ATE553382T1 - Verwendungen von krebsspezifischen glykanen - Google Patents

Verwendungen von krebsspezifischen glykanen

Info

Publication number
ATE553382T1
ATE553382T1 AT06764481T AT06764481T ATE553382T1 AT E553382 T1 ATE553382 T1 AT E553382T1 AT 06764481 T AT06764481 T AT 06764481T AT 06764481 T AT06764481 T AT 06764481T AT E553382 T1 ATE553382 T1 AT E553382T1
Authority
AT
Austria
Prior art keywords
glycans
cancer
present
methods
malignancies
Prior art date
Application number
AT06764481T
Other languages
English (en)
Inventor
Tero Satomaa
Jari Natunen
Annamari Heiskanen
Anne Olonen
Juhani Saarinen
Noora Salovuori
Jari Helin
Original Assignee
Glykos Finland Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glykos Finland Oy filed Critical Glykos Finland Oy
Application granted granted Critical
Publication of ATE553382T1 publication Critical patent/ATE553382T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Oncology (AREA)
AT06764481T 2005-07-20 2006-07-20 Verwendungen von krebsspezifischen glykanen ATE553382T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20055417A FI20055417A0 (fi) 2005-07-20 2005-07-20 Syöpäpesifiset glykaanit ja niiden käyttö
PCT/FI2006/000263 WO2007010089A2 (en) 2005-07-20 2006-07-20 Cancer specific glycans and use thereof

Publications (1)

Publication Number Publication Date
ATE553382T1 true ATE553382T1 (de) 2012-04-15

Family

ID=34803283

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06764481T ATE553382T1 (de) 2005-07-20 2006-07-20 Verwendungen von krebsspezifischen glykanen

Country Status (7)

Country Link
US (3) US20090117106A1 (de)
EP (2) EP2431743B1 (de)
AT (1) ATE553382T1 (de)
CA (1) CA2658311A1 (de)
DK (1) DK1910838T3 (de)
FI (1) FI20055417A0 (de)
WO (1) WO2007010089A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691774B2 (en) * 2005-07-11 2014-04-08 Glykos Finland Oy Carbohydrate profile compositions from human cells and methods for analysis and modification thereof
US8803080B2 (en) * 2007-06-02 2014-08-12 Cerno Bioscience Llc Self calibration approach for mass spectrometry
WO2009069776A1 (ja) * 2007-11-30 2009-06-04 National University Corporation Hokkaido University 糖鎖分析による肝疾患の診断方法
WO2010064683A1 (ja) * 2008-12-03 2010-06-10 財団法人野口研究所 前立腺癌の判定方法
US8232073B2 (en) 2009-01-02 2012-07-31 Zacharon Pharmaceuticals, Inc. Quantification of non-reducing end glycan residual compounds
US8809009B2 (en) 2009-01-02 2014-08-19 Biomarin Pharmaceutical Inc. Methods of diagnosing a disease and methods of monitoring treatment of a disease by quantifying a non-reducing end glycan residual compound and comparing to a second biomarker
US9029530B2 (en) 2009-01-02 2015-05-12 Biomarin Pharmaceutical Inc. Detection of oligosaccharides
US8183003B2 (en) 2009-01-02 2012-05-22 Zacharon Pharmaceuticals, Inc. Polymer end group detection
KR101456096B1 (ko) 2013-04-04 2014-11-03 충남대학교산학협력단 인간 혈청 당쇄 지도 및 이를 이용하여 혈청 시료를 검증하는 방법
IL285403B2 (en) 2014-01-27 2023-10-01 Molecular Templates Inc Polypeptides that remove an epitope for MHC group I
EP3102245B1 (de) 2014-02-05 2021-09-08 Molecular Templates, Inc. Verfahren zum abtasten, auswählen und identifizieren von cytotoxischen rekombinanten polypeptiden auf grundlage einer vorläufigen minderung der ribotoxizität
JP6935195B2 (ja) 2014-03-11 2021-09-15 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. 結合領域、志賀毒素ａサブユニットのエフェクター領域、及びカルボキシ末端小胞体局在化シグナルモチーフを含むタンパク質
SI3604333T1 (sl) 2014-03-11 2021-08-31 Molecular Templates, Inc. Proteini, ki obsegajo aminoterminalne proksimalne Shiga toksin podenota A efektorske regije in celico-ciljajoče vezavne regije imunogobulinskega tipa, ki so sposobne specifične vezave CD38
EP3137488B1 (de) 2014-06-11 2019-01-02 Molecular Templates, Inc. Proteasespaltungsbeständige shigatoxin-a-untereinheiteffektorpolypeptide und zellgerichtete moleküle damit
HUE051246T2 (hu) 2015-05-30 2021-03-01 Molecular Templates Inc Deimmunizált shigatoxin alegység vázak és azokat tartalmazó, sejthez irányító molekulák
MX2018001208A (es) 2015-07-26 2018-03-26 Molecular Templates Inc Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+.
JP6834747B2 (ja) * 2016-05-18 2021-02-24 東ソー株式会社 肺癌を検出する方法及び検出用キット
JP7082424B2 (ja) 2017-01-25 2022-06-08 モレキュラー テンプレーツ，インク． 脱免疫化された志賀毒素ａサブユニットエフェクター及びｃｄ８＋ｔ細胞エピトープを含む細胞標的化分子
WO2018148541A1 (en) 2017-02-10 2018-08-16 University Of Louisville Research Foundation, Inc. Actinohivin variant polypeptides and related methods
CN109142506B (zh) * 2017-06-18 2022-03-18 复旦大学 一种基于质谱的n-糖链相对定量的方法
AU2018324195B2 (en) 2017-09-01 2024-12-12 Venn Biosciences Corporation Identification and use of glycopeptides as biomarkers for diagnosis and treatment monitoring
KR20200143634A (ko) 2018-04-17 2020-12-24 몰레큘러 템플레이츠, 인코퍼레이션. 탈면역된 시가 독소 a 서브유닛 스캐폴드를 포함하는 her2-표적화 분자
WO2022087331A1 (en) * 2020-10-22 2022-04-28 Basf Se A method for measuring concentration of human milk oligosaccharides (hmo) molecules using glocometer
CA3203450C (en) * 2020-11-30 2025-05-13 Janssen Pharmaceuticals, Inc. METHOD FOR ANALYSIS OF GLYCOCONJUGATES USING A CAPILLARY-BASED IMMUNOASSAY SYSTEM
KR102727504B1 (ko) * 2021-03-17 2024-11-08 재단법인 아산사회복지재단 Maldi-tof ms를 이용한 유방암 진단 또는 예후 예측을 위한 정보제공방법 및 이를 위한 키트
EP4401786A1 (de) 2021-09-13 2024-07-24 GanNA Bio, Inc. Glycankonjugatzusammensetzungen und verfahren
CN113960232B (zh) * 2021-10-28 2024-02-20 苏州大学 一种基于唾液特异性岩藻糖基化结构糖谱及其检测方法和应用
AU2023364370A1 (en) 2022-10-21 2025-06-05 Ganna Bio, Inc. Glycan conjugate compositions and methods

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0111005B1 (de) 1982-06-03 1988-04-20 Otsuka Pharmaceutical Co., Ltd. Fucose-Antigene, Verfahren zu ihrer Herstellung und gegen diese gerichtete Antikörper, Testeinheit, enthaltend das Fucose Antigen und ein Verfahren zur Bestimmung von tumorassoziierten Zuckerketten
US5171667A (en) 1985-04-04 1992-12-15 Fred Hutchinson Cancer Research Center Hybridomas producing monoclonal antibodies to mono-, di- and trifucosylated type 2 chain
US4904596A (en) 1985-08-07 1990-02-27 Fred Hutchinson Cancer Research Center Hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside
US4851511A (en) 1986-01-30 1989-07-25 Fred Hutchinson Cancer Research Center Monoclonal antibody that specifically binds to disialosyl Lea
US5059520A (en) 1986-08-27 1991-10-22 Sloan-Kettering Institute For Cancer Research Monoclonal antibody panel for blood group a antigen
US5229289A (en) 1988-03-11 1993-07-20 The Biomembrane Institute Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with animal and human and with synthetic carbohydrate-carrier conjugates
US5660834A (en) 1988-03-11 1997-08-26 The Biomembrane Institute Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with carbohydrate-carrier conjugates
US5173292A (en) 1988-06-14 1992-12-22 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies which specifically recognize galactosyl-globoside, compositions containing same and methods of using same
US5102663A (en) 1988-10-18 1992-04-07 Sloan-Kettering Instutute For Cancer Research Vaccine for stimulating or enhancing production of antibodies against 9-O-acetyl GD3
US6083929A (en) 1991-05-06 2000-07-04 The Biomembrane Institute Extended type 1 chain glycosphingolipids as tumor-associated antigens
JPH0646880A (ja) 1992-07-28 1994-02-22 Tosoh Corp モノクロ−ナル抗体およびその製造方法
JPH06172219A (ja) 1992-12-09 1994-06-21 Tosoh Corp 癌関連医薬品組成物
US6310185B1 (en) 1994-03-08 2001-10-30 Memorial Sloan Kettering Cancer Center Recombinant human anti-Lewis Y antibodies
US5708163A (en) 1994-03-15 1998-01-13 Sloan-Kettering Institute Of Cancer Research Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof
US5795961A (en) 1995-02-14 1998-08-18 Ludwig Institute For Cancer Research Recombinant human anti-Lewis b antibodies
AU720802B2 (en) 1996-07-03 2000-06-15 Millenium Pharmaceuticals, Inc. Detection of cancer by assaying for cancer-specific antigens having linked oligosaccharides which are at least triantennary
JPH1084963A (ja) 1996-09-12 1998-04-07 Tosoh Corp 分岐ムチン型合成糖脂質を認識する抗体の遺伝子断片等
WO2000061636A2 (en) * 1999-04-14 2000-10-19 Research Corporation Technologies, Inc. Aberrantly glycosylated antibodies as marker for cancer
FI20011664A7 (fi) * 2001-08-17 2003-02-18 Carbion Oy Syöpäpesifiset oligoskkaridisekvenssit ja niiden käyttö
FI20011671A7 (fi) * 2001-08-20 2003-02-21 Carbion Oy Tuumorispesifiset oligosakkaridisekvenssit ja niiden käyttö
JP2005526711A (ja) * 2002-01-18 2005-09-08 バイオティ セラピィーズ コープ ヘリコバクターピロリに対する新規結合エピトープおよびその用途
AU2002950878A0 (en) * 2002-08-20 2002-09-12 Proteome Systems Intellectual Property Pty Ltd Method for diagnosing disorders
US20040147033A1 (en) * 2002-12-20 2004-07-29 Zachary Shriver Glycan markers for diagnosing and monitoring disease
EP1886144A1 (de) * 2005-04-26 2008-02-13 Raymond A. Dwek Glykosylierungsmarker zur diagnose und überwachung von krebs

Also Published As

Publication number Publication date
EP2431743A3 (de) 2012-07-18
FI20055417A0 (fi) 2005-07-20
WO2007010089A2 (en) 2007-01-25
EP2431743A2 (de) 2012-03-21
EP1910838A2 (de) 2008-04-16
DK1910838T3 (da) 2012-07-16
US20170002095A1 (en) 2017-01-05
EP2431743B1 (de) 2018-05-30
CA2658311A1 (en) 2007-01-25
US20150140576A1 (en) 2015-05-21
EP1910838B1 (de) 2012-04-11
EP1910838A4 (de) 2009-03-18
US20090117106A1 (en) 2009-05-07
WO2007010089A3 (en) 2007-05-31

Similar Documents

Publication Publication Date Title
DK1910838T3 (da) Anvendelser af cancerspecifikke glycaner
EA200801037A1 (ru) Ингибиторы фосфатидилинозит-3-киназы и способы их применения
WO2007016548A3 (en) Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer
WO2009019368A3 (fr) Procede de dosage de la liver fatty acid-binding protein, de l'ace et du ca19-9 pour le diagnostic in vitro du cancer colorectal
WO2005123993A8 (en) Phage microarray profiling of the humoral response to disease
PL1802625T3 (pl) Dwupodstawione pirazolobenzodiazepiny użyteczne jako inhibitory CDK2 i angiogenezy oraz w leczeniu raka sutka, okrężnicy, płuca i gruczołu krokowego
NO20091661L (no) Anvendelse av pegylert IL-10 for a behandle kreft
DK1893196T3 (da) Diarylhydantoin-forbindelse
WO2010017515A3 (en) Breast cancer specific markers and methods of use
WO2003004989A3 (en) Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
WO2007002535A3 (en) Biomarkers for ovarian cancer
WO2005034732A3 (en) Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
WO2009094148A3 (en) Ron antibodies and uses thereof
WO2003000012A3 (en) Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast and ovarian cancer
WO2008097466A3 (en) Metastasis specific splice variants of mena and uses thereof in diagnosis, prognosis and treatment of tumors
WO2002010436A3 (en) Prognostic classification of breast cancer
WO2006028655A3 (en) Genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of prostate cancer
WO2012015904A3 (en) Biomarkers for prostate cancer and methods using the same
WO2009153774A3 (en) Compositions and methods for prognosis of ovarian cancer
WO2007056049A3 (en) Molecular profiling of cancer
WO2006133923A3 (en) Diagnosis, prognosis and prediction of recurrence of breast cancer
ATE545867T1 (de) I-plastin-testverfahren zur in-vitro-diagnose von kolorektalkarzinom
WO2006095086A3 (fr) Traçabilite des anomalies du cycle cellulaire ciblant l'oncologie et la neurodegenerescence.
WO2012166700A3 (en) Molecular profiling of a lethal tumor microenvironment
WO2007033167A3 (en) Compositions and methods for detecting and treating cancer