PL1802625T3 - Dwupodstawione pirazolobenzodiazepiny użyteczne jako inhibitory CDK2 i angiogenezy oraz w leczeniu raka sutka, okrężnicy, płuca i gruczołu krokowego - Google Patents

Dwupodstawione pirazolobenzodiazepiny użyteczne jako inhibitory CDK2 i angiogenezy oraz w leczeniu raka sutka, okrężnicy, płuca i gruczołu krokowego

Info

Publication number: PL1802625T3
Authority: PL; Poland
Prior art keywords: angiogesis; cdk2; colon; breast; lung
Prior art date: 2004-10-13

Application number

PL05792946T

Other languages

English (en)

Inventor

Jin-Jun Liu

Kin-Chun Luk

Giacomo Pizzolato

Yi Ren

Kshitij Chhabilbhai Thakkar

Peter Michael Wovkulich

Zhuming Zhang

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-13

Filing date

2005-10-04

Publication date

2008-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35311946&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1802625(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-10-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-12-31 Publication of PL1802625T3 publication Critical patent/PL1802625T3/pl

Links

206010006187 Breast cancer Diseases 0.000 title 1
208000026310 Breast neoplasm Diseases 0.000 title 1
206010009944 Colon cancer Diseases 0.000 title 1
206010058467 Lung neoplasm malignant Diseases 0.000 title 1
206010060862 Prostate cancer Diseases 0.000 title 1
208000000236 Prostatic Neoplasms Diseases 0.000 title 1
210000000481 breast Anatomy 0.000 title 1
101150073031 cdk2 gene Proteins 0.000 title 1
210000001072 colon Anatomy 0.000 title 1
208000029742 colonic neoplasm Diseases 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
210000004072 lung Anatomy 0.000 title 1
201000005202 lung cancer Diseases 0.000 title 1
208000020816 lung neoplasm Diseases 0.000 title 1
QBCJSMSLBBCZGU-UHFFFAOYSA-N pyrazolo[3,4-i][1,2]benzodiazepine Chemical class C1=CN=NC2=C3C=NN=C3C=CC2=C1 QBCJSMSLBBCZGU-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL05792946T 2004-10-13 2005-10-04 Dwupodstawione pirazolobenzodiazepiny użyteczne jako inhibitory CDK2 i angiogenezy oraz w leczeniu raka sutka, okrężnicy, płuca i gruczołu krokowego PL1802625T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US61817404P	2004-10-13	2004-10-13
PCT/EP2005/010653 WO2006040036A1 (en)	2004-10-13	2005-10-04	Disubstituted pyrazolobenzodiazepines useful as inhibitors for cdk2 and angiogesis, and for the treatment of breast, colon, lung and prostate cancer
EP05792946A EP1802625B1 (en)	2004-10-13	2005-10-04	Disubstituted pyrazolobenzodiazepines useful as inhibitors for cdk2 and angiogesis, and for the treatment of breast, colon, lung and prostate cancer

Publications (1)

Publication Number	Publication Date
PL1802625T3 true PL1802625T3 (pl)	2008-12-31

Family

ID=35311946

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL05792946T PL1802625T3 (pl)	2004-10-13	2005-10-04	Dwupodstawione pirazolobenzodiazepiny użyteczne jako inhibitory CDK2 i angiogenezy oraz w leczeniu raka sutka, okrężnicy, płuca i gruczołu krokowego

Country Status (25)

Country	Link
US (1)	US7524840B2 (pl)
EP (1)	EP1802625B1 (pl)
JP (1)	JP2008515939A (pl)
KR (1)	KR100858262B1 (pl)
CN (2)	CN101899049A (pl)
AR (1)	AR051326A1 (pl)
AT (1)	ATE398619T1 (pl)
AU (1)	AU2005293818A1 (pl)
BR (1)	BRPI0518152A (pl)
CA (1)	CA2582985A1 (pl)
DE (1)	DE602005007623D1 (pl)
DK (1)	DK1802625T3 (pl)
ES (1)	ES2308551T3 (pl)
HR (1)	HRP20080429T3 (pl)
IL (1)	IL182423A0 (pl)
MX (1)	MX2007004464A (pl)
NO (1)	NO20071794L (pl)
NZ (1)	NZ554353A (pl)
PL (1)	PL1802625T3 (pl)
PT (1)	PT1802625E (pl)
RU (1)	RU2394826C2 (pl)
SI (1)	SI1802625T1 (pl)
TW (1)	TWI309652B (pl)
WO (1)	WO2006040036A1 (pl)
ZA (1)	ZA200702973B (pl)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007038215A1 (en) *	2005-09-22	2007-04-05	Incyte Corporation	Tetracyclic inhibitors of janus kinases
BRPI0617252A2 (pt) *	2005-10-14	2011-07-19	Hoffmann La Roche	regime de administração para benzodiazepina 5-2-clorofenil)-1,2-diidro-7-flìor-8-metóxi-3-metil-pira zolo [3,4-b] [1,4]
HUE028588T2 (hu)	2005-12-13	2016-12-28	Incyte Holdings Corp	Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok
EP2740731B1 (en)	2007-06-13	2016-03-23	Incyte Holdings Corporation	Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
CL2009001884A1 (es) *	2008-10-02	2010-05-14	Incyte Holdings Corp	Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
KR20100073454A (ko) *	2008-12-23	2010-07-01	국립암센터	트란스글루타미나제 억제제로 사용되는 신규한 피라졸로디아제핀계 화합물, 이의 제조방법 및 이를 포함하는 조성물
BRPI1012108B8 (pt)	2009-05-22	2021-05-25	Incyte Corp	composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octa no- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico
NZ596479A (en) *	2009-05-22	2014-01-31	Incyte Corp	N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
TW201113285A (en) *	2009-09-01	2011-04-16	Incyte Corp	Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
CA2792508C (en)	2010-03-10	2018-01-16	Incyte Corporation	Piperidin-4-yl azetidine derivatives as jak1 inhibitors
JP2011201794A (ja) *	2010-03-24	2011-10-13	Fujifilm Corp	５−アミノピラゾール誘導体及びその塩の製造方法
EA202091303A3 (ru)	2010-05-21	2021-05-31	Инсайт Холдингс Корпорейшн	Композиция ингибитора jak для местного применения
ES2536415T3 (es)	2010-11-19	2015-05-25	Incyte Corporation	Pirrolopiridinas y pirrolopirimidinas sustituidas heterocíclicas como inhibidores de JAK
CA2818542A1 (en)	2010-11-19	2012-05-24	Incyte Corporation	Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
US8691807B2 (en)	2011-06-20	2014-04-08	Incyte Corporation	Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
TW201313721A (zh)	2011-08-18	2013-04-01	Incyte Corp	作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk)	2011-09-07	2016-06-24	Інсайт Холдінгс Корпорейшн	Способи і проміжні сполуки для отримання інгібіторів jak
CN102603743B (zh) *	2012-02-24	2014-05-28	南京天易生物科技有限公司	抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途
TW201406761A (zh)	2012-05-18	2014-02-16	Incyte Corp	做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
CN103626761B (zh) *	2012-08-24	2015-07-29	上海医药工业研究院	苯并吡啶氮杂卓类化合物及其作为抗肿瘤药物的应用
KR102242077B1 (ko)	2012-11-15	2021-04-20	인사이트 홀딩스 코포레이션	룩솔리티니브의 서방성 제형
EP3489239B1 (en)	2013-03-06	2021-09-15	Incyte Holdings Corporation	Processes and intermediates for making a jak inhibitor
MX376856B (es)	2013-08-07	2025-03-07	Incyte Holdings Corp	Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1).
WO2015184305A1 (en)	2014-05-30	2015-12-03	Incyte Corporation	TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
HUE050567T2 (hu)	2015-09-23	2020-12-28	Janssen Pharmaceutica Nv	Triciklusos heterociklusok rák kezelésére
WO2017050865A1 (en)	2015-09-23	2017-03-30	Janssen Pharmaceutica Nv	Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
CN106928040A (zh) *	2015-12-31	2017-07-07	上海医药工业研究院	Sglt2抑制剂中间体的制备方法
RU2019120162A (ru) *	2016-12-12	2021-01-12	Де Юниверсити Оф Сидней	Непептидные агонисты рецепторов окситоцина
SI3447056T1 (sl) *	2016-12-13	2025-10-30	Transthera Sciences (Nanjing), Inc.	Spojina, ki zavira multikinaze in njena kristalna oblika ter njena uporaba
CN109020980B (zh) *	2017-06-09	2020-11-20	华东师范大学	一类抗肿瘤作用的吡唑并嘧啶二氮*衍生物
TW201924683A (zh)	2017-12-08	2019-07-01	美商英塞特公司	用於治療骨髓增生性贅瘤的低劑量組合療法
MD3746429T2 (ro)	2018-01-30	2022-08-31	Incyte Corp	Procedee pentru prepararea de (1-(3-fluoro-2-(trifluorometil)izonicotinil)piperidin-4-onă)
KR20260080448A (ko)	2018-03-30	2026-06-02	인사이트 코포레이션	Jak 억제제를 사용하는 화농성 한선염의 치료
BR112022022477A2 (pt)	2020-05-08	2022-12-13	Transthera Sciences Nanjing Inc	Método para sintetizar composto antitumoral e intermediários do mesmo
US11833155B2 (en)	2020-06-03	2023-12-05	Incyte Corporation	Combination therapy for treatment of myeloproliferative neoplasms
WO2022113003A1 (en)	2020-11-27	2022-06-02	Rhizen Pharmaceuticals Ag	Cdk inhibitors
WO2022149057A1 (en)	2021-01-05	2022-07-14	Rhizen Pharmaceuticals Ag	Cdk inhibitors
CA3217792A1 (en)	2021-05-07	2022-11-10	Kymera Therapeutics, Inc	Cdk2 degraders and uses thereof
WO2024039210A1 (ko)	2022-08-17	2024-02-22	한국화학연구원	Cdk2 및/또는 cdk9의 억제 또는 분해용 화합물 및 이들의 의약 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3681341A (en) *	1970-12-23	1972-08-01	Hoffmann La Roche	Process for preparing 1-lower alkyl-1,4-benzodiazepin-2-ones
MC1999A1 (fr) *	1987-12-18	1990-01-26	Hoffmann La Roche	Composes tricycliques
ZA889116B (en) *	1987-12-18	1989-08-30	Hoffmann La Roche	Tricyclic compounds
US5625031A (en)	1994-02-08	1997-04-29	Bristol-Myers Squibb Company	Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein
US5631156A (en) *	1994-06-21	1997-05-20	The University Of Michigan	DNA encoding and 18 KD CDK6 inhibiting protein
US5733920A (en)	1995-10-31	1998-03-31	Mitotix, Inc.	Inhibitors of cyclin dependent kinases
FR2741881B1 (fr)	1995-12-01	1999-07-30	Centre Nat Rech Scient	Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
US5866702A (en)	1996-08-02	1999-02-02	Cv Therapeutics, Incorporation	Purine inhibitors of cyclin dependent kinase 2
US6440959B1 (en) *	1999-04-21	2002-08-27	Hoffman-La Roche Inc.	Pyrazolobenzodiazepines
TWI241302B (en) *	2000-12-01	2005-10-11	Ajinomoto Kk	Lactam compounds and pharmaceutical use thereof

2005
- 2005-10-04 CN CN2010101585349A patent/CN101899049A/zh active Pending
- 2005-10-04 AT AT05792946T patent/ATE398619T1/de active
- 2005-10-04 HR HR20080429T patent/HRP20080429T3/xx unknown
- 2005-10-04 JP JP2007536037A patent/JP2008515939A/ja active Pending
- 2005-10-04 MX MX2007004464A patent/MX2007004464A/es active IP Right Grant
- 2005-10-04 PL PL05792946T patent/PL1802625T3/pl unknown
- 2005-10-04 NZ NZ554353A patent/NZ554353A/en not_active IP Right Cessation
- 2005-10-04 SI SI200530331T patent/SI1802625T1/sl unknown
- 2005-10-04 ES ES05792946T patent/ES2308551T3/es not_active Expired - Lifetime
- 2005-10-04 DE DE602005007623T patent/DE602005007623D1/de not_active Expired - Lifetime
- 2005-10-04 KR KR1020077008406A patent/KR100858262B1/ko not_active Expired - Fee Related
- 2005-10-04 CN CN2005800351219A patent/CN101039946B/zh not_active Expired - Fee Related
- 2005-10-04 EP EP05792946A patent/EP1802625B1/en not_active Expired - Lifetime
- 2005-10-04 AU AU2005293818A patent/AU2005293818A1/en not_active Abandoned
- 2005-10-04 PT PT05792946T patent/PT1802625E/pt unknown
- 2005-10-04 CA CA002582985A patent/CA2582985A1/en not_active Abandoned
- 2005-10-04 BR BRPI0518152-6A patent/BRPI0518152A/pt not_active IP Right Cessation
- 2005-10-04 WO PCT/EP2005/010653 patent/WO2006040036A1/en not_active Ceased
- 2005-10-04 DK DK05792946T patent/DK1802625T3/da active
- 2005-10-04 RU RU2007117770/04A patent/RU2394826C2/ru not_active IP Right Cessation
- 2005-10-05 US US11/244,251 patent/US7524840B2/en not_active Expired - Fee Related
- 2005-10-11 AR ARP050104254A patent/AR051326A1/es not_active Application Discontinuation
- 2005-10-12 TW TW094135532A patent/TWI309652B/zh not_active IP Right Cessation
2007
- 2007-04-03 NO NO20071794A patent/NO20071794L/no not_active Application Discontinuation
- 2007-04-10 IL IL182423A patent/IL182423A0/en unknown
- 2007-04-11 ZA ZA200702973A patent/ZA200702973B/xx unknown

Also Published As

Publication number	Publication date
RU2394826C2 (ru)	2010-07-20
TWI309652B (en)	2009-05-11
US7524840B2 (en)	2009-04-28
MX2007004464A (es)	2007-05-07
TW200628469A (en)	2006-08-16
SI1802625T1 (sl)	2008-10-31
CA2582985A1 (en)	2006-04-20
NO20071794L (no)	2007-07-10
WO2006040036A1 (en)	2006-04-20
HRP20080429T3 (en)	2008-09-30
CN101899049A (zh)	2010-12-01
AR051326A1 (es)	2007-01-03
ES2308551T3 (es)	2008-12-01
NZ554353A (en)	2010-01-29
PT1802625E (pt)	2008-08-06
ATE398619T1 (de)	2008-07-15
EP1802625A1 (en)	2007-07-04
KR20070054243A (ko)	2007-05-28
KR100858262B1 (ko)	2008-09-11
BRPI0518152A (pt)	2008-11-04
RU2007117770A (ru)	2008-11-20
CN101039946B (zh)	2010-12-08
DK1802625T3 (da)	2008-09-01
EP1802625B1 (en)	2008-06-18
CN101039946A (zh)	2007-09-19
IL182423A0 (en)	2007-07-24
US20060079511A1 (en)	2006-04-13
AU2005293818A1 (en)	2006-04-20
DE602005007623D1 (de)	2008-07-31
HK1108284A1 (en)	2008-05-02
JP2008515939A (ja)	2008-05-15
ZA200702973B (en)	2009-09-30

Publication	Publication Date	Title
ZA200702973B (en)	2009-09-30	Disubstituted pyrazolobenzodiazepines useful as inhibitors for CDK2 and angiogesis, and for the treatment of breast, colon, lung and prostate cancer
IL258880A (en)	2018-06-28	Diarylhydantoin compounds
IL188430A0 (en)	2008-11-03	Treatment of tumors
IL188746A0 (en)	2008-08-07	Treatment of cancer
AU2006226897B2 (en)	2009-05-07	Combinations for the treatment of cancer comprising anti-EGFR antibody and VEGFR inhibitors
IL178261A0 (en)	2006-12-31	Use of 5,10-methylene tetrahydrofolate for the treatment of cancer
IL189376A0 (en)	2008-06-05	Combinations comprising dmxaa for the treatment of cancer
IL189377A0 (en)	2008-06-05	Combinations comprising dmxaa for the treatment of cancer
PL1858929T3 (pl)	2013-09-30	Diagnostyka raka gruczołu krokowego
IL187792A0 (en)	2008-11-03	4-anilino-3-quinolinecarbonitriles for the treatment of cancer
IL226362A0 (en)	2013-06-27	compounds, and methods for treating cancer
ZA200805522B (en)	2009-04-29	Dioxoiane dérivates for the treatment of cancer
ZA200706871B (en)	2008-10-29	Treatment of metastasized tumors
GB0520067D0 (en)	2005-11-09	Treatment of cancer
IL180709A0 (en)	2008-03-20	Treatment of tumours
GB0410379D0 (en)	2004-06-16	Treatment of cancer
GB0423273D0 (en)	2004-11-24	Treatment of cancer
GB0517386D0 (en)	2005-10-05	Combinations for the treatment of cancer
ZA201000400B (en)	2010-10-27	Methods and compositions for the treatment of cancer, tumors, and tumor related disorders
GB0425873D0 (en)	2004-12-29	Diagnosis of prostate cancer
GB0420845D0 (en)	2004-10-20	Treatment of cancer
GB0421734D0 (en)	2004-11-03	Treatment of cancer
GB0422225D0 (en)	2004-11-03	Treatment of cancer
IL180460A0 (en)	2007-06-03	Treatment of cancer
ZA200700845B (en)	2008-09-25	Treatment of cancer