ATE556321T1 - Analyse des gpcr-signalweges mit biosensor- zelltests - Google Patents
Analyse des gpcr-signalweges mit biosensor- zelltestsInfo
- Publication number
- ATE556321T1 ATE556321T1 AT08834852T AT08834852T ATE556321T1 AT E556321 T1 ATE556321 T1 AT E556321T1 AT 08834852 T AT08834852 T AT 08834852T AT 08834852 T AT08834852 T AT 08834852T AT E556321 T1 ATE556321 T1 AT E556321T1
- Authority
- AT
- Austria
- Prior art keywords
- analysis
- signaling pathway
- gpcr signaling
- cell tests
- biosensor cell
- Prior art date
Links
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 title abstract 2
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 title abstract 2
- 230000019491 signal transduction Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 238000003068 pathway analysis Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99791007P | 2007-10-06 | 2007-10-06 | |
| US11/998,711 US8426148B2 (en) | 2007-10-06 | 2007-11-30 | Label-free methods using a resonant waveguide grating biosensor to determine GPCR signaling pathways |
| PCT/US2008/011401 WO2009045463A1 (en) | 2007-10-06 | 2008-10-02 | Gpcr signaling pathway analysis using biosensor-cell assays |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE556321T1 true ATE556321T1 (de) | 2012-05-15 |
Family
ID=40298645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08834852T ATE556321T1 (de) | 2007-10-06 | 2008-10-02 | Analyse des gpcr-signalweges mit biosensor- zelltests |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8426148B2 (de) |
| EP (1) | EP2201369B1 (de) |
| JP (1) | JP2011515065A (de) |
| AT (1) | ATE556321T1 (de) |
| WO (1) | WO2009045463A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110020843A1 (en) * | 2009-07-22 | 2011-01-27 | Ye Fang | Label-free methods related to phosphodiesterases |
| KR20230137387A (ko) | 2021-02-02 | 2023-10-04 | 옥탄트, 인크. | 세포 신호전달 단백질 활성을 측정하기 위한 시스템 및 방법 |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986007149A1 (de) | 1985-05-29 | 1986-12-04 | Kurt Tiefenthaler | Optischer sensor zum selektiven nachweis von substanzen und zum nachweis von brechzahländerungen in messubstanzen |
| US5830766A (en) | 1990-05-23 | 1998-11-03 | Ares-Serono Research & Development Ltd. Partnership | Enhanced signal-to-noise ratio and sensitivity optical immunoassay |
| US5305074A (en) | 1992-07-17 | 1994-04-19 | The United States Of America As Represented By The United States Department Of Energy | Achromatic self-referencing interferometer |
| US5512492A (en) | 1993-05-18 | 1996-04-30 | University Of Utah Research Foundation | Waveguide immunosensor with coating chemistry providing enhanced sensitivity |
| GB9314991D0 (en) | 1993-07-20 | 1993-09-01 | Sandoz Ltd | Mechanical device |
| US6727071B1 (en) | 1997-02-27 | 2004-04-27 | Cellomics, Inc. | System for cell-based screening |
| DE69914319T2 (de) | 1998-05-13 | 2004-11-18 | Cygnus, Inc., Redwood City | Signalverarbeitung zur messung von physiologischen analyten |
| US6771376B2 (en) | 1999-07-05 | 2004-08-03 | Novartis Ag | Sensor platform, apparatus incorporating the platform, and process using the platform |
| KR100883079B1 (ko) | 1999-07-05 | 2009-02-10 | 노파르티스 아게 | 플랫폼, 플랫폼을 가지는 장치, 및 플랫폼을 사용하는 방법 |
| AU2001233276A1 (en) | 2000-02-03 | 2001-08-14 | Immunomatrix Inc. | Method and apparatus for signal transduction pathway profiling |
| EP1265994A2 (de) | 2000-03-17 | 2002-12-18 | President And Fellows of Harvard College | Zellmusterungsverfahren |
| JP2003533692A (ja) | 2000-05-06 | 2003-11-11 | ツェプトゼンス アクチエンゲゼルシャフト | 多重分析対象物測定及びその使用のための格子導波路構造 |
| WO2002008762A1 (en) | 2000-07-21 | 2002-01-31 | Thaumdx, Llc | Apparatus and method for evanescent light fluoroassays |
| EP2275802A1 (de) | 2000-08-09 | 2011-01-19 | Artificial Sensing Instruments ASI AG | Wellenleitergitterstruktur und optische Messanordnung |
| AU2001281633A1 (en) | 2000-08-09 | 2002-02-18 | Artificial Sensing Instruments Asi Ag | Detection method |
| JP3795312B2 (ja) | 2000-09-06 | 2006-07-12 | 独立行政法人科学技術振興機構 | 細胞活性の評価方法 |
| US7202076B2 (en) | 2000-10-30 | 2007-04-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
| US20030092075A1 (en) | 2000-10-30 | 2003-05-15 | Sru Biosystems, Llc | Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors |
| US7101660B2 (en) | 2000-10-30 | 2006-09-05 | Sru Biosystems, Inc. | Method for producing a colorimetric resonant reflection biosensor on rigid surfaces |
| US20030113766A1 (en) | 2000-10-30 | 2003-06-19 | Sru Biosystems, Llc | Amine activated colorimetric resonant biosensor |
| US7153702B2 (en) | 2000-10-30 | 2006-12-26 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
| US7217574B2 (en) | 2000-10-30 | 2007-05-15 | Sru Biosystems, Inc. | Method and apparatus for biosensor spectral shift detection |
| US7118710B2 (en) | 2000-10-30 | 2006-10-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
| US6951715B2 (en) | 2000-10-30 | 2005-10-04 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
| US7023544B2 (en) | 2000-10-30 | 2006-04-04 | Sru Biosystems, Inc. | Method and instrument for detecting biomolecular interactions |
| US7175980B2 (en) | 2000-10-30 | 2007-02-13 | Sru Biosystems, Inc. | Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities |
| US7070987B2 (en) | 2000-10-30 | 2006-07-04 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
| US7142296B2 (en) | 2000-10-30 | 2006-11-28 | Sru Biosystems, Inc. | Method and apparatus for detecting biomolecular interactions |
| US7306827B2 (en) | 2000-10-30 | 2007-12-11 | Sru Biosystems, Inc. | Method and machine for replicating holographic gratings on a substrate |
| US7264973B2 (en) | 2000-10-30 | 2007-09-04 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant optical biosensor |
| US20020164824A1 (en) | 2001-02-16 | 2002-11-07 | Jianming Xiao | Method and apparatus based on bundled capillaries for high throughput screening |
| US20040023310A1 (en) | 2001-04-27 | 2004-02-05 | Genoptix, Inc | Quantitative determination of protein kinase C activation using optophoretic analysis |
| US20040009540A1 (en) | 2001-04-27 | 2004-01-15 | Genoptix, Inc | Detection and evaluation of cancer cells using optophoretic analysis |
| US20030124516A1 (en) | 2001-04-27 | 2003-07-03 | Genoptix, Inc. | Method of using optical interrogation to determine a biological property of a cell or population of cells |
| US20030194755A1 (en) | 2001-04-27 | 2003-10-16 | Genoptix, Inc. | Early detection of apoptotic events and apoptosis using optophoretic analysis |
| US6893705B2 (en) | 2001-05-25 | 2005-05-17 | Massachusetts Institute Of Technology | Large area orientation of block copolymer microdomains in thin films |
| EP1262764B1 (de) | 2001-05-25 | 2007-04-11 | Corning Incorporated | Verfahren zur Bestimmung der Reaktionen und der Metabolischen Aktivitat mit Fluoreszentem temperaturempfindlichem Material |
| US20040033539A1 (en) | 2002-05-01 | 2004-02-19 | Genoptix, Inc | Method of using optical interrogation to determine a biological property of a cell or population of cells |
| US20030211461A1 (en) | 2002-05-01 | 2003-11-13 | Genoptix, Inc | Optophoretic detection of durgs exhibiting inhibitory effect on Bcr-Abl positive tumor cells |
| US7105347B2 (en) | 2002-07-30 | 2006-09-12 | Corning Incorporated | Method and device for protein delivery into cells |
| WO2004023170A2 (en) | 2002-09-07 | 2004-03-18 | Lightwave Bioapplications | Bioanalysis systems including optical integrated circuit |
| US20040053209A1 (en) | 2002-09-12 | 2004-03-18 | Genoptix, Inc | Detection and evaluation of topoisomerase inhibitors using optophoretic analysis |
| US20040091397A1 (en) | 2002-11-07 | 2004-05-13 | Corning Incorporated | Multiwell insert device that enables label free detection of cells and other objects |
| CA2505886A1 (en) | 2002-11-13 | 2004-05-27 | David R. Wulfman | Waveguide system for detection of fluorescently labeled nucleic acid sequences |
| WO2004067191A2 (en) | 2003-01-29 | 2004-08-12 | President And Fellows Of Harward College | Alteration of surface affinities |
| US7566531B2 (en) | 2003-03-03 | 2009-07-28 | University Of Massachusetts | Selective whole cell quartz crystal microbalance biosensors |
| US7497992B2 (en) | 2003-05-08 | 2009-03-03 | Sru Biosystems, Inc. | Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers |
| US7292333B2 (en) | 2003-06-24 | 2007-11-06 | Corning Incorporated | Optical interrogation system and method for 2-D sensor arrays |
| US7057720B2 (en) | 2003-06-24 | 2006-06-06 | Corning Incorporated | Optical interrogation system and method for using same |
| DE60316044T2 (de) | 2003-07-14 | 2008-05-15 | MDS Inc., doing business as MDS Sciex, Concord | Markierungsfreies verfahren zur klassifizierung und charakterisierung zellulärer ereignisse |
| US20050018944A1 (en) | 2003-07-25 | 2005-01-27 | Mozdy Eric J. | Polarization modulation interrogation of grating-coupled waveguide sensors |
| US6985664B2 (en) | 2003-08-01 | 2006-01-10 | Corning Incorporated | Substrate index modification for increasing the sensitivity of grating-coupled waveguides |
| US20050070027A1 (en) | 2003-09-30 | 2005-03-31 | Jacques Gollier | Double resonance interrogation of grating-coupled waveguides |
| US7604984B2 (en) | 2004-12-29 | 2009-10-20 | Corning Incorporated | Spatially scanned optical reader system and method for using same |
| US8076090B2 (en) * | 2005-04-05 | 2011-12-13 | Corning Incorporated | Label free biosensors and cells |
| US20060223051A1 (en) | 2005-04-05 | 2006-10-05 | Ye Fang | System and method for performing G protein coupled receptor (GPCR) cell assays using waveguide-grating sensors |
| WO2007018872A1 (en) | 2005-07-20 | 2007-02-15 | Corning Incorporated | Label-free high throughput biomolecular screening system and method |
| JP2010524465A (ja) * | 2007-04-19 | 2010-07-22 | コーニング インコーポレイテッド | 病原体侵入の生細胞シグナルおよびその方法 |
-
2007
- 2007-11-30 US US11/998,711 patent/US8426148B2/en not_active Expired - Fee Related
-
2008
- 2008-10-02 EP EP08834852A patent/EP2201369B1/de not_active Not-in-force
- 2008-10-02 AT AT08834852T patent/ATE556321T1/de active
- 2008-10-02 JP JP2010527984A patent/JP2011515065A/ja active Pending
- 2008-10-02 WO PCT/US2008/011401 patent/WO2009045463A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20120135423A1 (en) | 2012-05-31 |
| EP2201369B1 (de) | 2012-05-02 |
| US8426148B2 (en) | 2013-04-23 |
| WO2009045463A1 (en) | 2009-04-09 |
| JP2011515065A (ja) | 2011-05-19 |
| EP2201369A1 (de) | 2010-06-30 |
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