ATE57836T1 - Nichtdenaturierte virusfreie biologisch aktive proteinderivate. - Google Patents

Nichtdenaturierte virusfreie biologisch aktive proteinderivate.

Info

Publication number
ATE57836T1
ATE57836T1 AT84106557T AT84106557T ATE57836T1 AT E57836 T1 ATE57836 T1 AT E57836T1 AT 84106557 T AT84106557 T AT 84106557T AT 84106557 T AT84106557 T AT 84106557T AT E57836 T1 ATE57836 T1 AT E57836T1
Authority
AT
Austria
Prior art keywords
protein
plasma
biologically active
active protein
protein derivatives
Prior art date
Application number
AT84106557T
Other languages
English (en)
Inventor
Alexander Robert Neurath
Bernhard Horowitz
Original Assignee
New York Blood Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24046877&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE57836(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by New York Blood Center Inc filed Critical New York Blood Center Inc
Application granted granted Critical
Publication of ATE57836T1 publication Critical patent/ATE57836T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y10S530/831—Cohn fractions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT84106557T 1983-07-14 1984-06-08 Nichtdenaturierte virusfreie biologisch aktive proteinderivate. ATE57836T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/514,375 US4540573A (en) 1983-07-14 1983-07-14 Undenatured virus-free biologically active protein derivatives
EP84106557A EP0131740B2 (de) 1983-07-14 1984-06-08 Nichtdenaturierte virusfreie biologisch aktive Proteinderivate

Publications (1)

Publication Number Publication Date
ATE57836T1 true ATE57836T1 (de) 1990-11-15

Family

ID=24046877

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84106557T ATE57836T1 (de) 1983-07-14 1984-06-08 Nichtdenaturierte virusfreie biologisch aktive proteinderivate.

Country Status (8)

Country Link
US (1) US4540573A (de)
EP (1) EP0131740B2 (de)
JP (1) JPH06102627B2 (de)
AT (1) ATE57836T1 (de)
AU (1) AU563925B2 (de)
CA (1) CA1221910A (de)
DE (1) DE3483499D1 (de)
ZA (1) ZA844596B (de)

Families Citing this family (201)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4720385A (en) * 1983-03-29 1988-01-19 Miles Laboratories, Inc. Protein compositions substantially free from infectious agents
US4820805A (en) * 1983-07-14 1989-04-11 New York Blood Center, Inc. Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives
US4831012A (en) * 1984-03-23 1989-05-16 Baxter International Inc. Purified hemoglobin solutions and method for making same
US5281579A (en) * 1984-03-23 1994-01-25 Baxter International Inc. Purified virus-free hemoglobin solutions and method for making same
US5185160A (en) * 1984-06-21 1993-02-09 Prp, Inc. Platelet membrane microvesicles
JPS61103836A (ja) * 1984-10-24 1986-05-22 Green Cross Corp:The フイブロネクチン製剤
US4670394A (en) * 1984-11-16 1987-06-02 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Isolation and culture of adrenal medullary endothelial cells producing blood clotting factor VIII:C
US4613501A (en) * 1984-12-21 1986-09-23 New York Blood Center, Inc. Inactivation of viruses in labile blood derivatives
JPH0825902B2 (ja) * 1985-02-21 1996-03-13 株式会社ミドリ十字 γ−グロブリンの加熱処理方法
US4632980A (en) * 1985-04-03 1986-12-30 Immunologics Ozone decontamination of blood and blood products
US4789545A (en) * 1986-03-31 1988-12-06 New York Blood Center, Inc. Removal of lipid soluble process chemicals from biological materials by extraction with naturally occurring oils or synthetic substitutes thereof
US4841023A (en) * 1986-06-25 1989-06-20 New York Blood Center, Inc. Inactivation of viruses in labile protein-containing compositions using fatty acids
US4952812A (en) * 1986-08-26 1990-08-28 Baxter International Inc. Irradiation of blood products
FR2603805A1 (fr) * 1986-09-16 1988-03-18 Transfusion Sanguine Assoc Rgl Procede d'inactivation par ozonolyse de micro-organismes contaminants presents dans des materiaux biologiques essentiellement proteiques, les produits obtenus et leurs applications biologiques et analytiques
DE3704550A1 (de) * 1987-02-13 1988-08-25 Behringwerke Ag Verfahren zur inaktivierung huellhaltiger viren in mittels einer zelle in vitro hergestellten protein-praeparationen
CA1339946C (en) * 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
FR2618784B1 (fr) * 1987-07-30 1990-04-06 Lille Transfusion Sanguine Concentre de proteines coagulables par la thrombine, son procede d'obtention et son utilisation a titre de colle biologique
DE3730533A1 (de) * 1987-09-11 1989-03-30 Biotest Pharma Gmbh Verfahren zur sterilisation von plasma oder plasmafraktionen
DE3733181C1 (de) * 1987-10-01 1989-01-19 Biotest Pharma Gmbh Verfahren zur Herstellung eines hochreinen,virussicheren,biologisch aktiven Transferrinpraeparates
DE3877529T2 (de) * 1987-10-23 1996-11-07 Centre Regional De Transfusion Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat und dessen therapeutische Verwendung.
EP0321835B1 (de) * 1987-12-21 1994-09-28 Miles Inc. Faktor VIII- Gelfiltration
US4909940A (en) * 1987-12-30 1990-03-20 New York Blood Center, Inc. Extraction of process chemicals from labile biological mixtures with organic alcohols or with halogenated hydrocarbons
FR2630115B1 (fr) * 1988-04-14 1994-10-28 Merieux Inst Procede de stabilisation des solutions d'albumine humaine et solution obtenue
GB8809177D0 (en) * 1988-04-19 1988-05-25 Merrell Doe Pharmaceuticals In Method of preventing aids transmission-resulting from blood transfusions
FR2632309B1 (fr) 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
DE3825429C2 (de) * 1988-07-27 1994-02-10 Biotest Pharma Gmbh Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt
US5094960A (en) * 1988-10-07 1992-03-10 New York Blood Center, Inc. Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography
EP0367840B1 (de) 1988-11-05 1993-02-03 Octapharma AG Verfahren zur Herstellung eines hochreinen, nicht infektiösen Antihämophiliefaktors mittels Chromatographie
JP2926728B2 (ja) * 1988-12-29 1999-07-28 吉富製薬株式会社 蛋白質含有組成物の製造方法
EP0378208B2 (de) * 1989-01-13 2003-01-15 Mitsubishi Pharma Corporation Verfahren zur Herstellung einer Protein enthaltenden Zusammensetzung
JP3005979B2 (ja) * 1989-01-13 2000-02-07 吉富製薬株式会社 蛋白質含有組成物
US5026686A (en) * 1989-02-01 1991-06-25 Washington University Antiviral peptides
JP2852307B2 (ja) * 1989-02-09 1999-02-03 吉富製薬株式会社 ウイルスの除去された蛋白質製剤の製造法
US5332578A (en) * 1989-04-14 1994-07-26 Prp, Inc. Platelet membrane microparticles
USH1509H (en) * 1989-06-09 1995-12-05 Eran; Harutyun Heparin enhanced process for separating antihemophilic factor (Factor VIII) and fibronectin from cryoprecipitate
ATE138575T1 (de) * 1989-06-15 1996-06-15 Rorer Int Overseas Verfahren zur inaktivierung von viren in mit viren verunreinigten pharmazeutischen zusammensetzungen
DE4001098A1 (de) * 1990-01-17 1991-07-18 Octapharma Ag Traegergebundene dialkoxyphosphorverbindungen, verfahren zu ihrer herstellung und ihre verwendung
DE4001099A1 (de) * 1990-01-17 1991-07-18 Octapharma Ag Verfahren zur entfernung von viren aus biologischen fluessigkeiten
US5177194A (en) * 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
US5945098A (en) * 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
DE4008852A1 (de) * 1990-03-20 1991-09-26 Octapharma Ag Verfahren zur herstellung von nicht-infektioesem blutplasma
US6187572B1 (en) 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
US5418130A (en) * 1990-04-16 1995-05-23 Cryopharm Corporation Method of inactivation of viral and bacterial blood contaminants
JP3145696B2 (ja) * 1990-10-05 2001-03-12 日本ケミカルリサーチ株式会社 分泌型免疫グロブリンａ製剤の製造法
AT395597B (de) * 1991-01-25 1993-01-25 Immuno Ag Reagens zur bestimmung von faktor viii-aktivitaet
US5110910A (en) * 1991-03-25 1992-05-05 Miles Inc. Virucidal euglobulin precipitation
AT402262B (de) * 1991-06-20 1997-03-25 Immuno Ag Arzneimittel enthaltend aktiviertes protein c
AT402891B (de) * 1991-06-20 1997-09-25 Immuno Ag Verfahren zur herstellung eines inaktivierten blutproduktes
EP0523406B1 (de) * 1991-07-05 1998-12-09 Bayer Corporation Verwendung von Tri-n-Butylphosphat bei niedrigem pH in Lösungen von biologisch aktiven Proteinen für eine verbesserte viruzide Wirkung
DE4125625C2 (de) * 1991-08-02 1999-12-02 Octapharma Ag Glarus Verfahren zur Herstellung von virusinaktivierten Immunglobulinlösungen
AT408191B (de) * 1991-08-19 2001-09-25 Haemosan Erzeugung Pharmazeuti Verfahren zur inaktivierung von prionen
DE4142908C2 (de) * 1991-12-24 1994-02-10 Octapharma Ag Glarus Verfahren zur Herstellung eines virusinaktivierten Prothrombinkomplex-Konzentrats (PPSB)
US5571166A (en) * 1992-03-19 1996-11-05 Medtronic, Inc. Method of making an intraluminal stent
US5599352A (en) * 1992-03-19 1997-02-04 Medtronic, Inc. Method of making a drug eluting stent
US5510077A (en) 1992-03-19 1996-04-23 Dinh; Thomas Q. Method of making an intraluminal stent
AT399818B (de) * 1992-04-24 1995-07-25 Immuno Ag Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation
JPH06166634A (ja) * 1992-12-01 1994-06-14 Green Cross Corp:The プラスミノーゲン含有組成物の製造方法
US5403834A (en) * 1992-12-07 1995-04-04 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
AU6653094A (en) * 1992-12-16 1994-07-04 Immuno Aktiengesellschaft Process for preparing a virus-safe biological composition
DE4318435C2 (de) * 1993-02-09 1997-01-23 Octapharma Ag Verfahren zur Inaktivierung von Viren, die nicht mit Lipidhüllen versehen sind
AU676011B2 (en) * 1993-02-09 1997-02-27 Octapharma Ag Method for inactivating viruses devoid of lipid envelopes
US20020055710A1 (en) 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
SE9301582D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Purification of plasma proteins
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
WO1995000631A1 (en) * 1993-06-23 1995-01-05 New York Blood Center, Inc. System for viral inactivation of blood
PT710126E (pt) 1993-07-30 2004-09-30 Aruba Internat Pty Ltd Sistema de deslipidacao do plasma
DE4325872C1 (de) * 1993-08-02 1994-08-04 Immuno Ag Virusinaktivierte Faktor Xa-Präparation
DE4337573C1 (de) * 1993-11-04 1995-05-18 Octapharma Ag Verfahren zur Herstellung einer virusinaktivierten Faktor VIII enthaltenden Fraktion mittels chromatographischer Methoden
DE4342132C1 (de) 1993-12-10 1994-11-03 Octapharma Ag Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie
US5486293A (en) * 1994-03-21 1996-01-23 Hemasure, Inc. Removal of small exogenous molecules from biological fluids
US6372716B1 (en) * 1994-04-26 2002-04-16 Genetics Institute, Inc. Formulations for factor IX
JPH07308190A (ja) * 1994-05-18 1995-11-28 Green Cross Corp:The トロンビンの製造方法
US6284874B1 (en) * 1994-06-17 2001-09-04 Alpha Therapeutic Corporation Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
CA2195127C (en) * 1994-07-14 2007-06-19 Ruth Laub Concentrate of fibrinogene obtained from blood plasma, process and plant for its preparation
DE4424935C1 (de) 1994-07-14 1996-03-21 Immuno Ag Humanes virussicheres monomeres Immunglobulin A und Verfahren zu seiner Herstellung
DE4431833C1 (de) * 1994-09-07 1995-05-18 Blutspendedienst Der Drk Lande Verfahren zur Herstellung eines AHF-Konzentrates
US5506127A (en) * 1994-09-21 1996-04-09 Proba; Zbigniew Therapeutic grade thrombin produced by chromatography
DE4435485C1 (de) * 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
AUPN030794A0 (en) 1994-12-22 1995-01-27 Aruba International Pty Ltd Discontinuous plasma or serum delipidation
DE19506633A1 (de) 1995-02-25 1996-08-29 Octapharma Ag Verfahren zur Herstellung von Faktor IX aus biologischen Quellen
US6034073A (en) * 1995-04-24 2000-03-07 Novavax, Inc. Solvent detergent emulsions having antiviral activity
FI952196A0 (fi) * 1995-05-08 1995-05-08 Suomen Punainen Risti Veripalv Framstaellning av immunoglobulin
DE19528221C2 (de) * 1995-08-01 1998-10-22 Blutspendedienst Der Drk Lande Verfahren zur Herstellung eines virussicheren, therapeutischen Präparates aus Humanplasma
US20040053208A1 (en) * 1995-08-29 2004-03-18 V. I. TECHNOLOGIES, Inc. Methods to selectively inactivate parasites in biological compositions
US5741894A (en) * 1995-09-22 1998-04-21 Baxter International, Inc. Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
US6686191B1 (en) * 1995-09-22 2004-02-03 Bayer Healthcare Llc Preparation of virally inactivated intravenously injectable immune serum globulin
US6005077A (en) * 1995-11-10 1999-12-21 Immuno Aktiengesellschaft Use of von willebrand factor and pharmaceutical formulation
DE19600939C1 (de) 1996-01-12 1997-08-28 Immuno Ag Verfahren zur Trennung von IgG und IgA
US5770700A (en) * 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
US6068838A (en) * 1996-04-29 2000-05-30 Baxter Aktiengesellschaft Purified multimerase
US5744586A (en) * 1996-06-26 1998-04-28 Alpha Therapeutic Corporation Manufacturing process for the production of purified transferrin
US5616693A (en) * 1996-07-01 1997-04-01 Alpha Therapeutic Corporation Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste
US5833651A (en) * 1996-11-08 1998-11-10 Medtronic, Inc. Therapeutic intraluminal stents
WO1998030230A1 (en) * 1997-01-09 1998-07-16 Yoshitomi Pharmaceutical Industries, Ltd. Protein-containing compositions and process for producing the same
AT405135B (de) * 1997-01-17 1999-05-25 Immuno Ag Präparation umfassend thiolgruppen-hältige proteine
AT404358B (de) 1997-02-04 1998-11-25 Immuno Ag Verfahren zur chromatographischen reinigung bzw. fraktionierung von von willebrand-faktor aus einem vwf-hältigen ausgangsmaterial
AT406373B (de) 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
US6124437A (en) * 1997-03-19 2000-09-26 Welfide Corporation Immunoglobulin preparation and preparation process thereof
US6126259A (en) * 1997-03-25 2000-10-03 Trident International, Inc. Method for increasing the throw distance and velocity for an impulse ink jet
AT405608B (de) * 1997-04-08 1999-10-25 Immuno Ag Verfahren zur inaktivierung von pathogenen, insbesondere von viren, in einem biologischen material
DK0973544T3 (da) 1997-04-08 2001-10-15 Baxter Ag Immuntolerant prothrombinkomplekspræparat
AT405485B (de) 1997-05-28 1999-08-25 Immuno Ag Eine das vwf-propeptid enthaltende pharmazeutische präparation
GB9711927D0 (en) * 1997-06-09 1997-08-06 Bristol Myers Squibb Co Compositions useful as fibrin sealants
AT407159B (de) † 1997-06-13 2001-01-25 Immuno Ag Verfahren zur abreicherung von viralen und molekularen pathogenen aus einem biologischen material
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US6203536B1 (en) 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US6955917B2 (en) * 1997-06-20 2005-10-18 Bayer Healthcare Llc Chromatographic method for high yield purification and viral inactivation of antibodies
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
AT406120B (de) 1997-08-28 2000-02-25 Immuno Ag Gewebekleber
AT407117B (de) 1997-09-19 2000-12-27 Immuno Ag Fibrinschwamm
AT405739B (de) 1997-09-19 1999-11-25 Immuno Ag Verfahren zur reinigung von antithrombin iii
US6015832A (en) * 1997-12-31 2000-01-18 The Regents Of The University Of Michigan Methods of inactivating bacteria including bacterial spores
US6369048B1 (en) 1998-01-12 2002-04-09 V.I. Technologies, Inc. Methods and compositions for inactivating viruses
US6013099A (en) * 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US6206914B1 (en) 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
US6429192B1 (en) * 1998-06-10 2002-08-06 Statens Serum Institut Purification process for production of mannan-binding lectin and an MBL medicinal product
ES2263451T3 (es) 1999-02-12 2006-12-16 Baxter Aktiengesellschaft Metodo para producir un preparado basado en fibrinogeno y fibronectina, asi como composiciones proteinicas que se pueden obtener segun este metodo.
ES2435141T3 (es) 1999-02-22 2013-12-18 University Of Connecticut Nuevas formulaciones de factor VIII libres de albúmina
US6270672B1 (en) 1999-08-06 2001-08-07 Baxter Aktiengesellschaft Devices and methods for removing pathogens from biological fluids
AT410218B (de) 1999-08-20 2003-03-25 Baxter Ag Verfahren zur herstellung eines qualitätsgesicherten pools biologischer proben
US6436344B1 (en) 1999-11-02 2002-08-20 American National Red Cross Method of inactivating pathogens
EP1250929A4 (de) * 1999-12-20 2004-12-29 Mitsubishi Pharma Corp MITTELS PORöSER MEMBRAN BEHANDELTE, VIREN-FREIE PLASMAPROTEIN-VERBINDUNG UND DEREN HERSTELLUNGSPROZESS
IL150358A0 (en) * 1999-12-22 2002-12-01 Univ Pennsylvania Cosmid dna constructs and methods of making the same
AUPQ486699A0 (en) * 1999-12-23 2000-02-03 Aruba International Pty Ltd A method of treating infectious diseases
DE10012732A1 (de) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
IL136552A (en) 2000-06-05 2005-05-17 Omrix Biopharmaceuticals Ltd Method for the inactivation of viruses by a solvent - detergent combination and by nanofiltration
US20020176796A1 (en) * 2000-06-20 2002-11-28 Purepulse Technologies, Inc. Inactivation of microbes in biological fluids
US7407663B2 (en) * 2000-06-29 2008-08-05 Lipid Sciences, Inc. Modified immunodeficiency virus particles
US20090017069A1 (en) 2000-06-29 2009-01-15 Lipid Sciences, Inc. SARS Vaccine Compositions and Methods of Making and Using Them
US7439052B2 (en) 2000-06-29 2008-10-21 Lipid Sciences Method of making modified immunodeficiency virus particles
US7407662B2 (en) * 2000-06-29 2008-08-05 Lipid Sciences, Inc. Modified viral particles with immunogenic properties and reduced lipid content
PT1343809E (pt) 2000-12-14 2015-09-22 Grifols Therapeutics Inc Método de preparação de inibidor de proteinase alfa-1
US20020146409A1 (en) * 2001-01-30 2002-10-10 Herring Steven W. Methods for stabilizing lyophilized blood proteins
AU2002318396A1 (en) * 2001-06-21 2003-01-08 The Cleveland Clinic Foundation Homocysteinylated transthyretin
US20030127386A1 (en) * 2001-06-25 2003-07-10 Bomberger David C. Hollow fiber contactor systems for removal of lipids from fluids
US6991727B2 (en) * 2001-06-25 2006-01-31 Lipid Sciences, Inc. Hollow fiber contactor systems for removal of lipids from fluids
AU2002322284A1 (en) * 2001-06-25 2003-01-08 Lipid Sciences, Inc. Systems and methods using multiple solvents for the removal of lipids from fluids
CA2451633C (en) * 2001-06-25 2010-11-30 Lipid Sciences, Inc. Systems and methods using a solvent for the removal of lipids from fluids
US20060060520A1 (en) 2001-06-25 2006-03-23 Bomberger David C Systems and methods using a solvent for the removal of lipids from fluids
US20030133829A1 (en) * 2001-12-21 2003-07-17 Baxter Healthcare Corporation Process for inactivating pathogens in a biological material
EP1534243A4 (de) * 2002-08-26 2008-08-13 Lipid Sciences Inc Behandlung von alzheimer mit entlipidierten protein-teilchen
DK2266630T3 (en) 2003-02-27 2014-03-17 Baxter Int Device for calibration by a method for validating inactivation of pathogens in a biological fluid by irradiation
EP1614424B1 (de) * 2003-04-09 2015-07-22 The Chemo-Sero-Therapeutic Research Institute Verfahren zur herstellung einer albumin-zubereitung
US20050208083A1 (en) * 2003-06-04 2005-09-22 Nanobio Corporation Compositions for inactivating pathogenic microorganisms, methods of making the compositons, and methods of use thereof
ES2547547T3 (es) * 2003-07-03 2015-10-07 Hdl Therapeutics, Inc. Enriquecimiento de lipoproteínas de alta densidad pre-beta
US7393826B2 (en) 2003-07-03 2008-07-01 Lipid Sciences, Inc. Methods and apparatus for creating particle derivatives of HDL with reduced lipid content
US20060034943A1 (en) * 2003-10-31 2006-02-16 Technology Innovations Llc Process for treating a biological organism
AU2012201036B2 (en) * 2003-12-01 2014-12-04 Novo Nordisk Health Care Ag Virus filtration of liquid factor VII compositions
ES2507091T3 (es) * 2003-12-01 2014-10-14 Novo Nordisk Health Care Ag Nanofiltración de soluciones del factor VII para eliminar virus
CA2556169C (en) * 2004-01-29 2011-11-22 Andrew Lees Use of amino-oxy functional groups in the preparation of vaccines
RU2337109C2 (ru) 2004-02-27 2008-10-27 Октафарма Аг ПРЕПАРАТ ИММУНОГЛОБУЛИНА IgG И СПОСОБ ЕГО ПОЛУЧЕНИЯ
WO2006011161A2 (en) * 2004-06-29 2006-02-02 Reliance Life Sciences Pvt Ltd Process for the preparation of virus-safe biological fluids
US7993580B2 (en) * 2004-08-24 2011-08-09 Baxter International Inc. Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors
GB0423196D0 (en) 2004-10-19 2004-11-24 Nat Blood Authority Method
AU2005229674B2 (en) * 2004-11-18 2010-11-04 Kedrion Melville Inc. Low concentration solvent/detergent process of immuneglobulin with pre-treatment
EP1685852A1 (de) 2005-02-01 2006-08-02 Fondation pour la Recherche Diagnostique Set von Einwegbeuteln zur Virusinaktivierung von biologischen Fluids
US20070054834A1 (en) * 2005-04-11 2007-03-08 Nanobio Corporation Quaternary ammonium halides for treatment of infectious conditions
WO2006122476A1 (fr) * 2005-04-29 2006-11-23 Chengdu Kuachang Medical Industrial Limited Procede d’inactivation de virus, systeme de traitement et dispositif correspondants
WO2006116899A1 (en) * 2005-04-29 2006-11-09 Chengdu Kuachang Medical Industrial Limited The system, solid phase medium, device and method for bio-fluid treatment
FR2887883B1 (fr) 2005-06-29 2007-08-31 Lab Francais Du Fractionnement Procede de separation des proteines fibrinogene, facteur xiii et colle biologique d'une fraction plasmatique solubilisee et de preparation de concentres lyophilises desdites proteines
EP1739179A1 (de) 2005-06-30 2007-01-03 Octapharma AG Serumfreie stabile Transfektion und Produktion von rekombinanten humanen Proteinen in humanen Zelllinien
EP1951200A2 (de) * 2005-08-09 2008-08-06 Nanobio Corporation Eine nanoemulsion enthaltende zusammensetzungen mit entzündungshemmender wirkung
US20070128693A1 (en) * 2005-12-06 2007-06-07 Advantek Serum Laboratories Limited3/F Method for the inactivation and removal of dengue virus from biological samples
EP1964579A1 (de) * 2007-02-14 2008-09-03 Fondation pour la Recherche Diagnostique Herstellung viral inaktiver biologischer Flüssigkeiten mit hoher Alpha-2-Antiplasmin-Aktivität
US8222015B2 (en) * 2007-05-11 2012-07-17 Toyota Motor Engineering & Manufacturing North America, Inc. Heat resistant bioactive composition
US9956272B2 (en) 2007-05-30 2018-05-01 Bio Products Laboratory Limited Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same
GB0710321D0 (en) * 2007-05-30 2007-07-11 Nhs Blood & Transplant Method
EP2077118A1 (de) * 2008-01-07 2009-07-08 Gwo Rei Biomedical Technology Corp. Gerinnungsfähiges Konzentrat von Plättchenwachstumsfaktoren und Herstellungsverfahren dafür
BRPI0909724A2 (pt) * 2008-03-28 2017-06-13 Res Foundation For Medical Devices método de inativação viral de fluidos biológicos por tratamento com solvente/detergente.
RU2567811C2 (ru) 2008-06-24 2015-11-10 Октафарма Аг Способ очистки фактора свертывания крови viii
NZ593190A (en) 2008-11-07 2013-01-25 Baxter Int Factor viii formulations
DK2350271T3 (en) 2008-11-20 2016-04-04 Biogen Ma Inc ARGININ INACTIVATION OF ENVIRONMENT VIRA
US20100150942A1 (en) * 2008-12-03 2010-06-17 Cantor Thomas L Affinity purified human polyclonal antibodies and methods of making and using them
US8647621B2 (en) 2009-07-27 2014-02-11 Fina Biosolutions, Llc Method of producing protein-carbohydrate vaccines reduced in free carbohydrate
US8945895B2 (en) 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
FR2952641B1 (fr) 2009-11-18 2012-01-13 Lfb Biomedicaments Procede de traitement du plasma sanguin comprenant une etape de lavage par dispersion
CA2836140C (en) 2009-12-17 2016-06-21 Fina Biosolutions, Llc Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines
MX2012011066A (es) 2010-03-30 2012-10-10 Octapharma Ag Proceso para purificar proteinas dependientes de vitamina k tal como el factor ix de coagulacion.
JP5948315B2 (ja) 2010-03-30 2016-07-06 オクタファルマ・アーゲー 成長因子タンパク質の精製方法
US8383783B2 (en) 2010-04-23 2013-02-26 Serum Institute Of India, Ltd. Simple method for simultaneous removal of multiple impurities from culture supernatants to ultralow levels
EP2399613A1 (de) 2010-06-22 2011-12-28 Research Foundation For Medical Devices Plasmafraktionierung mittels Verwendung der Caprylsäure
JP2013537215A (ja) 2010-09-20 2013-09-30 オクタファルマ・アーゲー フィブリノーゲンの生産方法
BR112013011277A2 (pt) * 2010-11-16 2016-11-01 Octapharma Ag processo para redução e/ou remoção de fxi e fxia a partir de soluções contendo os referidos fatores de coagulação
CA2826969C (en) 2010-11-29 2019-02-19 New York Blood Center, Inc. Method of blood pooling and storage
WO2012137199A1 (en) 2011-04-07 2012-10-11 Efranat Ltd. Macrophage activating factor for pharmaceutical compositions
EP2771358A4 (de) * 2011-10-26 2015-08-26 Bio Rad Laboratories Entfernung von virustötenden substanzen in einer mischmoduschromatographie
ES2642383T3 (es) 2012-03-13 2017-11-16 Octapharma Ag Procedimiento mejorado de producción de fibrinógeno y fibrinógeno producido por el mismo
ES2381828B1 (es) 2012-03-20 2012-11-16 Grifols, S.A. PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO
US9534029B2 (en) 2012-10-03 2017-01-03 Csl Behring Ag Method of purifying proteins
WO2014055552A1 (en) 2012-10-03 2014-04-10 Csl Behring Llc A method of purifying proteins
US20140154233A1 (en) 2012-12-05 2014-06-05 Csl Limited Method of purifying therapeutic proteins
US10188965B2 (en) 2012-12-05 2019-01-29 Csl Behring Gmbh Hydrophobic charge induction chromatographic depletion of a protein from a solution
JP6700197B2 (ja) 2014-04-30 2020-05-27 ノヴォ ノルディスク アー／エス カプリル酸を用いてタンパク質を精製する方法
CN107073084B (zh) * 2014-11-05 2022-03-25 雅培制药股份有限公司 用于生产具有改善的安全特性的具有脂肪酶活性的组合物和适用于药物用途的组合物的方法
SG11202000210UA (en) 2017-08-08 2020-02-27 Csl Behring Ag Hemopexin formulations
CN111511800B (zh) 2017-10-30 2023-11-28 武田药品工业株式会社 灭活脂包膜病毒的环境相容性去污剂
CN111868232B (zh) 2017-11-22 2024-05-28 Hdl治疗公司 用于对血浆处理系统的流体回路进行灌注的系统和方法
CN112040932A (zh) 2017-12-28 2020-12-04 Hdl治疗公司 一种保存和给药自人类血浆提取的前-β高密度脂蛋白的方法
EP3945095A1 (de) 2020-07-28 2022-02-02 Bia Separations D.O.O. Verfahren zur reinigung von prothrombinkomplexkonzentrat (pcc) und fixierung aus vollständigem plasma oder kryoarmem plasma
JP2026502812A (ja) 2022-12-22 2026-01-27 ツェー・エス・エル・ベーリング・アクチエンゲゼルシャフト 混合モードクロマトグラフィーを使用するヘモペキシンの精製方法
WO2025168750A1 (en) 2024-02-09 2025-08-14 Csl Behring Ag Haptoglobin for use in treating traumatic brain injury (tbi)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962421A (en) * 1973-06-18 1976-06-08 American Home Products Corporation Method for the disruption of lipid-containing viruses
DE3033932C2 (de) * 1980-09-10 1984-05-24 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Kaltsterilisation von Blutgerinnungsfaktor VIII enthaltenden Präparaten
US4315919A (en) * 1980-10-06 1982-02-16 Edward Shanbrom Depyrogenation process
US4314997A (en) * 1980-10-06 1982-02-09 Edward Shanbrom Purification of plasma protein products

Also Published As

Publication number Publication date
EP0131740A2 (de) 1985-01-23
EP0131740A3 (en) 1985-08-07
EP0131740B1 (de) 1990-10-31
ZA844596B (en) 1985-02-27
EP0131740B2 (de) 1994-09-28
CA1221910A (en) 1987-05-19
AU563925B2 (en) 1987-07-30
JPH06102627B2 (ja) 1994-12-14
AU3050384A (en) 1985-01-17
US4540573A (en) 1985-09-10
DE3483499D1 (de) 1990-12-06
JPS6051116A (ja) 1985-03-22

Similar Documents

Publication Publication Date Title
ATE57836T1 (de) Nichtdenaturierte virusfreie biologisch aktive proteinderivate.
ATE92107T1 (de) N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen.
EP0431129A4 (en) Methods for the inactivation of viruses in viral-contaminated pharmaceutical compositions
DK162983D0 (da) Fremgangsmade til fremstilling af steriliseret plasma og plasmaderivater
ATE180834T1 (de) Antikoagulierende proteine
DE3874798D1 (de) Therapeutisches proteinagens in form von aerosol.
DE3686295D1 (de) Reinigung von koagulationsfaktoren des blutes und von anderen proteinen auf sulfatierten nicht carbohydratierten matrizen.
DE68901098D1 (de) Zusammensetzung aus antikoagulantia.
DE3582973D1 (de) Neues derivat des humangammainterferon-polypeptids.
EP0225020A3 (de) Peptide, welche in der Sequenz Einheiten von Aminosäureresten 17 bis 24 von VIP enthalten
DE68917837D1 (de) Peptid-Verbindungen.
ES535409A0 (es) Procedimiento para pasterizar un plasma de radical-humano
DK226889A (da) Alkoholpeptidderivat samt anvendelse deraf til mindskning af blodkoagulation
NO892266D0 (no) Amblyommin, et nytt virkemiddel for antikoagulasjonsterapien.
PT92503A (pt) Processo para a preparacao de novos derivados peptidicos com accao anti-coagulante
DE69018275D1 (de) Peptide, deren Verwendung als Hemmer gegen Entwicklung von t-Lymphocyten und Wirksamkeit von Makrophagen und Verfahren zu deren Herstellung.
BG90414A (bg) 2-азабицикло (2,2,1)-хепт-5- ен-2-оцетна киселина и нейни производни, метод за получаване и приложението им
DE3888727D1 (de) Verwendung von Äthylamin-Derivaten als antihypertensive Wirkstoffe.
ATE24716T1 (de) Lenkotrien-antagonisten.
DK59785D0 (da) Fremgangsmaade til fremstilling af i det vaesentlige fibrinogenfrit ahf
DK708488D0 (da) Faktor i praeparat
IT1173763B (it) Derivati dell'acido 3-mercapto-2-oxo-1-pirrolidinacetico,procedimento di preparazione e composizioni farmaceutiche che li contengono
KR900701834A (ko) 사람 호중구 화학주성 인자를 사람에게 투여하는 것에 의한 면역결핍 상태에 의해 유발된 질병의 치료방법
NO881501L (no) Rekombinante htlv-111-proteiner og anvendelser av disse.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
UEP Publication of translation of european patent specification
EETV Partially withdrawn
EELA Cancelled due to lapse of time