ATE61405T1 - Hybride dns-synthese von reifem wachstumshormonausloesendem faktor. - Google Patents

Hybride dns-synthese von reifem wachstumshormonausloesendem faktor.

Info

Publication number: ATE61405T1
Authority: AT; Austria
Prior art keywords: growth hormone; dna synthesis; hybrid dna; mature growth; trigger
Prior art date: 1983-05-25

Application number

AT84105666T

Other languages

English (en)

Inventor

Philip J Barr

Anthony J Brake

Guy T Mullenbach

Original Assignee

Chiron Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-05-25

Filing date

1984-05-18

Publication date

1991-03-15

1984-05-18 Application filed by Chiron Corp filed Critical Chiron Corp

1991-03-15 Application granted granted Critical

1991-03-15 Publication of ATE61405T1 publication Critical patent/ATE61405T1/de

Links

230000006820 DNA synthesis Effects 0.000 title 1
102000018997 Growth Hormone Human genes 0.000 title 1
108010051696 Growth Hormone Proteins 0.000 title 1
239000000122 growth hormone Substances 0.000 title 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 abstract 1
239000000095 Growth Hormone-Releasing Hormone Substances 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
101710142969 Somatoliberin Proteins 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1
230000003248 secreting effect Effects 0.000 abstract 1
238000013518 transcription Methods 0.000 abstract 1
230000035897 transcription Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Mycology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT84105666T 1983-05-25 1984-05-18 Hybride dns-synthese von reifem wachstumshormonausloesendem faktor. ATE61405T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US49777683A	1983-05-25	1983-05-25
EP84105666A EP0129073B1 (de)	1983-05-25	1984-05-18	Hybride DNS-Synthese von reifem wachstumshormonauslösendem Faktor

Publications (1)

Publication Number	Publication Date
ATE61405T1 true ATE61405T1 (de)	1991-03-15

Family

ID=23978259

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT84105666T ATE61405T1 (de)	1983-05-25	1984-05-18	Hybride dns-synthese von reifem wachstumshormonausloesendem faktor.

Country Status (4)

Country	Link
EP (1)	EP0129073B1 (de)
JP (1)	JPS59227899A (de)
AT (1)	ATE61405T1 (de)
DE (1)	DE3484212D1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7198919B1 (en)	1983-04-25	2007-04-03	Genentech, Inc.	Use of alpha factor sequences in yeast expression systems
NZ207926A (en) *	1983-04-25	1988-04-29	Genentech Inc	Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast
IT1234977B (it)	1985-03-22	1992-06-09	Serono Ist Farm	Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita
FR2593518B1 (fr) *	1985-05-02	1989-09-08	Transgene Sa	Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
US5821079A (en) *	1985-05-02	1998-10-13	Transgene S.A.	Vectors for the expression and secretion of hirudin by transformed yeasts
FR2587359B1 (fr) *	1985-05-28	1987-12-24	Sanofi Sa	Derives non amides de la somatocrinine et procede de preparation par genie genetique
GB8513645D0 (en) *	1985-05-30	1985-07-03	Kingsman A J	Expression vector
JPS6236183A (ja) *	1985-06-20	1987-02-17	ザ・サルク・インステイチユ−ト・バイオテクノロジ−／インダストリアル・アソシエイツ・インコ−ポレ−テツド	サツカロミセス・セレビシエからのポリペプチドの発現および分泌
DE3540075A1 (de) *	1985-11-12	1987-05-14	Boehringer Ingelheim Int	Human-lysozym
EP0234871A3 (de) *	1986-02-28	1988-10-12	Merck & Co. Inc.	Regulierbare Expression rekombinanter Proteine in Hefe
EP0234862A3 (de) *	1986-02-28	1988-10-05	Merck & Co. Inc.	Expression rekombinanter Proteine in Hefe
US4828988A (en) *	1986-05-15	1989-05-09	Smith Kline - Rit	Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine
FR2599380A1 (fr) *	1986-05-29	1987-12-04	Centre Nat Rech Scient	Vecteur d'exportation de proteines chez escherichiacoli, bacteries transformees et procede pour la preparation de proteines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0108387B1 (de) *	1982-11-04	1990-05-16	F. Hoffmann-La Roche Ag	Hestellung von rekombinanten wachstumsauslösenden Faktoren

1984
- 1984-05-11 JP JP59093070A patent/JPS59227899A/ja active Pending
- 1984-05-18 EP EP84105666A patent/EP0129073B1/de not_active Expired - Lifetime
- 1984-05-18 DE DE8484105666T patent/DE3484212D1/de not_active Expired - Fee Related
- 1984-05-18 AT AT84105666T patent/ATE61405T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0129073A1 (de)	1984-12-27
EP0129073B1 (de)	1991-03-06
DE3484212D1 (de)	1991-04-11
JPS59227899A (ja)	1984-12-21

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Legal Events

Date	Code	Title	Description
1992-01-15	UEP	Publication of translation of european patent specification
1993-02-15	REN	Ceased due to non-payment of the annual fee