ATE555194T1 - Methode zur herstellung von proliferierenden und differenzierenden zelllinien - Google Patents

Methode zur herstellung von proliferierenden und differenzierenden zelllinien

Info

Publication number
ATE555194T1
ATE555194T1 AT02788154T AT02788154T ATE555194T1 AT E555194 T1 ATE555194 T1 AT E555194T1 AT 02788154 T AT02788154 T AT 02788154T AT 02788154 T AT02788154 T AT 02788154T AT E555194 T1 ATE555194 T1 AT E555194T1
Authority
AT
Austria
Prior art keywords
cell lines
differentiating cell
proliferating
producing
producing proliferating
Prior art date
Application number
AT02788154T
Other languages
English (en)
Inventor
Hergen Spits
M Naspetti
Ferenc Scheeren
Bianca Blom
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0130223A external-priority patent/GB0130223D0/en
Priority claimed from GB0206086A external-priority patent/GB0206086D0/en
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Application granted granted Critical
Publication of ATE555194T1 publication Critical patent/ATE555194T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0635—B lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/48—Regulators of apoptosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/52—CD40, CD40-ligand (CD154)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Electrotherapy Devices (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Ceramic Products (AREA)
AT02788154T 2001-12-18 2002-12-18 Methode zur herstellung von proliferierenden und differenzierenden zelllinien ATE555194T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0130223A GB0130223D0 (en) 2001-12-18 2001-12-18 Materials and methods relating to the production and maintenance of cell lines
GB0206086A GB0206086D0 (en) 2002-03-14 2002-03-14 Materials and methods relating to the production and maintenance of cell lines
PCT/GB2002/005753 WO2003052083A2 (en) 2001-12-18 2002-12-18 Methods for the generation of proliferating and differentiating cell lines

Publications (1)

Publication Number Publication Date
ATE555194T1 true ATE555194T1 (de) 2012-05-15

Family

ID=26246880

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02788154T ATE555194T1 (de) 2001-12-18 2002-12-18 Methode zur herstellung von proliferierenden und differenzierenden zelllinien

Country Status (10)

Country Link
US (2) US8318487B2 (de)
EP (2) EP2141228A1 (de)
JP (3) JP4818585B2 (de)
AT (1) ATE555194T1 (de)
AU (1) AU2002352436B2 (de)
DK (1) DK1458855T3 (de)
ES (1) ES2384960T3 (de)
NZ (1) NZ534107A (de)
SI (1) SI1458855T1 (de)
WO (1) WO2003052083A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060177932A1 (en) * 2002-11-08 2006-08-10 Hiromitsu Nakauchi Expansion agents for stem cells
DK1692276T3 (da) * 2003-11-19 2010-11-01 Us Gov Health & Human Serv Fremgangsmåde til induktion af udvikling og terminal differentiering af hukommelses-B-celler
JP2008509663A (ja) * 2004-08-10 2008-04-03 アカデミシュ メディシュ セントラム ビ デ ユニベルシテイト ファン アムステルダム 関心のある安定化された細胞を生産するための手段及び方法
EP1627563A1 (de) * 2004-08-10 2006-02-22 Academisch Medisch Centrum bij de Universiteit van Amsterdam Verfahren und Mittel zur Herstellung einer stabilisierten Zelle
US8383364B2 (en) 2005-11-17 2013-02-26 Tet Systems Gmbh & Co. Kg Inducible expression systems
USRE49583E1 (en) 2005-11-17 2023-07-18 Tet Systems Gmbh & Co. Kg Inducible expression systems
AU2006323315B2 (en) * 2005-12-09 2014-02-20 Kling Biotherapeutics B.V. Means and methods for influencing the stability of antibody producing cells
WO2007067032A1 (en) 2005-12-09 2007-06-14 Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam Means and methods for influencing the stability of cells
EP1997830A1 (de) * 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV-spezifische Bindemoleküle und Mittel zu ihrer Herstellung
WO2010053987A2 (en) * 2008-11-04 2010-05-14 Duke University Monoclonal antibody production in b cells and uses therof
US9273118B2 (en) 2009-07-15 2016-03-01 Aimm Therapeutics B.V. Means and methods for producing high affinity antibodies
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
ES2626671T3 (es) 2010-12-02 2017-07-25 Aimm Therapeutics B.V. Medios y métodos para producir anticuerpos de alta afinidad
JP6747975B2 (ja) 2014-01-31 2020-08-26 アイム・セラピューティクス・べー・フェー 安定な抗体を産生するための手段及び方法
WO2016002760A1 (ja) 2014-07-02 2016-01-07 学校法人東京理科大学 Ｂ細胞集団の製造方法
EP4149966A4 (de) * 2020-05-14 2024-08-07 Seattle Children's Hospital (DBA Seattle Children's Research Institute) Doppelpromotorsysteme
EP4341283A4 (de) * 2021-05-14 2025-06-25 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Aktivitätsinduzierbare fusionsproteine mit einem transkriptionsfaktor und einer hitzeschockprotein 90-bindungsdomäne

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0616640B1 (de) 1991-12-02 2004-09-01 Medical Research Council Herstellung von Antikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken.
CA2188165C (en) 1994-04-28 2007-08-28 Marilyn Kehry Methods for proliferating and differentiating b cells, and uses thereof
DE19541844C1 (de) 1995-11-09 1997-07-24 Gsf Forschungszentrum Umwelt Verfahren zur Herstellung von menschlichen Antikörpern und deren Verwendung
AU2736400A (en) * 1999-01-27 2000-08-18 University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy
US6159694A (en) * 1999-04-08 2000-12-12 Isis Pharmaceuticals Inc. Antisense modulation of stat3 expression
US20020090692A1 (en) * 1999-09-30 2002-07-11 Prayaga Sudhirdas K. Novel polynucleotides and polypeptides encoded thereby
JP2004537293A (ja) * 2001-05-31 2004-12-16 ノバルティス アクチエンゲゼルシャフト 新規なエストロゲン受容体リガンド結合ドメイン変異体及び新規なリガンド及び医薬組成物
DK1417231T3 (da) * 2001-07-23 2013-07-22 Immunex Corp Modificeret human thymisk stromal lymphopoietin

Also Published As

Publication number Publication date
US8389281B2 (en) 2013-03-05
ES2384960T3 (es) 2012-07-16
EP1458855B1 (de) 2012-04-25
DK1458855T3 (da) 2012-07-23
US20060153820A1 (en) 2006-07-13
WO2003052083A3 (en) 2003-11-27
WO2003052083A2 (en) 2003-06-26
EP2141228A1 (de) 2010-01-06
AU2002352436B2 (en) 2008-05-22
US20090275139A1 (en) 2009-11-05
JP2009142292A (ja) 2009-07-02
SI1458855T1 (sl) 2012-08-31
JP2012235795A (ja) 2012-12-06
NZ534107A (en) 2007-02-23
JP2005512540A (ja) 2005-05-12
US8318487B2 (en) 2012-11-27
AU2002352436A1 (en) 2003-06-30
JP4818585B2 (ja) 2011-11-16
EP1458855A2 (de) 2004-09-22

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