변이체 및 이의 용도 |
| US20250043269A1 (en) | 2021-11-03 | 2025-02-06 | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glad | Precise Genome Editing Using Retrons |
| US11723888B2 (en) | 2021-12-09 | 2023-08-15 | Nanopharmaceuticals Llc | Polymer conjugated thyrointegrin antagonists |
| WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| CN114949208B (zh) * | 2022-05-06 | 2023-07-04 | 温州医科大学 | 纳米光动力材料及其脉络膜新生血管的治疗的应用 |
| WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| AU2024335327A1 (en) | 2023-09-01 | 2026-03-26 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| CN121344097A (zh) * | 2025-12-22 | 2026-01-16 | 上海南方模式生物科技股份有限公司 | 一种c1r基因人源化动物细胞及动物模型的构建方法及其应用 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US653092A (en) * | 1899-12-11 | 1900-07-03 | Arthur F James | Necktie-fastener. |
| US4217344A (en) * | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4186183A (en) * | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
| US4261975A (en) | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
| US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4603044A (en) | 1983-01-06 | 1986-07-29 | Technology Unlimited, Inc. | Hepatocyte Directed Vesicle delivery system |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5049386A (en) * | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4946787A (en) * | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4797368A (en) * | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US4774085A (en) | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
| US5422251A (en) | 1986-11-26 | 1995-06-06 | Princeton University | Triple-stranded nucleic acids |
| US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5240848A (en) | 1988-11-21 | 1993-08-31 | Monsanto Company | Dna sequences encoding human vascular permeability factor having 189 amino acids |
| US5176996A (en) * | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US4957773A (en) | 1989-02-13 | 1990-09-18 | Syracuse University | Deposition of boron-containing films from decaborane |
| US5332671A (en) | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
| US5194596A (en) | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5219739A (en) | 1989-07-27 | 1993-06-15 | Scios Nova Inc. | DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121 |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| AU7979491A (en) | 1990-05-03 | 1991-11-27 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| US5210015A (en) * | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| DE69132040T2 (de) | 1990-09-21 | 2000-11-02 | Merck & Co., Inc. | Wachstumsfaktor II für vaskuläre Endothelzellen |
| US5173414A (en) * | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| EP0506477B1 (de) | 1991-03-28 | 1999-06-23 | Merck & Co. Inc. | Untereinheit-C des vaskulären endothelialen Zellwachstumsfaktors |
| US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| US6319687B1 (en) * | 1992-09-24 | 2001-11-20 | The United States Of America As Represented By The Department Of Health And Human Services | Pigment epithelium-derived factor: characterization, genomic organization and sequence of PEDF gene |
| US5840686A (en) * | 1992-09-24 | 1998-11-24 | The United States Of America As Represented By The Department Of Health And Human Services | Pigment epithelium-derived factor: characterization of its novel biological activity and sequences encoding and expressing the protein and methods of use |
| US6451763B1 (en) * | 1992-06-04 | 2002-09-17 | The United States Of America As Represented By The Department Of Health And Human Services | Retinal pigmented epithelium derived neurotrophic factor and methods of use |
| US5776755A (en) | 1992-10-09 | 1998-07-07 | Helsinki University Licensing, Ltd. | FLT4, a receptor tyrosine kinase |
| US5503022A (en) | 1993-01-25 | 1996-04-02 | Barone; Larry A. | Marine impeller tester |
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US6242568B1 (en) * | 1994-01-18 | 2001-06-05 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| DE69534629D1 (de) | 1994-01-18 | 2005-12-29 | Scripps Research Inst | Derivate von zinkfingerproteinen und methoden |
| EP0751992B1 (de) * | 1994-03-08 | 2005-11-09 | Human Genome Sciences, Inc. | Vaskularer endothelialer wachstumsfaktor 2 |
| US6040157A (en) * | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
| US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US5585245A (en) * | 1994-04-22 | 1996-12-17 | California Institute Of Technology | Ubiquitin-based split protein sensor |
| GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
| WO1996006166A1 (en) | 1994-08-20 | 1996-02-29 | Medical Research Council | Improvements in or relating to binding proteins for recognition of dna |
| US6645933B1 (en) | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
| US6130071A (en) | 1997-02-05 | 2000-10-10 | Helsinki University Licensing, Ltd. | Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof |
| WO1998033917A1 (en) | 1994-11-14 | 1998-08-06 | The Ludwig Institute For Cancer Research | Vascular endothelial growth factor c (vegf-c) protein and gene, mutants thereof, and uses thereof |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US5928939A (en) | 1995-03-01 | 1999-07-27 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b and dna coding therefor |
| US5607918A (en) | 1995-03-01 | 1997-03-04 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-B and DNA coding therefor |
| DE69630442T2 (de) | 1995-03-02 | 2004-08-19 | Amrad Operations Pty. Ltd., Richmond | Ein neuartiger wachstumsfaktor und eine genetische sequenz, die für diesen codiert |
| US20020026037A1 (en) | 1995-06-06 | 2002-02-28 | Jing-Shan Hu | Vascular endothelial growth factor 3 antibodies |
| ATE242809T1 (de) | 1995-09-08 | 2003-06-15 | Genentech Inc | Vegf-verwandtes protein |
| AU1116297A (en) | 1995-11-08 | 1997-05-29 | Immunex Corporation | Flk-1 binding protein |
| AU729880C (en) | 1996-08-23 | 2001-11-08 | Vegenics Limited | Recombinant vascular endothelial cell growth factor D (VEGF-D) |
| US6131071A (en) * | 1996-12-06 | 2000-10-10 | Bp Amoco Corporation | Spectral decomposition for seismic interpretation |
| AU5439998A (en) | 1996-12-06 | 1998-06-29 | Zymogenetics Inc. | Vascular endothelial growth factor |
| US6342345B1 (en) | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
| GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| US5863736A (en) | 1997-05-23 | 1999-01-26 | Becton, Dickinson And Company | Method, apparatus and computer program products for determining quantities of nucleic acid sequences in samples |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| CA2298018C (en) * | 1997-07-23 | 2008-12-16 | Northwestern University | Methods and compositions for inhibiting angiogenesis |
| US6797691B1 (en) * | 1997-07-23 | 2004-09-28 | Northwestern University | Methods and compositions for inhibiting angiogenesis |
| MY125849A (en) | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems |
| US6007408A (en) | 1997-08-21 | 1999-12-28 | Micron Technology, Inc. | Method and apparatus for endpointing mechanical and chemical-mechanical polishing of substrates |
| CA2315977A1 (en) | 1997-12-24 | 1999-07-08 | Ludwig Institute For Cancer Research | Expression vectors and cell lines expressing vascular endothelial growth factor d, and method of treating melanomas |
| US6410248B1 (en) | 1998-01-30 | 2002-06-25 | Massachusetts Institute Of Technology | General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites |
| AU746454B2 (en) | 1998-03-02 | 2002-05-02 | Massachusetts Institute Of Technology | Poly zinc finger proteins with improved linkers |
| WO1999046364A1 (en) | 1998-03-13 | 1999-09-16 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| JP2002539082A (ja) | 1999-02-08 | 2002-11-19 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 血管内皮増殖因子2 |
| US6794136B1 (en) * | 2000-11-20 | 2004-09-21 | Sangamo Biosciences, Inc. | Iterative optimization in the design of binding proteins |
| EP1250424B1 (de) * | 2000-01-24 | 2007-02-28 | Gendaq, Ltd. | Nucleinsäure bindende polypeptide gekennzeichnet durch flexible linker verbundene nucleinsäuredomäne |
| ATE353361T1 (de) | 2000-04-28 | 2007-02-15 | Sangamo Biosciences Inc | Gezielten modifikation der chromatinstruktur |
| WO2001083732A2 (en) | 2000-04-28 | 2001-11-08 | Sangamo Biosciences, Inc. | Databases of regulatory sequences; methods of making and using same |
| CA2407695C (en) * | 2000-04-28 | 2015-03-31 | Sangamo Biosciences, Inc. | Methods for binding an exogenous molecule to cellular chromatin |
| US6573092B1 (en) * | 2000-10-10 | 2003-06-03 | Genvec, Inc. | Method of preparing a eukaryotic viral vector |
| US7026462B2 (en) | 2000-12-07 | 2006-04-11 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| NZ535100A (en) * | 2002-03-20 | 2008-04-30 | Univ Florida | RAAV vector compositions and methods for the treatment of choroidal neovascularization |
| CN1836048A (zh) * | 2003-06-10 | 2006-09-20 | 图尔金株式会社 | 可转导的dna结合蛋白 |
| US9405700B2 (en) | 2010-11-04 | 2016-08-02 | Sonics, Inc. | Methods and apparatus for virtualization in an integrated circuit |
-
2006
- 2006-02-28 CA CA2599004A patent/CA2599004C/en not_active Expired - Fee Related
- 2006-02-28 EP EP10185937.9A patent/EP2314614B1/de not_active Expired - Lifetime
- 2006-02-28 WO PCT/US2006/007382 patent/WO2006094106A2/en not_active Ceased
- 2006-02-28 JP JP2007558205A patent/JP4988606B2/ja not_active Expired - Fee Related
- 2006-02-28 AT AT06736663T patent/ATE553122T1/de active
- 2006-02-28 EP EP06736663A patent/EP1869075B1/de not_active Expired - Lifetime
- 2006-02-28 US US11/365,390 patent/US7358085B2/en not_active Expired - Lifetime
-
2007
- 2007-10-31 US US11/981,385 patent/US7795209B2/en active Active
- 2007-10-31 US US11/981,386 patent/US7893022B2/en active Active
- 2007-12-06 US US11/999,549 patent/US7732196B2/en active Active
-
2008
- 2008-01-09 US US12/008,245 patent/US8012946B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006094106A2 (en) | 2006-09-08 |
| JP2008531056A (ja) | 2008-08-14 |
| US20080118469A1 (en) | 2008-05-22 |
| US7732196B2 (en) | 2010-06-08 |
| CA2599004C (en) | 2015-05-26 |
| US8012946B1 (en) | 2011-09-06 |
| US20080187523A1 (en) | 2008-08-07 |
| US20060210539A1 (en) | 2006-09-21 |
| EP2314614A1 (de) | 2011-04-27 |
| US7358085B2 (en) | 2008-04-15 |
| CA2599004A1 (en) | 2006-09-08 |
| EP1869075A2 (de) | 2007-12-26 |
| EP1869075B1 (de) | 2012-04-11 |
| US7795209B2 (en) | 2010-09-14 |
| JP4988606B2 (ja) | 2012-08-01 |
| US20080108556A1 (en) | 2008-05-08 |
| EP2314614B1 (de) | 2015-11-25 |
| US7893022B2 (en) | 2011-02-22 |
| WO2006094106A3 (en) | 2007-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE553122T1 (de) | Antiangiogene methoden und zusammensetzungen | |
| SG10201907164SA (en) | Rna containing composition for treatment of tumor diseases | |
| WO2012145624A3 (en) | Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies | |
| MX2020013853A (es) | Compuestos innovadores. | |
| WO2018069500A3 (en) | Anti-lag-3 antibodies and compositions | |
| CY1126007T1 (el) | Προαγωγεις αποπτωσης | |
| SA519401379B1 (ar) | علاج فيروس مرتبط بغدة لمرض هنتنجتون | |
| EA200901166A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr 119 | |
| EA201001639A1 (ru) | Композиции и способы их получения и применения | |
| WO2009089635A9 (en) | Treating neurodegenerative diseases with progranulin (pgrn) | |
| MX2009009761A (es) | Composiciones y estuches para tratamiento de la influenza. | |
| WO2008133663A3 (en) | Codon modified immunogenic compositions and methods of use | |
| UA108193C2 (uk) | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань | |
| WO2009013543A3 (en) | Targeted binging agents directed to kdr and uses thereof - 035 | |
| EP1765391A4 (de) | Bakterielle zusammensetzungen zur behandlung von krebs | |
| WO2010130830A3 (en) | Anti-sclerostin vhh and their use for treating bone diseases | |
| WO2007092622A3 (en) | Compositions and methods for treating bone | |
| WO2006091459A3 (en) | Compositions and methods for treating vascular permeability | |
| BR112012004284B8 (pt) | ácidos biliares poli-hidroxilados para tratamento de transtornos biliares | |
| WO2007101864A3 (en) | Compounds that modulate ppar activity, their preparation and use | |
| PH12022551228A1 (en) | Trem2 antibodies and uses thereof | |
| TNSN08370A1 (en) | Tetrahydropyridothienopyrimidine compounds and methods of use thereof | |
| WO2017182783A3 (en) | Inactivation of dna repair as an anticancer therapy | |
| WO2011116212A3 (en) | Bone morphogenetic protein receptor binding agents and methods of their use | |
| EP4276089A3 (de) | Modulatoren der lypoxygenase- und cyclooxygenaseenzymaktivität |