ATE510831T1 - Hydrierte benzoäcüthiophenderivate als immunmodulatoren - Google Patents

Hydrierte benzoäcüthiophenderivate als immunmodulatoren

Info

Publication number: ATE510831T1
Authority: AT; Austria
Prior art keywords: benzocethiophene; hydrogenated; derivatives; immune modulators; modulators
Prior art date: 2005-03-23

Application number

AT06727679T

Other languages

English (en)

Inventor

Martin Bolli

David Lehmann

Boris Mathys

Claus Mueller

Oliver Nayler

Joerg Velker

Thomas Weller

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-23

Filing date

2006-03-20

Publication date

2011-06-15

2006-03-20 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2011-06-15 Application granted granted Critical

2011-06-15 Publication of ATE510831T1 publication Critical patent/ATE510831T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT06727679T 2005-03-23 2006-03-20 Hydrierte benzoäcüthiophenderivate als immunmodulatoren ATE510831T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP2005003071		2005-03-23
PCT/IB2006/050845 WO2006100631A1 (en)	2005-03-23	2006-03-20	Hydrogenated benzo (c) thiophene derivatives as immunomodulators

Publications (1)

Publication Number	Publication Date
ATE510831T1 true ATE510831T1 (de)	2011-06-15

Family

ID=36592888

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06727679T ATE510831T1 (de)	2005-03-23	2006-03-20	Hydrierte benzoäcüthiophenderivate als immunmodulatoren

Country Status (26)

Country	Link
US (2)	US7723378B2 (de)
EP (1)	EP1863787B1 (de)
JP (1)	JP5047941B2 (de)
KR (1)	KR101382733B1 (de)
CN (1)	CN101180290B (de)
AR (1)	AR053452A1 (de)
AT (1)	ATE510831T1 (de)
AU (1)	AU2006226018B2 (de)
BR (1)	BRPI0609515A8 (de)
CA (1)	CA2602474C (de)
CY (1)	CY1111767T1 (de)
DK (1)	DK1863787T3 (de)
ES (1)	ES2365747T3 (de)
HR (1)	HRP20110613T1 (de)
IL (1)	IL186148A (de)
MX (1)	MX2007011670A (de)
MY (1)	MY147949A (de)
NO (1)	NO340192B1 (de)
NZ (1)	NZ562562A (de)
PL (1)	PL1863787T3 (de)
PT (1)	PT1863787E (de)
RU (1)	RU2412179C2 (de)
SI (1)	SI1863787T1 (de)
TW (1)	TWI402262B (de)
WO (1)	WO2006100631A1 (de)
ZA (1)	ZA200709088B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4678139B2 (ja) *	2004-05-10	2011-04-27	トヨタ自動車株式会社	自動車の暖房制御システム
WO2006010379A1 (en)	2004-07-29	2006-02-02	Actelion Pharmaceuticals Ltd.	Novel thiophene derivatives as immunosuppressive agents
US7605269B2 (en) *	2005-03-23	2009-10-20	Actelion Pharmaceuticals Ltd.	Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists
KR20080002850A (ko)	2005-03-23	2008-01-04	액테리온 파마슈티칼 리미티드	신규한 티오펜 유도체
US7951794B2 (en) *	2005-06-24	2011-05-31	Actelion Pharmaceuticals Ltd.	Thiophene derivatives
AR057894A1 (es) *	2005-11-23	2007-12-26	Actelion Pharmaceuticals Ltd	Derivados de tiofeno
TWI404706B (zh) *	2006-01-11	2013-08-11	Actelion Pharmaceuticals Ltd	新穎噻吩衍生物
AU2007209051A1 (en) *	2006-01-24	2007-08-02	Actelion Pharmaceuticals Ltd	Novel pyridine derivatives
PT2069336E (pt) *	2006-09-07	2013-03-07	Actelion Pharmaceuticals Ltd	Derivados de piridin-4-ilo como agentes imunomoduladores
AR061841A1 (es) *	2006-09-07	2008-09-24	Actelion Pharmaceuticals Ltd	Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores.
PL2069335T3 (pl) *	2006-09-08	2013-05-31	Actelion Pharmaceuticals Ltd	Pochodne pirydyn-3-ylu jako środki immunomodulujące
ES2393412T3 (es)	2006-09-21	2012-12-21	Actelion Pharmaceuticals Ltd.	Derivados de fenilo y su uso como inmunomoduladores
BRPI0808789A2 (pt)	2007-03-16	2014-08-12	Actelion Pharmaceuticals Ltd	Compostos e composição farmacêutica de derivados aminopiridina e uso destes
MX2010005889A (es) *	2007-12-10	2010-06-22	Actelion Pharmaceuticals Ltd	Derivados de tiofeno como agonistas de s1p1/edg1.
PE20091339A1 (es) *	2007-12-21	2009-09-26	Glaxo Group Ltd	Derivados de oxadiazol con actividad sobre receptores s1p1
EP2262799B1 (de) *	2008-03-06	2012-07-04	Actelion Pharmaceuticals Ltd.	Pyridinverbindungen
WO2009109872A1 (en) *	2008-03-07	2009-09-11	Actelion Pharmaceuticals Ltd	Pyridin-2-yl derivatives as immunomodulating agents
PL2278960T5 (pl)	2008-03-17	2020-06-29	Actelion Pharmaceuticals Ltd.	Schemat dawkowania dla selektywnego agonisty receptora sip1
US8580841B2 (en)	2008-07-23	2013-11-12	Arena Pharmaceuticals, Inc.	Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
HRP20160890T1 (hr)	2008-08-27	2016-09-23	Arena Pharmaceuticals, Inc.	Derivati supstituirane tricikličke kiseline kao agonisti s1p1-receptora korisni u liječenju autoimunih i upalnih poremećaja
ES2405054T3 (es)	2009-01-23	2013-05-30	Bristol-Myers Squibb Company	Derivados de pirazol-1,2,4-oxadiazol como agonistas de esfingosina-1-fosfato
WO2010085582A1 (en)	2009-01-23	2010-07-29	Bristol-Myers Squibb Company	Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
JP2012515787A (ja)	2009-01-23	2012-07-12	ブリストル−マイヤーズスクイブカンパニー	自己免疫疾患および炎症性疾患の処置におけるｓ１ｐアゴニストとしての置換オキサジアゾール誘導体
CA2767585C (en)	2009-07-16	2017-09-26	Actelion Pharmaceuticals Ltd	Pyridin-4-yl derivatives
US8399451B2 (en)	2009-08-07	2013-03-19	Bristol-Myers Squibb Company	Heterocyclic compounds
JP5856980B2 (ja)	2010-01-27	2016-02-10	アリーナファーマシューティカルズ，インコーポレイテッド	（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸およびその塩の調製のためのプロセス
CN105503882B (zh)	2010-03-03	2019-07-05	艾尼纳制药公司	制备s1p1受体调节剂及其晶体形式的方法
EP2619190B1 (de)	2010-09-24	2015-08-12	Bristol-Myers Squibb Company	Substituierte oxadiazolverbindungen und ihre verwendung als s1p1-agonisten
MA34910B1 (fr)	2011-01-19	2014-02-01	Actelion Pharmaceuticals Ltd	Dérivés de 2-methoxy-pyridin-4-yl
ES2595240T3 (es)	2012-07-09	2016-12-28	Lupin Limited	Derivados de tetrahidroquinazolinona como inhibidores de PARP
SMT202000298T1 (it)	2012-08-17	2020-07-08	Actelion Pharmaceuticals Ltd	Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo
PL3242666T3 (pl)	2015-01-06	2025-02-17	Arena Pharmaceuticals, Inc.	Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1
PH12017502097B1 (en)	2015-05-20	2023-05-05	Idorsia Pharmaceuticals Ltd	Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol
US10111841B2 (en)	2015-06-19	2018-10-30	University Of South Florida	Stabilization of alcohol intoxication-induced cardiovascular instability
BR112017027656B1 (pt)	2015-06-22	2023-12-05	Arena Pharmaceuticals, Inc.	Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo
MX2019009843A (es)	2017-02-16	2020-01-30	Arena Pharm Inc	Compuestos y metodos para el tratamiento de la enfermedad inflamatoria intestinal con manifestaciones extraintestinales.
MX2019009841A (es)	2017-02-16	2020-01-30	Arena Pharm Inc	Compuestos y metodos para el tratamiento de la colangitis biliar primaria.
CA3102136A1 (en)	2018-06-06	2019-12-12	Arena Pharmaceuticals, Inc.	Methods of treating conditions related to the s1p1 receptor
CN112955431A (zh)	2018-09-06	2021-06-11	艾尼纳制药公司	可用于治疗自身免疫性病症和炎性病症的化合物
KR20240018890A (ko)	2022-08-03	2024-02-14	이진수	절개선을 갖는 종이 원단의 연신 특성을 이용한 과일 트레이 제조방법 및 이로부터 제조된 친환경 과일 트레이
KR20240078837A (ko)	2022-11-28	2024-06-04	이진수	폐지를 활용한 임산물 트레이 제조방법 및 이로부터 제조된 친환경 임산물 트레이

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1989480A (en) *	1932-06-27	1935-01-29	Associated Patents Inc	Process of preparing cereal foods
US2000615A (en) *	1935-03-04	1935-05-07	Chester H Roth	Hosiery
FR2599740B1 (fr) *	1986-06-05	1988-08-12	Rhone Poulenc Sante	Derives de benzo(b)thiophene de benzo(b)furannecarboxamides, leurs procedes de preparation et les medicaments les contenant
US4963557A (en)	1987-09-28	1990-10-16	Smithkline Beecham Corporation	Immunomodulatory azaspiranes
AU7686891A (en)	1990-04-05	1991-10-30	American National Red Cross, The	A protein family related to immediate-early protein expressed by human endothelial cells during differentiation
AU653957B2 (en)	1990-09-20	1994-10-20	Merrell Dow Pharmaceuticals Inc.	1-aryl-3-pyridinyl-2-propene-1-ones
DE19642451A1 (de) *	1996-10-15	1998-04-16	Merck Patent Gmbh	Aminothiophencarbonsäureamide
US6423508B1 (en)	1998-03-09	2002-07-23	Smithkline Beecham Corporation	Polynucleotide sequences of human EDG-1c
GB9808665D0 (en) *	1998-04-23	1998-06-24	Merck Sharp & Dohme	Therapeutic compounds
CA2400858A1 (en) *	2000-03-31	2001-10-11	Shokyo Miki	Fused heterocyclic derivatives, their production and use
US20040058894A1 (en) *	2002-01-18	2004-03-25	Doherty George A.	Selective S1P1/Edg1 receptor agonists
ATE448193T1 (de)	2002-01-18	2009-11-15	Merck & Co Inc	ßN-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATE, PHOSPHONATE UND TETRAZOLE ALS EDG REZEPTORAGONISTENß
JP4430941B2 (ja)	2002-01-18	2010-03-10	メルクエンドカムパニーインコーポレーテッド	Ｅｄｇ受容体作動薬
JP2005533058A (ja) *	2002-06-17	2005-11-04	メルク　エンド　カムパニー　インコーポレーテッド	Ｅｄｇ受容体アゴニストとしての１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）アゼチジン−３−カルボキシラートおよび１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）ピロリジン−３−カルボキシラート
WO2004035538A1 (en)	2002-10-15	2004-04-29	Merck & Co., Inc.	Process for making azetidine-3-carboxylic acid
AU2004240586A1 (en)	2003-05-15	2004-12-02	Merck & Co., Inc.	3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as S1P receptor agonists
GB0313677D0 (en) *	2003-06-13	2003-07-16	Oxford Glycosciences Uk Ltd	Novel compound
US20070043014A1 (en)	2003-10-01	2007-02-22	Merck & Co., Inc.	3,5-Aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists
EP1697333A4 (de)	2003-12-17	2009-07-08	Merck & Co Inc	(3,4-disubstituierte)propansäurecarboxylate als agonisten des s1p (edg) rezeptors
WO2006010379A1 (en)	2004-07-29	2006-02-02	Actelion Pharmaceuticals Ltd.	Novel thiophene derivatives as immunosuppressive agents
KR20080002850A (ko) *	2005-03-23	2008-01-04	액테리온 파마슈티칼 리미티드	신규한 티오펜 유도체
US7605269B2 (en) *	2005-03-23	2009-10-20	Actelion Pharmaceuticals Ltd.	Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists
AR057894A1 (es) *	2005-11-23	2007-12-26	Actelion Pharmaceuticals Ltd	Derivados de tiofeno
AU2007209051A1 (en) *	2006-01-24	2007-08-02	Actelion Pharmaceuticals Ltd	Novel pyridine derivatives
GB0601744D0 (en)	2006-01-27	2006-03-08	Novartis Ag	Organic compounds

2006
- 2006-03-20 CA CA2602474A patent/CA2602474C/en not_active Expired - Fee Related
- 2006-03-20 ES ES06727679T patent/ES2365747T3/es not_active Expired - Lifetime
- 2006-03-20 CN CN2006800172389A patent/CN101180290B/zh not_active Expired - Fee Related
- 2006-03-20 SI SI200631088T patent/SI1863787T1/sl unknown
- 2006-03-20 BR BRPI0609515A patent/BRPI0609515A8/pt active Search and Examination
- 2006-03-20 PT PT06727679T patent/PT1863787E/pt unknown
- 2006-03-20 AT AT06727679T patent/ATE510831T1/de active
- 2006-03-20 EP EP06727679A patent/EP1863787B1/de not_active Expired - Lifetime
- 2006-03-20 WO PCT/IB2006/050845 patent/WO2006100631A1/en not_active Ceased
- 2006-03-20 US US11/909,429 patent/US7723378B2/en not_active Expired - Fee Related
- 2006-03-20 NZ NZ562562A patent/NZ562562A/en not_active IP Right Cessation
- 2006-03-20 DK DK06727679.0T patent/DK1863787T3/da active
- 2006-03-20 JP JP2008502538A patent/JP5047941B2/ja not_active Expired - Fee Related
- 2006-03-20 AU AU2006226018A patent/AU2006226018B2/en not_active Ceased
- 2006-03-20 HR HR20110613T patent/HRP20110613T1/hr unknown
- 2006-03-20 MX MX2007011670A patent/MX2007011670A/es active IP Right Grant
- 2006-03-20 PL PL06727679T patent/PL1863787T3/pl unknown
- 2006-03-20 KR KR1020077024309A patent/KR101382733B1/ko not_active Expired - Fee Related
- 2006-03-20 RU RU2007138875/04A patent/RU2412179C2/ru not_active IP Right Cessation
- 2006-03-21 MY MYPI20061242A patent/MY147949A/en unknown
- 2006-03-22 TW TW095109919A patent/TWI402262B/zh not_active IP Right Cessation
- 2006-03-23 AR ARP060101156A patent/AR053452A1/es unknown
2007
- 2007-09-20 IL IL186148A patent/IL186148A/en not_active IP Right Cessation
- 2007-10-17 NO NO20075299A patent/NO340192B1/no not_active IP Right Cessation
- 2007-10-22 ZA ZA200709088A patent/ZA200709088B/xx unknown
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JP5047941B2 (ja)	2012-10-10
US7723378B2 (en)	2010-05-25
KR20080003360A (ko)	2008-01-07
NZ562562A (en)	2010-11-26
IL186148A (en)	2012-05-31
AR053452A1 (es)	2007-05-09
CN101180290A (zh)	2008-05-14
CN101180290B (zh)	2012-12-12
TWI402262B (zh)	2013-07-21
US8039644B2 (en)	2011-10-18
BRPI0609515A8 (pt)	2017-12-26
MX2007011670A (es)	2007-11-15
PL1863787T3 (pl)	2011-10-31
AU2006226018A1 (en)	2006-09-28
EP1863787B1 (de)	2011-05-25
KR101382733B1 (ko)	2014-04-14
EP1863787A1 (de)	2007-12-12
NO340192B1 (no)	2017-03-20
ES2365747T3 (es)	2011-10-10
DK1863787T3 (da)	2011-08-01
WO2006100631A1 (en)	2006-09-28
CA2602474A1 (en)	2006-09-28
MY147949A (en)	2013-02-15
US20100204198A1 (en)	2010-08-12
CA2602474C (en)	2014-06-10
CY1111767T1 (el)	2015-10-07
AU2006226018B2 (en)	2012-07-12
JP2008534490A (ja)	2008-08-28
IL186148A0 (en)	2008-01-20
BRPI0609515A2 (pt)	2010-04-13
TW200716591A (en)	2007-05-01
NO20075299L (no)	2007-12-27
RU2412179C2 (ru)	2011-02-20
US20080176926A1 (en)	2008-07-24
ZA200709088B (en)	2008-09-25
SI1863787T1 (sl)	2011-10-28
RU2007138875A (ru)	2009-04-27
HRP20110613T1 (hr)	2011-09-30
PT1863787E (pt)	2011-07-29

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