ATE510831T1 - Hydrierte benzoäcüthiophenderivate als immunmodulatoren - Google Patents

Hydrierte benzoäcüthiophenderivate als immunmodulatoren

Info

Publication number: ATE510831T1
Authority: AT; Austria
Prior art keywords: benzocethiophene; hydrogenated; derivatives; immune modulators; modulators
Prior art date: 2005-03-23

Application number

AT06727679T

Other languages

English (en)

Inventor

Martin Bolli

David Lehmann

Boris Mathys

Claus Mueller

Oliver Nayler

Joerg Velker

Thomas Weller

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-23

Filing date

2006-03-20

Publication date

2011-06-15

2006-03-20 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2011-06-15 Application granted granted Critical

2011-06-15 Publication of ATE510831T1 publication Critical patent/ATE510831T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Transplantation (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT06727679T 2005-03-23 2006-03-20 Hydrierte benzoäcüthiophenderivate als immunmodulatoren ATE510831T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP2005003071		2005-03-23
PCT/IB2006/050845 WO2006100631A1 (en)	2005-03-23	2006-03-20	Hydrogenated benzo (c) thiophene derivatives as immunomodulators

Publications (1)

Publication Number	Publication Date
ATE510831T1 true ATE510831T1 (de)	2011-06-15

Family

ID=36592888

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06727679T ATE510831T1 (de)	2005-03-23	2006-03-20	Hydrierte benzoäcüthiophenderivate als immunmodulatoren

Country Status (26)

Country	Link
US (2)	US7723378B2 (de)
EP (1)	EP1863787B1 (de)
JP (1)	JP5047941B2 (de)
KR (1)	KR101382733B1 (de)
CN (1)	CN101180290B (de)
AR (1)	AR053452A1 (de)
AT (1)	ATE510831T1 (de)
AU (1)	AU2006226018B2 (de)
BR (1)	BRPI0609515A8 (de)
CA (1)	CA2602474C (de)
CY (1)	CY1111767T1 (de)
DK (1)	DK1863787T3 (de)
ES (1)	ES2365747T3 (de)
HR (1)	HRP20110613T1 (de)
IL (1)	IL186148A (de)
MX (1)	MX2007011670A (de)
MY (1)	MY147949A (de)
NO (1)	NO340192B1 (de)
NZ (1)	NZ562562A (de)
PL (1)	PL1863787T3 (de)
PT (1)	PT1863787E (de)
RU (1)	RU2412179C2 (de)
SI (1)	SI1863787T1 (de)
TW (1)	TWI402262B (de)
WO (1)	WO2006100631A1 (de)
ZA (1)	ZA200709088B (de)

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JP4678139B2 (ja) *	2004-05-10	2011-04-27	トヨタ自動車株式会社	自動車の暖房制御システム
WO2006010379A1 (en)	2004-07-29	2006-02-02	Actelion Pharmaceuticals Ltd.	Novel thiophene derivatives as immunosuppressive agents
BRPI0609668A2 (pt) *	2005-03-23	2011-10-18	Actelion Pharmaceuticals Ltd	composto, composição farmacêutica, e, uso de um composto
KR20080002850A (ko) *	2005-03-23	2008-01-04	액테리온 파마슈티칼 리미티드	신규한 티오펜 유도체
AU2006260573A1 (en) *	2005-06-24	2006-12-28	Actelion Pharmaceuticals Ltd.	Novel thiophene derivatives
AR057894A1 (es)	2005-11-23	2007-12-26	Actelion Pharmaceuticals Ltd	Derivados de tiofeno
TWI404706B (zh) *	2006-01-11	2013-08-11	Actelion Pharmaceuticals Ltd	新穎噻吩衍生物
KR20080092385A (ko)	2006-01-24	2008-10-15	액테리온 파마슈티칼 리미티드	신규한 피리딘 유도체
CL2007002593A1 (es) *	2006-09-07	2008-06-13	Actelion Pharmaceuticals Ltd	Compuestos derivados de 4-heteroaril-piridina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como rechazo de organos transplantados, sindromes autoinmunes y cancer.
AR061841A1 (es) *	2006-09-07	2008-09-24	Actelion Pharmaceuticals Ltd	Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores.
SI2069335T1 (sl) *	2006-09-08	2013-04-30	Actelion Pharmaceuticals Ltd.	Derivati piridin-3-ila kot imunomodulacijska sredstva
EP2069318B1 (de) *	2006-09-21	2012-09-12	Actelion Pharmaceuticals Ltd.	Phenylderivate und ihre verwendung als immunmodulatoren
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BRPI0820868A2 (pt) *	2007-12-10	2019-09-24	Actelion Pharmaceuticals Ltd	composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado
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SI2252609T1 (sl) *	2008-03-07	2013-07-31	Actelion Pharmaceuticals Ltd.	Derivati piridin-2-ila kot imunomodulacijska sredstva
WO2009115954A1 (en)	2008-03-17	2009-09-24	Actelion Pharmaceuticals Ltd	Dosing regimen for a selective s1p1 receptor agonist
HRP20161133T1 (hr)	2008-07-23	2016-12-02	Arena Pharmaceuticals, Inc.	DERIVATI SUSPSTITUIRANE 1,2,3,4-TETRAHIDROCIKLOPENTA[b]INDOL-3-IL-OCTENE KISELINE KORISNI U LIJEČENJU AUTOIMUNIH I UPALNIH POREMEĆAJA
CN105816453B (zh)	2008-08-27	2021-03-05	艾尼纳制药公司	用于治疗自身免疫性病症和炎性病症的作为s1p1受体激动剂的经取代的三环酸衍生物
WO2010085584A1 (en)	2009-01-23	2010-07-29	Bristol-Myers Squibb Company	Pyrazole-i, 2, 4 -oxad iazole derivatives as s.phing0sine-1-ph0sphate agonists
WO2010085581A1 (en)	2009-01-23	2010-07-29	Bristol-Myers Squibb Company	Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
WO2010085582A1 (en)	2009-01-23	2010-07-29	Bristol-Myers Squibb Company	Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
KR101409131B1 (ko)	2009-07-16	2014-06-17	액테리온 파마슈티칼 리미티드	피리딘-4-일 유도체
US8399451B2 (en)	2009-08-07	2013-03-19	Bristol-Myers Squibb Company	Heterocyclic compounds
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CN105503882B (zh)	2010-03-03	2019-07-05	艾尼纳制药公司	制备s1p1受体调节剂及其晶体形式的方法
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SG191742A1 (en)	2011-01-19	2013-08-30	Actelion Pharmaceuticals Ltd	2-methoxy-pyridin-4-yl derivatives
IN2015MN00002A (de)	2012-07-09	2015-10-16	Lupin Ltd
SMT202000298T1 (it)	2012-08-17	2020-07-08	Actelion Pharmaceuticals Ltd	Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo
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US10111841B2 (en)	2015-06-19	2018-10-30	University Of South Florida	Stabilization of alcohol intoxication-induced cardiovascular instability
PL3310760T3 (pl)	2015-06-22	2023-03-06	Arena Pharmaceuticals, Inc.	Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
KR20190116416A (ko)	2017-02-16	2019-10-14	아레나 파마슈티칼스, 인크.	원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
JP2020507610A (ja)	2017-02-16	2020-03-12	アリーナファーマシューティカルズ，インコーポレイテッド	腸管外症状を伴う炎症性腸疾患の治療のための化合物および方法
AU2019280822A1 (en)	2018-06-06	2021-01-07	Arena Pharmaceuticals, Inc.	Methods of treating conditions related to the S1P1 receptor
EP3847158A1 (de)	2018-09-06	2021-07-14	Arena Pharmaceuticals, Inc.	Verbindungen zur verwendung bei der behandlung von autoimmun- und entzündlichen erkrankungen
KR20240018890A (ko)	2022-08-03	2024-02-14	이진수	절개선을 갖는 종이 원단의 연신 특성을 이용한 과일 트레이 제조방법 및 이로부터 제조된 친환경 과일 트레이
KR20240078837A (ko)	2022-11-28	2024-06-04	이진수	폐지를 활용한 임산물 트레이 제조방법 및 이로부터 제조된 친환경 임산물 트레이

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2006
- 2006-03-20 AU AU2006226018A patent/AU2006226018B2/en not_active Ceased
- 2006-03-20 RU RU2007138875/04A patent/RU2412179C2/ru not_active IP Right Cessation
- 2006-03-20 SI SI200631088T patent/SI1863787T1/sl unknown
- 2006-03-20 DK DK06727679.0T patent/DK1863787T3/da active
- 2006-03-20 ES ES06727679T patent/ES2365747T3/es not_active Expired - Lifetime
- 2006-03-20 US US11/909,429 patent/US7723378B2/en not_active Expired - Fee Related
- 2006-03-20 EP EP06727679A patent/EP1863787B1/de not_active Expired - Lifetime
- 2006-03-20 AT AT06727679T patent/ATE510831T1/de active
- 2006-03-20 CA CA2602474A patent/CA2602474C/en not_active Expired - Fee Related
- 2006-03-20 MX MX2007011670A patent/MX2007011670A/es active IP Right Grant
- 2006-03-20 HR HR20110613T patent/HRP20110613T1/hr unknown
- 2006-03-20 PT PT06727679T patent/PT1863787E/pt unknown
- 2006-03-20 PL PL06727679T patent/PL1863787T3/pl unknown
- 2006-03-20 NZ NZ562562A patent/NZ562562A/en not_active IP Right Cessation
- 2006-03-20 WO PCT/IB2006/050845 patent/WO2006100631A1/en not_active Ceased
- 2006-03-20 KR KR1020077024309A patent/KR101382733B1/ko not_active Expired - Fee Related
- 2006-03-20 CN CN2006800172389A patent/CN101180290B/zh not_active Expired - Fee Related
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Publication number	Publication date
JP2008534490A (ja)	2008-08-28
JP5047941B2 (ja)	2012-10-10
PT1863787E (pt)	2011-07-29
IL186148A (en)	2012-05-31
CA2602474A1 (en)	2006-09-28
KR20080003360A (ko)	2008-01-07
ZA200709088B (en)	2008-09-25
BRPI0609515A2 (pt)	2010-04-13
KR101382733B1 (ko)	2014-04-14
CA2602474C (en)	2014-06-10
US8039644B2 (en)	2011-10-18
HRP20110613T1 (hr)	2011-09-30
ES2365747T3 (es)	2011-10-10
US20080176926A1 (en)	2008-07-24
AU2006226018B2 (en)	2012-07-12
MX2007011670A (es)	2007-11-15
CN101180290B (zh)	2012-12-12
TWI402262B (zh)	2013-07-21
NZ562562A (en)	2010-11-26
RU2412179C2 (ru)	2011-02-20
SI1863787T1 (sl)	2011-10-28
NO20075299L (no)	2007-12-27
IL186148A0 (en)	2008-01-20
AR053452A1 (es)	2007-05-09
EP1863787A1 (de)	2007-12-12
DK1863787T3 (da)	2011-08-01
NO340192B1 (no)	2017-03-20
US7723378B2 (en)	2010-05-25
RU2007138875A (ru)	2009-04-27
US20100204198A1 (en)	2010-08-12
MY147949A (en)	2013-02-15
EP1863787B1 (de)	2011-05-25
PL1863787T3 (pl)	2011-10-31
BRPI0609515A8 (pt)	2017-12-26
CN101180290A (zh)	2008-05-14
WO2006100631A1 (en)	2006-09-28
CY1111767T1 (el)	2015-10-07
AU2006226018A1 (en)	2006-09-28
TW200716591A (en)	2007-05-01

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