ATE55694T1 - Pharmazeutische praeparate enthaltend flavanoneoder thioflavanone-derivate, deren verwendung, neue flavanone oder thioflavanone und verfahren zu deren herstellung. - Google Patents

Pharmazeutische praeparate enthaltend flavanoneoder thioflavanone-derivate, deren verwendung, neue flavanone oder thioflavanone und verfahren zu deren herstellung.

Info

Publication number: ATE55694T1
Authority: AT; Austria
Prior art keywords: thioflavanone; free; unsubstituted; flavanone; compounds
Prior art date: 1983-08-31

Application number

AT84810422T

Other languages

English (en)

Inventor

Christian Gerard Dr Rimbault

Original Assignee

Zyma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-08-31

Filing date

1984-08-27

Publication date

1990-09-15

1984-08-27 Application filed by Zyma Sa filed Critical Zyma Sa

1990-09-15 Application granted granted Critical

1990-09-15 Publication of ATE55694T1 publication Critical patent/ATE55694T1/de

Links

238000000034 method Methods 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
WBQCGMRGZQQQNG-UHFFFAOYSA-N 2-phenyl-2,3-dihydrochromene-4-thione Chemical class O1C2=CC=CC=C2C(=S)CC1C1=CC=CC=C1 WBQCGMRGZQQQNG-UHFFFAOYSA-N 0.000 title 2
ZONYXWQDUYMKFB-UHFFFAOYSA-N SJ000286395 Natural products O1C2=CC=CC=C2C(=O)CC1C1=CC=CC=C1 ZONYXWQDUYMKFB-UHFFFAOYSA-N 0.000 title 2
229930003949 flavanone Natural products 0.000 title 2
150000002207 flavanone derivatives Chemical class 0.000 title 2
235000011981 flavanones Nutrition 0.000 title 2
238000004519 manufacturing process Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 2
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 2
239000004215 Carbon black (E152) Substances 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229930195733 hydrocarbon Natural products 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 abstract 1
208000019423 liver disease Diseases 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
210000002345 respiratory system Anatomy 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT84810422T 1983-08-31 1984-08-27 Pharmazeutische praeparate enthaltend flavanoneoder thioflavanone-derivate, deren verwendung, neue flavanone oder thioflavanone und verfahren zu deren herstellung. ATE55694T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB838323291A GB8323291D0 (en)	1983-08-31	1983-08-31	Flavanone and thioflavanone derivatives
EP84810422A EP0139614B1 (de)	1983-08-31	1984-08-27	Pharmazeutische Präparate enthaltend Flavanone- oder Thioflavanone-Derivate, deren Verwendung, neue Flavanone oder Thioflavanone und Verfahren zu deren Herstellung

Publications (1)

Publication Number	Publication Date
ATE55694T1 true ATE55694T1 (de)	1990-09-15

Family

ID=10548079

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT84810422T ATE55694T1 (de)	1983-08-31	1984-08-27	Pharmazeutische praeparate enthaltend flavanoneoder thioflavanone-derivate, deren verwendung, neue flavanone oder thioflavanone und verfahren zu deren herstellung.

Country Status (20)

Country	Link
US (1)	US4885298A (de)
EP (1)	EP0139614B1 (de)
JP (1)	JPS60155176A (de)
AT (1)	ATE55694T1 (de)
AU (1)	AU580006B2 (de)
CA (1)	CA1251213A (de)
DD (1)	DD222311A5 (de)
DE (1)	DE3483033D1 (de)
DK (1)	DK415984A (de)
ES (1)	ES8800191A1 (de)
FI (1)	FI843362A7 (de)
GB (2)	GB8323291D0 (de)
GR (1)	GR80258B (de)
HU (1)	HUT36817A (de)
IL (1)	IL72775A (de)
NO (1)	NO843453L (de)
NZ (1)	NZ209393A (de)
PH (2)	PH23456A (de)
PT (1)	PT79144B (de)
ZA (1)	ZA846785B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3431534A1 (de) *	1984-08-28	1986-03-13	Merck Patent Gmbh, 6100 Darmstadt	Flavanonderivate
AU2004249614B2 (en) *	2003-06-20	2008-04-03	Pokka Corporation	Flavanone compound and uses thereof
KR100985103B1 (ko) *	2008-08-07	2010-10-05	덕성여자대학교 산학협력단	티오플라바논 유도체의 제조 방법
PL2423213T3 (pl) *	2009-04-23	2014-04-30	Yang Gengliang	Wytwarzanie i stosowanie nowych związków antybiotycznych, przeciwnowotworowych i ich pochodnych
CN110615784B (zh) *	2019-10-25	2022-10-25	南开大学	具有黄酮骨架的内酯类似物的合成及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2727057A (en) *	1952-03-01	1955-12-13	Monsanto Chemicals	Preparation of ethylene sulfonates
GB1250388A (de) *	1968-11-27	1971-10-20
US3678044A (en) *	1970-10-22	1972-07-18	Chevron Res	Substituted flavanones
US3772243A (en) *	1970-10-26	1973-11-13	Chevron Res	Polypropylene stabilized with substituted chalcones and flavanones
GB1522057A (en) *	1975-11-03	1978-08-23	Pfizer	9-hydroxydibenzo(b,d)pyrans and intermediates therefor
US4235913A (en) *	1977-06-07	1980-11-25	Pfizer Inc.	9-Hydroxyhexahydrodibeno[b,d]pyrans, 1-substituted-9-hydroxyhexahydrodibenzo]b,d]pyrans
US4162162A (en) *	1978-05-08	1979-07-24	E. I. Du Pont De Nemours And Company	Derivatives of aryl ketones and p-dialkyl-aminoarylaldehydes as visible sensitizers of photopolymerizable compositions
US4228177A (en) *	1979-08-08	1980-10-14	E. R. Squibb & Sons, Inc.	2,3-Dihydro-3-(1H-imidazol-1-ylmethylene)-4H-1-benzothiopyran-4-ones
US4241069A (en) *	1979-09-04	1980-12-23	Miles Laboratories, Inc.	3-Methylene flavanones and 3-methylene chromanones
CH648030A5 (de) *	1980-12-15	1985-02-28	Sandoz Ag	Benzopyran-allylaminderivate, verfahren zu ihrer herstellung und ihre verwendung.
GB8421801D0 (en) *	1984-08-29	1984-10-03	Unilever Plc	Detergent composition

1983
- 1983-08-31 GB GB838323291A patent/GB8323291D0/en active Pending
1984
- 1984-08-27 FI FI843362A patent/FI843362A7/fi not_active Application Discontinuation
- 1984-08-27 IL IL72775A patent/IL72775A/xx unknown
- 1984-08-27 EP EP84810422A patent/EP0139614B1/de not_active Expired - Lifetime
- 1984-08-27 DE DE8484810422T patent/DE3483033D1/de not_active Expired - Lifetime
- 1984-08-27 AT AT84810422T patent/ATE55694T1/de active
- 1984-08-28 PT PT79144A patent/PT79144B/pt not_active IP Right Cessation
- 1984-08-29 GB GB08421776A patent/GB2145718B/en not_active Expired
- 1984-08-29 CA CA000462000A patent/CA1251213A/en not_active Expired
- 1984-08-29 DD DD84266739A patent/DD222311A5/de not_active IP Right Cessation
- 1984-08-30 ZA ZA846785A patent/ZA846785B/xx unknown
- 1984-08-30 PH PH31165A patent/PH23456A/en unknown
- 1984-08-30 AU AU32570/84A patent/AU580006B2/en not_active Ceased
- 1984-08-30 NZ NZ209393A patent/NZ209393A/en unknown
- 1984-08-30 HU HU843261A patent/HUT36817A/hu unknown
- 1984-08-30 NO NO843453A patent/NO843453L/no unknown
- 1984-08-30 PH PH31166A patent/PH24450A/en unknown
- 1984-08-30 GR GR80258A patent/GR80258B/el unknown
- 1984-08-30 DK DK415984A patent/DK415984A/da not_active Application Discontinuation
- 1984-08-31 ES ES535588A patent/ES8800191A1/es not_active Expired
- 1984-08-31 JP JP59180890A patent/JPS60155176A/ja active Pending
1988
- 1988-08-02 US US07/229,798 patent/US4885298A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0139614A2 (de)	1985-05-02
DK415984D0 (da)	1984-08-30
DK415984A (da)	1985-03-01
PH23456A (en)	1989-08-07
ES535588A0 (es)	1987-11-01
DD222311A5 (de)	1985-05-15
PH24450A (en)	1990-06-25
CA1251213A (en)	1989-03-14
EP0139614A3 (en)	1985-12-27
GR80258B (en)	1985-01-02
GB2145718A (en)	1985-04-03
IL72775A0 (en)	1984-11-30
EP0139614B1 (de)	1990-08-22
PT79144A (en)	1984-09-01
US4885298A (en)	1989-12-05
NO843453L (no)	1985-03-01
NZ209393A (en)	1987-11-27
GB8421776D0 (en)	1984-10-03
IL72775A (en)	1988-11-15
DE3483033D1 (de)	1990-09-27
FI843362A0 (fi)	1984-08-27
HUT36817A (en)	1985-10-28
PT79144B (en)	1986-11-14
AU3257084A (en)	1985-03-07
FI843362A7 (fi)	1985-03-01
GB8323291D0 (en)	1983-10-05
GB2145718B (en)	1987-02-04
ES8800191A1 (es)	1987-11-01
ZA846785B (en)	1985-04-24
AU580006B2 (en)	1988-12-22
JPS60155176A (ja)	1985-08-15

Publication	Publication Date	Title
AU577308B2 (en)	1988-09-22	Flayene and thioflavene derivative
ATE28641T1 (de)	1987-08-15	Pharmazeutische praeparate, (+)-cyanidan-3-olderivate enthaltend, deren verwendung, substituierte (+)-cyanidan-3-ol derivate und verfahren zu deren herstellung.
AU580006B2 (en)	1988-12-22	Pharmaceutical preparations containing flavanone or thioflavanone derivatives, the use thereof, novel flavanones and thioflavanones, and processes for their manufacture
DE3381964D1 (de)	1990-12-06	Dithio-verbindungen, diese enthaltende pharmazeutische praeparate und deren verwendung.
AT353762B (de)	1979-12-10	Verfahren zur herstellung von neuen omega- aminocarbonsaeurederivaten und deren salzen
ATE42285T1 (de)	1989-05-15	Flaven- und thioflaven-derivate, verfahren zu deren herstellung, diese verbindungen enthaltende pharmazeutische praeparate und deren verwendung.