ATE557017T1 - Pyrrolidinonglucokinase-aktivatoren - Google Patents
Pyrrolidinonglucokinase-aktivatorenInfo
- Publication number
- ATE557017T1 ATE557017T1 AT09732665T AT09732665T ATE557017T1 AT E557017 T1 ATE557017 T1 AT E557017T1 AT 09732665 T AT09732665 T AT 09732665T AT 09732665 T AT09732665 T AT 09732665T AT E557017 T1 ATE557017 T1 AT E557017T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrrolidinone
- glucokinase activators
- glucokinase
- activators
- pyrrolidinone glucokinase
- Prior art date
Links
- 102000030595 Glucokinase Human genes 0.000 title 1
- 108010021582 Glucokinase Proteins 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4537008P | 2008-04-16 | 2008-04-16 | |
| US14576109P | 2009-01-20 | 2009-01-20 | |
| PCT/EP2009/054067 WO2009127546A1 (en) | 2008-04-16 | 2009-04-06 | Pyrrolidinone glucokinase activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE557017T1 true ATE557017T1 (de) | 2012-05-15 |
Family
ID=40785354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09732665T ATE557017T1 (de) | 2008-04-16 | 2009-04-06 | Pyrrolidinonglucokinase-aktivatoren |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7741327B2 (de) |
| EP (1) | EP2274297B1 (de) |
| JP (1) | JP5518838B2 (de) |
| KR (1) | KR101259249B1 (de) |
| CN (1) | CN102007118B (de) |
| AR (1) | AR071474A1 (de) |
| AT (1) | ATE557017T1 (de) |
| AU (1) | AU2009237794B2 (de) |
| BR (1) | BRPI0911035B8 (de) |
| CA (1) | CA2720524C (de) |
| CL (1) | CL2009000889A1 (de) |
| CY (1) | CY1112921T1 (de) |
| DK (1) | DK2274297T3 (de) |
| ES (1) | ES2386192T3 (de) |
| HR (1) | HRP20120589T1 (de) |
| IL (1) | IL207503A (de) |
| MX (1) | MX2010011226A (de) |
| PE (1) | PE20091842A1 (de) |
| PL (1) | PL2274297T3 (de) |
| PT (1) | PT2274297E (de) |
| RU (1) | RU2010146384A (de) |
| SI (1) | SI2274297T1 (de) |
| TW (1) | TW200944519A (de) |
| WO (1) | WO2009127546A1 (de) |
| ZA (1) | ZA201006159B (de) |
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| US20110021570A1 (en) * | 2009-07-23 | 2011-01-27 | Nancy-Ellen Haynes | Pyridone glucokinase activators |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| CN102959076B (zh) | 2010-03-31 | 2015-09-16 | 斯克里普斯研究所 | 重编程细胞 |
| US8178689B2 (en) * | 2010-06-17 | 2012-05-15 | Hoffman-La Roche Inc. | Tricyclic compounds |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
| US20120142705A1 (en) * | 2010-12-06 | 2012-06-07 | Robert Francis Kester | Isatin and oxindole compounds |
| US8470866B2 (en) * | 2011-05-03 | 2013-06-25 | Hoffmann-La Roche Inc. | Isoindolinone derivatives |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| PL2938609T3 (pl) * | 2012-12-25 | 2017-08-31 | Hua Medicine | Sposób wytwarzania 1-([1,3]dioksolan-4-ylometylo)-1h-pirazol-3- iloaminy |
| JP7072557B2 (ja) | 2016-07-22 | 2022-05-20 | ブリストル－マイヤーズ スクイブ カンパニー | グルコキナーゼ活性化剤およびその使用方法 |
| EP3556354B1 (de) * | 2016-12-15 | 2025-05-21 | Hua Medicine (Shanghai) Ltd. | Orale herstellung eines glucokinaseaktivators und herstellungsverfahren dafür |
| CN110337436A (zh) | 2016-12-22 | 2019-10-15 | 拜耳作物科学股份公司 | 取代的1,2,4-噻二唑基吡咯酮和1,2,4-噻二唑基乙内酰脲及其盐及其作为除草剂的用途 |
| BR112019012584A2 (pt) | 2016-12-22 | 2019-11-19 | Bayer Ag | heteroarilpirrolonas substituídas e sais das mesmas e uso das mesmas como substâncias ativas herbicidas |
| JP2021507894A (ja) | 2017-12-19 | 2021-02-25 | バイエル、アクチエンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 置換されたｎ−ヘテロシクリル−およびｎ−ヘテロアリール−テトラヒドロピリミジノンならびにその塩、ならびに除草活性物質としてのその使用 |
| AU2019278015B2 (en) * | 2018-05-31 | 2024-10-03 | Hua Medicine (Shanghai) Ltd. | Pharmaceutical combination, composition, and combination formulation comprising glucokinase activator and SGLT-2 inhibitor and preparation methods and uses thereof |
| CN113493442B (zh) * | 2020-04-03 | 2024-11-08 | 天津药物研究院有限公司 | 作为葡萄糖激酶活化剂的吡咯烷酮衍生物及其制备方法和用途 |
| US11813274B2 (en) | 2020-04-22 | 2023-11-14 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
| AU2020443475A1 (en) * | 2020-04-22 | 2022-11-17 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
| IL300893A (en) * | 2020-08-24 | 2023-04-01 | Hua Medicine Shanghai Ltd | Preparation of modified acrylate compounds |
| TWI817307B (zh) * | 2021-01-04 | 2023-10-01 | 大陸商華領醫藥技術（上海）有限公司 | 多扎格列艾汀（ｄｏｒｚａｇｌｉａｔｉｎ）和胰高血糖素樣肽-１類似物的藥物組成物 |
| CN113527265B9 (zh) * | 2021-02-02 | 2022-07-19 | 湖南南新制药股份有限公司 | 一种氘代吡咯烷酮衍生物、药物组合物及其用途 |
| CN113750100B (zh) * | 2021-08-31 | 2022-12-30 | 海南中济医药科技有限公司 | 一种含有多扎格列艾汀与西格列汀的药物组合物及其制备方法 |
| AR127064A1 (es) | 2021-09-15 | 2023-12-13 | Hua Medicine Shanghai Ltd | Prodroga de derivados de pirrolidona como activador de glucoquinasa |
| EP4516778A4 (de) | 2022-04-25 | 2026-04-29 | Nippon Shinyaku Co Ltd | Verbindung als ddr1-kinasehemmer und medikament |
| AR132113A1 (es) * | 2023-03-13 | 2025-05-28 | Hua Medicine Shanghai Ltd | Forma sólida de derivados de pirrolidona como activador de glucoquinasa |
| TW202541799A (zh) | 2023-12-14 | 2025-11-01 | 美商華領醫藥美國有限公司 | 包含葡萄糖激酶激活劑之醫藥調配物及其用途 |
| CN118812408A (zh) * | 2024-09-18 | 2024-10-22 | 潍坊市海欣药业有限公司 | 一种多格列艾汀关键中间体的合成方法 |
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| EP1948614A2 (de) | 2005-11-18 | 2008-07-30 | Takeda San Diego, Inc. | Glucokinaseaktivatoren |
| CN101437512A (zh) | 2006-01-27 | 2009-05-20 | 阿雷生物药品公司 | 葡萄糖激酶活化剂 |
| EP2001875A2 (de) | 2006-03-08 | 2008-12-17 | Takeda San Diego, Inc. | Glucokinase-aktivatoren |
| RU2457207C2 (ru) | 2006-03-24 | 2012-07-27 | Эррэй Биофарма Инк. | Активаторы глюкокиназы |
| WO2007115968A2 (en) | 2006-04-12 | 2007-10-18 | F. Hoffmann-La Roche Ag | Process for the preparation of a glucokinase activator |
| EP2010520B1 (de) | 2006-04-20 | 2012-09-12 | Pfizer Products Inc. | Heterobicyclische amide zur prävention und behandlung von durch glucokinase-vermittelten krankheiten |
| WO2007125103A2 (en) | 2006-04-28 | 2007-11-08 | Transtech Pharma, Inc. | Benzamide glucokinase activators |
| US7888504B2 (en) | 2006-07-06 | 2011-02-15 | Bristol-Myers Squibb Company | Glucokinase activators and methods of using same |
| US7910747B2 (en) | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
| KR20090025358A (ko) | 2006-07-24 | 2009-03-10 | 에프. 호프만-라 로슈 아게 | 글루코키나제 활성화제로서의 피라졸 |
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| CN101121688A (zh) | 2007-09-14 | 2008-02-13 | 南开大学 | 合成奥拉西坦的改进方法 |
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- 2009-03-09 US US12/400,065 patent/US7741327B2/en active Active
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- 2009-04-06 KR KR1020107022936A patent/KR101259249B1/ko active Active
- 2009-04-06 CN CN200980113416.1A patent/CN102007118B/zh active Active
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- 2009-04-06 RU RU2010146384/04A patent/RU2010146384A/ru not_active Application Discontinuation
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