ATE556049T1 - Prolinamidderivate als natirumkanalmodulatoren - Google Patents

Prolinamidderivate als natirumkanalmodulatoren

Info

Publication number
ATE556049T1
ATE556049T1 AT06806110T AT06806110T ATE556049T1 AT E556049 T1 ATE556049 T1 AT E556049T1 AT 06806110 T AT06806110 T AT 06806110T AT 06806110 T AT06806110 T AT 06806110T AT E556049 T1 ATE556049 T1 AT E556049T1
Authority
AT
Austria
Prior art keywords
sodium channel
channel modulators
prolinamide derivatives
prolinamide
derivatives
Prior art date
Application number
AT06806110T
Other languages
English (en)
Inventor
Giuseppe Alvaro
Markus Bergauer
Riccardo Giovannini
Roberto Profeta
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0520581A external-priority patent/GB0520581D0/en
Priority claimed from GB0523045A external-priority patent/GB0523045D0/en
Priority claimed from GB0603900A external-priority patent/GB0603900D0/en
Priority claimed from GB0618336A external-priority patent/GB0618336D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE556049T1 publication Critical patent/ATE556049T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
AT06806110T 2005-10-10 2006-10-06 Prolinamidderivate als natirumkanalmodulatoren ATE556049T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0520581A GB0520581D0 (en) 2005-10-10 2005-10-10 Novel compounds
GB0523045A GB0523045D0 (en) 2005-11-11 2005-11-11 Novel compounds
GB0603900A GB0603900D0 (en) 2006-02-27 2006-02-27 Novel compounds
GB0618336A GB0618336D0 (en) 2006-09-18 2006-09-18 Novel compounds
PCT/EP2006/009731 WO2007042239A1 (en) 2005-10-10 2006-10-06 Prolinamide derivatives as sodium channel modulators

Publications (1)

Publication Number Publication Date
ATE556049T1 true ATE556049T1 (de) 2012-05-15

Family

ID=37546777

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06806110T ATE556049T1 (de) 2005-10-10 2006-10-06 Prolinamidderivate als natirumkanalmodulatoren

Country Status (20)

Country Link
US (2) US7655693B2 (de)
EP (1) EP1934177B8 (de)
JP (1) JP5139305B2 (de)
KR (1) KR101282464B1 (de)
AR (1) AR056575A1 (de)
AT (1) ATE556049T1 (de)
AU (1) AU2006301470B2 (de)
BR (1) BRPI0616944B8 (de)
CA (1) CA2625642C (de)
CR (1) CR9898A (de)
EA (1) EA015736B1 (de)
ES (1) ES2387405T3 (de)
IL (1) IL192627A0 (de)
MA (1) MA29817B1 (de)
NO (1) NO20082145L (de)
NZ (1) NZ567051A (de)
PE (1) PE20070592A1 (de)
PL (1) PL1934177T3 (de)
TW (1) TW200730494A (de)
WO (1) WO2007042239A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1943216B1 (de) * 2005-10-10 2010-06-30 Glaxo Group Limited Prolinamidderivate als natriumkanalmodulatoren
US8143306B2 (en) * 2005-10-10 2012-03-27 Convergence Pharmaceuticals Limited Methods of treating bipolar disorders
GB0701365D0 (en) * 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) * 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
WO2011015537A1 (en) * 2009-08-05 2011-02-10 Glaxo Group Limited Co-therapy for the treatment of epilepsy and related disorders
PT2477964E (pt) * 2009-09-14 2015-06-04 Convergence Pharmaceuticals Processo para a preparação de derivados de alfa-carboxamida
EP3009427B1 (de) 2011-03-03 2019-12-18 Zalicus Pharmaceuticals Ltd. Benzimidazolhemmer des natriumkanals
GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
CN106255679B (zh) 2014-02-27 2019-09-06 默克专利有限公司 用作nav通道抑制剂的杂环化合物及其用途
GB201417497D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417500D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417499D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
ES2912881T3 (es) * 2014-12-23 2022-05-30 Convergence Pharmaceuticals Procedimiento para preparar derivados de alfa-carboxamida pirrolidina
MX2019005121A (es) * 2016-11-02 2019-10-07 Biogen Ma Inc Novedoso regimen de dosificacion.
MX2019013758A (es) * 2017-05-19 2020-07-20 Biogen Ma Inc Formas cristalinas novedosas.
JP2020536870A (ja) * 2017-10-05 2020-12-17 バイオジェン インコーポレイテッド アルファカルボキサミドピロリジン誘導体の調製方法
KR20200068678A (ko) 2017-10-10 2020-06-15 바이오젠 인크. 스피로 유도체를 제조하기 위한 공정
KR20210002472A (ko) * 2018-04-16 2021-01-08 바이오젠 엠에이 인코포레이티드 신경병증성 통증을 치료하는 방법
CA3136536A1 (en) * 2019-04-10 2020-10-15 Biogen Ma Inc. Process for preparing alpha-carboxamide pyrrolidine derivatives
EP3953328A4 (de) * 2019-04-10 2023-03-08 Biogen Inc. Verfahren zur herstellung von alpha-carboxamid-pyrolidin-derivaten
EP4096508A4 (de) 2020-01-30 2024-03-27 Javed, Mohammad Kombinationsarzneitherapien für zns-erkrankungen

Family Cites Families (25)

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Publication number Priority date Publication date Assignee Title
IL94466A (en) 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US6201016B1 (en) 1994-06-27 2001-03-13 Cytomed Incorporated Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US6136131A (en) * 1998-06-02 2000-10-24 Instrument Specialties Company, Inc. Method of shielding and obtaining access to a component on a printed circuit board
UA72244C2 (en) 1999-03-26 2005-02-15 Aryl-substituted pyrazols, imidazols, oxazols, thiazols, pyrrols and their use
GB9923748D0 (en) * 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
GB0115517D0 (en) * 2001-06-25 2001-08-15 Ferring Bv Novel antidiabetic agents
TW200404796A (en) * 2002-08-19 2004-04-01 Ono Pharmaceutical Co Nitrogen-containing compound
MY134480A (en) 2002-09-20 2007-12-31 Hoffmann La Roche 4-pyrrolidino-phenyl-benzyl ether derivatives
AR044503A1 (es) 2003-03-18 2005-09-14 Merck & Co Inc Triazoles sustituidos con biarilo como bloqueantes del canal de sodio
US7589116B2 (en) 2003-04-03 2009-09-15 Merck & Co. Inc. Biaryl substituted pyrazoles as sodium channel blockers
JP2006523701A (ja) * 2003-04-18 2006-10-19 メルク　エンド　カムパニー　インコーポレーテッド ナトリウムチャネルブロッカーとしてのビアリール置換チアゾール、オキサゾール、およびイミダゾール
WO2005000309A2 (en) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
EP1524265A1 (de) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Prolinamide-Derivate als Natrium- und/oder Kalziumkanalblocker oder selektive MAO-B Inhibitoren
WO2005100334A1 (en) * 2004-04-14 2005-10-27 Pfizer Products Inc. Dipeptidyl peptidase-iv inhibitors
EP1877385A1 (de) 2005-05-04 2008-01-16 Vertex Pharmaceuticals Incorporated Pyrimidine und pyrazine zur verwendung als modulatoren von ionenkanälen
WO2006119390A1 (en) 2005-05-04 2006-11-09 Vertex Pharmaceuticals Incorporated Pyridines useful as modulators of ion channels
JP2008540665A (ja) 2005-05-19 2008-11-20 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なビアリール
HRP20110457T1 (hr) * 2005-09-09 2011-07-31 Glaxosmithkline Llc Derivati piridina i njihova upotreba u liječenju psihotičnih poremećaja
TW200728258A (en) * 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
EP1943216B1 (de) 2005-10-10 2010-06-30 Glaxo Group Limited Prolinamidderivate als natriumkanalmodulatoren
GB0701366D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
JP2010516734A (ja) 2007-01-24 2010-05-20 グラクソ グループ リミテッド ３，５−ジアミノ−６−（２，３−ジクロロフェニル）−１，２，４−トリアジンまたはｒ（−）−２，４−ジアミノ−５−（２，３−ジクロロフェニル）−６−フルオロメチルピリミジンを含む医薬組成物
GB0701365D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
CR9898A (es) 2008-07-29
JP2009511519A (ja) 2009-03-19
PE20070592A1 (es) 2007-06-23
US20080280969A1 (en) 2008-11-13
KR101282464B1 (ko) 2013-07-04
KR20080059296A (ko) 2008-06-26
PL1934177T3 (pl) 2013-03-29
TW200730494A (en) 2007-08-16
WO2007042239A1 (en) 2007-04-19
EA015736B1 (ru) 2011-10-31
CA2625642A1 (en) 2007-04-19
AU2006301470A1 (en) 2007-04-19
IL192627A0 (en) 2011-08-01
JP5139305B2 (ja) 2013-02-06
ES2387405T3 (es) 2012-09-21
US8153681B2 (en) 2012-04-10
AR056575A1 (es) 2007-10-10
CA2625642C (en) 2013-12-24
NO20082145L (no) 2008-05-07
US20100105754A1 (en) 2010-04-29
NZ567051A (en) 2011-03-31
EP1934177B8 (de) 2012-09-05
MA29817B1 (fr) 2008-09-01
AU2006301470B2 (en) 2012-06-14
BRPI0616944B1 (pt) 2020-04-14
EP1934177B1 (de) 2012-05-02
US7655693B2 (en) 2010-02-02
EP1934177A1 (de) 2008-06-25
BRPI0616944A2 (pt) 2011-07-05
EA200801054A1 (ru) 2008-08-29
BRPI0616944B8 (pt) 2021-05-25

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