ATE60061T1 - Ankondensierte siebengliedrige ringverbindungen, ihre herstellung und ihre verwendung. - Google Patents

Ankondensierte siebengliedrige ringverbindungen, ihre herstellung und ihre verwendung.

Info

Publication number: ATE60061T1
Authority: AT; Austria
Prior art keywords: sup; membered ring; condensed; ring compounds; production
Prior art date: 1983-04-22

Application number

AT84302564T

Other languages

English (en)

Inventor

Hirosada Sugihara

Kohei Nishikawa

Katsumi Ito

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-22

Filing date

1984-04-13

Publication date

1991-02-15

1983-04-22 Priority claimed from PCT/JP1983/000127 external-priority patent/WO1984004306A1/ja

1983-10-13 Priority claimed from PCT/JP1983/000342 external-priority patent/WO1985001730A1/ja

1984-03-24 Priority claimed from PCT/JP1984/000119 external-priority patent/WO1985004402A1/ja

1984-04-13 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1991-02-15 Application granted granted Critical

1991-02-15 Publication of ATE60061T1 publication Critical patent/ATE60061T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
External Artificial Organs (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT84302564T 1983-04-22 1984-04-13 Ankondensierte siebengliedrige ringverbindungen, ihre herstellung und ihre verwendung. ATE60061T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
PCT/JP1983/000127 WO1984004306A1 (fr)	1983-04-22	1983-04-22	C0mposes cycliques a 7 membres fusionnes et leur procede de preparation
PCT/JP1983/000342 WO1985001730A1 (fr)	1983-10-13	1983-10-13	Composes cycliques fusionnes a 7 membres et leur procede de preparation
PCT/JP1984/000119 WO1985004402A1 (fr)	1984-03-24	1984-03-24	Composes cycliques fusionnes a sept membres et leur procede de preparation
EP84302564A EP0125056B1 (de)	1983-04-22	1984-04-13	Ankondensierte siebengliedrige Ringverbindungen, ihre Herstellung und ihre Verwendung

Publications (1)

Publication Number	Publication Date
ATE60061T1 true ATE60061T1 (de)	1991-02-15

Family

ID=27304084

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT84302564T ATE60061T1 (de)	1983-04-22	1984-04-13	Ankondensierte siebengliedrige ringverbindungen, ihre herstellung und ihre verwendung.

Country Status (17)

Country	Link
US (1)	US4564612A (de)
EP (1)	EP0125056B1 (de)
KR (1)	KR910007965B1 (de)
AT (1)	ATE60061T1 (de)
AU (1)	AU565188B2 (de)
CA (1)	CA1209993A (de)
DE (1)	DE3483920D1 (de)
ES (2)	ES531740A0 (de)
FI (1)	FI82455C (de)
GR (1)	GR79905B (de)
HU (1)	HU193008B (de)
IE (1)	IE57599B1 (de)
IL (1)	IL71617A (de)
NO (1)	NO162235C (de)
NZ (1)	NZ207915A (de)
PH (1)	PH21294A (de)
PT (1)	PT78454B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2143816A (en) *	1983-06-29	1985-02-20	Mitsui Toatsu Chemicals	Benzothiazepine derivatives
AU570710B2 (en) *	1983-08-12	1988-03-24	Takeda Chemical Industries Ltd.	4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives
US4512988A (en) *	1984-03-01	1985-04-23	E. R. Squibb & Sons, Inc.	Acylamino oxo or hydroxy substituted alkylamino thiazines and thiazepines
IL74004A (en) *	1984-03-24	1991-12-15	Takeda Chemical Industries Ltd	3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine derivatives,their production and pharmaceutical compositions containing them
EP0187037A3 (de) *	1984-12-21	1988-03-23	Takeda Chemical Industries, Ltd.	Piperidinderivate, deren Herstellung und Benützung
US4692522A (en) *	1985-04-01	1987-09-08	Merck & Co., Inc.	Benzofused lactams useful as cholecystokinin antagonists
JPH0657707B2 (ja) *	1987-05-25	1994-08-03	吉富製薬株式会社	ピペリジン化合物
JPS6450872A (en) *	1987-08-21	1989-02-27	Tanabe Seiyaku Co	Production of 1,5-benzothiazepine derivative
EP0322779A3 (de) *	1987-12-29	1991-05-08	Yoshitomi Pharmaceutical Industries, Ltd.	Benzolaktam-Verbindungen und deren pharmazeutische Verwendungen
US5290927A (en) *	1988-03-01	1994-03-01	Ajinomoto Co., Inc.	Process for preparing 2',3'-dideoxyadenosine
AT393998B (de) *	1990-02-16	1992-01-10	Troendle Peter Paul	Buch
EP0648213A1 (de) *	1992-07-01	1995-04-19	Pfizer Inc.	Benzothiazepin ind Benzoxazepin Derivate als Cholecystokinin Rezeptor Inhibitoren
ZA941003B (en) *	1993-02-15	1995-08-14	Wellcome Found	Hypolipidaemic compounds
ZA956647B (en) *	1994-08-10	1997-02-10	Wellcome Found	Hypolipidaemic compounds.
DE19510566A1 (de) *	1995-03-23	1996-09-26	Kali Chemie Pharma Gmbh	Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2781483A1 (fr) *	1998-07-21	2000-01-28	Hoechst Marion Roussel Inc	Derives de thioazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicament et compositions pharmaceutiques les renfermant
FR2807039A1 (fr) *	2000-03-31	2001-10-05	Adir	NOUVEAU PROCEDE DE PREPARATION DE LA 11-AMINO-3-CHLORO-6,11- DIHYDRO-5,5-DIOXO-6-METHYL-DIBENZO[c,f][1,2]-THIAZEPINE ET APPLICATION A LA SYNTHESE DE LA TIANEPTINE

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3341519A (en) *	1965-04-28	1967-09-12	Squibb & Sons Inc	Novel benzoxazines, benzothiazines, benzoxazepins and benzothiazepins
AU543804B2 (en) *	1980-10-31	1985-05-02	Takeda Chemical Industries Ltd.	Amides having bicyclic substituents on nitrogen
DE3260505D1 (en) *	1981-01-23	1984-09-13	Takeda Chemical Industries Ltd	Alicyclic compounds, their production and use
EP0068173B1 (de) *	1981-06-05	1984-09-26	Merck & Co. Inc.	Perhydro-1,4-thiazepin-5-one und Perhydro-1,4-thiazocin-5-one, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CY1403A (en) *	1981-08-11	1987-12-18	Ciba Geigy Ag	Benzazepin-2-ones
JPS5829779A (ja) *	1981-08-17	1983-02-22	Nippon Iyakuhin Kogyo Kk	Ｎ−アミノアルキル−１，５−ベンゾチアゼピン誘導体の製造法
US4477464A (en) *	1983-02-10	1984-10-16	Ciba-Geigy Corporation	Hetero-benzazepine derivatives and their pharmaceutical use
US4460579A (en) *	1983-02-28	1984-07-17	E. R. Squibb & Sons, Inc.	Thiazine and thiazepine containing compounds
GB2143816A (en) *	1983-06-29	1985-02-20	Mitsui Toatsu Chemicals	Benzothiazepine derivatives

1984
- 1984-04-11 US US06/599,187 patent/US4564612A/en not_active Expired - Fee Related
- 1984-04-13 AT AT84302564T patent/ATE60061T1/de not_active IP Right Cessation
- 1984-04-13 IE IE927/84A patent/IE57599B1/en not_active IP Right Cessation
- 1984-04-13 EP EP84302564A patent/EP0125056B1/de not_active Expired - Lifetime
- 1984-04-13 DE DE8484302564T patent/DE3483920D1/de not_active Expired - Fee Related
- 1984-04-17 NO NO841555A patent/NO162235C/no unknown
- 1984-04-18 GR GR74460A patent/GR79905B/el unknown
- 1984-04-18 ES ES531740A patent/ES531740A0/es active Granted
- 1984-04-18 PH PH30584A patent/PH21294A/en unknown
- 1984-04-19 AU AU27092/84A patent/AU565188B2/en not_active Ceased
- 1984-04-19 NZ NZ207915A patent/NZ207915A/en unknown
- 1984-04-19 PT PT78454A patent/PT78454B/pt not_active IP Right Cessation
- 1984-04-19 FI FI841590A patent/FI82455C/fi not_active IP Right Cessation
- 1984-04-19 CA CA000452446A patent/CA1209993A/en not_active Expired
- 1984-04-20 HU HU841550A patent/HU193008B/hu not_active IP Right Cessation
- 1984-04-21 KR KR1019840002110A patent/KR910007965B1/ko not_active Expired
- 1984-04-22 IL IL71617A patent/IL71617A/xx unknown
1985
- 1985-07-01 ES ES544748A patent/ES8609290A1/es not_active Expired

Also Published As

Publication number	Publication date
HUT34176A (en)	1985-02-28
PT78454B (en)	1986-08-28
AU2709284A (en)	1984-10-25
ES8609290A1 (es)	1986-07-16
EP0125056A3 (en)	1986-04-16
FI841590A0 (fi)	1984-04-19
ES544748A0 (es)	1986-07-16
CA1209993A (en)	1986-08-19
FI82455B (fi)	1990-11-30
ES8602699A1 (es)	1985-12-01
IE840927L (en)	1984-10-22
NZ207915A (en)	1986-10-08
NO162235C (no)	1989-11-29
ES531740A0 (es)	1985-12-01
IL71617A0 (de)	1984-07-31
KR910007965B1 (ko)	1991-10-04
US4564612A (en)	1986-01-14
PT78454A (en)	1984-05-01
GR79905B (de)	1984-10-31
IL71617A (en)	1988-05-31
KR840008346A (ko)	1984-12-14
DE3483920D1 (de)	1991-02-21
NO162235B (no)	1989-08-21
FI841590A7 (fi)	1984-10-23
FI82455C (fi)	1991-03-11
PH21294A (en)	1987-09-28
IE57599B1 (en)	1993-01-27
NO841555L (no)	1984-10-23
EP0125056B1 (de)	1991-01-16
AU565188B2 (en)	1987-09-10
EP0125056A2 (de)	1984-11-14
HU193008B (en)	1987-08-28

Legal Events

Date	Code	Title	Description
1991-11-15	UEP	Publication of translation of european patent specification
1995-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE60061T1 (de)	1991-02-15	Ankondensierte siebengliedrige ringverbindungen, ihre herstellung und ihre verwendung.
ATE38383T1 (de)	1988-11-15	Kondensierte siebengliedrige ringverbindungen und deren herstellung und verwendung.
DE69111029D1 (de)	1995-08-10	Kondensierte heterocyclische Verbindungen, ihre Herstellung und Verwendung.
ATE117681T1 (de)	1995-02-15	Chinolinderivate, ihre herstellung und verwendung.
EP0348523A4 (en)	1991-10-09	Thienodiazepine compounds and their medicinal use
DE69311837D1 (de)	1997-08-07	Steroide zur Behandlung von Prostatisch-Hypertrophe, ihre Herstellung und Verwendung
ES8801653A1 (es)	1988-02-16	Un procedimiento para preparar derivados de 3-amino-4-oxo-2,3,4,5-benzoxapina
ES8801635A1 (es)	1988-02-16	Un procedimiento para preparar derivados de 3-amino-4-oxo-2,3,4,5-tetrahidro-1,5-benzoxazepina.
ATE4639T1 (de)	1983-09-15	Neue 1-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung.
ATE15669T1 (de)	1985-10-15	Derivate der 3-amino-1-heteroaryloxy-propanolklasse, ihre verwendung in der therapie und ein verfahren zu ihrer herstellung.