ATE555079T1 - Verfahren zur synthese von 9-substituiertem minocyclin - Google Patents

Verfahren zur synthese von 9-substituiertem minocyclin

Info

Publication number
ATE555079T1
ATE555079T1 AT08826197T AT08826197T ATE555079T1 AT E555079 T1 ATE555079 T1 AT E555079T1 AT 08826197 T AT08826197 T AT 08826197T AT 08826197 T AT08826197 T AT 08826197T AT E555079 T1 ATE555079 T1 AT E555079T1
Authority
AT
Austria
Prior art keywords
tetracycline compound
conditions
substituted tetracycline
reacting
synthesis
Prior art date
Application number
AT08826197T
Other languages
English (en)
Inventor
Farzaneh Seyedi
Tadeusz Warchol
Mark Grier
Original Assignee
Paratek Pharm Innc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharm Innc filed Critical Paratek Pharm Innc
Application granted granted Critical
Publication of ATE555079T1 publication Critical patent/ATE555079T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT08826197T 2007-07-06 2008-07-07 Verfahren zur synthese von 9-substituiertem minocyclin ATE555079T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94838507P 2007-07-06 2007-07-06
US6035108P 2008-06-10 2008-06-10
PCT/US2008/008355 WO2009009042A1 (en) 2007-07-06 2008-07-07 Methods for synthesizing substituted tetracycline compounds

Publications (1)

Publication Number Publication Date
ATE555079T1 true ATE555079T1 (de) 2012-05-15

Family

ID=39926392

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08826197T ATE555079T1 (de) 2007-07-06 2008-07-07 Verfahren zur synthese von 9-substituiertem minocyclin

Country Status (17)

Country Link
US (3) US9522872B2 (de)
EP (2) EP2192111A3 (de)
JP (2) JP2010532759A (de)
KR (1) KR20100042276A (de)
CN (2) CN101784517A (de)
AT (1) ATE555079T1 (de)
AU (2) AU2008275701B2 (de)
BR (2) BRPI0823405A2 (de)
CA (1) CA2693376A1 (de)
DK (1) DK2176216T3 (de)
EA (2) EA201070048A1 (de)
ES (1) ES2386926T3 (de)
HR (1) HRP20120605T1 (de)
IL (1) IL204133A0 (de)
PT (1) PT2176216E (de)
WO (1) WO2009009042A1 (de)
ZA (2) ZA201000034B (de)

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* Cited by examiner, † Cited by third party
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AU2006210406C1 (en) 2005-02-04 2013-03-07 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
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PL2120963T3 (pl) 2006-12-21 2019-05-31 Paratek Pharm Innc Podstawione związki tetracyklinowe do leczenia zaburzeń zapalnych skóry
IL270446B2 (en) * 2006-12-21 2023-10-01 Paratek Pharm Innc A tetracycline compound, a pharmaceutical preparation containing the tetracycline compound, and the tetracycline compound or the pharmaceutical preparation for the treatment of the tetracycline-responsive condition
EP2144614A1 (de) 2007-04-12 2010-01-20 Paratek Pharmaceuticals, Inc. Verfahren zur behandlung von spinaler muskelatrophie mittels tetracyclinverbindungen
EP2144870A2 (de) * 2007-04-27 2010-01-20 Paratek Pharmaceuticals, Inc. Verfahren zur synthese und reinigung von aminoalkyl-tetracyclin-verbindungen
MX2010009693A (es) * 2008-03-05 2010-12-20 Paratek Pharm Innc Compuestos de monociclina y metodos de uso de la misma.
JP2011517697A (ja) * 2008-04-14 2011-06-16 パラテック ファーマシューティカルズ インコーポレイテッド 置換テトラサイクリン化合物
EP2341771A4 (de) * 2008-09-19 2012-08-15 Paratek Pharm Innc Tetracyclinverbindungen zur behandlung rheumatoider arthritis sowie entsprechende behandlungsverfahren
EP2470500B1 (de) * 2009-08-28 2017-10-04 Tetraphase Pharmaceuticals, Inc. Tetracyclinverbindungen
WO2012065028A2 (en) 2010-11-11 2012-05-18 Concert Pharmaceuticals Inc. Substituted tetracyclines
TR201902057T4 (tr) 2012-08-31 2019-03-21 Tetraphase Pharmaceuticals Inc Tetrasiklin bileşikleri.
MA46567A (fr) 2016-10-19 2019-08-28 Tetraphase Pharmaceuticals Inc Formes cristallines de l'éravacycline
SG11201903846TA (en) 2016-11-01 2019-05-30 Paratek Pharm Innc 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
EP3774723A4 (de) * 2018-04-06 2022-03-09 Paratek Pharmaceuticals, Inc. Verfahren zur herstellung von sarecyclin-hydrochlorid
PT117254B (pt) * 2021-05-26 2024-04-18 Hovione Farm S A Método de síntese de compostos 9-aminometil tetraciclinas
CN119751291A (zh) * 2025-01-07 2025-04-04 重庆圣华曦药业股份有限公司 一种奥玛环素的合成方法及其在制剂中的应用

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Also Published As

Publication number Publication date
US9522872B2 (en) 2016-12-20
CN101811980A (zh) 2010-08-25
US20250340507A1 (en) 2025-11-06
IL204133A0 (en) 2011-07-31
BRPI0823405A2 (pt) 2012-12-25
EP2192111A3 (de) 2010-10-06
US20090156842A1 (en) 2009-06-18
CA2693376A1 (en) 2009-01-15
EA201070233A1 (ru) 2010-08-30
US20170283368A1 (en) 2017-10-05
EP2176216A1 (de) 2010-04-21
KR20100042276A (ko) 2010-04-23
BRPI0813990A2 (pt) 2011-09-13
PT2176216E (pt) 2012-07-27
CN101784517A (zh) 2010-07-21
AU2010200845A1 (en) 2010-04-01
EP2192111A2 (de) 2010-06-02
EA201070048A1 (ru) 2010-10-29
EP2176216B1 (de) 2012-04-25
HK1139386A1 (en) 2010-09-17
AU2008275701B2 (en) 2013-04-04
ES2386926T3 (es) 2012-09-06
ZA201000034B (en) 2011-10-26
WO2009009042A1 (en) 2009-01-15
AU2010200845B2 (en) 2013-01-17
JP2010532759A (ja) 2010-10-14
HRP20120605T1 (hr) 2012-09-30
DK2176216T3 (da) 2012-07-30
JP2011020996A (ja) 2011-02-03
AU2008275701A1 (en) 2009-01-15
ZA201008646B (en) 2012-02-29

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