ATE60228T1 - Ibuprofen-formulation mit verzoegerter wirkstoffabgabe. - Google Patents

Ibuprofen-formulation mit verzoegerter wirkstoffabgabe.

Info

Publication number: ATE60228T1
Authority: AT; Austria
Prior art keywords: parts; ibuprofen; core; delayed; water
Prior art date: 1986-08-01

Application number

AT87306837T

Other languages

English (en)

Inventor

Brian William Barry

Peter York

Bryan Arthur Mulley

Original Assignee

Aps Res Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-01

Filing date

1987-07-31

Publication date

1991-02-15

1987-07-31 Application filed by Aps Res Ltd filed Critical Aps Res Ltd

1991-02-15 Application granted granted Critical

1991-02-15 Publication of ATE60228T1 publication Critical patent/ATE60228T1/de

Links

229960001680 ibuprofen Drugs 0.000 title abstract 4
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title abstract 3
238000009472 formulation Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
239000011248 coating agent Substances 0.000 abstract 2
238000000576 coating method Methods 0.000 abstract 2
239000008187 granular material Substances 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
229920000168 Microcrystalline cellulose Polymers 0.000 abstract 1
235000010980 cellulose Nutrition 0.000 abstract 1
229920002678 cellulose Polymers 0.000 abstract 1
239000001913 cellulose Substances 0.000 abstract 1
235000019813 microcrystalline cellulose Nutrition 0.000 abstract 1
239000008108 microcrystalline cellulose Substances 0.000 abstract 1
229940016286 microcrystalline cellulose Drugs 0.000 abstract 1
229920000058 polyacrylate Polymers 0.000 abstract 1
238000013268 sustained release Methods 0.000 abstract 1
239000012730 sustained-release form Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Rheumatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

AT87306837T 1986-08-01 1987-07-31 Ibuprofen-formulation mit verzoegerter wirkstoffabgabe. ATE60228T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB868618811A GB8618811D0 (en)	1986-08-01	1986-08-01	Sustained release ibuprofen formulation
EP87306837A EP0255404B1 (de)	1986-08-01	1987-07-31	Ibuprofen-Formulation mit verzögerter Wirkstoffabgabe

Publications (1)

Publication Number	Publication Date
ATE60228T1 true ATE60228T1 (de)	1991-02-15

Family

ID=10602077

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87306837T ATE60228T1 (de)	1986-08-01	1987-07-31	Ibuprofen-formulation mit verzoegerter wirkstoffabgabe.

Country Status (7)

Country	Link
US (1)	US4900558A (de)
EP (1)	EP0255404B1 (de)
JP (1)	JPS63107917A (de)
AT (1)	ATE60228T1 (de)
DE (1)	DE3767600D1 (de)
ES (1)	ES2020277B3 (de)
GB (1)	GB8618811D0 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8705083D0 (en) *	1987-03-04	1987-04-08	Euro Celtique Sa	Spheroids
GB8722306D0 (en) *	1987-09-22	1987-10-28	Aps Research Ltd	Sustained-release formulation
GB8724763D0 (en) *	1987-10-22	1987-11-25	Aps Research Ltd	Sustained-release formulations
EP0330284B1 (de) *	1988-02-25	1994-07-27	Yamanouchi Europe B.V.	Verfahren zur Herstellung eines pharmazeutischen Granulats
US5009895A (en) *	1990-02-02	1991-04-23	Merck & Co., Inc.	Sustained release with high and low viscosity HPMC
EP0452862B1 (de) *	1990-04-18	1995-07-19	Asahi Kasei Kogyo Kabushiki Kaisha	Kugelförmige Keimkerne, kugelförmige Granulate sowie Verfahren zu deren Herstellung
JP2542122B2 (ja) *	1990-04-18	1996-10-09	旭化成工業株式会社	球状核、球形顆粒およびその製造方法
US5213807A (en) *	1990-05-03	1993-05-25	Chemburkar Pramod B	Pharmaceutical composition containing ibuprofen and a prostaglandin
US5075114A (en) *	1990-05-23	1991-12-24	Mcneil-Ppc, Inc.	Taste masking and sustained release coatings for pharmaceuticals
US5460825A (en) *	1990-05-23	1995-10-24	Mcneil-Ppc, Inc.	Taste mask coatings for preparing chewable pharmaceutical tablets
SE9002017D0 (sv) *	1990-06-06	1990-06-06	Kabivitrum Ab	Process for manufacture of matrices
WO1992001446A1 (en) *	1990-07-20	1992-02-06	Aps Research Limited	Sustained-release formulations
GB9025372D0 (en) *	1990-11-22	1991-01-09	Nat Res Dev	Pharmaceutical dosage forms
US5376384A (en) *	1992-12-23	1994-12-27	Kinaform Technology, Inc.	Delayed, sustained-release pharmaceutical preparation
SE9301220D0 (sv) *	1993-04-14	1993-04-14	Kabi Pharmacia Ab	Manufacturing matrices
KR950007873A (ko) *	1993-09-20	1995-04-15	후꾸하라 요시하루	생리 활성 물질 지속 방출형의 의약 제제
US5874029A (en) *	1996-10-09	1999-02-23	The University Of Kansas	Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
US5833891A (en) *	1996-10-09	1998-11-10	The University Of Kansas	Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
NZ333474A (en) *	1998-01-02	1999-06-29	Mcneil Ppc Inc	A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat
US7122207B2 (en)	1998-05-22	2006-10-17	Bristol-Myers Squibb Company	High drug load acid labile pharmaceutical composition
UA69413C2 (uk) *	1998-05-22	2004-09-15	Брістол-Майерс Сквібб Компані	Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції
GB2367002A (en) *	2000-09-25	2002-03-27	British Sugar Plc	Coating composition
JP2004525109A (ja)	2001-02-15	2004-08-19	キング・ファーマシューティカルズ・インコーポレイティッド	安定化された甲状腺ホルモン医薬組成物、及びその製法
US7101569B2 (en)	2001-08-14	2006-09-05	Franz G Andrew	Methods of administering levothyroxine pharmaceutical compositions
JP4331930B2 (ja) *	2001-10-17	2009-09-16	武田薬品工業株式会社	酸に不安定な薬物の高含量顆粒
US9060941B2 (en) *	2002-09-20	2015-06-23	Actavis, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7959946B2 (en)	2002-09-20	2011-06-14	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7785627B2 (en) *	2002-09-20	2010-08-31	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
EP2717860A4 (de) *	2011-06-08	2014-11-05	Sti Pharma Llc	Formulierung aus einer wasserlöslichen und pharmazeutisch wirksamen organischen verbindung mit gesteuerter absorption zur einmal täglichen anwendung
CN105343033B (zh) *	2015-12-14	2018-03-20	西南药业股份有限公司	一种布洛芬缓释微丸及其制备方法
CN106924205A (zh) *	2015-12-29	2017-07-07	北京阜康仁生物制药科技有限公司	一种含有Baricitinib的缓释制剂

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1561204A (en) *	1977-06-01	1980-02-13	Ici Ltd	Sustained release pharmaceutical composition
DD146547A5 (de) *	1978-07-15	1981-02-18	Boehringer Sohn Ingelheim	Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen
US4205060A (en) *	1978-12-20	1980-05-27	Pennwalt Corporation	Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use
CA1146866A (en) *	1979-07-05	1983-05-24	Yamanouchi Pharmaceutical Co. Ltd.	Process for the production of sustained release pharmaceutical composition of solid medical material
US4555399A (en) *	1983-11-18	1985-11-26	Key Pharmaceuticals, Inc.	Aspirin tablet
US4609675A (en) *	1984-08-17	1986-09-02	The Upjohn Company	Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing
US4772475A (en) *	1985-03-08	1988-09-20	Yamanouchi Pharmaceutical Co., Ltd.	Controlled-release multiple units pharmaceutical formulation
US4695591A (en) *	1985-03-29	1987-09-22	Schering Corporation	Controlled release dosage forms comprising hydroxypropylmethylcellulose
CH666405A5 (de) *	1985-06-24	1988-07-29	Ciba Geigy Ag	Feste, haltbare darreichungsformen mit elastischem filmueberzug.
US4710384A (en) *	1986-07-28	1987-12-01	Avner Rotman	Sustained release tablets made from microcapsules

1986
- 1986-08-01 GB GB868618811A patent/GB8618811D0/en active Pending
1987
- 1987-07-30 US US07/079,206 patent/US4900558A/en not_active Expired - Lifetime
- 1987-07-31 JP JP62192545A patent/JPS63107917A/ja active Pending
- 1987-07-31 ES ES87306837T patent/ES2020277B3/es not_active Expired - Lifetime
- 1987-07-31 AT AT87306837T patent/ATE60228T1/de not_active IP Right Cessation
- 1987-07-31 EP EP87306837A patent/EP0255404B1/de not_active Expired - Lifetime
- 1987-07-31 DE DE8787306837T patent/DE3767600D1/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US4900558A (en)	1990-02-13
JPS63107917A (ja)	1988-05-12
DE3767600D1 (de)	1991-02-28
GB8618811D0 (en)	1986-09-10
EP0255404B1 (de)	1991-01-23
EP0255404A1 (de)	1988-02-03
ES2020277B3 (es)	1991-08-01

Legal Events

Date	Code	Title	Description
1991-09-15	UEP	Publication of translation of european patent specification
1994-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
GB8618811D0 (en)	1986-09-10	Sustained release ibuprofen formulation
NO853407L (no)	1986-03-07	Preparat med kontrollert utskillelse av virkestoff.
NO167183C (no)	1991-10-16	Fremgangsmaate for fremstilling av et utleveringssystem hvor kjernematerialet beskyttes av et matriks-belegg.
DK0946145T3 (da)	2008-12-15	Antitussive lægemidler afgivet af ionbytterharpikser
EP0213083A3 (de)	1988-02-03	Tablette mit gesteuerter Wirkstoffabgabe
DE3855852D1 (de)	1997-05-07	Kugelförmige Granula mit Kern sowie deren Herstellung
FI103475B1 (fi)	1999-07-15	Menetelmä kontrolloidusti vapauttavan valmisteen valmistamiseksi
SE8603247D0 (sv)	1986-07-29	Farmaceutiskt granulat
ES2080796T3 (es)	1996-02-16	Formulaciones de productos farmaceuticos de liberacion prolongada.
FI912952A0 (fi)	1991-06-18	Kontrollerbart frigoerande farmaceutiskt preparat.
SE8600402D0 (sv)	1986-01-30	Forfarande for behandling av doseringsformer
FR2704146B1 (fr)	1995-07-13	Microcapsules d'acide acétylsalicylique à libération contrôlée.
KR880001289A (ko)	1988-04-22	서방성 제제 및 그의 제조방법
FI823420L (fi)	1983-04-16	Enteriska mikrokapslar och foerfarande foer deras framstaellning
IE883810L (en)	1989-06-21	Sustained release pharmaceutical compositions
GB8913889D0 (en)	1989-08-02	New compositions of matter
JPS52139715A (en)	1977-11-21	Coated granules of alkali polyacrylate
SE8803822D0 (sv)	1988-10-26	Novel dosage form
NO153418C (no)	1986-03-19	Fremgangsmaate for fremstilling av et preparat av terapeutisk brukbar galaktomannan.
NO153638C (no)	1986-05-07	Polymer diffusjonsmatrise for forlenget frigivelse av et legemiddel.
NO307093B1 (no)	2000-02-07	Fremgangsmåte for fremstilling av et baryttkjelestensinhiberende preparat
FI101855B1 (fi)	1998-09-15	Menetelmä asetatsolamidia jatkuvasti vapauttavan asetatsolamidivalmisteen valmistamiseksi
JPS56121438A (en)	1981-09-24	Bait for fishing
NO873571D0 (no)	1987-08-24	Fremgangsmaate for fremstilling av et terapeutisk virksomt preparat.
MY101518A (en)	1991-11-30	Sustained release quinidine dosage form.