ATE555114T1 - Verfahren zur herstellung von mirtazapin - Google Patents

Verfahren zur herstellung von mirtazapin

Info

Publication number: ATE555114T1
Authority: AT; Austria
Prior art keywords: mirtazapine; phenylpiperazin; cyclization; propanol; pyridine
Prior art date: 2007-03-22

Application number

AT08722032T

Other languages

English (en)

Inventor

Chiharu Maeda

Takuma Maeda

Original Assignee

Sumitomo Chemical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-22

Filing date

2008-03-13

Publication date

2012-05-15

2008-03-13 Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co

2012-05-15 Application granted granted Critical

2012-05-15 Publication of ATE555114T1 publication Critical patent/ATE555114T1/de

Links

RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 title abstract 6
229960001785 mirtazapine Drugs 0.000 title abstract 6
238000004519 manufacturing process Methods 0.000 title abstract 3
PYZPABZGIRHQTA-UHFFFAOYSA-N [2-(4-methyl-2-phenylpiperazin-1-yl)pyridin-3-yl]methanol Chemical compound C1N(C)CCN(C=2C(=CC=CN=2)CO)C1C1=CC=CC=C1 PYZPABZGIRHQTA-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 2
239000011541 reaction mixture Substances 0.000 abstract 2
238000007363 ring formation reaction Methods 0.000 abstract 2
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
238000010790 dilution Methods 0.000 abstract 1
239000012895 dilution Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT08722032T 2007-03-22 2008-03-13 Verfahren zur herstellung von mirtazapin ATE555114T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2007075573A JP5192707B2 (ja)	2007-03-22	2007-03-22	ミルタザピンの製造方法
PCT/JP2008/054628 WO2008114691A1 (ja)	2007-03-22	2008-03-13	ミルタザピンの製造方法

Publications (1)

Publication Number	Publication Date
ATE555114T1 true ATE555114T1 (de)	2012-05-15

Family

ID=39765800

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08722032T ATE555114T1 (de)	2007-03-22	2008-03-13	Verfahren zur herstellung von mirtazapin

Country Status (16)

Country	Link
US (1)	US8173804B2 (de)
EP (1)	EP2135870B1 (de)
JP (1)	JP5192707B2 (de)
KR (1)	KR101418620B1 (de)
CN (1)	CN101541798B (de)
AT (1)	ATE555114T1 (de)
AU (1)	AU2008227637B2 (de)
BR (1)	BRPI0805835A2 (de)
CA (1)	CA2664286A1 (de)
DK (1)	DK2135870T3 (de)
ES (1)	ES2386165T3 (de)
IL (1)	IL197572A (de)
PL (1)	PL2135870T3 (de)
PT (1)	PT2135870E (de)
WO (1)	WO2008114691A1 (de)
ZA (1)	ZA200901559B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2016138357A1 (en)	2015-02-27	2016-09-01	Kindred Biosciences, Inc.	Stimulation of appetite, management of weight loss, and treatment of anorexia in dogs and cats
JP6452575B2 (ja) *	2015-08-19	2019-01-16	株式会社トクヤマ	ミルタザピンの製造方法
JP2017088564A (ja) *	2015-11-13	2017-05-25	株式会社トクヤマ	ミルタザピンの製造方法
JP6571497B2 (ja) *	2015-11-13	2019-09-04	株式会社トクヤマ	ミルタザピンの製造方法
JP7018840B2 (ja) *	2018-07-04	2022-02-14	住友化学株式会社	フェニルピペラジンピリジンメチルアセテートの製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL189199C (nl) *	1975-04-05	1993-02-01	Akzo Nv	Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
US6545149B2 (en)	1999-04-19	2003-04-08	Teva Pharmaceutical Industries Ltd.	Synthesis and crystallization of piperazine ring-containing compounds
CA2368815A1 (en)	1999-04-19	2000-10-26	Claude Singer	Novel synthesis and crystallization of piperazine ring-containing compounds
WO2001038329A1 (en) *	1999-11-24	2001-05-31	Sumika Fine Chemicals Co., Ltd.	Anhydrous mirtazapine crystals and process for producing the same
US6660730B2 (en)	2000-11-27	2003-12-09	Sumika Fine Chemicals Co., Ltd.	Anhydrous mirtazapine and process for preparing the same
US6434049B1 (en) *	2000-12-29	2002-08-13	Intel Corporation	Sample and hold voltage reference source
UA83666C2 (ru)	2003-07-10	2008-08-11	Н.В. Органон	Способ получения энантиомерно чистого миртазапина

2007
- 2007-03-22 JP JP2007075573A patent/JP5192707B2/ja not_active Expired - Fee Related
2008
- 2008-03-13 PT PT08722032T patent/PT2135870E/pt unknown
- 2008-03-13 KR KR1020097006525A patent/KR101418620B1/ko not_active Expired - Fee Related
- 2008-03-13 AU AU2008227637A patent/AU2008227637B2/en not_active Ceased
- 2008-03-13 DK DK08722032.3T patent/DK2135870T3/da active
- 2008-03-13 PL PL08722032T patent/PL2135870T3/pl unknown
- 2008-03-13 ES ES08722032T patent/ES2386165T3/es active Active
- 2008-03-13 WO PCT/JP2008/054628 patent/WO2008114691A1/ja not_active Ceased
- 2008-03-13 BR BRPI0805835-0A patent/BRPI0805835A2/pt not_active IP Right Cessation
- 2008-03-13 EP EP08722032A patent/EP2135870B1/de not_active Not-in-force
- 2008-03-13 US US12/443,662 patent/US8173804B2/en not_active Expired - Fee Related
- 2008-03-13 CA CA002664286A patent/CA2664286A1/en not_active Abandoned
- 2008-03-13 CN CN2008800007408A patent/CN101541798B/zh not_active Expired - Fee Related
- 2008-03-13 AT AT08722032T patent/ATE555114T1/de active
2009
- 2009-03-04 ZA ZA2009/01559A patent/ZA200901559B/en unknown
- 2009-03-12 IL IL197572A patent/IL197572A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU2008227637A1 (en)	2008-09-25
EP2135870A4 (de)	2011-06-08
CN101541798B (zh)	2011-09-14
JP2008231062A (ja)	2008-10-02
CA2664286A1 (en)	2008-09-25
US20100029934A1 (en)	2010-02-04
IL197572A (en)	2013-03-24
IL197572A0 (en)	2009-12-24
PT2135870E (pt)	2012-05-11
ES2386165T3 (es)	2012-08-10
EP2135870B1 (de)	2012-04-25
WO2008114691A1 (ja)	2008-09-25
JP5192707B2 (ja)	2013-05-08
KR20090121270A (ko)	2009-11-25
EP2135870A1 (de)	2009-12-23
US8173804B2 (en)	2012-05-08
KR101418620B1 (ko)	2014-07-14
AU2008227637B2 (en)	2012-02-16
BRPI0805835A2 (pt)	2011-08-30
DK2135870T3 (da)	2012-07-16
PL2135870T3 (pl)	2012-07-31
ZA200901559B (en)	2010-02-24
CN101541798A (zh)	2009-09-23

Similar Documents

Publication	Publication Date	Title
JOP20210064B1 (ar)	2024-12-22	طريقة لانتاج ( z)-ألفا-فلورو-بيتا-أمينو-أكريل الدهيدات مستبدلة
ATE446941T1 (de)	2009-11-15	Verfahren zur gekoppelten herstellung von chlor und isocyanaten
ATE555114T1 (de)	2012-05-15	Verfahren zur herstellung von mirtazapin
IN2012DN03176A (de)	2015-09-25
EA201200652A1 (ru)	2012-12-28	Способ получения кальцобутрола
EP2123636A4 (de)	2010-12-15	Verfahren zur herstellung eines aminoacetylpyrrolidincarbonitrilderivats
DE602007003024D1 (de)	2009-12-10	Neues verfahren zur salzherstellung
ATE487702T1 (de)	2010-11-15	Verfahren zum herstellen von 3-dihalomethyl- pyrazol-4-carbonsäurederivaten
EP2592064A4 (de)	2013-12-25	Verfahren zur herstellung eines gereinigten chlorogensäurehaltigen pharmazeutischen präparats
NZ751256A (en)	2020-05-29	Method for producing the crystalline form of modification a of calcobutrol
ATE499320T1 (de)	2011-03-15	Verfahren zur herstellung von wasserstoffperoxid
ATE550296T1 (de)	2012-04-15	Verfahren zur herstellung von hochreiner phosphorsäure
EP2660246A4 (de)	2014-09-10	Verbindung, nukleinsäure, verfahren zur herstellung der nukleinsäure und kit zur herstellung der nukleinsäure
DE602007007743D1 (de)	2010-08-26	Verfahren zur herstellung eines organischen hydroperoxids, industrielle einrichtung dafür und verfahren mittels verwendung eines derartigen hydroperoxids zur herstellung eines alkylenoxids
EA200971019A1 (ru)	2010-04-30	Способы получения (r)-2-метилпирролидина и (s)-2-метилпирролидина и их солей винной кислоты
RU2010142809A (ru)	2012-04-27	Способ получения синтетического диоксида кремния высокой чистоты
CY1114331T1 (el)	2016-08-31	Μεθοδος για την παρασκευη αμιδιων καρβοξυλικου οξεος χρησιμων στη θεραπευτικη αγωγη μυϊκων παθησεων
DE602005013007D1 (de)	2009-04-09	Verfahren zur herstellung von lactonen
AR090916A1 (es)	2014-12-17	Metodo para la fabricacion de naltrexona
ATE533758T1 (de)	2011-12-15	Verfahren zur herstellung von enantiomerenreinem esomeprazol
IN2012DN04967A (de)	2015-09-25
ATE512143T1 (de)	2011-06-15	Verbessertes verfahren zur herstellung von nevirapin
ATE466010T1 (de)	2010-05-15	Verfahren zur herstellung von candesartan
ATE543820T1 (de)	2012-02-15	Verfahren zur herstellung von 2,3,4,9-tetrahydro- 1h-beta-carbolin-3-carbonsäureestern
MY193062A (en)	2022-09-26	Process for preparing indigo carmine