ATE556140T1 - Aav vektoren für die gentherapie von rheumatischer arthritis - Google Patents

Aav vektoren für die gentherapie von rheumatischer arthritis

Info

Publication number
ATE556140T1
ATE556140T1 AT04774913T AT04774913T ATE556140T1 AT E556140 T1 ATE556140 T1 AT E556140T1 AT 04774913 T AT04774913 T AT 04774913T AT 04774913 T AT04774913 T AT 04774913T AT E556140 T1 ATE556140 T1 AT E556140T1
Authority
AT
Austria
Prior art keywords
gene therapy
aav vectors
rheumatic arthritis
virions
aav
Prior art date
Application number
AT04774913T
Other languages
English (en)
Inventor
Paul Peter Tak
Christian Jorgensen
Original Assignee
Amc Amsterdam
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amc Amsterdam, Inst Nat Sante Rech Med filed Critical Amc Amsterdam
Application granted granted Critical
Publication of ATE556140T1 publication Critical patent/ATE556140T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0033Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/48Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04774913T 2003-09-01 2004-09-01 Aav vektoren für die gentherapie von rheumatischer arthritis ATE556140T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL0300611 2003-09-01
PCT/NL2004/000607 WO2005021768A1 (en) 2003-09-01 2004-09-01 Aav vectors for in vivo gene therapy of rheumatoid arthritis

Publications (1)

Publication Number Publication Date
ATE556140T1 true ATE556140T1 (de) 2012-05-15

Family

ID=34270790

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04774913T ATE556140T1 (de) 2003-09-01 2004-09-01 Aav vektoren für die gentherapie von rheumatischer arthritis

Country Status (10)

Country Link
EP (2) EP1664315B1 (de)
JP (1) JP4863874B2 (de)
AT (1) ATE556140T1 (de)
AU (1) AU2004269279B2 (de)
CA (1) CA2536471C (de)
DK (1) DK1664315T3 (de)
ES (1) ES2384975T3 (de)
PL (1) PL1664315T3 (de)
PT (1) PT1664315E (de)
WO (1) WO2005021768A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009534394A (ja) * 2006-04-21 2009-09-24 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 結合組織障害の治療
RU2771490C2 (ru) 2016-01-13 2022-05-05 Мериал, Инк. Рекомбинантные aav векторы, экспрессирующие остеопротективные гены, включая has2 и лубрицин, пригодные при лечении остеоартрита и сходных заболеваний суставов у млекопитающих
SI3740222T1 (sl) * 2018-01-17 2023-11-30 Meiragtx Uk Ii Limited Modificiran kapsidni protein raav za gensko terapijo
CN113557036A (zh) 2019-01-18 2021-10-26 奥泽生物疗法公司 基因编辑以改善关节功能
US20250213727A1 (en) 2022-03-25 2025-07-03 Regenxbio Inc. Dominant-negative tumor necrosis factor alpha adeno-associated virus gene therapy
CN116983432A (zh) * 2023-07-07 2023-11-03 深圳先进技术研究院 用于治疗类风湿性关节炎的药物
WO2025077768A1 (en) * 2023-10-11 2025-04-17 Sichuan Real & Best Biotech Co., Ltd. Compositions and methods for treating arthritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US6277969B1 (en) 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
US5952221A (en) 1996-03-06 1999-09-14 Avigen, Inc. Adeno-associated virus vectors comprising a first and second nucleic acid sequence
CA2248762A1 (en) 1997-10-22 1999-04-22 University Technologies International, Inc. Antisense oligodeoxynucleotides regulating expression of tnf-.alpha.
WO1999061601A2 (en) 1998-05-28 1999-12-02 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Aav5 vector and uses thereof
DK1180159T3 (da) * 1999-05-28 2008-11-17 Targeted Genetics Corp Fremgangsmåder og sammensætninger til at sænke niveauet af Tumor-Nekrose-Faktor (TNF) i TNF-associerede lidelser
CA2379166C (en) * 1999-08-09 2013-03-26 Targeted Genetics Corporation Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms instrastrand base pairs
US20040191221A1 (en) * 2001-05-22 2004-09-30 Keiya Ozawa Methods of treating skeletal disorders using recombinant adeno-associated virus virions
US20030003583A1 (en) * 2001-06-08 2003-01-02 Raphael Hirsch Regulation of transgene expression following AAV transduction
WO2003093440A2 (en) * 2002-04-30 2003-11-13 University Of Florida Methods and compositions for expressing a nucleic acid in a dendritic cell

Also Published As

Publication number Publication date
PL1664315T3 (pl) 2012-09-28
WO2005021768A1 (en) 2005-03-10
PT1664315E (pt) 2012-07-31
JP2007504219A (ja) 2007-03-01
CA2536471C (en) 2013-10-08
JP4863874B2 (ja) 2012-01-25
EP1664315B1 (de) 2012-05-02
EP2322638A1 (de) 2011-05-18
DK1664315T3 (da) 2012-07-09
ES2384975T3 (es) 2012-07-16
AU2004269279B2 (en) 2010-02-25
AU2004269279A1 (en) 2005-03-10
EP1664315A1 (de) 2006-06-07
CA2536471A1 (en) 2005-03-10

Similar Documents

Publication Publication Date Title
CY1108297T1 (el) Μεσα ανταγωνιστικης επιλεκτικης συνδεσης της πρωτεϊνης συνδεσης οστεοπροτεγερινης
CY1117401T1 (el) Πρωτεϊνες συντηξης αλβουμινης
AR038568A1 (es) Anticuerpos anti-a beta y su uso
BRPI0514396A2 (pt) polipeptìdeos dependentes de vitamina k modificada
DE60335794D1 (de) Multigene vectoren und methoden für eine erhöhte expression von rekombinanten polypeptiden
WO2004076489A8 (en) Modified antibody
MXPA02012743A (es) Moleculas tipo il-17 y usos de las mismas.
DK2077279T3 (da) Tymiske stromale lymfopoietinreceptormolekyler og anvendelser heraf
EP1546343A4 (de) Produktion von rekombinantem aav mit hohem titer
ATE556140T1 (de) Aav vektoren für die gentherapie von rheumatischer arthritis
WO2002102316A3 (en) Histone deacetylase and methods of use thereof
DK1536006T3 (da) Cancerantigener og anvendelse deraf
IL165170A (en) Dna vaccines encoding heat shock protein 70
BR9902019A (pt) Moléculas de polinucleotìdios que codificam proteìnas de neospora.
MXPA04004561A (es) Distribuidor de aire para sistema de biolixiviacion.
DE60129069D1 (de) Hepatitis B Virus Vektoren für Gentherapie
CY1105947T1 (el) Νουκλεϊνικα οξεα και πρωτεϊνες του γονιδιου mhp3 του mycoplasma hyopneumoniae και χρησεις αυτων
DK1636261T3 (da) Thrombopoietinproteiner med forbedrede egenskaber
WO2004087886A3 (en) Modified adenoviral e1a constructs and methods of use thereof
PL374550A1 (en) Il-17 like molecules and uses thereof
DK1673391T3 (da) Modificeret cDNA til höje ekspressionsniveauer af faktor VIII og dens derivater
DE60120187D1 (de) Verkürztes bard1 protein und dessen diagnostische und therapeutische anwendungen
DK1664097T3 (da) Piroplasmidvaccine
ATE476194T1 (de) Ein mitglied der menschlichen proteinkinasefamilie, und verwendungen dafür
DK2186898T3 (da) Blomstrings-induktion