ATE57703T1 - Verfahren zur herstellung von 2,6-substituierten 9-(1,3-dihydroxy-2-propoxymethyl)-purinen und einige derivate. - Google Patents

Verfahren zur herstellung von 2,6-substituierten 9-(1,3-dihydroxy-2-propoxymethyl)-purinen und einige derivate.

Info

Publication number: ATE57703T1
Authority: AT; Austria
Prior art keywords: propoxymethyl; purines; dihydroxy; derivatives; substituted
Prior art date: 1984-02-23

Application number

AT85102000T

Other languages

English (en)

Inventor

Julien P H Verheyden

John C Martin

Gee Daniel P C Mc

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-02-23

Filing date

1985-02-22

Publication date

1990-11-15

1985-02-22 Application filed by Syntex Inc filed Critical Syntex Inc

1990-11-15 Application granted granted Critical

1990-11-15 Publication of ATE57703T1 publication Critical patent/ATE57703T1/de

Links

239000000543 intermediate Substances 0.000 abstract 2
VRMNUBZQJCWRKA-UHFFFAOYSA-N 2-[(2,6-diaminopurin-9-yl)methoxy]propane-1,3-diol Chemical compound NC1=NC(N)=C2N=CN(COC(CO)CO)C2=N1 VRMNUBZQJCWRKA-UHFFFAOYSA-N 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT85102000T 1984-02-23 1985-02-22 Verfahren zur herstellung von 2,6-substituierten 9-(1,3-dihydroxy-2-propoxymethyl)-purinen und einige derivate. ATE57703T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/582,696 US4621140A (en)	1984-02-23	1984-02-23	Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
EP85102000A EP0152965B1 (de)	1984-02-23	1985-02-22	Verfahren zur Herstellung von 2,6-substituierten 9-(1,3-Dihydroxy-2-propoxymethyl)-purinen und einige Derivate

Publications (1)

Publication Number	Publication Date
ATE57703T1 true ATE57703T1 (de)	1990-11-15

Family

ID=24330156

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT85102000T ATE57703T1 (de)	1984-02-23	1985-02-22	Verfahren zur herstellung von 2,6-substituierten 9-(1,3-dihydroxy-2-propoxymethyl)-purinen und einige derivate.

Country Status (5)

Country	Link
US (1)	US4621140A (de)
EP (1)	EP0152965B1 (de)
JP (1)	JPH064631B2 (de)
AT (1)	ATE57703T1 (de)
DE (1)	DE3580169D1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4826981A (en) *	1984-12-22	1989-05-02	Krka	Process for preparing 9-(2-hydroxyethoxymethyl)-guanine
DE3627024A1 (de) *	1985-09-24	1987-04-02	Hoechst Ag	In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
US4965270A (en) *	1987-05-30	1990-10-23	Beecham Group P.L.C.	Purine derivatives
US5055296A (en) *	1988-08-04	1991-10-08	Wagle Sudhakar S	Method of treating chronic fatigue syndrome
US5316775A (en) *	1988-08-04	1994-05-31	Kremers-Urban Company	Method of treating hepatitis B infection
US5334395A (en) *	1988-08-04	1994-08-02	Kremers-Urban Company	Method of treating an epstein-barr viral infection
US5284664A (en) *	1988-08-04	1994-02-08	Kremers-Urban Company	Method of treating the symptoms of Alzheimer's disease
DE4020481A1 (de) *	1990-06-27	1992-01-02	Hoechst Ag	Verfahren zur herstellung von substituierten acyclischen nukleosiden und dabei auftretende zwischenprodukte
US5233041A (en) *	1991-10-07	1993-08-03	Glaxo Group Limited	Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone from a 2,3-unsaturated-1-cyclopentanylpurinone
CA2076886C (en) *	1991-11-22	2002-06-11	Masami Igi	Method for production of 2-amino-6-halogenopurine and synthesis intermediate therefor
US5329008A (en) *	1993-04-07	1994-07-12	Glaxo Inc.	Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone
US5565565A (en) *	1994-08-04	1996-10-15	Syntex (U.S.A.) Inc.	Preparation of N-9 substituted guanine compounds
US6359114B1 (en)	1995-06-07	2002-03-19	Aphton Corp.	System for method for the modification and purification of proteins
JP5220253B2 (ja) *	1999-10-27	2013-06-26	株式会社ダイセル	アダマンチル（メタ）アクリレート類の製造法
CN1091445C (zh) *	1999-12-29	2002-09-25	湖北省医药工业研究院	抗病毒药物中间体、它们的制备及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4423050A (en) *	1981-05-21	1983-12-27	Syntex (U.S.A.) Inc.	9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4355032B2 (en) *	1981-05-21	1990-10-30		9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
ES8403128A1 (es) *	1981-08-11	1983-10-01	Wellcome Found	"un procedimiento para preparar derivados de purina".

1984
- 1984-02-23 US US06/582,696 patent/US4621140A/en not_active Expired - Lifetime
1985
- 1985-02-22 EP EP85102000A patent/EP0152965B1/de not_active Expired - Lifetime
- 1985-02-22 AT AT85102000T patent/ATE57703T1/de not_active IP Right Cessation
- 1985-02-22 DE DE8585102000T patent/DE3580169D1/de not_active Expired - Lifetime
- 1985-02-22 JP JP60035185A patent/JPH064631B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH064631B2 (ja)	1994-01-19
EP0152965B1 (de)	1990-10-24
EP0152965A2 (de)	1985-08-28
JPS60208954A (ja)	1985-10-21
US4621140A (en)	1986-11-04
DE3580169D1 (de)	1990-11-29
EP0152965A3 (en)	1986-07-23

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Legal Events

Date	Code	Title	Description
1991-04-15	UEP	Publication of translation of european patent specification
2005-05-15	EELA	Cancelled due to lapse of time