ATE554391T1 - Verfahren zur analyse von metaboliten - Google Patents

Verfahren zur analyse von metaboliten

Info

Publication number
ATE554391T1
ATE554391T1 AT04804051T AT04804051T ATE554391T1 AT E554391 T1 ATE554391 T1 AT E554391T1 AT 04804051 T AT04804051 T AT 04804051T AT 04804051 T AT04804051 T AT 04804051T AT E554391 T1 ATE554391 T1 AT E554391T1
Authority
AT
Austria
Prior art keywords
metabolites
biological sample
isotopically labeled
sample
determining
Prior art date
Application number
AT04804051T
Other languages
English (en)
Inventor
Alexander Luedemann
Alexander Erban
Cornelia Wagner
Joachim Kopka
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of ATE554391T1 publication Critical patent/ATE554391T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y10T436/144444—Glucose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25625—Dilution

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT04804051T 2003-12-19 2004-12-17 Verfahren zur analyse von metaboliten ATE554391T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03029370 2003-12-19
PCT/EP2004/014450 WO2005059556A1 (en) 2003-12-19 2004-12-17 Method for analysing metabolites

Publications (1)

Publication Number Publication Date
ATE554391T1 true ATE554391T1 (de) 2012-05-15

Family

ID=34684550

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04804051T ATE554391T1 (de) 2003-12-19 2004-12-17 Verfahren zur analyse von metaboliten

Country Status (8)

Country Link
US (1) US8420406B2 (de)
EP (1) EP1695088B1 (de)
AT (1) ATE554391T1 (de)
AU (1) AU2004299949B2 (de)
CA (1) CA2547755C (de)
DK (1) DK1695088T3 (de)
ES (1) ES2385330T3 (de)
WO (1) WO2005059556A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2385330T3 (es) 2003-12-19 2012-07-23 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Procedimiento para analizar metabolitos
US20060200316A1 (en) * 2005-03-01 2006-09-07 Harin Kanani Data correction, normalization and validation for quantitative high-throughput metabolomic profiling
US20090203145A1 (en) * 2008-02-07 2009-08-13 Min Huang Methods for analysis of vitamins
PT2373988E (pt) * 2008-12-05 2015-06-03 C2N Diagnostics Métodos para medir concentrações de biomoléculas
TWI540319B (zh) * 2010-03-29 2016-07-01 中央研究院 以細胞質譜分析定量細胞所攝入之奈米/微米粒子
WO2011139930A1 (en) * 2010-05-01 2011-11-10 Nms Labs A method for clinically monitoring niacin and niacin metabolites in serum or plasma
CN104220873B (zh) * 2012-02-10 2017-12-22 儿童医疗中心公司 基于nmr的代谢物筛选平台
US10607723B2 (en) * 2016-07-05 2020-03-31 University Of Kentucky Research Foundation Method and system for identification of metabolites using mass spectra
AU2018224235B2 (en) 2017-02-24 2024-12-05 Iroa Technologies, Llc IROA metabolomics workflow for improved accuracy, identification and quantitation
CN107589194B (zh) * 2017-11-02 2019-01-29 武汉迈特维尔生物科技有限公司 一种肺癌早期诊断用小分子标志物及在诊断方面的应用
US20220137057A1 (en) * 2019-03-08 2022-05-05 Basf Se Metabolic analysis method
KR102333499B1 (ko) * 2019-06-17 2021-12-01 고려대학교 산학협력단 대사체 분석을 이용한 류마티스 관절염 중증도 예측 또는 구분용 바이오마커
CN112697894A (zh) * 2020-11-30 2021-04-23 重庆医科大学附属口腔医院 氨基酸同位素标记物的定量分析方法
CN113514531B (zh) * 2021-04-27 2022-10-25 清华大学 一种化合物的碎片离子预测方法及应用
WO2025090085A1 (en) * 2023-10-26 2025-05-01 The Regents Of The University Of Colorado, A Body Corporate System and method for nadome analysis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9117634D0 (en) * 1991-08-15 1991-10-02 Evans Lloyd T Method of treating plants or plant tissues
US6391649B1 (en) 1999-05-04 2002-05-21 The Rockefeller University Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy
US20030077572A1 (en) * 2001-10-11 2003-04-24 Abramson Fred P. Quantitative differential display using isotope ratio monitoring
US20030180710A1 (en) * 2002-03-22 2003-09-25 Lee Wai-Nang Paul Method of enhancing the efficiency of a pharmaceutical business
TW200502394A (en) * 2002-09-16 2005-01-16 Univ California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
US20050112706A1 (en) * 2002-11-07 2005-05-26 Susan Kasper Diagnostic and prognostic methods for prostate cancers
US6872516B2 (en) * 2003-04-16 2005-03-29 Advanced Breath Diagnostics, Llc Methods of producing carbon-13 labeled biomass
US7759130B2 (en) 2003-11-21 2010-07-20 Eisai R & D Management Co., Ltd. Mass spectrometric quantitation method for biomolecules based on metabolically labeled internal standards
ES2385330T3 (es) 2003-12-19 2012-07-23 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Procedimiento para analizar metabolitos

Also Published As

Publication number Publication date
CA2547755A1 (en) 2005-06-30
US20070141712A1 (en) 2007-06-21
CA2547755C (en) 2014-06-03
ES2385330T3 (es) 2012-07-23
AU2004299949B2 (en) 2011-11-24
US8420406B2 (en) 2013-04-16
AU2004299949A1 (en) 2005-06-30
WO2005059556A1 (en) 2005-06-30
EP1695088A1 (de) 2006-08-30
EP1695088B1 (de) 2012-04-18
DK1695088T3 (da) 2012-06-25

Similar Documents

Publication Publication Date Title
ATE554391T1 (de) Verfahren zur analyse von metaboliten
Christoforou et al. Isobaric tagging approaches in quantitative proteomics: the ups and downs
Valen et al. Determination of 21 drugs in oral fluid using fully automated supported liquid extraction and UHPLC‐MS/MS
DE60325482D1 (de) Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie
ATE350666T1 (de) Verfahren zur analyse von proteinproben
ATE515702T1 (de) Verfahren, mixturen, kits und zusammensetzungen bezüglich der analytbestimmung
WO2007140291A3 (en) Expression quantification using mass spectrometry
US9068995B2 (en) Method for determining derivatized analytes in a separated biological fluid
US20210080469A1 (en) Anoliter-scale sample processing and mass spectrometry acquisition method for single cell proteomics
DE602005013957D1 (de) Verfahren zur durchführung von vollbluttests
SG111139A1 (en) Mediator stabilized reagent compositions and methods for their use in electrochemical analyte detection assays
MY145833A (en) Micro-hydrocarbon analysis
WO2008022205A3 (en) Thyroxine-containing compound analysis methods
KR20160143804A (ko) 세포의 분화 상태의 평가 방법
NO20085063L (no) Analyse for lantanhydroksykarbon
WO2005114700A3 (en) Expression quantification using mass spectrometry
ATE548651T1 (de) Verfahren zur klassifizierung chemisch quervernetzter zellulärer proben unter verwendung von massenspektren
TW200801506A (en) Method and device of identifying individuals
WO2004008480A3 (en) Quantitative analysis via isotopically differentitated derivatization
SE0003566D0 (sv) A method for the quantitative determination of one or more compounds
EP1327883A3 (de) Kombinierte metabolomische, proteomische and transkriptomische Analyse derselben Probe und entsprechende statistische Datenauswertung
SE0004094D0 (sv) A method for the quantification of carbohudrates
DE602004021193D1 (de) Erstellung von digitalaufnahmen einzelner radialer immundiffusionstests
GB2417078A (en) System and method for processing identified metabolites
DE602005015627D1 (de) Verfahren zur messung von proinsulin und c-peptid sowie kit dafür