ATE554392T1 - Diagnoseverfahren für sprue/zöliakie - Google Patents
Diagnoseverfahren für sprue/zöliakieInfo
- Publication number
- ATE554392T1 ATE554392T1 AT03789958T AT03789958T ATE554392T1 AT E554392 T1 ATE554392 T1 AT E554392T1 AT 03789958 T AT03789958 T AT 03789958T AT 03789958 T AT03789958 T AT 03789958T AT E554392 T1 ATE554392 T1 AT E554392T1
- Authority
- AT
- Austria
- Prior art keywords
- sprue
- celiac disease
- diagnostic procedure
- digestion
- refractory
- Prior art date
Links
- 208000015943 Coeliac disease Diseases 0.000 title abstract 3
- 238000002405 diagnostic procedure Methods 0.000 title 1
- 108010068370 Glutens Proteins 0.000 abstract 1
- 102000015636 Oligopeptides Human genes 0.000 abstract 1
- 108010038807 Oligopeptides Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000029087 digestion Effects 0.000 abstract 1
- 235000021312 gluten Nutrition 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Rehabilitation Therapy (AREA)
- Botany (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42803302P | 2002-11-20 | 2002-11-20 | |
| PCT/US2003/037434 WO2004045392A2 (en) | 2002-11-20 | 2003-11-20 | Diagnostic method for celiac sprue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE554392T1 true ATE554392T1 (de) | 2012-05-15 |
Family
ID=32326628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03789958T ATE554392T1 (de) | 2002-11-20 | 2003-11-20 | Diagnoseverfahren für sprue/zöliakie |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7776545B2 (de) |
| EP (1) | EP1563300B1 (de) |
| AT (1) | ATE554392T1 (de) |
| AU (1) | AU2003294473A1 (de) |
| CA (1) | CA2502700C (de) |
| DK (1) | DK1563300T3 (de) |
| ES (1) | ES2383595T3 (de) |
| WO (1) | WO2004045392A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9923306D0 (en) * | 1999-10-01 | 1999-12-08 | Isis Innovation | Diagnostic and therapeutic epitope, and transgenic plant |
| US7780961B2 (en) | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
| DK1572127T4 (da) * | 2002-02-14 | 2014-11-24 | Univ Leland Stanford Junior | Enzymbehandling af fødevarer til cøliaki |
| US8143210B2 (en) * | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| CA2487247A1 (en) * | 2002-05-14 | 2003-11-27 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| US7462688B2 (en) * | 2002-05-14 | 2008-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for diagnostic and therapeutic methods for celiac sprue |
| US7202216B2 (en) * | 2002-05-14 | 2007-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| US7265093B2 (en) * | 2002-05-14 | 2007-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
| GB0212885D0 (en) * | 2002-06-05 | 2002-07-17 | Isis Innovation | Therapeutic epitopes and uses thereof |
| ATE554392T1 (de) | 2002-11-20 | 2012-05-15 | Univ Leland Stanford Junior | Diagnoseverfahren für sprue/zöliakie |
| US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
| US10105437B2 (en) * | 2004-04-28 | 2018-10-23 | Btg International Limited | Epitopes related to coeliac disease |
| CN104056251B (zh) * | 2004-04-28 | 2019-09-17 | 英国技术集团国际有限公司 | 与腹部疾病有关的表位 |
| AU2011247868B2 (en) * | 2004-04-28 | 2014-05-22 | Btg International Limited | Epitopes related to coeliac disease |
| DK2119450T3 (da) | 2005-11-29 | 2013-05-06 | Actogenix Nv | Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener |
| CN103933563B (zh) | 2007-01-25 | 2016-09-28 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 使用遗传修饰的乳杆菌通过抗原的粘膜递送治疗免疫疾病 |
| CA2680590C (en) * | 2007-03-16 | 2017-10-17 | Jonathan David Gass | Combination enzyme therapy for digestion of dietary gluten |
| US8148105B2 (en) * | 2007-03-16 | 2012-04-03 | The Board Of Trustees Of The Leland Stanford Junior University | Scaleable manufacturing process for cysteine endoprotease B, isoform 2 |
| ES2421719T3 (es) * | 2008-04-21 | 2013-09-05 | Bio Rad Laboratories | Antígeno de gliadina recombinante desamidada |
| CN105079781B (zh) | 2008-11-30 | 2018-07-20 | 免疫桑特公司 | 用于治疗乳糜泻的组合物和方法 |
| HU0900195D0 (en) * | 2009-04-01 | 2009-06-29 | Debreceni Egyetem | Diagnosis and treatment of gluten-induced autoimmune diseases |
| HU0900199D0 (en) * | 2009-04-01 | 2009-06-29 | Debreceni Egyetem | Diagnosis of gluten-induced autoimmune diseases |
| WO2011000773A1 (en) * | 2009-07-02 | 2011-01-06 | Dsm Ip Assets B.V. | Testing efficacy for celiac disease |
| DE102009045268A1 (de) * | 2009-10-01 | 2011-04-07 | Charité - Universitätsmedizin Berlin | Neue Marker für die Diagnose von Zöliakie |
| US8685392B2 (en) | 2009-10-07 | 2014-04-01 | Trustees Of Boston University | Rothia species glutamine endopeptidases and use thereof |
| CN102858795A (zh) | 2010-02-02 | 2013-01-02 | 天野酶制品美国有限公司 | 蛋白酶针对谷蛋白不耐受的用途 |
| WO2012006384A2 (en) | 2010-07-07 | 2012-01-12 | Trustees Of Boston University | Rothia species gluten-degrading enzymes and uses thereof |
| ES2385455B2 (es) * | 2010-12-28 | 2013-09-25 | Universidad De Sevilla | Determinación de niveles de péptidos inmunogénicos del gluten en muestras humanas. |
| ES2896489T3 (es) | 2011-08-10 | 2022-02-24 | Univ Washington Through Its Center For Commercialization | Composiciones y procedimientos para el tratamiento de la enfermedad esprúe celíaco |
| ES2402286B1 (es) * | 2011-09-29 | 2014-03-04 | Universidad De Valladolid | Péptido inmunogénico del gluten y sus aplicaciones. |
| WO2013085851A2 (en) * | 2011-12-05 | 2013-06-13 | Bio-Rad Laboratories, Inc. | Recombinant deamidated gliadin antigen |
| EP3033100B1 (de) | 2013-08-14 | 2018-10-03 | University Of Washington Through Its Center For Commercialization | Zusammensetzungen zur behandlung von zöliakie |
| EP3043812A1 (de) | 2013-09-10 | 2016-07-20 | Immusant Inc. | Dosierung einer glutenpeptidzusammensetzung |
| AU2015249383A1 (en) * | 2014-04-24 | 2016-12-15 | Immusant, Inc. | Compositions comprising gluten peptides and uses thereof |
| ES2556177B1 (es) * | 2014-07-09 | 2016-10-20 | Universidad De Sevilla | Detección de péptidos del gluten en fluidos humanos |
| US10370718B2 (en) | 2014-09-29 | 2019-08-06 | Immusant, Inc. | Use of HLA genetic status to assess or select treatment of celiac disease |
| SG10201911867YA (en) | 2015-06-08 | 2020-01-30 | Univ Washington | Compositions and methods for treating celiac sprue disease |
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| US7534426B2 (en) * | 2004-04-26 | 2009-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Glutenase enzyme assays |
| US7521427B2 (en) | 2004-11-09 | 2009-04-21 | Georgia Tech Research Corporation | Peptidyl allyl sulfones |
| EP1949093A2 (de) | 2005-10-11 | 2008-07-30 | Alvine Pharmaceuticals, Inc. | Zusammensetzungen und verfahren zur verbesserten stabilität von oligopeptiden und polypeptiden im magen-darm-trakt |
| WO2007047303A2 (en) * | 2005-10-12 | 2007-04-26 | Alvine Pharmaceuticals, Inc. | Pegylated glutenase polypeptides |
| WO2007050795A2 (en) * | 2005-10-25 | 2007-05-03 | Alvine Pharmaceuticals, Inc. | Transglutaminase inhibitors and methods of use thereof |
| US20070099238A1 (en) | 2005-10-31 | 2007-05-03 | Sigalas Mihail M | Enhancement of emission using metal coated dielectric nanoparticles |
| EP1845103B1 (de) | 2006-04-10 | 2015-02-25 | Boehringer Ingelheim RCV GmbH & Co KG | Verfahren zur Proteinfaltung |
| US8148105B2 (en) | 2007-03-16 | 2012-04-03 | The Board Of Trustees Of The Leland Stanford Junior University | Scaleable manufacturing process for cysteine endoprotease B, isoform 2 |
| CA2680590C (en) | 2007-03-16 | 2017-10-17 | Jonathan David Gass | Combination enzyme therapy for digestion of dietary gluten |
| ES2616231T3 (es) | 2008-08-21 | 2017-06-12 | Immunogenics Llc | Formulación para administración oral de proteínas |
| NZ591940A (en) | 2008-10-10 | 2013-08-30 | Alvine Pharmaceuticals Inc | Dosage forms that facilitate rapid activation of zymogen |
-
2003
- 2003-11-20 AT AT03789958T patent/ATE554392T1/de active
- 2003-11-20 AU AU2003294473A patent/AU2003294473A1/en not_active Abandoned
- 2003-11-20 CA CA2502700A patent/CA2502700C/en not_active Expired - Lifetime
- 2003-11-20 US US10/531,547 patent/US7776545B2/en active Active
- 2003-11-20 DK DK03789958.0T patent/DK1563300T3/da active
- 2003-11-20 ES ES03789958T patent/ES2383595T3/es not_active Expired - Lifetime
- 2003-11-20 EP EP03789958A patent/EP1563300B1/de not_active Expired - Lifetime
- 2003-11-20 WO PCT/US2003/037434 patent/WO2004045392A2/en not_active Ceased
-
2010
- 2010-07-19 US US12/839,278 patent/US8071316B2/en not_active Expired - Fee Related
-
2011
- 2011-11-04 US US13/289,905 patent/US8426145B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7776545B2 (en) | 2010-08-17 |
| ES2383595T3 (es) | 2012-06-22 |
| US8071316B2 (en) | 2011-12-06 |
| WO2004045392A3 (en) | 2004-08-26 |
| WO2004045392A2 (en) | 2004-06-03 |
| US20100317025A1 (en) | 2010-12-16 |
| EP1563300A2 (de) | 2005-08-17 |
| DK1563300T3 (da) | 2012-07-23 |
| US20120083004A1 (en) | 2012-04-05 |
| AU2003294473A8 (en) | 2004-06-15 |
| US20060240475A1 (en) | 2006-10-26 |
| EP1563300B1 (de) | 2012-04-18 |
| CA2502700C (en) | 2017-01-17 |
| CA2502700A1 (en) | 2004-06-03 |
| AU2003294473A1 (en) | 2004-06-15 |
| EP1563300A4 (de) | 2010-08-11 |
| US8426145B2 (en) | 2013-04-23 |
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