ATE71661T1 - Hybrid-dns-synthese von insulin. - Google Patents

Hybrid-dns-synthese von insulin.

Info

Publication number: ATE71661T1
Authority: AT; Austria
Prior art keywords: insulin; dna synthesis; hybrid dna; secretion; pyins1
Prior art date: 1983-04-07

Application number

AT84103611T

Other languages

English (en)

Inventor

Anthony J Brake

Lawrence S Cousens

Mikey S Urdea

Pablo D T Valenzuela

Original Assignee

Chiron Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-07

Filing date

1984-04-02

Publication date

1992-02-15

1984-04-02 Application filed by Chiron Corp filed Critical Chiron Corp

1992-02-15 Application granted granted Critical

1992-02-15 Publication of ATE71661T1 publication Critical patent/ATE71661T1/de

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
230000006820 DNA synthesis Effects 0.000 title 1
230000028327 secretion Effects 0.000 abstract 2
108010076181 Proinsulin Proteins 0.000 abstract 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
235000015097 nutrients Nutrition 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Mycology (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)

AT84103611T 1983-04-07 1984-04-02 Hybrid-dns-synthese von insulin. ATE71661T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US48302383A	1983-04-07	1983-04-07
EP84103611A EP0121884B1 (de)	1983-04-07	1984-04-02	Hybrid-DNS-Synthese von Insulin

Publications (1)

Publication Number	Publication Date
ATE71661T1 true ATE71661T1 (de)	1992-02-15

Family

ID=23918330

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT84103611T ATE71661T1 (de)	1983-04-07	1984-04-02	Hybrid-dns-synthese von insulin.

Country Status (6)

Country	Link
EP (1)	EP0121884B1 (de)
JP (2)	JP2512416B2 (de)
AT (1)	ATE71661T1 (de)
CA (1)	CA1341372C (de)
DE (1)	DE3485444D1 (de)
DK (1)	DK172738B1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7198919B1 (en)	1983-04-25	2007-04-03	Genentech, Inc.	Use of alpha factor sequences in yeast expression systems
NZ207926A (en) *	1983-04-25	1988-04-29	Genentech Inc	Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
DE3587205T2 (de) *	1984-07-30	1993-08-26	Wakunaga Seiyaku Kk	Verfahren zur herstellung eines proteins und dafuer zu verwendender vektor, rekombinante dns und transformierte zelle.
JP2549504B2 (ja) *	1984-12-21	1996-10-30	ア−ス製薬株式会社	Ｄｎａ塩基配列、ポリペプチド分泌発現ベクター及び形質転換微生物
DK129385A (da) *	1985-03-22	1986-09-23	Novo Industri As	Peptider og fremstilling deraf
EP0201208B1 (de) *	1985-04-09	1992-07-15	Collaborative Research Inc.	Mutanten von Saccharomyces cerevisiae mit stark vermehrter Sekretion
JPS61271988A (ja) *	1985-05-27	1986-12-02	Agency Of Ind Science & Technol	プラスミド
RU2091490C1 (ru) *	1985-10-25	1997-09-27	Зимодженетикс, Инк.	Способ получения гетерологичного полипептида в эукариотических микроорганизмов
US5024941A (en) *	1985-12-18	1991-06-18	Biotechnica International, Inc.	Expression and secretion vector for yeast containing a glucoamylase signal sequence
US5037743A (en) *	1988-08-05	1991-08-06	Zymogenetics, Inc.	BAR1 secretion signal
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
DE4336810A1 (de) *	1993-10-28	1995-05-18	Basf Ag	Verfahren zur rekombinanten Herstellung von Proteinen in Hefe
US6142857A (en) *	1998-01-06	2000-11-07	Speedfam-Ipec Corporation	Wafer polishing with improved backing arrangement
JPH11300608A (ja) *	1998-04-20	1999-11-02	Nec Corp	化学機械研磨装置
JP2003530838A (ja)	2000-04-12	2003-10-21	ヒューマンゲノムサイエンシズインコーポレイテッド	アルブミン融合タンパク質
ES2425738T3 (es)	2001-12-21	2013-10-17	Human Genome Sciences, Inc.	Proteínas de fusión de la albúmina
EP1594530A4 (de)	2003-01-22	2006-10-11	Human Genome Sciences Inc	Albuminfusionsproteine
CN120060321A (zh)	2014-02-28	2025-05-30	诺和诺德股份有限公司	交配因子α原肽变体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ207926A (en) *	1983-04-25	1988-04-29	Genentech Inc	Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast

1984
- 1984-02-23 DK DK198400927A patent/DK172738B1/da not_active IP Right Cessation
- 1984-02-29 CA CA000448492A patent/CA1341372C/en not_active Expired - Fee Related
- 1984-03-23 JP JP59054554A patent/JP2512416B2/ja not_active Expired - Lifetime
- 1984-04-02 AT AT84103611T patent/ATE71661T1/de not_active IP Right Cessation
- 1984-04-02 EP EP84103611A patent/EP0121884B1/de not_active Expired - Lifetime
- 1984-04-02 DE DE8484103611T patent/DE3485444D1/de not_active Expired - Lifetime
1994
- 1994-08-08 JP JP6185950A patent/JP2511251B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH0767665A (ja)	1995-03-14
DK92784A (da)	1984-10-08
EP0121884A2 (de)	1984-10-17
DK172738B1 (da)	1999-06-21
DK92784D0 (da)	1984-02-23
JP2511251B2 (ja)	1996-06-26
JP2512416B2 (ja)	1996-07-03
EP0121884B1 (de)	1992-01-15
JPS59196093A (ja)	1984-11-07
CA1341372C (en)	2002-07-02
EP0121884A3 (en)	1987-01-14
DE3485444D1 (de)	1992-02-27

Legal Events

Date	Code	Title	Description
1992-10-15	UEP	Publication of translation of european patent specification
2004-07-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
DE3485444D1 (de)	1992-02-27	Hybrid-dns-synthese von insulin.
ES8500324A1 (es)	1984-11-01	Procedimiento para la obtencion de proteina heterologa.
AU586855B2 (en)	1989-07-27	Insulin precursors, process for their preparation and process for the preparation of human insulin
SE8100713L (sv)	1981-08-07	Fermentationsforfarande
ATE79900T1 (de)	1992-09-15	Tierzellenkultur.
EP0283942A3 (en)	1989-11-15	Basal nutrient medium for cell culture
ATE77104T1 (de)	1992-06-15	Menge und verfahren zur herstellung rekombinierter erzeugnisse in grosser ausbeute.
AU551726B2 (en)	1986-05-08	Cocultures production of butanol by fermentation
EP0248637A3 (de)	1988-11-17	Induktion von Galaktose regulierter Genexpression in Hefe
AU7387287A (en)	1987-12-10	Process for producing biologically active plasminogen activator
AU7126487A (en)	1987-10-09	Production of proteins by cell culture
AU621810B2 (en)	1992-03-26	Amylolytic enzymes producing microorganisms, constructed by recombinant DNA technology and their use for fermentation processes
AU589896B2 (en)	1989-10-26	A genetic engineering process for the preparation of human interleukin-2 and means for carrying out this process
ES2057183T3 (es)	1994-10-16	Procedimiento para la obtencion de lisozima humano.
EP0310056A3 (de)	1989-06-14	T-Zellen-Wachstumsfaktor aus Thymusdrüsen-Stroma und Verfahren zu seiner Herstellung
DE3264296D1 (en)	1985-07-25	Process for culturing human fibroblasts and fibroblast-like cells
ATE129287T1 (de)	1995-11-15	Bakterielles kollagenase-gen.
AU5009679A (en)	1980-02-28	Purified serum factors in animal cell culture medium
AU6280686A (en)	1987-03-05	Process for the production of a protein-vitamin food supplement from autotrophic micro-organism, in particular for alga spirulina
ATE97958T1 (de)	1993-12-15	Zellenzuchtverfahren fuer die produktion von aktiviertem protein-c.
EP0313009A3 (de)	1989-11-23	Verfahren zur Genamplifikation zur Erhöhung der Proteinproduktion in kultivierten tierischen Zellen
JPS57146579A (en)	1982-09-10	Increased production of cellulase
Breierova et al.	1982	Effect of sulphur dioxide on biological purity of production yeast culture.
AU3628384A (en)	1985-06-13	Production of single cell protein and sucrose by fermentation
EP0169907A4 (de)	1986-07-24	Herstellungsverfahren von polypeptiden mit zutat von zucker.